Effect of black cumin (Nigella sativa) on heart rate, some hematological values, and pancreatic β-cell damage in cadmium-treated rats

Biological Trace Element Research

Volumn 110, Issue 2, 2006, Pages 151-162

  Demir, Halit ^a   Kanter, Mehmet ^b   Coskun, Omer ^b   Uz, Yesim Hulya ^b   Koc, Ahmet ^c   Yildiz, Abdulmelik ^d  

^a YUZUNCU YIL UNIVERSITY   (Turkey)

^b TRAKYA UNIVERSITY   (Turkey)

^c MUSTAFA KEMAL UNIVERSITY   (Turkey)

^d FIRAT UNIVERSITY   (Turkey)

Author keywords

Cadmium; Heart rate; Hematological values; Nigella sativa; Pancreatic cell; Rat

Indexed keywords

CADMIUM; CADMIUM CHLORIDE; INSULIN; NIGELLA SATIVA EXTRACT; SODIUM CHLORIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLACK CUMIN; BLOOD SAMPLING; CADMIUM POISONING; CELL DEATH; CELL DEGENERATION; CONTROLLED STUDY; DEGRANULATION; DOSE RESPONSE; ELECTROCARDIOGRAM; ERYTHROCYTE COUNT; GLUCOSE BLOOD LEVEL; HEART RATE; HEMOGLOBIN DETERMINATION; IMMUNOHISTOCHEMISTRY; INSULIN BLOOD LEVEL; LEUKOCYTE COUNT; MALE; NEUTROPHIL; NONHUMAN; PANCREAS ISLET BETA CELL; RAT;

ANIMALS; BLOOD CELL COUNT; CADMIUM; HEART RATE; HEMATOLOGIC TESTS; INSULIN-SECRETING CELLS; MALE; NIGELLA SATIVA; PLANT EXTRACTS; RATS; RATS, WISTAR;

ANIMALIA; NIGELLA SATIVA;

EID: 33745726077     PISSN: 01634984     EISSN: None     Source Type: Journal    
DOI: 10.1385/BTER:110:2:151     Document Type: Article

References (44)

1. M. Kanter, O. Coskun, and A Gurel, The effect of black cumin (Nigella sativa) on cadmium induced oxidative stress in the blood of rats, Biol. Trace Element Res., 107, 277-287 (2005).
2. R. Swiergosz, M. Zakrzewska, K. Sawicka-Kapusta, K. Bacia, and I. Jankowska, Accumulation of cadmium and its effect on bank vole tissues after chronic exposure, Ecotoxicol. Environ. Safety 41, 130-136 (1998).
3. S. Stohs, D. Bagchi, E. Hassoun, and M. Bagchi, Oxidative mechanisms in the toxicity of chromium and cadmium ions, J. Environ. Pathol. Toxicol. Oncol. 19, 201-213 (2000).
4. J. Bauman, J. Liu, and C. Klaassen, Production of metalothionein and heat-shock proteins in response to metals, Fundam. Appl. Toxicol. 21, 15-22 (1993).
5. C. Simpkins, T. Lloyd, S. Li, and S. Balderman, Metallothionein-induced increase in mitochondrial inner membrane permeability, J. Surg. Res. 75, 30-34 (1998).
6. S. Sarkar, P. Yadav, R. Trivedi, A. Bansal, and D. Bhatnager, Cadmium-induced lipid peroxidation and the status antioxidant system in rat tissues, J. Trace Elements Med. Biol. 9, 144-149 (1995).
7. M. Johansson-Sjöbeck and A. Larsson, The effect of cadmium on the hematology and the activity of deltaaminolevulic acid dehydratase (ALA-D) in blood and hematopoetic tissues of the flounder, Pleuronectes flesus. L, Environ. Res. 17, 191-204 (1978).
8. T. Gill and A. Epple, Stress-related changes in the hematological profile of the American eel (Anguilla rostrata), Ecotoxicol. Environ. Safety 25, 227-235 (1993).
9. R. R. Bell, J. L. Early, V. K. Nonavinakere, and Z. Mallory Effect of cadmium on blood glucose level in the rat, Toxicol. Lett. 54 (2-3), 199-205 (1990).
10. Z. Merali and RL. Singhal, Diabetogenic effects of chronic oral cadmium adminstration to neonatal rats, Br. J. Pharmacol. 69(1), 151-157 (1980).
11. K. D. Chapatwala, M. Boykin, A. Butts, and B. Rajanna, Effect of intraperitoneally injected cadmium on renal and hepatic gluconeogenic enzymes in rats, Drug. Chem. Toxicol. 5(3), 305-317 (1982).
12. C. D. Klaassen and J. Liu, Role of metallothionein in cadmium-induced hepatotoxicity and nephrotoxicity Drug Metab. Rev. 29(1-2), 79-102 (1997).
13. J. H. Choi and S. J. Rhee, Effects of vitamin E on renal dysfunction in chronic cadmium-poisoned rats, J. Med. Food 6(3), 209-215 (2003).
14. M. Carmignani and P. Boscolo, Cardiovascular responsiveness to physiological agonists of male rats made hypertensive by long-term exposure to cadmium, Sci. Total Environ. 34(1-2), 19-33 (1984).
15. V. N. Puri, Effect of cadmium and captopril on serum angiotensin converting enzyme activity in rats, Indian. Heart. J. 49(3), 297-299 (1997).
16. K. E. H. El-Tahir, M. M. S. Al-Harbi, and MM. Ashour, The cardiovascular actions of the volatile oil of the black seed (Nigella sativa) in rats: elucidation of the mechanism of action, Gen. Pharmacol. 24, 1123-1131 (1993).
17. M. S. M. Hanafy and M. E. Hatem, Studies on the antimicrobial activity of Nigella sativa seed (black cumin), J. Ethnopharmacol. 34, 275-278 (1991).
18. A. El-Kadi and O. Kandil, The black seed (Nigella sativa) and immunity: its effect on human T cell subset, Fed. Proc. 46, 1222 (1987).
19. P. J. Houghton, R. Zarka, B. Heras, and J. R. Hoult, Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation, Planta Med. 61, 33-36 (1995).
20. E. S. El-Daly Protective effect of cysteine and vitamin E, Crocus sativus and Nigella sativa extracts on cisplatin-induced toxicity in rats, J. Pharm. Belg. 53, 87-93 (1998).
21. A. Al-Hader, M. Aqel, and Z. Hasan, Hypoglycemic effects of the volatile oil of Nigella sativa seeds, Int. J. Pharmacognosy 31, 96-100 (1993).
22. O. A. El-Shabrawy and S. A. Nada, Biological evaluation of multicomponent tea used as hypoglycemic in rats, Fitoterapia 67, 99-102 (1996).
23. M. Kanter, I. Meral, Z. Yener, H. Ozbek, and H. Demir, Partial regeneration/proliferation of the beta-cells in the islets of Langerhans by Nigella sativa L. in streptozotocin-induced diabetic rats, Tohoku J. Exp. Med. 201, 213-219 (2003).
24. M. Kanter, O. Coskun, A. Korkmaz, and S. Oter, Effects of Nigella sativa on oxidative stress and beta cell damage in streptozotocin-induced diabetic rats, Anatom. Rec. A 279, 685-691 (2004).
25. M. El-Dakhakhny, N. Mady, N. Lembert, and H. P. Ammon, The hypoglycemic effect of Nigella sativa oil is mediated by extrapancreatic actions, Planta Med. 68, 465-466 (2002).
26. K. M. Fararh, Y. Atoji, Y. Shimizu, and T. Takewaki, Insulinotropic properties of Nigella sativa oil in streptozotocin plus nicotinamide diabetic hamster, Res. Vet. Sci. 73(3), 279-282 (2002).
27. M. Kanter, M. Yoruk, A. Koc, I. Meral, and T. Karaca, Effects of cadmium exposure on morphological aspects of pancreas, weights of fetus and placenta in streptozotocin-induced diabetic pregnant rats, Biol. Trace Element Res. 93(1-3), 189-200 (2003).
28. M. Yenson, Clinical Biochemistry, Beta Press, Istanbul (1986).
29. S. M.Hsu, L. Raine, and H. Fanger, Use of avidin-biotin-peroxidase complex (ABC) in immunperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures, J. Histochem. Cytochem. 29, 577-580 (1981).
30. M. M. Kostić, B. Ognjanović, R. V. Zikić, A. Stajn, G. L. Rosic, and R. V. Zivkovic, Cadmium-induced changes of antioxidant and metabolic status in red blood cells of rats: in vivo effects, Eur. J. Haematol. 51, 86-92 (1993).
31. F. M. El-Demerdash, M. I. Yousef, F. S. Kedwany and H. H. Baghdadi, Cadmium-induced changes in lipid peroxidation, blood hematology, biochemical parameters and semen quality of male rats: protective role of vitamin E and β-carotene, Food Chem. Toxicol. 42, 1563-1571 (2004).
32. R. Karmakar, R. Bhattacharya, and M. Chatterjee, Biochemical, haematological and histopathological study in relation to timerelated cadmium-induced hepatotoxicity in mice, Biometals 13(3), 231-239 (2000).
33. H. T. Tung, F. W. Cook, R. D. Wyatt, and P. B. Hamilton, The anemia caused by aflatoxin, Poult. Sci. 54, 1962-1969 (1975).
34. M. I. Yousef, H. Z. Ibrahim, H. M. Yacout, and A. A. Hassan, Effects of cypermethrin and dimethoate on some physiological and biochemical parameters in Barki sheep, Egypt. J. Nut. Feeds 1, 41-52 (1998).
35. M. I. Yousef, H. Z. Ibrahim, H. M. Salem, G. A. Hassan, S. Helmi, and K. Bertheussen, Hematological and biochemical change induced by carbofuran and glyphosate in rabbits, Environ. Nutr. Interact. 3, 179-194 (1999).
36. D. T. Hart and J. L. Borowitz, Arch. Int. Pharmacodyn. Ther. 209, 94-99 (1974).
37. I. O. Shanbaky J. L. Borowitz, and W. V. Kessler, Toxicol. Appl. Pharmacol. 44, 99-105 (1978).
38. WHO, Cadmium, Environmental Health Criteria 134, World Health Organization, Geneva (1992).
39. US Department of Health Services, Toxicological profile for cadmium, Draft for public comment, Agency for Toxic Substances and Disease Registry, Atlanta (1997).
40. M. A. Amoruso, G. Witz, and B. D. Goldstein, Enhancement of rat and human phagocyte superoxide anion radical production by cadmium in vitro, Toxicol. Lett. 10, 133-138 (1982).
41. 2 formation by human polymorphonuclear leukocytes, Cancer Res. 20, 7564-7570 (1990).
42. T. Ochi, F. Otkusa, K. Takahashi, and M. Oshawa, Glutathione and metallothioneins as cellular defense against cadmium toxicity in culture Chinese hamster cells, Chem. Biol. Interact. 65, 1-14 (1988).
43. S. J. Stohs and D. Bagchi, Oxidative mechanism in the toxicity of metal ions, Free Radical Biol. Med. 18, 321-336 (1995).
44. M. Sugiyama, Role of cellular antioxidants in metal-induced damage, Cell. Biol. Toxicol. 10, 1-22 (1994).