Pharmacological and toxicological properties of Nigella sativa

Phytotherapy Research

Volumn 17, Issue 4, 2003, Pages 299-305

  Ali, B H ^a   Blunden, Gerald ^b  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b UNIVERSITY OF PORTSMOUTH   (United Kingdom)

Author keywords

Antiinflammatory; Antineoplastic; Nigella sativa; Thymoquinone

Indexed keywords

ALKALOID DERIVATIVE; ESSENTIAL OIL; HEMOGLOBIN; NIGELLA SATIVA EXTRACT; SAPONIN DERIVATIVE; THYMOQUINONE;

ANALGESIC ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; CARDIOVASCULAR EFFECT; DRUG ISOLATION; DRUG STRUCTURE; IMMUNOMODULATION; LIVER PROTECTION; MUTAGENICITY; NONHUMAN; PLANT SEED; REVIEW; TOXICITY TESTING;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTINEOPLASTIC AGENTS; BENZOQUINONES; HUMANS; MEDICINE, TRADITIONAL; NIGELLA SATIVA; PHYTOTHERAPY; PLANT EXTRACTS; PLANT OILS; RATS; SEEDS;

CUMINUM CYMINUM; NIGELLA SATIVA; RANUNCULACEAE;

EID: 0038559976     PISSN: 0951418X     EISSN: None     Source Type: Journal    
DOI: 10.1002/ptr.1309     Document Type: Review

References (63)

1. Abdel Fatah M, Matsumoto K, Watanake H. 2000. Antinociceptive effects of Nigella sativa oil and its major components in mice. Eur J Pharmacol 400: 89-97.
2. Aboul-Ela EL. 2002. Cytogenetic studies on Nigella sativa seeds and thymoquinone on mouse cells infected with schistosomiasis using karyotyping. Mutat Res 51: 11-17.
3. Agrawal R, Kharya MD, Shrivastava R. 1979. Antimicrobial and anthelmintic activities of the essential oil of Nigella sativa Linn. Indian J Exp Biol 17: 1264-1265.
4. Akhtar AH, Ahmad KD, Gilani SN, Nazir A. 1996. Antiulcer effects of aqueous extracts of Nigella sativa and Pongamia pinnata in rats. Fitoterapia 38: 195-199.
5. Al-Awadi F, Fatania H, Shamte U. 1991. The effect of a plant mixture extract on liver gluconeogenesis in streptozotocin induced diabetic rats. Diab Res 18: 163-168.
6. Al-Awadi F, Gumaa KA. 1987. Studies on the activity of individual plants of an antidiabetic plant mixture. Acta Diab Lat 24: 37-41.
7. Al-Ghamdi MS. 2001. The anti-inflammatory, analgesic and antipyretic activity of Nigella sativa. J Ethnopharmacol 76: 45-48.
8. Al-Gharably NM, Badary O, Nagi M, et al. 1997. Protective effect of thymoquinone against carbon tetrachloride-induced hepatotoxicity in mice. Res Comm Pharmacol Toxicol 2: 41-50.
9. Al-Hader A, Aqel M, Hasan Z. 1993. Hypoglycemic effects of the volatile oil of Nigella sativa seeds. Int J Pharmacog 31: 96-100.
10. Atta-ur-Rahman, Malik S, Ahmed S, Choudhary MI, Habib-urRehman. 1985a. Nigellimine-N-oxide-a new isoquinoline alkaloid from the seeds of Nigella sativa. Heterocycles 23: 953-955.
11. Atta-ur-Rahman, Malik S, Cun-heng H, Clardy J. 1985b. Isolation and structure determination of nigellicine, a novel alkaloid from the seeds of Nigella sativa. Tetrahedron Lett 23: 2759-2762.
12. Atta-ur-Rahman, Malik S, Hasan SS, Choudhary MI, Ni C-Z, Clardy J. 1995. Nigellidine, a new indazole alkaloid from the seeds of Nigella sativa. Tetrahedron Lett 36: 1993-1996.
13. Atta-ur-Rahman, Malik S, Zaman K. 1992. Nigellimine, a new isoquinoline alkaloid from the seeds of Nigella sativa. J Nat Prod 55: 676-678.
14. Badary OA. 1999. Thymoquinone attenuates ifosfamide-induced Fanconi syndrome in rats and enhances its antitumor activity in mice. J Ethnopharmacol 67: 135-142.
15. Badary OA, Al-Shabanah OA, Nagi MN, Al-Bekairi AM, Almazar MMA. 1998. Acute and subchronic toxicity of thymoquinone in mice. Drug Develop Res 44: 56-61.
16. Badary OA, Al-Shabanah OA, Nagi MN, Al-Rikabi AC, Almazar MMA. 1999. Inhibition of benzo(a)pyrene-induced forestomach carcinogenesis in mice by thymoquinone. Eur J Cancer Prev 8: 435-440.
17. Badary OA, Gamal AM. 2001. Inhibitory effects of thymoquinone against 20-methylcholantherene-induced fibrosarcoma tumorigenesis. Cancer Detec Prev 25: 362-368.
18. Badary OA, Nagi MN, Al-Shabanah OA, Al-Shawaf HA, Al-Sohaibani MO, Al-Bekairi AM. 1997. Thymoquinone ameliorates the nephrotoxicity induced by cisplatin in rodents and potentiates its antitumor activity. Can J Physiol Pharmacol 75: 1356-1361.
19. Beckstrom-Sternberg SM, Duke JA. 1994. Potential for synergistic action of phytochemicals in spices. In Spices Herbs and Edible Fungi. Elsevier Science: Oxford, 201-223.
20. Burits M, Bucar F. 2000. Antioxidant activity of Nigella sativa essential oil. Phytother Res 14: 323-328.
21. Chakravarty N. 1993. Inhibition of histamine release from mast cells by nigellone. Ann Allergy 70: 237-242.
22. Daba MH, Abdel Rahman MS. 1998. Hepatoprotective activity of thymoquinone in isolated rat hepatocytes. Toxicol Lett 95: 23-29.
23. El-Dakhakhny M. 1963. Studies on the chemical constituents of Egyptian Nigella sativa L. seeds. The essential oil. Planta Med 11: 465-470.
24. El-Dakhakhny M, Barakat M, Abd El-Halim M, Aly SM. 2000a. Effect of Nigella sativa oil on gastric secretion and ethanol induced ulcer in rats. J Ethnopharmacol 72: 299-304.
25. El-Dakhakhny M, Mady NI, Halim MA. 2000b. Nigella sativa L. protects against induced hepatotoxicity and improves serum lipid profile in rats. Arzneimittelforsch 50: 832-836.
26. El Daly ES. 1998. Protective effect of cysteine and vitamin E, Crocus sativus and Nigella sativa extracts on cisplatin-induced toxicity in rats. J Pharm Bel 53: 87-95.
27. El-Kadi A, Kandil O. 1987. The black seed (Nigella sativa) and immunity: its effect on human T cell subset. Fed Proc 46: 1222.
28. El-Kadi A, Kandil O, Tabuni AM. 1987. Nigella sativa cell-mediated immunity. Arch AIDS Res 1: 232-233.
29. El-Kamali HH, Ahmed AH, Mohammed AS, Yahia IA, El-Tayeb IH, Ali AA. 1998. Antibacterial properties of essential oils from Nigella sativa seeds, Cymbopogon citatus leaves and Pulicaria undulata aerial parts. Fitoterapia 34: 77-78.
30. El-Tahir KE, Ashour MM, Al-Harbi MM. 1993a. The respiratory effects of the volatile oil of the black seed (Nigella sativa) in guinea pigs: elucidation of the mechanism(s) of action. Gen Pharmacol 24: 1115-1122.
31. El-Tahir KE, Ashour MM, Al-Harbi MM. 1993b. The cardiovascular actions of the volatile oil of the black seed (Nigella sativa) in rats: elucidation of the mechanism of action. Gen Pharmacol 24: 1123-1131.
32. El-Zawahrawy B, Fatma Al-Zahraa AH. 1998. Effect of Nigella sativa on blood level and structure of liver and pancreas in adult male albino rats. Al-Azhar Med J 27: 479-483.
33. Enomoto S, Asano R, Iwahori Y, et al. 2001. Hematological studies on black cumin oil from the seeds of Nigella sativa L. Biol Pharm Bull 24: 307-310.
34. Gilani AH, Aziz N, Khurram IM, Chaudary KS, Iqbal A. 2001. Bronchodilator, spasmolytic and calcium antagonist activities of Nigella sativa seeds (Kalonji). J Pak Med Assoc 51: 115-120.
35. Hailat N, Batainch Z, Lafi S, et al. 1995. Effect of Nigella sativa volatile oil on Jukart T cell leukemia polypeptides. Int J Pharmacogen 33: 16-20.
36. Haq A, Abdullatif M, Lobo PI, Khabar KSA, Sheth KV, Al-Sedairy ST. 1995. Nigella sativa: effect on human lymphocytes and polymorphonuclear leukocyte phagocytic activity. Immunopharmacology 30: 147-155.
37. Haq A, Lobo P, Al-Tufail M, Rama N, Al-Sedairy ST. 1999. Immunomodulatory effect of Nigella sativa proteins fractionated by ion exchange chromatography. Int J Immunopharmacol 21: 283-295.
38. Houghton PJ, Zarka R, de las Heras B, Hoult JRS. 1995. Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation. Planta Med 61: 33-36.
39. Khanna T, Zaidi FA, Dandiya PC. 1993. CNS and analgesic studies on Nigella sativa. Fitoterapia 5: 407-410.
40. Kumara SS, Huat BT. 2001. Extraction, isolation and characterization of antitumor principle, alpha-hederin, from the seeds of Nigella sativa. Planta Med 67: 29-32.
41. Lautenbacher LM. 1997. Schwarzkümmelöl. Dtsch Apoth Ztg 137: 68-69.
42. Mahmoud MR, El-Abhar HS, Saleh S. 2002. The effects of Nigella sativa oil against the liver damage induced by Schistosoma mansoni in mice. J Ethnopharmacol 79: 1-11.
43. Marozzi FJ, Koclalski AB, Malone MH. 1970. Studies on the antihistaminic effects of thymoquinone, thymohydroquinone and quercitin. Drug Res 20: 1574-1577.
44. Meral I, Yener Z, Kahraman T, Mert N. 2001. Effect of Nigella sativa on glucose concentration, lipid peroxidation, anti-oxidant defence system and liver damage in experimentally-induced diabetic rabbits. J Vet Med A 48: 593-599.
45. Morsi NM. 2000. Antimicrobial effect of crude extracts of Nigella sativa on multiple antibiotics-resistant bacteria. Acta Microbiol Pol 49: 63-74.
46. Mutabagani A, El-Mahdi SM. 1997. A study of the anti-inflammatory activity of Nigella sativa L. and thymoquinone in rats. Saudi Pharmacol J 5: 110-113.
47. Nadkarni AK. 1976. Indian Materia Medica. Popular Parkishan: Bombay, India, 854.
48. Nagi MN, Alam K, Badary OA. 1999. Thymoquinone protects against carbon tetrachloride hepatotoxicity in mice via an antioxidant mechanism. Biochem Mol Biol Int 47: 143-159.
49. Nair SC, Salomi MJ, Panikkar B, Panikkar KP. 1991. Modulatory effects of Crocus sativus and Nigella sativa extracts on cisplatin-induced toxicity in mice. J Ethnopharmacol 31: 16-20.
50. Salem ML, Hossain MS. 2000. Protective effect of black seed oil from Nigella sativa against murine cytomegalovirus infection. Int J Immunopharmacol 22: 729-740.
51. Salomi NJ, Nair SC, Jayawardhanan KK, Varghese CD, Panikkar LR. 1992. Anti-tumor principles from Nigella sativa and saffron (Crocus sativus) on chemical carcinogenesis in mice. Nutr Cancer 16: 67-72.
52. Salomi NJ, Nair SC, Panikkar LR. 1991. Inhibitory effects of Nigella sativa and saffron (Crocus sativus) on chemical carcinogenesis seeds. Cancer Lett 63: 41-46.
53. Sayed MD. 1980. Traditional medicine in health care. J Ethnopharmacol 2: 19-22.
54. Steinmann A, Scatze M, Agathos M, Brett R. 1997. Allergic contact dermatitis from black cumin (Nigella sativa) oil after topical use. Contact Dermat 36: 268-269.
55. Swamy SMK, Benny TKH. 2001. Extraction, isolation and characterisation of antitumor principle, α-hederin, from the seeds of Nigella sativa. Planta Med 67: 29-32.
56. Swamy SMK, Tan BKH. 2000. Cytotoxic and immunopotentiating effects of ethanolic extract of Nigella sativa L. seeds. J Ethnopharmacol 70: 1-7.
57. Turkdogan MK, Agaoglu Z, Yener Z, Sekeroglu R, Akkan HA, Avci ME. 2000. The role of antioxidant vitamins (C and E), selenium and Nigella sativa in the prevention of liver fibrosis and cirrhosis in rabbits, new hopes. Dtscch Tierarzt Wschr 108: 71-73.
58. Worthen DR, Ghosheh O, Crooks PA. 1998. The in vitro anti-tumor activity of some crude and purified components of blackseed, Nigella sativa. Anticancer Res 18: 1527-1532.
59. Zahira M, Gabra S. 1943. Melanthigenin and its identity with hederagenin. J Chem Soc 42: 70-71.
60. Zaoui A, Cherrah Y, Alaoui K, Mahassine N, Amarouch H, Hassar M. 2002a. Effects of Nigella sativa fixed oil on blood homeostasis in rat. J Ethnopharmacol 79: 23-26.
61. Zaoui A, Cherrah Y, Lacaille-Dubois MA, Settaf A, Amarouch H, Hassar M. 2000. Diuretic and hypotensive effects of Nigella sativa in the spontaneously hypertensive rat. Therapie 55: 379-382.
62. Zaoui A, Cherrah Y, Mahassine N, Alaoui K, Amarouch H, Hassar M. 2002b. Acute and chronic toxicity of Nigella sativa fixed oil. Phytomedicine 9: 69-74.
63. Zedlitz S, Kaufmann R, Bochncke WH. 2002. Allergic contact dermatitis from black cumin (Nigella sativa) oil-containing ointment. Contact Derm 46: 188.