-
1
-
-
0028053053
-
Conservation analysis and structure prediction of the protein serine/threonine phosphatases. Sequence similarity with diadenosine tetraphosphatase from Escherichia coli suggests homology to the protein phosphatases
-
Barton GJ, Cohen PT, Barford D, (1994) Conservation analysis and structure prediction of the protein serine/threonine phosphatases. Sequence similarity with diadenosine tetraphosphatase from Escherichia coli suggests homology to the protein phosphatases. Eur J Biochem 220: 225-237.
-
(1994)
Eur J Biochem
, vol.220
, pp. 225-237
-
-
Barton, G.J.1
Cohen, P.T.2
Barford, D.3
-
2
-
-
0031860103
-
The structure and mechanism of protein phosphatases: insights into catalysis and regulation
-
Barford D, Das AK, Egloff MP, (1998) The structure and mechanism of protein phosphatases: insights into catalysis and regulation. Annu Rev Biophys Biomol Struct 27: 133-164.
-
(1998)
Annu Rev Biophys Biomol Struct
, vol.27
, pp. 133-164
-
-
Barford, D.1
Das, A.K.2
Egloff, M.P.3
-
3
-
-
36849053513
-
Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling
-
Lammers T, Lavi S, (2007) Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling. Crit Rev Biochem Mol Biol 42: 437-461.
-
(2007)
Crit Rev Biochem Mol Biol
, vol.42
, pp. 437-461
-
-
Lammers, T.1
Lavi, S.2
-
4
-
-
33845881426
-
Evolution of the metazoan protein phosphatase 2C superfamily
-
Stern A, Privman E, Rasis M, Lavi S, Pupko T, (2007) Evolution of the metazoan protein phosphatase 2C superfamily. J Mol Evol 64: 61-70.
-
(2007)
J Mol Evol
, vol.64
, pp. 61-70
-
-
Stern, A.1
Privman, E.2
Rasis, M.3
Lavi, S.4
Pupko, T.5
-
5
-
-
0032541227
-
Protein phosphatase 2Calpha inhibits the human stress-responsive p38 and JNK MAPK pathways
-
Takekawa M, Maeda T, Saito H, (1998) Protein phosphatase 2Calpha inhibits the human stress-responsive p38 and JNK MAPK pathways. EMBO J 17: 4744-4752.
-
(1998)
EMBO J
, vol.17
, pp. 4744-4752
-
-
Takekawa, M.1
Maeda, T.2
Saito, H.3
-
6
-
-
0035937111
-
Regulation of the TAK1 signaling pathway by protein phosphatase 2C
-
Hanada M, Ninomiya-Tsuji J, Komaki K, Ohnishi M, Katsura K, et al. (2001) Regulation of the TAK1 signaling pathway by protein phosphatase 2C. J Biol Chem 276: 5753-5759.
-
(2001)
J Biol Chem
, vol.276
, pp. 5753-5759
-
-
Hanada, M.1
Ninomiya-Tsuji, J.2
Komaki, K.3
Ohnishi, M.4
Katsura, K.5
-
7
-
-
0032751695
-
Dephosphorylation of cyclin-dependent kinases by type 2C protein phosphatases
-
Cheng A, Ross KE, Kaldis P, Solomon MJ, (1999) Dephosphorylation of cyclin-dependent kinases by type 2C protein phosphatases. Genes Dev 13: 2946-2957.
-
(1999)
Genes Dev
, vol.13
, pp. 2946-2957
-
-
Cheng, A.1
Ross, K.E.2
Kaldis, P.3
Solomon, M.J.4
-
8
-
-
0034602268
-
Dephosphorylation of human cyclin-dependent kinases by protein phosphatase type 2C alpha and beta 2 isoforms
-
Cheng A, Kaldis P, Solomon MJ, (2000) Dephosphorylation of human cyclin-dependent kinases by protein phosphatase type 2C alpha and beta 2 isoforms. J Biol Chem 275: 34744-34749.
-
(2000)
J Biol Chem
, vol.275
, pp. 34744-34749
-
-
Cheng, A.1
Kaldis, P.2
Solomon, M.J.3
-
9
-
-
0035929214
-
Uniquely conserved non-translated regions are involved in generation of the two major transcripts of protein phosphatase 2Cbeta
-
Seroussi E, Shani N, Ben-Meir D, Chajut A, Divinski I, et al. (2001) Uniquely conserved non-translated regions are involved in generation of the two major transcripts of protein phosphatase 2Cbeta. J Mol Biol 312: 439-451.
-
(2001)
J Mol Biol
, vol.312
, pp. 439-451
-
-
Seroussi, E.1
Shani, N.2
Ben-Meir, D.3
Chajut, A.4
Divinski, I.5
-
10
-
-
0345096584
-
An inducible system to study the growth arrest properties of protein phosphatase 2C
-
Ofek P, Ben-Meir D, Lavi S, (2003) An inducible system to study the growth arrest properties of protein phosphatase 2C. Methods Enzymol 366: 338-347.
-
(2003)
Methods Enzymol
, vol.366
, pp. 338-347
-
-
Ofek, P.1
Ben-Meir, D.2
Lavi, S.3
-
11
-
-
0037515747
-
Cell cycle regulation and p53 activation by protein phosphatase 2C alpha
-
Ofek P, Ben-Meir D, Kariv-Inbal Z, Oren M, Lavi S, (2003) Cell cycle regulation and p53 activation by protein phosphatase 2C alpha. J Biol Chem 278: 14299-14305.
-
(2003)
J Biol Chem
, vol.278
, pp. 14299-14305
-
-
Ofek, P.1
Ben-Meir, D.2
Kariv-Inbal, Z.3
Oren, M.4
Lavi, S.5
-
12
-
-
36849029929
-
Role of PP2Calpha in cell growth, in radio- and chemosensitivity, and in tumorigenicity
-
Lammers T, Peschke P, Ehemann V, Debus J, Slobodin B, et al. (2007) Role of PP2Calpha in cell growth, in radio- and chemosensitivity, and in tumorigenicity. Mol Cancer 6: 65.
-
(2007)
Mol Cancer
, vol.6
, pp. 65
-
-
Lammers, T.1
Peschke, P.2
Ehemann, V.3
Debus, J.4
Slobodin, B.5
-
13
-
-
0026594109
-
Localization of mRNA for protein phosphatase 2C in the brain of adult rats
-
Abe H, Tamura S, Kondo H, (1992) Localization of mRNA for protein phosphatase 2C in the brain of adult rats. Brain Res Mol Brain Res 13: 283-288.
-
(1992)
Brain Res Mol Brain Res
, vol.13
, pp. 283-288
-
-
Abe, H.1
Tamura, S.2
Kondo, H.3
-
14
-
-
0034743213
-
Protein phosphatase 2Calpha expression in normal human tissues: an immunohistochemical study
-
Lifschitz-Mercer B, Sheinin Y, Ben-Meir D, Bramante-Schreiber L, Leider-Trejo L, et al. (2001) Protein phosphatase 2Calpha expression in normal human tissues: an immunohistochemical study. Histochem Cell Biol 116: 31-39.
-
(2001)
Histochem Cell Biol
, vol.116
, pp. 31-39
-
-
Lifschitz-Mercer, B.1
Sheinin, Y.2
Ben-Meir, D.3
Bramante-Schreiber, L.4
Leider-Trejo, L.5
-
15
-
-
0033153258
-
Brain protein serine/threonine phosphatases
-
Price NE, Mumby MC, (1999) Brain protein serine/threonine phosphatases. Curr Opin Neurobiol 9: 336-342.
-
(1999)
Curr Opin Neurobiol
, vol.9
, pp. 336-342
-
-
Price, N.E.1
Mumby, M.C.2
-
16
-
-
0030561862
-
Gene activation pathways of nerve growth factor signaling: a minireview
-
Szeberenyi J, (1996) Gene activation pathways of nerve growth factor signaling: a minireview. Neurobiology (Bp) 4: 1-11.
-
(1996)
Neurobiology (Bp)
, vol.4
, pp. 1-11
-
-
Szeberenyi, J.1
-
17
-
-
0037205044
-
Signaling pathways for PC12 cell differentiation: making the right connections
-
Vaudry D, Stork PJ, Lazarovici P, Eiden LE, (2002) Signaling pathways for PC12 cell differentiation: making the right connections. Science 296: 1648-1649.
-
(2002)
Science
, vol.296
, pp. 1648-1649
-
-
Vaudry, D.1
Stork, P.J.2
Lazarovici, P.3
Eiden, L.E.4
-
18
-
-
8344236658
-
Useful cell lines derived from the adrenal medulla
-
Eaton MJ, Duplan H, (2004) Useful cell lines derived from the adrenal medulla. Mol Cell Endocrinol 228: 39-52.
-
(2004)
Mol Cell Endocrinol
, vol.228
, pp. 39-52
-
-
Eaton, M.J.1
Duplan, H.2
-
19
-
-
0036830613
-
Overexpression of the protein phosphatase 2A regulatory subunit Bgamma promotes neuronal differentiation by activating the MAP kinase (MAPK) cascade
-
Strack S, (2002) Overexpression of the protein phosphatase 2A regulatory subunit Bgamma promotes neuronal differentiation by activating the MAP kinase (MAPK) cascade. J Biol Chem 277: 41525-41532.
-
(2002)
J Biol Chem
, vol.277
, pp. 41525-41532
-
-
Strack, S.1
-
20
-
-
0141432134
-
Differential roles of ERK and JNK in early and late stages of neuritogenesis: a study in a novel PC12 model system
-
Xiao J, Liu Y, (2003) Differential roles of ERK and JNK in early and late stages of neuritogenesis: a study in a novel PC12 model system. J Neurochem 86: 1516-1523.
-
(2003)
J Neurochem
, vol.86
, pp. 1516-1523
-
-
Xiao, J.1
Liu, Y.2
-
21
-
-
0032522924
-
Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons
-
Crowder RJ, Freeman RS, (1998) Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons. J Neurosci 18: 2933-2943.
-
(1998)
J Neurosci
, vol.18
, pp. 2933-2943
-
-
Crowder, R.J.1
Freeman, R.S.2
-
22
-
-
0033563189
-
Trks: signal transduction and intracellular pathways
-
Klesse LJ, Parada LF, (1999) Trks: signal transduction and intracellular pathways. Microsc Res Tech 45: 210-216.
-
(1999)
Microsc Res Tech
, vol.45
, pp. 210-216
-
-
Klesse, L.J.1
Parada, L.F.2
-
23
-
-
0032544550
-
Requirement of p38 mitogen-activated protein kinase for neuronal differentiation in PC12 cells
-
Morooka T, Nishida E, (1998) Requirement of p38 mitogen-activated protein kinase for neuronal differentiation in PC12 cells. J Biol Chem 273: 24285-24288.
-
(1998)
J Biol Chem
, vol.273
, pp. 24285-24288
-
-
Morooka, T.1
Nishida, E.2
-
24
-
-
0033970158
-
JNK and p38 stresskinases-degenerative effectors of signal-transduction-cascades in the nervous system
-
Mielke K, Herdegen T, (2000) JNK and p38 stresskinases-degenerative effectors of signal-transduction-cascades in the nervous system. Prog Neurobiol 61: 45-60.
-
(2000)
Prog Neurobiol
, vol.61
, pp. 45-60
-
-
Mielke, K.1
Herdegen, T.2
-
25
-
-
0037134020
-
A system for stable expression of short interfering RNAs in mammalian cells
-
Brummelkamp TR, Bernards R, Agami R, (2002) A system for stable expression of short interfering RNAs in mammalian cells. Science 296: 550-553.
-
(2002)
Science
, vol.296
, pp. 550-553
-
-
Brummelkamp, T.R.1
Bernards, R.2
Agami, R.3
-
26
-
-
0023774747
-
Protein phosphatase-2C from rabbit skeletal muscle and liver: an Mg2+-dependent enzyme
-
McGowan CH, Cohen P, (1988) Protein phosphatase-2C from rabbit skeletal muscle and liver: an Mg2+-dependent enzyme. Methods Enzymol 159: 416-426.
-
(1988)
Methods Enzymol
, vol.159
, pp. 416-426
-
-
McGowan, C.H.1
Cohen, P.2
-
27
-
-
2342618936
-
Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression
-
Liang J, Slingerland JM, (2003) Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression. Cell Cycle 2: 339-345.
-
(2003)
Cell Cycle
, vol.2
, pp. 339-345
-
-
Liang, J.1
Slingerland, J.M.2
-
28
-
-
20744437413
-
Akt/protein kinase B-dependent phosphorylation and inactivation of WEE1Hu promote cell cycle progression at G2/M transition
-
Katayama K, Fujita N, Tsuruo T, (2005) Akt/protein kinase B-dependent phosphorylation and inactivation of WEE1Hu promote cell cycle progression at G2/M transition. Mol Cell Biol 25: 5725-5737.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 5725-5737
-
-
Katayama, K.1
Fujita, N.2
Tsuruo, T.3
-
30
-
-
0030750557
-
FIN13, a novel growth factor-inducible serine-threonine phosphatase which can inhibit cell cycle progression
-
Guthridge MA, Bellosta P, Tavoloni N, Basilico C, (1997) FIN13, a novel growth factor-inducible serine-threonine phosphatase which can inhibit cell cycle progression. Mol Cell Biol 17: 5485-5498.
-
(1997)
Mol Cell Biol
, vol.17
, pp. 5485-5498
-
-
Guthridge, M.A.1
Bellosta, P.2
Tavoloni, N.3
Basilico, C.4
-
31
-
-
0032567444
-
Cloning and characterization of a novel mammalian PP2C isozyme
-
Tong Y, Quirion R, Shen SH, (1998) Cloning and characterization of a novel mammalian PP2C isozyme. J Biol Chem 273: 35282-35290.
-
(1998)
J Biol Chem
, vol.273
, pp. 35282-35290
-
-
Tong, Y.1
Quirion, R.2
Shen, S.H.3
-
32
-
-
26444484932
-
Akt-induced promotion of cell-cycle progression at G2/M phase involves upregulation of NF-Y binding activity in PC12 cells
-
Lee SR, Park JH, Park EK, Chung CH, Kang SS, et al. (2005) Akt-induced promotion of cell-cycle progression at G2/M phase involves upregulation of NF-Y binding activity in PC12 cells. J Cell Physiol 205: 270-277.
-
(2005)
J Cell Physiol
, vol.205
, pp. 270-277
-
-
Lee, S.R.1
Park, J.H.2
Park, E.K.3
Chung, C.H.4
Kang, S.S.5
-
33
-
-
0037044838
-
Ceramide and reactive oxygen species generated by H2O2 induce caspase-3-independent degradation of Akt/protein kinase B
-
Martin D, Salinas M, Fujita N, Tsuruo T, Cuadrado A, (2002) Ceramide and reactive oxygen species generated by H2O2 induce caspase-3-independent degradation of Akt/protein kinase B. J Biol Chem 277: 42943-42952.
-
(2002)
J Biol Chem
, vol.277
, pp. 42943-42952
-
-
Martin, D.1
Salinas, M.2
Fujita, N.3
Tsuruo, T.4
Cuadrado, A.5
-
34
-
-
1642471831
-
PI3K/Akt and apoptosis: size matters
-
Franke TF, Hornik CP, Segev L, Shostak GA, Sugimoto C, (2003) PI3K/Akt and apoptosis: size matters. Oncogene 22: 8983-8998.
-
(2003)
Oncogene
, vol.22
, pp. 8983-8998
-
-
Franke, T.F.1
Hornik, C.P.2
Segev, L.3
Shostak, G.A.4
Sugimoto, C.5
-
35
-
-
0141482027
-
Akt as a mediator of cell death
-
Luo HR, Hattori H, Hossain MA, Hester L, Huang Y, et al. (2003) Akt as a mediator of cell death. Proc Natl Acad Sci U S A 100: 11712-11717.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 11712-11717
-
-
Luo, H.R.1
Hattori, H.2
Hossain, M.A.3
Hester, L.4
Huang, Y.5
-
36
-
-
0036063636
-
Relationship between protein phosphatase type-2C activity and induction of apoptosis in cultured neuronal cells
-
Klumpp S, Selke D, Ahlemeyer B, Schaper C, Krieglstein J, (2002) Relationship between protein phosphatase type-2C activity and induction of apoptosis in cultured neuronal cells. Neurochem Int 41: 251-259.
-
(2002)
Neurochem Int
, vol.41
, pp. 251-259
-
-
Klumpp, S.1
Selke, D.2
Ahlemeyer, B.3
Schaper, C.4
Krieglstein, J.5
-
37
-
-
34248670864
-
Protein phosphatases types 2Calpha and 2Cbeta in apoptosis
-
Klumpp S, Thissen MC, Krieglstein J, (2006) Protein phosphatases types 2Calpha and 2Cbeta in apoptosis. Biochem Soc Trans 34: 1370-1375.
-
(2006)
Biochem Soc Trans
, vol.34
, pp. 1370-1375
-
-
Klumpp, S.1
Thissen, M.C.2
Krieglstein, J.3
-
38
-
-
0037809234
-
Regulation of the interleukin-1-induced signaling pathways by a novel member of the protein phosphatase 2C family (PP2Cepsilon)
-
Li MG, Katsura K, Nomiyama H, Komaki K, Ninomiya-Tsuji J, et al. (2003) Regulation of the interleukin-1-induced signaling pathways by a novel member of the protein phosphatase 2C family (PP2Cepsilon). J Biol Chem 278: 12013-12021.
-
(2003)
J Biol Chem
, vol.278
, pp. 12013-12021
-
-
Li, M.G.1
Katsura, K.2
Nomiyama, H.3
Komaki, K.4
Ninomiya-Tsuji, J.5
-
39
-
-
2542475897
-
Protein phosphatase-2C alpha as a positive regulator of insulin sensitivity through direct activation of phosphatidylinositol 3-kinase in 3T3-L1 adipocytes
-
Yoshizaki T, Maegawa H, Egawa K, Ugi S, Nishio Y, et al. (2004) Protein phosphatase-2C alpha as a positive regulator of insulin sensitivity through direct activation of phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. J Biol Chem 279: 22715-22726.
-
(2004)
J Biol Chem
, vol.279
, pp. 22715-22726
-
-
Yoshizaki, T.1
Maegawa, H.2
Egawa, K.3
Ugi, S.4
Nishio, Y.5
-
40
-
-
0035964486
-
Trk receptor tyrosine kinases: a bridge between cancer and neural development
-
Nakagawara A, (2001) Trk receptor tyrosine kinases: a bridge between cancer and neural development. Cancer Lett 169: 107-114.
-
(2001)
Cancer Lett
, vol.169
, pp. 107-114
-
-
Nakagawara, A.1
-
41
-
-
0034941330
-
Nerve growth factor signaling, neuroprotection, and neural repair
-
Sofroniew MV, Howe CL, Mobley WC, (2001) Nerve growth factor signaling, neuroprotection, and neural repair. Annu Rev Neurosci 24: 1217-1281.
-
(2001)
Annu Rev Neurosci
, vol.24
, pp. 1217-1281
-
-
Sofroniew, M.V.1
Howe, C.L.2
Mobley, W.C.3
-
42
-
-
0032561413
-
Selective suppression of stress-activated protein kinase pathway by protein phosphatase 2C in mammalian cells
-
Hanada M, Kobayashi T, Ohnishi M, Ikeda S, Wang H, et al. (1998) Selective suppression of stress-activated protein kinase pathway by protein phosphatase 2C in mammalian cells. FEBS Lett 437: 172-176.
-
(1998)
FEBS Lett
, vol.437
, pp. 172-176
-
-
Hanada, M.1
Kobayashi, T.2
Ohnishi, M.3
Ikeda, S.4
Wang, H.5
-
43
-
-
0035150732
-
Overexpression of Akt inhibits NGF-induced growth arrest and neuronal differentiation of PC12 cells
-
Bang OS, Park EK, Yang SI, Lee SR, Franke TF, et al. (2001) Overexpression of Akt inhibits NGF-induced growth arrest and neuronal differentiation of PC12 cells. J Cell Sci 114: 81-88.
-
(2001)
J Cell Sci
, vol.114
, pp. 81-88
-
-
Bang, O.S.1
Park, E.K.2
Yang, S.I.3
Lee, S.R.4
Franke, T.F.5
-
44
-
-
1542723390
-
Inhibition of neuronal phenotype by PTEN in PC12 cells
-
Musatov S, Roberts J, Brooks AI, Pena J, Betchen S, et al. (2004) Inhibition of neuronal phenotype by PTEN in PC12 cells. Proc Natl Acad Sci U S A 101: 3627-3631.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 3627-3631
-
-
Musatov, S.1
Roberts, J.2
Brooks, A.I.3
Pena, J.4
Betchen, S.5
-
45
-
-
0036637660
-
PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum
-
Marino S, Krimpenfort P, Leung C, van der Korput HA, Trapman J, et al. (2002) PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum. Development 129: 3513-3522.
-
(2002)
Development
, vol.129
, pp. 3513-3522
-
-
Marino, S.1
Krimpenfort, P.2
Leung, C.3
van der Korput, H.A.4
Trapman, J.5
-
46
-
-
33745858715
-
Protein phosphatase type 2Calpha and 2Cbeta are involved in fatty acid-induced apoptosis of neuronal and endothelial cells
-
Schwarz S, Hufnagel B, Dworak M, Klumpp S, Krieglstein J, (2006) Protein phosphatase type 2Calpha and 2Cbeta are involved in fatty acid-induced apoptosis of neuronal and endothelial cells. Apoptosis 11: 1111-1119.
-
(2006)
Apoptosis
, vol.11
, pp. 1111-1119
-
-
Schwarz, S.1
Hufnagel, B.2
Dworak, M.3
Klumpp, S.4
Krieglstein, J.5
|