Threonine-290 regulates nuclear translocation of the human pregnane X receptor through its phosphorylation/dephosphorylation by Ca2+/calmodulin-dependent protein kinase II and protein phosphatase 1

Drug Metabolism and Disposition

Volumn 42, Issue 10, 2014, Pages 1708-1718

  Sugatani, Junko ^a   Hattori, Yoshiki ^a   Noguchi, Yuji ^a   Yamaguchi, Masahiko ^a   Yamazaki, Yasuhiro ^a   Ikari, Akira ^a,b  

^a UNIVERSITY OF SHIZUOKA   (Japan)

^b GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; HYBRID PROTEIN; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE 1; PREGNANE X RECEPTOR; RIFAMPICIN; ROSCOVITINE; SMALL INTERFERING RNA; THREONINE; THREONINE 290; UNCLASSIFIED DRUG; YELLOW FLUORESCENT PROTEIN; BENZYLAMINE DERIVATIVE; GLUCURONOSYLTRANSFERASE; HEAT SHOCK PROTEIN 90; PURINE DERIVATIVE; STEROID RECEPTOR; SULFONAMIDE; UGT1A1 ENZYME;

ARTICLE; CANCER CELL LINE; CELL NUCLEUS; CONTROLLED STUDY; CYTOPLASM; ENZYME ASSAY; GENETIC TRANSFECTION; HEPG2 CELL LINE; HUH6 CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER; MUTATION; NUCLEOTIDE SEQUENCE; PROTEIN DEPHOSPHORYLATION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; SW480 CELL LINE; WESTERN BLOTTING; WILD TYPE; ANIMAL; BIOSYNTHESIS; CELL LINE; CHEMISTRY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOUSE; PHOSPHORYLATION; PROTEIN TRANSPORT;

ANIMALS; BENZYLAMINES; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CELL LINE; CELL NUCLEUS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCURONOSYLTRANSFERASE; HSP90 HEAT-SHOCK PROTEINS; HUMANS; LIVER; MICE; MUTATION; OKADAIC ACID; PHOSPHORYLATION; PROTEIN PHOSPHATASE 1; PROTEIN TRANSPORT; PURINES; RECEPTORS, STEROID; RIFAMPIN; RNA, SMALL INTERFERING; SULFONAMIDES; THREONINE;

EID: 84907916714     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.114.059139     Document Type: Article

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