Hydrogen sulphide-releasing diclofenac derivatives inhibit breast cancer-induced osteoclastogenesis in vitro and prevent osteolysis ex vivo

British Journal of Pharmacology

Volumn 165, Issue 6, 2012, Pages 1914-1925

  Frantzias, J ^a   Logan, J G ^a   Mollat, P ^b   Sparatore, A ^c   Del Soldato, P ^d   Ralston, S H ^a   Idris, A I ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b Galapagos SASU   (France)

^c UNIVERSITY OF MILAN   (Italy)

^d DoxaPharma Srl   (Italy)

Author keywords

4T1; breast cancer; diclofenac; hydrogen sulphide; MCF7; MDA MB 231; NSAID; osteoblast; osteoclast

Indexed keywords

2 [(2,6 DICHLOROPHENYL)AMINO]BENZENEACETIC ACID 4 (3 THIOXO 3H 1,2 DITHIOL 5 YL)PHENYL ESTER; ACS 15; ACS 32; CASPASE 3; DICLOFENAC; DICLOFENAC DERIVATIVE; I KAPPA B BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; OSTEOCLAST DIFFERENTIATION FACTOR; UNCLASSIFIED DRUG; [3 (2,6 DICHLOROPHENYLAMINO)PHENYL]ACETIC ACID 2 METHANESULPHONYLSULPHANYL ETHYL ESTER;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALVARIA; CELL DIFFERENTIATION; CELL VIABILITY; CONTROLLED STUDY; DRUG STRUCTURE; EX VIVO STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NEWBORN; NONHUMAN; OSTEOBLAST; OSTEOCLAST; OSTEOCLASTOGENESIS; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 84857042660     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01704.x     Document Type: Article

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