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Volumn 17, Issue 12, 2014, Pages 967-980

Cardio-protective and anti-cancer therapeutic potential of Nigella sativa

Author keywords

Anti diabetic; Cancer; Cardiovascular; Nigella sativa

Indexed keywords

ALKALOID; ALPHA HEDERIN; CASPASE 3; CASPASE 8; CASPASE 9; GLUCOSE; HEMOGLOBIN A1C; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MALONALDEHYDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NIGELLA SATIVA EXTRACT; PROTEIN BAX; PROTEIN BCL 2; SUPEROXIDE DISMUTASE; THYMOQUINONE; TRANSCRIPTION FACTOR E2F; TRIACYLGLYCEROL;

EID: 84921675411     PISSN: 20083866     EISSN: 20083874     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (58)

References (143)
  • 1
    • 79551627107 scopus 로고    scopus 로고
    • Nigella sativa Linn.–A comprehensive review
    • Paarakh PM. Nigella sativa Linn.–A comprehensive review. Indian J Natu Prod Res 2010; 1:409-429.
    • (2010) Indian J Natu Prod Res , vol.1 , pp. 409-429
    • Paarakh, P.M.1
  • 2
    • 2942538292 scopus 로고    scopus 로고
    • Pharmacological actions and potential uses of Momordica charantia: A review
    • Grover J, Yadav S. Pharmacological actions and potential uses of Momordica charantia: a review. J Ethnopharmacol 2004; 93:123-132.
    • (2004) J Ethnopharmacol , vol.93 , pp. 123-132
    • Grover, J.1    Yadav, S.2
  • 5
    • 84894676743 scopus 로고    scopus 로고
    • Antimicrobial and Anti-cancer Activity of Nigella sativa oil-A Review
    • Al-Khalaf MI, Ramadan KS. Antimicrobial and Anti-cancer Activity of Nigella sativa oil-A Review. Aus J Basic Appl Sci 2013;7:505-514.
    • (2013) Aus J Basic Appl Sci , vol.7 , pp. 505-514
    • Al-Khalaf, M.I.1    Ramadan, K.S.2
  • 6
    • 84890492066 scopus 로고    scopus 로고
    • Therapeutic Role of Prophetic Medicine Habbat El Baraka (Nigella sativa L.)-A Review
    • Ismail MYM. Therapeutic Role of Prophetic Medicine Habbat El Baraka (Nigella sativa L.)-A Review. World Appl Sci J 2009;7:1203-1208.
    • (2009) World Appl Sci J , vol.7 , pp. 1203-1208
    • Ismail, Y.M.1
  • 7
    • 16844377925 scopus 로고    scopus 로고
    • A review of medicinal uses and pharmacological activities of Nigella sativa
    • Gilani A, Jabeen Q, Khan M. A review of medicinal uses and pharmacological activities of Nigella sativa. Pak J Biol Sci 2004;7:441-451.
    • (2004) Pak J Biol Sci , vol.7 , pp. 441-451
    • Gilani, A.1    Jabeen, Q.2    Khan, M.3
  • 9
    • 79954519003 scopus 로고    scopus 로고
    • Medicinal and phamacological potential of Nigella sativa: A review
    • Sharma NK, Ahirwar D, Jhade D, Gupta S. Medicinal and phamacological potential of Nigella sativa: A review. Ethnobot Rev 2009; 13:946-955.
    • (2009) Ethnobot Rev , vol.13 , pp. 946-955
    • Sharma, N.K.1    Ahirwar, D.2    Jhade, D.3    Gupta, S.4
  • 10
    • 81155135198 scopus 로고    scopus 로고
    • Anti-cancer activity of Nigella sativa (black seed)—A review
    • Randhawa MA, Alghamdi MS. Anti-cancer activity of Nigella sativa (black seed)—A review. Am J Chin Med 2011; 39:1075-1091.
    • (2011) Am J Chin Med , vol.39 , pp. 1075-1091
    • Randhawa, M.A.1    Alghamdi, M.S.2
  • 11
    • 84921635626 scopus 로고    scopus 로고
    • Therapeutic Uses of Shoneez (Nigella sativa Linn.) Mentioned in Unani System of Medicine-A Review
    • Nasir A, Siddiqui MY, Mohsin M. Therapeutic Uses of Shoneez (Nigella sativa Linn.) Mentioned in Unani System of Medicine-A Review. Int J Pharm Phytopharmaco Res 2014; 4: 47-49.
    • (2014) Int J Pharm Phytopharmaco Res , vol.4 , pp. 47-49
    • Nasir, A.1    Siddiqui, M.Y.2    Mohsin, M.3
  • 12
    • 84924374135 scopus 로고
    • The Collection of Authentic Sayings of Prophet Mohammad (peace be upon him)
    • 2nd ed. Ankara, Turkey: Hilal Yayinlari
    • Al-Bukhari MI, Sahih Al-Bukhari. The Collection of Authentic Sayings of Prophet Mohammad (peace be upon him), Division 71 on Medicine. 2nd ed. Ankara, Turkey: Hilal Yayinlari; 1976.
    • (1976) Division 71 on Medicine
    • Al-Bukhari, M.I.1    Al-Bukhari, S.2
  • 13
    • 84871649451 scopus 로고    scopus 로고
    • Global status report on noncommunicable diseases 2010
    • Alwan A. Global status report on noncommunicable diseases 2010: World Health Organization; 2011.
    • (2011) World Health Organization
    • Alwan, A.1
  • 14
    • 27644573085 scopus 로고    scopus 로고
    • [25/4/2014]. Available from
    • WHO. Cardiovascular diseases 2013 [25/4/2014]. Available from: http://www.-who.int/diabetes/facts/en/.
    • (2013) Cardiovascular diseases
  • 15
    • 33845338724 scopus 로고    scopus 로고
    • Projections of global mortality and burden of disease from 2002 to 2030
    • Mathers CD, Loncar D. Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med 2006; 3:e442.
    • (2006) PLoS Med , vol.3 , pp. 442
    • Mathers, C.D.1    Loncar, D.2
  • 16
    • 84921681273 scopus 로고    scopus 로고
    • WHO. Cancer fact sheet 2013 [25/4/2014]. Available from
    • WHO. Cancer fact sheet 2013 [25/4/2014]. Available from: http://www.who.int/mediacentre/- factsheets/ fs297/en/.
  • 18
    • 2942756946 scopus 로고    scopus 로고
    • Indian medicinal plants: A compendium of 500 species: Orient Longman Ltd
    • Warrier P, Nambiar V, Ramankutty C. Indian medicinal plants: a compendium of 500 species: Orient Longman Ltd. Chennai. 1996; 3:38-90.
    • (1996) Chennai , vol.3 , pp. 38-90
    • Warrier, P.1    Nambiar, V.2    Ramankutty, C.3
  • 19
    • 79955839724 scopus 로고    scopus 로고
    • Nigella sativa: Holy herb of the middle East
    • Yarnell E, Abascal K. Nigella sativa: holy herb of the middle East. Altern Complement Ther 2011; 17:99-105.
    • (2011) Altern Complement Ther , vol.17 , pp. 99-105
    • Yarnell, E.1    Abascal, K.2
  • 20
    • 34548659073 scopus 로고    scopus 로고
    • Nutritional value, functional properties and nutraceutical applications of black cumin (Nigella sativa L.): An overview
    • Ramadan MF. Nutritional value, functional properties and nutraceutical applications of black cumin (Nigella sativa L.): an overview. Int J Food Sci Technol 2007; 42:1208-1218.
    • (2007) Int J Food Sci Technol , vol.42 , pp. 1208-1218
    • Ramadan, M.F.1
  • 22
    • 62549153670 scopus 로고    scopus 로고
    • From here to eternity-the secret of Pharaohs: Therapeutic potential of black cumin seeds and beyond
    • Padhye S, Banerjee S, Ahmad A, Mohammad R, Sarkar FH. From here to eternity-the secret of Pharaohs: Therapeutic potential of black cumin seeds and beyond. Canc ther 2008; 6:495-510.
    • (2008) Canc ther , vol.6 , pp. 495-510
    • Padhye, S.1    Banerjee, S.2    Ahmad, A.3    Mohammad, R.4    Sarkar, F.H.5
  • 24
    • 0027528479 scopus 로고
    • Inhibition of histamine release from mast cells by nigellone
    • Chakravarty N. Inhibition of histamine release from mast cells by nigellone. Ann Allergy 1993; 70:237-242.
    • (1993) Ann Allergy , vol.70 , pp. 237-242
    • Chakravarty, N.1
  • 25
    • 0038559976 scopus 로고    scopus 로고
    • Pharmacological and toxicological properties of Nigella sativa
    • Ali B, Blunden G. Pharmacological and toxicological properties of Nigella sativa. Phytother Res 2003; 17:299-305.
    • (2003) Phytother Res , vol.17 , pp. 299-305
    • Ali, B.1    Blunden, G.2
  • 26
    • 0037326010 scopus 로고    scopus 로고
    • The in vivo antifungal activity of the aqueous extract from Nigella sativa seeds
    • Khan M, Ashfaq M, Zuberi H, Mahmood M, Gilani A. The in vivo antifungal activity of the aqueous extract from Nigella sativa seeds. Phytother Res 2003; 17:183-186.
    • (2003) Phytother Res , vol.17 , pp. 183-186
    • Khan, M.1    Ashfaq, M.2    Zuberi, H.3    Mahmood, M.4    Gilani, A.5
  • 27
    • 0034987355 scopus 로고    scopus 로고
    • The anti-inflammatory, analgesic and antipyretic activity of Nigella sativa
    • Al-Ghamdi M. The anti-inflammatory, analgesic and antipyretic activity of Nigella sativa. J Ethnopharmacol 2001; 76:45-48.
    • (2001) J Ethnopharmacol , vol.76 , pp. 45-48
    • Al-Ghamdi, M.1
  • 29
    • 0027323712 scopus 로고
    • Chemical composition of Nigella sativa L. seeds
    • Nergiz C, Ötleş S. Chemical composition of Nigella sativa L. seeds. Food Chem 1993; 48:259-261.
    • (1993) Food Chem , vol.48 , pp. 259-261
    • Nergiz, C.1    Ötleş, S.2
  • 30
    • 0033059343 scopus 로고    scopus 로고
    • Chemical composition and medicinal properties of Nigella sativa Linn
    • Khan MA. Chemical composition and medicinal properties of Nigella sativa Linn. Inflammopharmacol 1999; 7:15-35.
    • (1999) Inflammopharmacol , vol.7 , pp. 15-35
    • Khan, M.A.1
  • 31
  • 33
    • 0035960630 scopus 로고    scopus 로고
    • Global burden of cardiovascular diseases part I: General considerations, the epidemiologic transition, risk factors, and impact of urbanization
    • Yusuf S, Reddy S, Ôunpuu S, Anand S. Global burden of cardiovascular diseases part I: general considerations, the epidemiologic transition, risk factors, and impact of urbanization. Circulation 2001; 104:2746-2753.
    • (2001) Circulation , vol.104 , pp. 2746-2753
    • Yusuf, S.1    Reddy, S.2    Ôunpuu, S.3    Anand, S.4
  • 35
    • 84865102720 scopus 로고    scopus 로고
    • Clinical evaluation of Nigella sativa seeds for the treatment of hyperlipidemia: A randomized, placebo controlled clinical trial
    • Sabzghabaee AM, Dianatkhah M, Sarrafzadegan N, Asgary S, Ghannadi A. Clinical evaluation of Nigella sativa seeds for the treatment of hyperlipidemia: a randomized, placebo controlled clinical trial. Med Arch 2012; 66:198-200.
    • (2012) Med Arch , vol.66 , pp. 198-200
    • Sabzghabaee, A.M.1    Dianatkhah, M.2    Sarrafzadegan, N.3    Asgary, S.4    Ghannadi, A.5
  • 36
    • 0033800305 scopus 로고    scopus 로고
    • Nigella sativa L. oil protects against induced hepatotoxicity and improves serum lipid profile in rats
    • El-Dakhakhny M, Mady NI, Halim MA. Nigella sativa L. oil protects against induced hepatotoxicity and improves serum lipid profile in rats. Arzneimittelforschung 2000; 50:832-836.
    • (2000) Arzneimittelforschung , vol.50 , pp. 832-836
    • El-Dakhakhny, M.1    Mady, N.I.2    Halim, M.A.3
  • 39
    • 77954527277 scopus 로고    scopus 로고
    • Protective effects of propolis and thymoquinone on development of atherosclerosis in cholesterol-fed rabbits
    • Nader MA, El-Agamy DS, Suddek GM. Protective effects of propolis and thymoquinone on development of atherosclerosis in cholesterol-fed rabbits. Arch Pharmacal Res 2010; 33:637-643.
    • (2010) Arch Pharmacal Res , vol.33 , pp. 637-643
    • Nader, M.A.1    El-Agamy, D.S.2    Suddek, G.M.3
  • 40
    • 4344587232 scopus 로고    scopus 로고
    • The petroleum ether extract of Nigella sativa exerts lipid-lowering and insulinsensitizing actions in the rat
    • Le PM, Benhaddou-Andaloussi A, Elimadi A, Settaf A, Cherrah Y, Haddad PS. The petroleum ether extract of Nigella sativa exerts lipid-lowering and insulinsensitizing actions in the rat. J Ethnopharmacol 2004; 94:251-259.
    • (2004) J Ethnopharmacol , vol.94 , pp. 251-259
    • Le, P.M.1    Benhaddou-Andaloussi, A.2    Elimadi, A.3    Settaf, A.4    Cherrah, Y.5    Haddad, P.S.6
  • 42
    • 77955013372 scopus 로고    scopus 로고
    • Effect of prophetic medicine kalonji (Nigella sativa L.) on lipid profile of human beings. An in vivo approach
    • Bhatti IU, Rehman FU, Khan M, Marwat S. Effect of prophetic medicine kalonji (Nigella sativa L.) on lipid profile of human beings. An in vivo approach. World Appl Sci J 2009; 6:1053-1057.
    • (2009) World Appl Sci J , vol.6 , pp. 1053-1057
    • Bhatti, I.U.1    Rehman, F.U.2    Khan, M.3    Marwat, S.4
  • 43
    • 79953666846 scopus 로고    scopus 로고
    • The effects of Nigelia sativa (Kalonji) on lipid profile in patients with stable coronary artery disease in multan, Pakistan
    • Tasawar Z, Siraj Z, Ahmad N, Lashari MH. The effects of Nigelia sativa (Kalonji) on lipid profile in patients with stable coronary artery disease in multan, Pakistan. Pak J Nutr 2011; 10:162.
    • (2011) Pak J Nutr , vol.10 , pp. 162
    • Tasawar, Z.1    Siraj, Z.2    Ahmad, N.3    Lashari, M.H.4
  • 44
    • 0030875392 scopus 로고    scopus 로고
    • Effect of oral ingestion Nigella sativa seeds on some blood parameters
    • Bamosa AO, Ali B, Sowayan S. Effect of oral ingestion Nigella sativa seeds on some blood parameters. Saudi Pharm J 1997; 5:126-129.
    • (1997) Saudi Pharm J , vol.5 , pp. 126-129
    • Bamosa, A.O.1    Ali, B.2    Sowayan, S.3
  • 46
    • 30444452089 scopus 로고    scopus 로고
    • Hepatoprotective effects of Nigella sativa L and Urtica dioica L on lipid peroxidation, antioxidant enzyme systems and liver enzymes in carbon tetrachloridetreated rats
    • Kanter M, Coskun O, Budancamanak M. Hepatoprotective effects of Nigella sativa L and Urtica dioica L on lipid peroxidation, antioxidant enzyme systems and liver enzymes in carbon tetrachloridetreated rats. World J Gastroenterol 2005; 11: 6684-6688.
    • (2005) World J Gastroenterol , vol.11 , pp. 6684-6688
    • Kanter, M.1    Coskun, O.2    Budancamanak, M.3
  • 47
    • 0028824908 scopus 로고
    • Diabetes mellitus and associated hypertension, vascular disease, and nephropathy an update
    • Sowers JR, Epstein M. Diabetes mellitus and associated hypertension, vascular disease, and nephropathy an update. Hypertension 1995; 26: 869-879.
    • (1995) Hypertension , vol.26 , pp. 869-879
    • Sowers, J.R.1    Epstein, M.2
  • 48
    • 33644841145 scopus 로고    scopus 로고
    • Type 1 diabetes
    • Daneman D. Type 1 diabetes. The Lancet 2006; 367:847-858.
    • (2006) The Lancet , vol.367 , pp. 847-858
    • Daneman, D.1
  • 49
    • 84856120266 scopus 로고    scopus 로고
    • Anaemia management in people with chronic kidney disease (CKD)
    • London: Royal College of Physicians
    • Anonymous. Guidelines N. Anaemia management in people with chronic kidney disease (CKD). Clinical Guidance. N.C.c.f.C. Conditions, London: Royal College of Physicians; 2006. p. 1-172.
    • (2006) Clinical Guidance. N.C.c.f.C. Conditions , pp. 1-172
    • Guidelines, N.1
  • 50
    • 84907851875 scopus 로고    scopus 로고
    • Oxidative stress in diabetes
    • Stadler K. Oxidative stress in diabetes. Adv Exp Med Biol 2012; 771:272-287.
    • (2012) Adv Exp Med Biol , vol.771 , pp. 272-287
    • Stadler, K.1
  • 52
    • 77951023404 scopus 로고    scopus 로고
    • Protective effects of the volatile oil of Nigella sativa seeds on β-cell damage in streptozotocin-induced diabetic rats: A light and electron microscopic study
    • Kanter M, Akpolat M, Aktas C. Protective effects of the volatile oil of Nigella sativa seeds on β-cell damage in streptozotocin-induced diabetic rats: a light and electron microscopic study. J Molecular Histol 2009; 40:379-385.
    • (2009) J Molecular Histol , vol.40 , pp. 379-385
    • Kanter, M.1    Akpolat, M.2    Aktas, C.3
  • 53
    • 78649673581 scopus 로고    scopus 로고
    • Effects of Nigella sativa and thymoquinone on biochemical and subcellular changes in pancreatic β-cells of streptozotocin-induced diabetic rats
    • Abdelmeguid NE, Fakhoury R, Kamal SM, Al Wafai RJ. Effects of Nigella sativa and thymoquinone on biochemical and subcellular changes in pancreatic β-cells of streptozotocin-induced diabetic rats. J Diabetes 2010; 2:256-266.
    • (2010) J Diabetes , vol.2 , pp. 256-266
    • Abdelmeguid, N.E.1    Fakhoury, R.2    Kamal, S.M.3    Al Wafai, R.J.4
  • 54
    • 3042776475 scopus 로고    scopus 로고
    • Effects of Nigella sativa on oxidative stress and β-cell damage in streptozotocin-induced diabetic rats
    • Kanter M, Coskun O, Korkmaz A, Oter S. Effects of Nigella sativa on oxidative stress and β-cell damage in streptozotocin-induced diabetic rats. Anat Rec A Discov Mol Cell Evol Biol 2004; 279:685-691.
    • (2004) Anat Rec A Discov Mol Cell Evol Biol , vol.279 , pp. 685-691
    • Kanter, M.1    Coskun, O.2    Korkmaz, A.3    Oter, S.4
  • 55
    • 7944227115 scopus 로고    scopus 로고
    • Nigella sativa seed extracts enhance glucose-induced insulin release from rat-isolated Langerhans islets
    • Rchid H, Chevassus H, Nmila R, Guiral C, Petit P, Chokaïri M, et al. Nigella sativa seed extracts enhance glucose-induced insulin release from rat-isolated Langerhans islets. Fundam Clin Pharmacol 2004; 18:525-529.
    • (2004) Fundam Clin Pharmacol , vol.18 , pp. 525-529
    • Rchid, H.1    Chevassus, H.2    Nmila, R.3    Guiral, C.4    Petit, P.5    Chokaïri, M.6
  • 56
    • 0027309568 scopus 로고
    • Hypoglycemic effects of the volatile oil of Nigella sativa seeds
    • Al-Hader A, Aqel M, Hasan Z. Hypoglycemic effects of the volatile oil of Nigella sativa seeds. Pharm Biol 1993; 31:96-100.
    • (1993) Pharm Biol , vol.31 , pp. 96-100
    • Al-Hader, A.1    Aqel, M.2    Hasan, Z.3
  • 57
    • 0036901812 scopus 로고    scopus 로고
    • Isulinotropic properties of Nigella sativa oil in Streptozotocin plus Nicotinamide diabetic hamster
    • Fararh K, Atoji Y, Shimizu Y, Takewaki T. Isulinotropic properties of Nigella sativa oil in Streptozotocin plus Nicotinamide diabetic hamster. Res Vet Sci 2002; 73:279-282.
    • (2002) Res Vet Sci , vol.73 , pp. 279-282
    • Fararh, K.1    Atoji, Y.2    Shimizu, Y.3    Takewaki, T.4
  • 58
    • 33748534126 scopus 로고    scopus 로고
    • Biochemical effects of Nigella sativa L seeds in diabetic rats
    • Kaleem M, Kirmani D, Asif M, Ahmed Q, Bano B. Biochemical effects of Nigella sativa L seeds in diabetic rats. Indian J Exp Biol 2006; 44:745-748.
    • (2006) Indian J Exp Biol , vol.44 , pp. 745-748
    • Kaleem, M.1    Kirmani, D.2    Asif, M.3    Ahmed, Q.4    Bano, B.5
  • 59
    • 77951556746 scopus 로고    scopus 로고
    • Protective effects of Nigella sativa oil and thymoquinone against toxicity induced by the anti-cancer drug cyclophosphamide
    • Alenzi F, El-Bolkiny Y-S, Salem M. Protective effects of Nigella sativa oil and thymoquinone against toxicity induced by the anti-cancer drug cyclophosphamide. Br J Biomed Sci 2010; 67:20-28.
    • (2010) Br J Biomed Sci , vol.67 , pp. 20-28
    • Alenzi, F.1    El-Bolkiny, Y.-S.2    Salem, M.3
  • 60
    • 0035719313 scopus 로고    scopus 로고
    • Effect of Nigella sativa (black seed) and thymoquinone on blood glucose in albino rats
    • Hawsawi ZA, Ali BA, Bamosa AO. Effect of Nigella sativa (black seed) and thymoquinone on blood glucose in albino rats. Ann Saudi Med 2001; 21:242-244.
    • (2001) Ann Saudi Med , vol.21 , pp. 242-244
    • Hawsawi, Z.A.1    Ali, B.A.2    Bamosa, A.O.3
  • 61
    • 0028835878 scopus 로고
    • Antidiabetic plants and their active constituents
    • Marles RJ, Farnsworth NR. Antidiabetic plants and their active constituents. Phytomedicine 1995; 2:137-189.
    • (1995) Phytomedicine , vol.2 , pp. 137-189
    • Marles, R.J.1    Farnsworth, N.R.2
  • 63
    • 84886434186 scopus 로고    scopus 로고
    • Hypoglycemic effect of lipoic acid, carnitine and Nigella sativa in diabetic rat model
    • Salama RH. Hypoglycemic effect of lipoic acid, carnitine and Nigella sativa in diabetic rat model. Int J Health Sci 2011; 5:126-134.
    • (2011) Int J Health Sci , vol.5 , pp. 126-134
    • Salama, R.H.1
  • 64
    • 70649088771 scopus 로고    scopus 로고
    • Beneficial effects of thymoquinone on hepatic key enzymes in streptozotocin–nicotinamide induced diabetic rats
    • Pari L, Sankaranarayanan C. Beneficial effects of thymoquinone on hepatic key enzymes in streptozotocin–nicotinamide induced diabetic rats. Life Sci 2009; 85:830-834.
    • (2009) Life Sci , vol.85 , pp. 830-834
    • Pari, L.1    Sankaranarayanan, C.2
  • 65
    • 79956213144 scopus 로고    scopus 로고
    • Effect of Nigella sativa seeds on the glycemic control of patients with type 2 diabetes mellitus
    • Bamosa AO, Kaatabi H, Lebda FM, Elq A-MA, Al- Sultan A. Effect of Nigella sativa seeds on the glycemic control of patients with type 2 diabetes mellitus. Indian J Physiol Pharmacol 2010; 54:344-354.
    • (2010) Indian J Physiol Pharmacol , vol.54 , pp. 344-354
    • Bamosa, A.O.1    Kaatabi, H.2    Lebda, F.M.3    Elq, A.-M.4    Al-Sultan, A.5
  • 66
    • 84893195042 scopus 로고    scopus 로고
    • Nigella sativa Fixed and Essential Oil Supplementation Modulates Hyperglycemia and Allied Complications in Streptozotocin-Induced Diabetes Mellitus
    • Sultan MT, Butt MS, Karim R, Zia-Ul-Haq M, Batool R, Ahmad S, et al. Nigella sativa Fixed and Essential Oil Supplementation Modulates Hyperglycemia and Allied Complications in Streptozotocin-Induced Diabetes Mellitus. Evid Based Complement Alternat Med 2014; 2014:826380.
    • (2014) Evid Based Complement Alternat Med , vol.6380 , pp. 2014
    • Sultan, M.T.1    Butt, M.S.2    Karim, R.3    Zia-Ul-Haq, M.4    Batool, R.5    Ahmad, S.6
  • 67
    • 84899871835 scopus 로고    scopus 로고
    • A randomised controlled trial on hypolipidemic effects of Nigella Sativa seeds powder in menopausal women
    • Ibrahim RM, Hamdan NS, Mahmud R, Imam MU, Saini SM, Rashid SN, et al. A randomised controlled trial on hypolipidemic effects of Nigella Sativa seeds powder in menopausal women. J Transl Med 2014; 12:82.
    • (2014) J Transl Med , vol.12 , pp. 82
    • Ibrahim, R.M.1    Hamdan, N.S.2    Mahmud, R.3    Imam, M.U.4    Saini, S.M.5    Rashid, S.N.6
  • 68
    • 84886837750 scopus 로고    scopus 로고
    • Protective role of Nigella sativa against experimentally induced type- II diabetic nuclear damage in Wistar rats
    • Sheikh T, Joshi D, Patel B, Modi C. Protective role of Nigella sativa against experimentally induced type- II diabetic nuclear damage in Wistar rats. Veterinary World 2013; 6:698-702.
    • (2013) Veterinary World , vol.6 , pp. 698-702
    • Sheikh, T.1    Joshi, D.2    Patel, B.3    Modi, C.4
  • 69
    • 84875470074 scopus 로고    scopus 로고
    • Evaluation of antidiabetic and anti-lipidimic potential of kalongi sugar powder water extract in stz induced diabetic rats
    • Alam S, Reddy SK, Baig A, Reddy MK, Mohiuddin M, Reddy MV, et al. Evaluation of antidiabetic and anti-lipidimic potential of kalongi sugar powder water extract in stz induced diabetic rats. Int J Pharm Pharm Sci 2013; 5:94-96.
    • (2013) Int J Pharm Pharm Sci , vol.5 , pp. 94-96
    • Alam, S.1    Reddy, S.K.2    Baig, A.3    Reddy, M.K.4    Mohiuddin, M.5    Reddy, M.V.6
  • 70
    • 84873268879 scopus 로고    scopus 로고
    • Nigella sativa L. improves lipid profile and prevents atherosclerosis: Evidence from an experimental study on hypercholesterolemic rabbits
    • Asgary S, Ghannadi A, Dashti G, Helalat A, Sahebkar A, Najafi S. Nigella sativa L. improves lipid profile and prevents atherosclerosis: Evidence from an experimental study on hypercholesterolemic rabbits. J Functional Foods 2013; 5:228-234.
    • (2013) J Functional Foods , vol.5 , pp. 228-234
    • Asgary, S.1    Ghannadi, A.2    Dashti, G.3    Helalat, A.4    Sahebkar, A.5    Najafi, S.6
  • 71
    • 84921632782 scopus 로고    scopus 로고
    • Effect of Nigella Sativa (Kalonji) on Serum Lipid Profile
    • Ali SA, Asghar F, Nafees M, Tayyab M. Effect of Nigella Sativa (Kalonji) on Serum Lipid Profile. ANNALS 2012; 18:224-228.
    • (2012) ANNALS , vol.18 , pp. 224-228
    • Ali, S.A.1    Asghar, F.2    Nafees, M.3    Tayyab, M.4
  • 72
    • 84921667089 scopus 로고    scopus 로고
    • Efficacy of Saboos-e-Asapghol (Plantago ovata) and Kalonji (Nigella sativa) in the Management of Hypertriglyceridemia
    • Nasir A, Siddiqui MY, Mohsin M. Efficacy of Saboos-e-Asapghol (Plantago ovata) and Kalonji (Nigella sativa) in the Management of Hypertriglyceridemia. Int J Pharm India 2013; 2:560-568.
    • (2013) Int J Pharm India , vol.2 , pp. 560-568
    • Nasir, A.1    Siddiqui, M.Y.2    Mohsin, M.3
  • 73
    • 84900400619 scopus 로고    scopus 로고
    • Effect of High Protein Diet Containing Fortified Bread with Fenugreek and Nigella sativa Seeds on Rats Suffering from Diabetes
    • Mahmoud MY. Effect of High Protein Diet Containing Fortified Bread with Fenugreek and Nigella sativa Seeds on Rats Suffering from Diabetes. Pak J Nutr 2013; 12:736-747.
    • (2013) Pak J Nutr , vol.12 , pp. 736-747
    • Mahmoud, M.Y.1
  • 74
    • 84921681272 scopus 로고    scopus 로고
    • Effects of volatile oil and nonsaponifiable fractions from Nigella sativa oil and it’s constituent, thymoquinone against cardiovascular risk parameters in experimental hyperlipidemia
    • Shafeeque A. Effects of volatile oil and nonsaponifiable fractions from Nigella sativa oil and it’s constituent, thymoquinone against cardiovascular risk parameters in experimental hyperlipidemia. Indian ETD Repository @ INFLIBNET 2013.
    • (2013) Indian ETD Repository @ INFLIBNET
    • Shafeeque, A.1
  • 75
    • 84881402430 scopus 로고    scopus 로고
    • Protective and antidiabetic effects of extract from Nigella sativa on blood glucose concentrations against streptozotocin (STZ)-induced diabetic in rats: An experimental study with histopathological evaluation
    • Alimohammadi S, Hobbenaghi R, Javanbakht J, Kheradmand D, Mortezaee R, Tavakoli M, et al. Protective and antidiabetic effects of extract from Nigella sativa on blood glucose concentrations against streptozotocin (STZ)-induced diabetic in rats: an experimental study with histopathological evaluation. Diagnostic Pathol 2013; 8:137.
    • (2013) Diagnostic Pathol , vol.8 , pp. 137
    • Alimohammadi, S.1    Hobbenaghi, R.2    Javanbakht, J.3    Kheradmand, D.4    Mortezaee, R.5    Tavakoli, M.6
  • 76
    • 84856593932 scopus 로고    scopus 로고
    • Hepatotoxicity and Langerhans islets regenerative effects of polar and neutral lipids of Nigella sativa L. in nicotinamide/streptozotocin-induced diabetic rats
    • Sobhi W, Khettal B, Belmouhoub M, Atmani D, Duez P, Benboubetra M. Hepatotoxicity and Langerhans islets regenerative effects of polar and neutral lipids of Nigella sativa L. in nicotinamide/streptozotocin-induced diabetic rats. Pteridines 2013; 22:97-104.
    • (2013) Pteridines , vol.22 , pp. 97-104
    • Sobhi, W.1    Khettal, B.2    Belmouhoub, M.3    Atmani, D.4    Duez, P.5    Benboubetra, M.6
  • 77
    • 84876433148 scopus 로고    scopus 로고
    • Nigella sativa Oil Has Significant Repairing Ability of Damaged Pancreatic Tissue Occurs in Induced Type 1 Diabetes Mellitus
    • Jamal A, Hmza A, Omar E, Adnan A, Osman MT. Nigella sativa Oil Has Significant Repairing Ability of Damaged Pancreatic Tissue Occurs in Induced Type 1 Diabetes Mellitus. Global J Pharmacol 2013; 7:14-19.
    • (2013) Global J Pharmacol , vol.7 , pp. 14-19
    • Jamal, A.1    Hmza, A.2    Omar, E.3    Adnan, A.4    Osman, M.T.5
  • 79
    • 84862854073 scopus 로고    scopus 로고
    • Thymoquinone improves aging-related endothelial dysfunction in the rat mesenteric artery
    • Idris-Khodja N, Schini-Kerth V. Thymoquinone improves aging-related endothelial dysfunction in the rat mesenteric artery. Naunyn Schmiedebergs Arch Pharmacol 2012; 385:749-758.
    • (2012) Naunyn Schmiedebergs Arch Pharmacol , vol.385 , pp. 749-758
    • Idris-Khodja, N.1    Schini-Kerth, V.2
  • 80
    • 0034186616 scopus 로고    scopus 로고
    • Diuretic and hypotensive effects of Nigella sativa in the spontaneously hypertensive rat
    • Zaoui A, Cherrah Y, Lacaille-Dubois M, Settaf A, Amarouch H, Hassar M. Diuretic and hypotensive effects of Nigella sativa in the spontaneously hypertensive rat. Therapie 1999; 55:379-82.
    • (1999) Therapie , vol.55 , pp. 379-382
    • Zaoui, A.1    Cherrah, Y.2    Lacaille-Dubois, M.3    Settaf, A.4    Amarouch, H.5    Hassar, M.6
  • 81
    • 33745726077 scopus 로고    scopus 로고
    • Effect of black cumin (Nigella sativa) on heart rate, some hematological values, and pancreatic β-cell damage in cadmium-treated rats
    • Demir H, Kanter M, Coskun O, Uz YH, Koc A, Yildiz A. Effect of black cumin (Nigella sativa) on heart rate, some hematological values, and pancreatic β-cell damage in cadmium-treated rats. Biol Trace Elem Res 2006; 110:151-162.
    • (2006) Biol Trace Elem Res , vol.110 , pp. 151-162
    • Demir, H.1    Kanter, M.2    Coskun, O.3    Uz, Y.H.4    Koc, A.5    Yildiz, A.6
  • 82
    • 0027264732 scopus 로고
    • The cardiovascular actions of the volatile oil of the black seed (Nigella sativa) in rats: Elucidation of the mechanism of action
    • El Tahir KE, Ashour MM, Al-Harbi MM. The cardiovascular actions of the volatile oil of the black seed (Nigella sativa) in rats: elucidation of the mechanism of action. Gen Pharmacol 1993; 24:1123-1131.
    • (1993) Gen Pharmacol , vol.24 , pp. 1123-1131
    • El Tahir, K.E.1    Ashour, M.M.2    Al-Harbi, M.M.3
  • 83
    • 34248165186 scopus 로고    scopus 로고
    • Thymoquinone supplementation attenuates hypertension and renal damage in nitric oxide deficient hypertensive rats
    • Khattab MM, Nagi MN. Thymoquinone supplementation attenuates hypertension and renal damage in nitric oxide deficient hypertensive rats. Phytother Res 2007; 21:410-414.
    • (2007) Phytother Res , vol.21 , pp. 410-414
    • Khattab, M.M.1    Nagi, M.N.2
  • 84
    • 1842525226 scopus 로고    scopus 로고
    • Effect of Nigella sativa L. on heart rate and some haematological values of alloxan-induced diabetic rabbits
    • Meral I, Donmez N, Baydas B, Belge F, Kanter M. Effect of Nigella sativa L. on heart rate and some haematological values of alloxan-induced diabetic rabbits. Scand J Lab Anim Sci 2004; 31:49-53.
    • (2004) Scand J Lab Anim Sci , vol.31 , pp. 49-53
    • Meral, I.1    Donmez, N.2    Baydas, B.3    Belge, F.4    Kanter, M.5
  • 85
    • 55949121968 scopus 로고    scopus 로고
    • Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension
    • Dehkordi FR, Kamkhah AF. Antihypertensive effect of Nigella sativa seed extract in patients with mild hypertension. Fundam Clini Pharmacol 2008; 22:447-452.
    • (2008) Fundam Clini Pharmacol , vol.22 , pp. 447-452
    • Dehkordi, F.R.1    Kamkhah, A.F.2
  • 86
    • 69449083235 scopus 로고    scopus 로고
    • Effectiveness, safety, and tolerability of powdered Nigella sativa (kalonji) seed in capsules on serum lipid levels, blood sugar, blood pressure, and body weight in adults: Results of a randomized, doubleblind controlled trial
    • Qidwai W, Hamza HB, Qureshi R, Gilani A. Effectiveness, safety, and tolerability of powdered Nigella sativa (kalonji) seed in capsules on serum lipid levels, blood sugar, blood pressure, and body weight in adults: results of a randomized, doubleblind controlled trial. J Altern Complement Med 2009; 15:639-644.
    • (2009) J Altern Complement Med , vol.15 , pp. 639-644
    • Qidwai, W.1    Hamza, H.B.2    Qureshi, R.3    Gilani, A.4
  • 87
    • 84903952501 scopus 로고    scopus 로고
    • [25/4/2014]. Avalible from:
    • American Cancer Society. Cancer Facts and Statistics 2014 [25/4/2014]. Avalible from: http://www.cancer.org/research/cancerfactsstatistics/index
    • (2014) Cancer Facts and Statistics
  • 89
    • 80054687430 scopus 로고    scopus 로고
    • Can phytochemical antioxidant rich foods act as anti-cancer agents?
    • Wang S, Meckling KA, Marcone MF, Kakuda Y, Tsao R. Can phytochemical antioxidant rich foods act as anti-cancer agents? Food Res Int 2011; 44:2545-2554.
    • (2011) Food Res Int , vol.44 , pp. 2545-2554
    • Wang, S.1    Meckling, K.A.2    Marcone, M.F.3    Kakuda, Y.4    Tsao, R.5
  • 90
    • 0033944720 scopus 로고    scopus 로고
    • Anti-cancer properties of fruits and vegetables
    • Wargovich MJ. Anti-cancer properties of fruits and vegetables. HortSci 2000; 35:573-575.
    • (2000) HortSci , vol.35 , pp. 573-575
    • Wargovich, M.J.1
  • 93
    • 21344452084 scopus 로고    scopus 로고
    • Effects of alpha-hederin and thymoquinone, constituents of Nigella sativa, on human cancer cell lines
    • Rooney S, Ryan M. Effects of alpha-hederin and thymoquinone, constituents of Nigella sativa, on human cancer cell lines. Anticanc Res 2005; 25:2199-2204.
    • (2005) Anticanc Res , vol.25 , pp. 2199-2204
    • Rooney, S.1    Ryan, M.2
  • 94
    • 68349118245 scopus 로고    scopus 로고
    • Oral and intraperitoneal LD50 of thymoquinone, an active principle of Nigella sativa, in mice and rats
    • Al-Ali A, Alkhawajah AA, Randhawa MA, Shaikh NA. Oral and intraperitoneal LD50 of thymoquinone, an active principle of Nigella sativa, in mice and rats. J Ayub Med Coll Abbottabad 2008; 20:25-27.
    • (2008) J Ayub Med Coll Abbottabad , vol.20 , pp. 25-27
    • Al-Ali, A.1    Alkhawajah, A.A.2    Randhawa, M.A.3    Shaikh, N.A.4
  • 95
    • 84921681271 scopus 로고
    • Effects of Nigella sativa (the black seed) on immunity. Proceeding of the 4 th International Conference on Islamic Medicine
    • El-Kadi A, Kandil O, editors. Effects of Nigella sativa (the black seed) on immunity. Proceeding of the 4 th International Conference on Islamic Medicine, Kuwait Bull Islamic Med; 1986.
    • (1986) Kuwait Bull Islamic Med
    • El-Kadi, A.1    Kandil, O.2
  • 96
    • 0036736903 scopus 로고    scopus 로고
    • Inhibition of methylnitrosourea (MNU) induced oxidative stress and carcinogenesis by orally administered bee honey and Nigella grains in Sprague Dawely rats
    • Mabrouk GM, Moselhy SS, Zohny SF, Ali EM, Helal TE, Amin AA, et al. Inhibition of methylnitrosourea (MNU) induced oxidative stress and carcinogenesis by orally administered bee honey and Nigella grains in Sprague Dawely rats. J Exp Clinical Canc Res 2002; 21:341-346.
    • (2002) J Exp Clinical Canc Res , vol.21 , pp. 341-346
    • Mabrouk, G.M.1    Moselhy, S.S.2    Zohny, S.F.3    Ali, E.M.4    Helal, T.E.5    Amin, A.A.6
  • 97
    • 0034108281 scopus 로고    scopus 로고
    • Cytotoxic and immunopotentiating effects of ethanolic extract of Nigella sativa L. seeds
    • Swamy S, Tan B. Cytotoxic and immunopotentiating effects of ethanolic extract of Nigella sativa L. seeds. J Ethnopharmacol 2000; 70:1-7.
    • (2000) J Ethnopharmacol , vol.70 , pp. 1-7
    • Swamy, S.1    Tan, B.2
  • 98
    • 0035098984 scopus 로고    scopus 로고
    • Extraction, isolation and characterisation of antitumor principle, α-hederin, from the seeds of Nigella sativa
    • Kumara SS, Huat BT. Extraction, isolation and characterisation of antitumor principle, α-hederin, from the seeds of Nigella sativa. Planta medica 2001; 67:29-32.
    • (2001) Planta medica , vol.67 , pp. 29-32
    • Kumara, S.S.1    Huat, B.T.2
  • 100
    • 77950859405 scopus 로고    scopus 로고
    • Bioactivities of black cumin essential oil and its main terpenes from Tunisia
    • Bourgou S, Pichette A, Marzouk B, Legault J. Bioactivities of black cumin essential oil and its main terpenes from Tunisia. South Afr J Bot 2010; 76:210-216.
    • (2010) South Afr J Bot , vol.76 , pp. 210-216
    • Bourgou, S.1    Pichette, A.2    Marzouk, B.3    Legault, J.4
  • 102
    • 84870824355 scopus 로고    scopus 로고
    • [27/4/2014]. Available from
    • Globocan. Fact sheet [27/4/2014]. Available from: http://globocan.iarc.fr/Pages/fact_sheets_cancer.aspx
    • Fact sheet
  • 103
    • 0037258633 scopus 로고    scopus 로고
    • Effect of Nigella sativa (N. sativa L.) and oxidative stress on the survival pattern of MCF-7 breast cancer cells
    • Farah IO, Begum RA. Effect of Nigella sativa (N. sativa L.) and oxidative stress on the survival pattern of MCF-7 breast cancer cells. Biomed Sci instrum 2002; 39:359-364.
    • (2002) Biomed Sci instrum , vol.39 , pp. 359-364
    • Farah, I.O.1    Begum, R.A.2
  • 104
    • 35448934006 scopus 로고    scopus 로고
    • Assessment of cellular responses to oxidative stress using MCF-7 breast cancer cells, black seed (N. Sativa L.) extracts and H2O2
    • Farah IO. Assessment of cellular responses to oxidative stress using MCF-7 breast cancer cells, black seed (N. Sativa L.) extracts and H2O2. Int J Envir Res Publ Health 2005; 2:411-419.
    • (2005) Int J Envir Res Publ Health , vol.2 , pp. 411-419
    • Farah, I.O.1
  • 105
    • 28544450783 scopus 로고    scopus 로고
    • The biochemical and morphological alterations following administration of melatonin, retinoic acid and Nigella sativa in mammary carcinoma: An animal model
    • El-Aziz MA, Hassan HA, Mohamed MH, Meki AR, Abdel-Ghaffar SK, Hussein MR. The biochemical and morphological alterations following administration of melatonin, retinoic acid and Nigella sativa in mammary carcinoma: an animal model. Int J Exp pathol 2005; 86:383-396.
    • (2005) Int J Exp pathol , vol.86 , pp. 383-396
    • Ma, E.A.1    Hassan, H.A.2    Mohamed, M.H.3    Meki, A.R.4    Abdel-Ghaffar, S.K.5    Hussein, M.R.6
  • 106
    • 75449101581 scopus 로고    scopus 로고
    • Terpene Conjugates of the Nigella sativa Seed-Oil Constituent Thymoquinone with Enhanced Efficacy in Cancer Cells
    • Effenberger K, Breyer S, Schobert R. Terpene Conjugates of the Nigella sativa Seed-Oil Constituent Thymoquinone with Enhanced Efficacy in Cancer Cells. Chem biodivers 2010; 7:129-139.
    • (2010) Chem biodivers , vol.7 , pp. 129-139
    • Effenberger, K.1    Breyer, S.2    Schobert, R.3
  • 107
    • 84890515067 scopus 로고    scopus 로고
    • Proapoptotic and Antimetastatic Properties of Supercritical CO2 Extract of Nigella sativa Linn. Against Breast Cancer Cells
    • Baharetha HM, Nassar ZD, Aisha AF, Ahamed MB, Al-Suede FS, Kadir MO, et al. Proapoptotic and Antimetastatic Properties of Supercritical CO2 Extract of Nigella sativa Linn. Against Breast Cancer Cells. J Med Food 2013; 16:1121-1130.
    • (2013) J Med Food , vol.16 , pp. 1121-1130
    • Baharetha, H.M.1    Nassar, Z.D.2    Aisha, A.F.3    Ahamed, M.B.4    Al-Suede, F.S.5    Kadir, M.O.6
  • 108
    • 0042011407 scopus 로고    scopus 로고
    • Chemopreventive potential of volatile oil from black cumin (Nigella sativa L.) seeds against rat colon carcinogenesis
    • Salim EI, Fukushima S. Chemopreventive potential of volatile oil from black cumin (Nigella sativa L.) seeds against rat colon carcinogenesis. Nutr Canc 2003; 45:195-202.
    • (2003) Nutr Canc , vol.45 , pp. 195-202
    • Salim, E.I.1    Fukushima, S.2
  • 109
    • 13244285843 scopus 로고    scopus 로고
    • Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53- dependent mechanism
    • Gali-Muhtasib H, Diab-Assaf M, Boltze C, Al- Hmaira J, Hartig R, Roessner A, et al. Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53- dependent mechanism. Int J Oncol 2004; 25:857-866.
    • (2004) Int J Oncol , vol.25 , pp. 857-866
    • Gali-Muhtasib, H.1    Diab-Assaf, M.2    Boltze, C.3    Al-Hmaira, J.4    Hartig, R.5    Roessner, A.6
  • 110
    • 27944477663 scopus 로고    scopus 로고
    • Modes of action of alpha-hederin and thymoquinone, active constituents of Nigella sativa, against HEp-2 cancer cells
    • Rooney S, Ryan M. Modes of action of alpha-hederin and thymoquinone, active constituents of Nigella sativa, against HEp-2 cancer cells. Anticanc Res 2005; 25:4255-4259.
    • (2005) Anticanc Res , vol.25 , pp. 4255-4259
    • Rooney, S.1    Ryan, M.2
  • 111
    • 17144404169 scopus 로고    scopus 로고
    • Inhibition of two stage renal carcinogenesis, oxidative damage and hyperproliferative response by Nigella sativa
    • Khan N, Sultana S. Inhibition of two stage renal carcinogenesis, oxidative damage and hyperproliferative response by Nigella sativa. Eur J Canc Prev 2005; 14:159-168.
    • (2005) Eur J Canc Prev , vol.14 , pp. 159-168
    • Khan, N.1    Sultana, S.2
  • 112
    • 84912021667 scopus 로고    scopus 로고
    • Cytotoxic and apoptogenic properties of Nigella sativa and thymoquinone, its constituent, in human renal cell carcinoma are comparable with cisplatin
    • Tabasi N, Mahmoudi M, Rastin M, Sadeghnia HR, HosseinPour Mashhadi M, Zamani Taghizade Rabe S, et al. Cytotoxic and apoptogenic properties of Nigella sativa and thymoquinone, its constituent, in human renal cell carcinoma are comparable with cisplatin. Food Agric Immunol 2015; 26:138-156.
    • (2015) Food Agric Immunol , vol.26 , pp. 138-156
    • Tabasi, N.1    Mahmoudi, M.2    Rastin, M.3    Sadeghnia, H.R.4    Hosseinpour Mashhadi, M.5    Zamani Taghizade Rabe, S.6
  • 113
    • 2942547469 scopus 로고    scopus 로고
    • Protection against diethylnitrosoamine-induced hepatocarcinogenesis by an indigenous medicine comprised of Nigella sativa, Hemidesmus indicus and Smilax glabra: A preliminary study
    • Iddamaldeniya SS, Wickramasinghe N, Thabrew I, Ratnatunge N, Thammitiyagodage MG. Protection against diethylnitrosoamine-induced hepatocarcinogenesis by an indigenous medicine comprised of Nigella sativa, Hemidesmus indicus and Smilax glabra: a preliminary study. J Carcinogenesis 2003; 2:1-6.
    • (2003) J Carcinogenesis , vol.2 , pp. 1-6
    • Iddamaldeniya, S.S.1    Wickramasinghe, N.2    Thabrew, I.3    Ratnatunge, N.4    Thammitiyagodage, M.G.5
  • 114
    • 33745111222 scopus 로고    scopus 로고
    • Thammitiyagodage MG. A long-term investigation of the anti-hepatocarcinogenic potential of an indigenous medicine comprised of Nigella sativa, Hemidesmus indicus and Smilax glabra
    • Iddamaldeniya SS, Thabrew M, Wickramasinghe S, Ratnatunge N, Thammitiyagodage MG. A long-term investigation of the anti-hepatocarcinogenic potential of an indigenous medicine comprised of Nigella sativa, Hemidesmus indicus and Smilax glabra. J Carcinogenesis 2006; 5:1-7.
    • (2006) J Carcinogenesis , vol.5 , pp. 1-7
    • Iddamaldeniya, S.S.1    Thabrew, M.2    Wickramasinghe, S.3    Ratnatunge, N.4
  • 115
    • 21744456053 scopus 로고    scopus 로고
    • Cytotoxic effects of a decoction of Nigella sativa, Hemidesmus indicus and Smilax glabra on human hepatoma HepG2 cells
    • Thabrew MI, Mitry RR, Morsy MA, Hughes RD. Cytotoxic effects of a decoction of Nigella sativa, Hemidesmus indicus and Smilax glabra on human hepatoma HepG2 cells. Life Sci 2005; 77:1319-1330.
    • (2005) Life Sci , vol.77 , pp. 1319-1330
    • Thabrew, M.I.1    Mitry, R.R.2    Morsy, M.A.3    Hughes, R.D.4
  • 116
    • 78951481966 scopus 로고    scopus 로고
    • comparison of the cytotoxic potential of standardized aqueous and ethanolic extracts of a polyherbal mixture comprised of Nigella sativa (seeds), Hemidesmus indicus (roots) and Smilax glabra (rhizome)
    • Samarakoon SR, Thabrew I, Galhena PB, De Silva D, Tennekoon KH. A comparison of the cytotoxic potential of standardized aqueous and ethanolic extracts of a polyherbal mixture comprised of Nigella sativa (seeds), Hemidesmus indicus (roots) and Smilax glabra (rhizome). Pharmacognosy Res 2010; 2:335-342.
    • (2010) Pharmacognosy Res , vol.2 , pp. 335-342
    • Samarakoon, S.R.1    Thabrew, I.2    Galhena, P.B.3    De Silva, D.4    Tennekoon, K.H.5
  • 117
    • 0025774015 scopus 로고
    • Inhibitory effects of Nigella sativa and saffron (Crocus sativus) on chemical carcinogenesis in mice
    • Salomi MJ, Nair SC, Panikkar KR. Inhibitory effects of Nigella sativa and saffron (Crocus sativus) on chemical carcinogenesis in mice. Nutr Canc 1991; 16:67-72.
    • (1991) Nutr Canc , vol.16 , pp. 67-72
    • Salomi, M.J.1    Nair, S.C.2    Panikkar, K.R.3
  • 118
    • 70349528180 scopus 로고    scopus 로고
    • Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells
    • Chehl N, Chipitsyna G, Gong Q, Yeo CJ, Arafat HA. Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells. HPB 2009; 11:373-381.
    • (2009) HPB , vol.11 , pp. 373-381
    • Chehl, N.1    Chipitsyna, G.2    Gong, Q.3    Yeo, C.J.4    Arafat, H.A.5
  • 119
    • 67650466020 scopus 로고    scopus 로고
    • Antitumor activity of gemcitabine and oxaliplatin is augmented by thymoquinone in pancreatic cancer
    • Banerjee S, Kaseb AO, Wang Z, Kong D, Mohammad M, Padhye S, et al. Antitumor activity of gemcitabine and oxaliplatin is augmented by thymoquinone in pancreatic cancer. Canc Res 2009; 69:5575-5583.
    • (2009) Canc Res , vol.69 , pp. 5575-5583
    • Banerjee, S.1    Kaseb, A.O.2    Wang, Z.3    Kong, D.4    Mohammad, M.5    Padhye, S.6
  • 120
    • 77952140698 scopus 로고    scopus 로고
    • Effects of thymoquinone in the expression of mucin 4 in pancreatic cancer cells: Implications for the development of novel cancer therapies
    • Torres MP, Ponnusamy MP, Chakraborty S, Smith LM, Das S, Arafat HA, et al. Effects of thymoquinone in the expression of mucin 4 in pancreatic cancer cells: implications for the development of novel cancer therapies. Mol Canc Therapeutics 2010; 9:1419-1431.
    • (2010) Mol Canc Therapeutics , vol.9 , pp. 1419-1431
    • Torres, M.P.1    Ponnusamy, M.P.2    Chakraborty, S.3    Smith, L.M.4    Das, S.5    Arafat, H.A.6
  • 121
    • 73149092315 scopus 로고    scopus 로고
    • Induction of apoptosis in HeLa cells by chloroform fraction of seed extracts of Nigella sativa
    • Shafi G, Munshi A, Hasan TN, Alshatwi AA, Jyothy A, Lei DK. Induction of apoptosis in HeLa cells by chloroform fraction of seed extracts of Nigella sativa. Cancer Cell Int 2009; 9:29.
    • (2009) Cancer Cell Int , vol.9 , pp. 29
    • Shafi, G.1    Munshi, A.2    Hasan, T.N.3    Alshatwi, A.A.4    Jyothy, A.5    Lei, D.K.6
  • 122
    • 84875777905 scopus 로고    scopus 로고
    • Methanolic extract of Nigella sativa seed inhibits SiHa human cervical cancer cell proliferation through apoptosis
    • Hasan TN, Shafi G, Syed NA, Alfawaz MA, Alsaif MA, Munshi A, et al. Methanolic extract of Nigella sativa seed inhibits SiHa human cervical cancer cell proliferation through apoptosis. Natur Prod Commun 2013; 8:213-216.
    • (2013) Natur Prod Commun , vol.8 , pp. 213-216
    • Hasan, T.N.1    Shafi, G.2    Syed, N.A.3    Alfawaz, M.A.4    Alsaif, M.A.5    Munshi, A.6
  • 124
    • 0031878048 scopus 로고    scopus 로고
    • The in vitro anti-tumor activity of some crude and purified components of blackseed, Nigella sativa L
    • Worthen DR, Ghosheh OA, Crooks P. The in vitro anti-tumor activity of some crude and purified components of blackseed, Nigella sativa L. Anticanc Res 1997; 18:1527-1532.
    • (1997) Anticanc Res , vol.18 , pp. 1527-1532
    • Worthen, D.R.1    Ghosheh, O.A.2    Crooks, P.3
  • 125
    • 0033379794 scopus 로고    scopus 로고
    • Inhibition of benzo (a) pyrene-induced forestomach carcinogenesis in mice by thymoquinone
    • Badary O, AI-Shabanah O, Nagi M, AI-Rikabi A, Elmazar M. Inhibition of benzo (a) pyrene-induced forestomach carcinogenesis in mice by thymoquinone. Eur J Canc Prev 1999; 8:435-440.
    • (1999) Eur J Canc Prev , vol.8 , pp. 435-440
    • Badary, O.1    Ai-Shabanah, O.2    Nagi, M.3    Ai-Rikabi, A.4    Elmazar, M.5
  • 126
    • 0035237915 scopus 로고    scopus 로고
    • Inhibitory effects of thymoquinone against 20-methylcholanthreneinduced fibrosarcoma tumorigenesis
    • Badary OA, El-Din AMG. Inhibitory effects of thymoquinone against 20-methylcholanthreneinduced fibrosarcoma tumorigenesis. Canc Detect Prev 2001; 25:362-368.
    • (2001) Canc Detect Prev , vol.25 , pp. 362-368
    • Badary, O.A.1    El-Din, M.G.2
  • 127
    • 34247580036 scopus 로고    scopus 로고
    • comparison of 5-fluorouracil and natural chemotherapeutic agents, EGCG and thymoquinone, delivered by sustained drug delivery on colon cancer cells
    • Norwood A, Tucci M, Benghuzzi H. A comparison of 5-fluorouracil and natural chemotherapeutic agents, EGCG and thymoquinone, delivered by sustained drug delivery on colon cancer cells. Biomed Sci Instrum 2006; 43:272-277.
    • (2006) Biomed Sci Instrum , vol.43 , pp. 272-277
    • Norwood, A.1    Tucci, M.2    Benghuzzi, H.A.3
  • 128
    • 70449089588 scopus 로고    scopus 로고
    • Comparison of potential chemotherapeutic agents, 5-fluoruracil, green tea, and thymoquinone on colon cancer cells
    • Norwood A, Tan M, May M, Tucci M, Benghuzzi H. Comparison of potential chemotherapeutic agents, 5-fluoruracil, green tea, and thymoquinone on colon cancer cells. Biomed Sci Instrum 2005; 42:350-356.
    • (2005) Biomed Sci Instrum , vol.42 , pp. 350-356
    • Norwood, A.1    Tan, M.2    May, M.3    Tucci, M.4    Benghuzzi, H.5
  • 129
    • 26444457920 scopus 로고    scopus 로고
    • Thymoquinone induces apoptosis through activation of caspase-8 and mitochondrial events in p53-null myeloblastic leukemia HL-60 cells
    • El-Mahdy MA, Zhu Q, Wang QE, Wani G, Wani AA. Thymoquinone induces apoptosis through activation of caspase-8 and mitochondrial events in p53-null myeloblastic leukemia HL-60 cells. Int J Canc 2005; 117:409-417.
    • (2005) Int J Canc , vol.117 , pp. 409-417
    • El Mahdy, M.A.1    Zhu, Q.2    Wang, Q.E.3    Wani, G.4    Wani, A.A.5
  • 130
    • 81155156991 scopus 로고    scopus 로고
    • The in vitro promising therapeutic activity of thymoquinone on hepatocellular carcinoma (HepG2) cell line
    • Ahmed WA, Hassan SA, Galeb FM, El-Taweel MA, Abu-Bedair FA. The in vitro promising therapeutic activity of thymoquinone on hepatocellular carcinoma (HepG2) cell line. Global Veterinaria 2008; 2:233-241.
    • (2008) Global Veterinaria , vol.2 , pp. 233-241
    • Ahmed, W.A.1    Hassan, S.A.2    Galeb, F.M.3    El-Taweel, M.A.4    Abu-Bedair, F.A.5
  • 131
    • 67549099839 scopus 로고    scopus 로고
    • M.Galeb F, El-Taweel M, A.Abu-Bedair f. In vitro challenge using thymoquinone on hepatocellular carcinoma (HepG2) cell line
    • Hassan S, Ahmed W, M.Galeb F, El-Taweel M, A.Abu-Bedair f. In vitro challenge using thymoquinone on hepatocellular carcinoma (HepG2) cell line. Iran J Pharm Res 2010; 7:283-90.
    • (2010) Iran J Pharm Res , vol.7 , pp. 283-290
    • Hassan, S.1    Ahmed, W.2
  • 132
    • 77949263613 scopus 로고    scopus 로고
    • Reactive oxygen species mediate thymoquinone-induced apoptosis and activate ERK and JNK signaling
    • El-Najjar N, Chatila M, Moukadem H, Vuorela H, Ocker M, Gandesiri M, et al. Reactive oxygen species mediate thymoquinone-induced apoptosis and activate ERK and JNK signaling. Apoptosis 2010; 15:183-195.
    • (2010) Apoptosis , vol.15 , pp. 183-195
    • El-Najjar, N.1    Chatila, M.2    Moukadem, H.3    Vuorela, H.4    Ocker, M.5    Gandesiri, M.6
  • 133
    • 0025774015 scopus 로고
    • Inhibitory effects of Nigella sativa and saffron (Crocus sativus) on chemical carcinogenesis in mice
    • Salomi M, Nair SC, Panikkar K. Inhibitory effects of Nigella sativa and saffron (Crocus sativus) on chemical carcinogenesis in mice. Nutr Cancer 1991; 16:67-72.
    • (1991) Nutr Cancer , vol.16 , pp. 67-72
    • Salomi, M.1    Nair, S.C.2    Panikkar, K.3
  • 134
    • 34548015409 scopus 로고    scopus 로고
    • Androgen receptor–and E2F- 1–targeted thymoquinone therapy for hormone-refractory prostate cancer
    • Kaseb AO, Chinnakannu K, Chen D, Sivanandam A, Tejwani S, Menon M, et al. Androgen receptor–and E2F- 1–targeted thymoquinone therapy for hormone-refractory prostate cancer. Canc Res 2007; 67:7782-7788.
    • (2007) Canc Res , vol.67 , pp. 7782-7788
    • Kaseb, A.O.1    Chinnakannu, K.2    Chen, D.3    Sivanandam, A.4    Tejwani, S.5    Menon, M.6
  • 135
    • 77953178795 scopus 로고    scopus 로고
    • Studies on molecular mechanisms of growth inhibitory effects of thymoquinone against prostate cancer cells: Role of reactive oxygen species
    • Koka PS, Mondal D, Schultz M, Abdel-Mageed AB, Agrawal KC. Studies on molecular mechanisms of growth inhibitory effects of thymoquinone against prostate cancer cells: role of reactive oxygen species. Exp Biol Med 2010; 235:751-760.
    • (2010) Exp Biol Med , vol.235 , pp. 751-760
    • Koka, P.S.1    Mondal, D.2    Schultz, M.3    Abdel-Mageed, A.B.4    Agrawal, K.C.5
  • 136
    • 51049120763 scopus 로고    scopus 로고
    • Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways
    • Yi T, Cho S-G, Yi Z, Pang X, Rodriguez M, Wang Y, et al. Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways. Mol Canc Therapeutics 2008; 7:1789-1796.
    • (2008) Mol Canc Therapeutics , vol.7 , pp. 1789-1796
    • Yi, T.1    Cho, S.-G.2    Yi, Z.3    Pang, X.4    Rodriguez, M.5    Wang, Y.6
  • 138
    • 50349098189 scopus 로고    scopus 로고
    • Targeting nuclear factor-κB activation pathway by thymoquinone: Role in suppression of antiapoptotic gene products and enhancement of apoptosis
    • Sethi G, Ahn KS, Aggarwal BB. Targeting nuclear factor-κB activation pathway by thymoquinone: role in suppression of antiapoptotic gene products and enhancement of apoptosis. Mol Canc Res 2008; 6:1059-1070.
    • (2008) Mol Canc Res , vol.6 , pp. 1059-1070
    • Sethi, G.1    Ahn, K.S.2    Aggarwal, B.B.3
  • 139
    • 75149187342 scopus 로고    scopus 로고
    • Nigella sativa thymoquinone-rich fraction greatly improves plasma antioxidant capacity and expression of antioxidant genes in hypercholesterolemic rats
    • Ismail M, Al-Naqeep G, Chan KW. Nigella sativa thymoquinone-rich fraction greatly improves plasma antioxidant capacity and expression of antioxidant genes in hypercholesterolemic rats. Free Radical Biol Med 2010; 48:664-672.
    • (2010) Free Radical Biol Med , vol.48 , pp. 664-672
    • Ismail, M.1    Al-Naqeep, G.2    Chan, K.W.3
  • 140
    • 56049113023 scopus 로고    scopus 로고
    • Cardioprotective effects of Nigella sativa oil on cyclosporine A-induced cardiotoxicity in rats
    • Ebru U, Burak U, Yusuf S, Reyhan B, Arif K, Faruk TH, et al. Cardioprotective effects of Nigella sativa oil on cyclosporine A-induced cardiotoxicity in rats. Basic Clin Pharmacol Toxicol 2008; 103:574-580.
    • (2008) Basic Clin Pharmacol Toxicol , vol.103 , pp. 574-580
    • Ebru, U.1    Burak, U.2    Yusuf, S.3    Reyhan, B.4    Arif, K.5    Faruk, T.H.6
  • 141
    • 42949175548 scopus 로고    scopus 로고
    • Effects of thymoquinone and selenium on the proliferation of mg 63 cells in tissue culture
    • Barron J, Benghuzzi H, Tucci M. Effects of thymoquinone and selenium on the proliferation of mg 63 cells in tissue culture. Biomed Sci Instrum 2007; 44:434-440.
    • (2007) Biomed Sci Instrum , vol.44 , pp. 434-440
    • Barron, J.1    Benghuzzi, H.2    Tucci, M.3
  • 142
    • 84921662567 scopus 로고    scopus 로고
    • Thymoquinone in the control of hypoxia-induced angiogenic disease biomarkers: Insight into the mechanism of action in vitro
    • Bawadi H. A, Bansode R. R, Losso J. N. Thymoquinone in the control of hypoxia-induced angiogenic disease biomarkers: Insight into the mechanism of action in vitro, IFT Annual Meeting 2004; Las Vegas NV USA, 2004: 7-8
    • (2004) IFT Annual Meeting 2004; Las Vegas NV USA , pp. 7-8
    • Bawadi, H.A.1    Bansode, R.R.2    Losso, J.N.3
  • 143
    • 0037357643 scopus 로고    scopus 로고
    • Intracellular glutathione depletion and reactive oxygen species generation are important in α-hederin-induced apoptosis of P388 cells
    • Swamy SM, Huat BT. Intracellular glutathione depletion and reactive oxygen species generation are important in α-hederin-induced apoptosis of P388 cells. Mol Cell Biochem 2003; 245:127-139.
    • (2003) Mol Cell Biochem , vol.245 , pp. 127-139
    • Swamy, S.M.1    Huat, B.T.2


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