Folate dependence of hyperhomocysteinemia and vascular dysfunction in cystathionine β-synthase-deficient mice

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 279, Issue 3 48-3, 2000, Pages

  Lentz, Steven R ^a,b   Erger, Rochelle A ^a   Dayal, Sanjana ^b   Maeda, Nobuyo ^c   Malinow, M René ^d   Heistad, Donald D ^a,b   Faraci, Frank M ^b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Acetylcholine; Atherosclerosis; Endothelium; Homocysteine; Thrombomodulin

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; ACETYLCHOLINE; CYSTATHIONINE BETA SYNTHASE; FOLIC ACID; HOMOCYSTEINE; LM 485; NITROPRUSSIDE SODIUM; THROMBOMODULIN; VASODILATOR AGENT;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; ENDOTHELIUM CELL; ENDOTHELIUM INJURY; ENZYME DEFECT; FOLIC ACID BLOOD LEVEL; GENETIC ASSOCIATION; HOMOCYSTINURIA; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RISK FACTOR; VASCULAR DISEASE;

EID: 0033826673     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.2000.279.3.h970     Document Type: Article

References (39)

1. Hyperhomocysteinemia after an oral methionine load acutely impairs endothelial function in healthy adults
2. Atherosclerosis, vascular remodeling, and impairment of endothelium-dependent relaxation in genetically altered hyperlipidemic mice
3. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: Probable benefits of increasing folic acid intakes
4. Acute hyperhomocysteinemia and endothelial dysfunction
5. Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia. An effect, reversible with vitamin C therapy
6. Endothelial dysfunction in mice lacking the cystathionine β-synthase gene
7. Homocyst(e)ine and cardiovascular disease: A critical review of the epidemiologic evidence
8. Impaired relaxation of the carotid artery during activation of ATP-sensitive potassium channels in atherosclerotic monkeys
9. Responses of carotid artery in mice deficient in expression of the gene for endothelial NO synthase
10. The metabolism of homocysteine - Pathways and regulation
11. Oxidation of a specific methionine in thrombomodulin by activated neutrophil products blocks cofactor activity. A potential rapid mechanism for modulation of coagulation
12. Kinetics of plasma homocysteine in healthy subjects after peroral homocysteine loading
13. Tissue plasminogen activator binding to the annexin II tail domain - Direct modulation by homocysteine
14. An atherogenic stimulus homocysteine inhibits cofactor activity of thrombomodulin and enhances thrombomodulin expression in human umbilical vein endothelial cells
15. Hypertension in mice lacking the gene for endothelial nitric oxide synthase
16. Role of oxidant stress in endothelial dysfunction produced by experimental hyperhomocyst(e)inemia in humans
17. Protein expression, vascular reactivity and soluble guanylate cyclase activity in mice lacking the endothelial cell nitric oxide synthase: Contributions of NOS isoforms to blood pressure and heart rate control
18. Gene transfer of endothelial nitric oxide synthase (eNOS) in eNOS-deficient mice
19. Homocysteine and hypomethylation - A novel link to vascular disease
20. Homocysteine and vascular dysfunction
21. Mechanisms of thrombosis in hyperhomocysteinemia
22. Consequences of hyperhomocyst(e)inemia on vascular function in atherosclerotic monkeys
23. Inhibition of thrombomodulin surface expression and protein C activation by the thrombogenic agent homocysteine
24. The molecular basis of thrombomodulin function
25. Vascular dysfunction in monkeys with diet-induced hyperhomocyst(e)inemia
26. The oxidant stress of hyperhomocyst(e)inemia
27. Homocyst(e)ine, diet, and cardiovascular diseases - A statement for healthcare professionals from the Nutrition Committee, American Heart Association
28. Prevalence of hyperhomocyt(e)inemia in patients with peripheral arterial occlusive disease
29. Homocyst(e)inemia in daily practice: Levels in coronary artery disease
30. Homocysteine and vascular disease
31. Disorders of transsulfuration
32. Total homocysteine and cardiovascular disease
33. Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells
34. Homocysteine, an atherogenic stimulus, reduces protein C activation by arterial and venous endothelial cells
35. Dietary beta-carotene and alpha-tocopherol combination does not inhibit atherogenesis in an ApoE-deficient mouse model
36. Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen
37. Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase
38. Endothelial dysfunction by acute hyperhomocyst(e)inemia: Restoration by folic acid
39. Mice deficient in cystathionine beta-synthase: Animal models for mild and severe homocyst(e)inemia