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Volumn 40, Issue 6, 2007, Pages 839-847

Anti-tumor properties of blackseed (Nigella sativa L.) extracts

Author keywords

Anti tumor activity; Cytotoxicity; Extracts; Nigella sativa L.

Indexed keywords

ACETIC ACID ETHYL ESTER; BUTANOL; DOXORUBICIN; ESSENTIAL OIL; NIGELLA SATIVA EXTRACT;

EID: 34347325012     PISSN: 0100879X     EISSN: 1414431X     Source Type: Journal    
DOI: 10.1590/s0100-879x2006005000108     Document Type: Article
Times cited : (167)

References (28)
  • 1
    • 34347329177 scopus 로고
    • Methods in drugs development
    • De Vita Jr and Busch H Editors, New York: Academic Press;
    • Suffness M, Douras J. Methods in drugs development. De Vita Jr and Busch H (Editors), Drugs of plant origin. New York: Academic Press; 1982.
    • (1982) Drugs of plant origin
    • Suffness, M.1    Douras, J.2
  • 3
    • 0010417597 scopus 로고
    • Crocus sativus, Nigella sativa
    • Nadkami KM Editor, Bombay: Popular Prakashan;
    • Nadkami K. Crocus sativus, Nigella sativa. In: Nadkami KM (Editor), Indian materia medica. Bombay: Popular Prakashan; 1976. p 386-411.
    • (1976) Indian materia medica , pp. 386-411
    • Nadkami, K.1
  • 4
    • 0031878048 scopus 로고    scopus 로고
    • The in vitro anti-tumor activity of some crude and purified components of blackseed
    • Worthen DR, Ghosheh OA, Crooks PA. The in vitro anti-tumor activity of some crude and purified components of blackseed, Nigella sativa L. Anticancer Res 1998; 18: 1527-1532.
    • (1998) Nigella sativa L. Anticancer Res , vol.18 , pp. 1527-1532
    • Worthen, D.R.1    Ghosheh, O.A.2    Crooks, P.A.3
  • 6
    • 0001645850 scopus 로고
    • The effect of nigellon therapy on the histaminopexic power of blood sera asthmatic patients
    • Mahfouz M, Abdel-maguid R, El-Dakhakhny M. The effect of nigellon therapy on the histaminopexic power of blood sera asthmatic patients. Arzneimittelforschung 1965; 15:1230-1231.
    • (1965) Arzneimittelforschung , vol.15 , pp. 1230-1231
    • Mahfouz, M.1    Abdel-maguid, R.2    El-Dakhakhny, M.3
  • 7
    • 0027309568 scopus 로고
    • Hypoglycaemic effects of the volatile oil of Nigella sativa
    • Al-Hader A, Aqel M, Hassan Z. Hypoglycaemic effects of the volatile oil of Nigella sativa. Int J Pharmacognosy 1993; 31: 96-100.
    • (1993) Int J Pharmacognosy , vol.31 , pp. 96-100
    • Al-Hader, A.1    Aqel, M.2    Hassan, Z.3
  • 8
    • 0027264732 scopus 로고
    • The cardiovascular actions of the volatile oil of the black seed (Nigella sativa) in rats: Elucidation of the mechanism of action
    • El Tahir KE, Ashour MM, al-Harbi MM. The cardiovascular actions of the volatile oil of the black seed (Nigella sativa) in rats: elucidation of the mechanism of action. Gen Pharmacol 1993; 24:1123-1131.
    • (1993) Gen Pharmacol , vol.24 , pp. 1123-1131
    • El Tahir, K.E.1    Ashour, M.M.2    al-Harbi, M.M.3
  • 9
    • 0028852880 scopus 로고
    • Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation
    • Houghton PJ, Zarka R, de las Heras B, Hoult JR. Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation. Planta Med 1995; 61: 33-36.
    • (1995) Planta Med , vol.61 , pp. 33-36
    • Houghton, P.J.1    Zarka, R.2    de las Heras, B.3    Hoult, J.R.4
  • 10
    • 0016431808 scopus 로고
    • Isolation and structure assignment of an anti-microbial principle from the volatile oil Nigella sativa L
    • El-Alfy T, El-Fatatry H, Toama M. Isolation and structure assignment of an anti-microbial principle from the volatile oil Nigella sativa L. Pharmazia 1975; 30:109-111.
    • (1975) Pharmazia , vol.30 , pp. 109-111
    • El-Alfy, T.1    El-Fatatry, H.2    Toama, M.3
  • 11
    • 0001900638 scopus 로고
    • The isolation of a crystalline active principle from Nigella sativa seeds
    • Mahfouz M, El-Dakhakhny M. The isolation of a crystalline active principle from Nigella sativa seeds. Pharm Sci United Arab Rep 1960; 1: 19.
    • (1960) Pharm Sci United Arab Rep , vol.1 , pp. 19
    • Mahfouz, M.1    El-Dakhakhny, M.2
  • 12
    • 0038559976 scopus 로고    scopus 로고
    • Pharmacological and toxicological properties of Nigella sativa
    • Ali BH, Blunden G. Pharmacological and toxicological properties of Nigella sativa. Phytother Res 2003; 17: 299-305.
    • (2003) Phytother Res , vol.17 , pp. 299-305
    • Ali, B.H.1    Blunden, G.2
  • 14
    • 0025774015 scopus 로고
    • Inhibitory effects of Nigella sativa and saffron (Crocus sativus) on chemical caminogenesis in mice
    • Salomi MJ, Nair SC, Panikkar KR. Inhibitory effects of Nigella sativa and saffron (Crocus sativus) on chemical caminogenesis in mice. Nutr Cancer 1991; 16: 67-72.
    • (1991) Nutr Cancer , vol.16 , pp. 67-72
    • Salomi, M.J.1    Nair, S.C.2    Panikkar, K.R.3
  • 15
    • 0035098984 scopus 로고    scopus 로고
    • Extraction, isolation and characterization of anti-tumor principle, alpha-Hederin, from the seeds of Nigella sativa
    • Swamy SMK, Tan BKH. Extraction, isolation and characterization of anti-tumor principle, alpha-Hederin, from the seeds of Nigella sativa Planta Medica 2001; 67: 29-32.
    • (2001) Planta Medica , vol.67 , pp. 29-32
    • Swamy, S.M.K.1    Tan, B.K.H.2
  • 16
    • 13244285843 scopus 로고    scopus 로고
    • Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism
    • Gali-Muhtasib H, Diab-Assaf M, Boltze C, Al-Hmaira J, Hartig R, Roessner A, et al. Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism. Int J Oncol 2004; 25: 857-866.
    • (2004) Int J Oncol , vol.25 , pp. 857-866
    • Gali-Muhtasib, H.1    Diab-Assaf, M.2    Boltze, C.3    Al-Hmaira, J.4    Hartig, R.5    Roessner, A.6
  • 17
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
    • Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983; 65: 55-63.
    • (1983) J Immunol Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 18
    • 0026621489 scopus 로고
    • The development of human tumor-cell resistance to TNF-alpha does not confer resistance to cytokine-induced cellular cytotoxic mechanisms
    • Zyad A, Branellec D, Mahe Y, Tursz T, Chouaib S. The development of human tumor-cell resistance to TNF-alpha does not confer resistance to cytokine-induced cellular cytotoxic mechanisms. Int J Cancer 1992; 52: 953-958.
    • (1992) Int J Cancer , vol.52 , pp. 953-958
    • Zyad, A.1    Branellec, D.2    Mahe, Y.3    Tursz, T.4    Chouaib, S.5
  • 19
    • 0028175470 scopus 로고
    • Resistance to TNF-alpha and adriamycin in the human breast cancer MCF-7 cell line: Relationship to MDR1, MnSOD, and TNF gene expression
    • Zyad A, Benard J, Tursz T, Clarke R, Chouaib S. Resistance to TNF-alpha and adriamycin in the human breast cancer MCF-7 cell line: relationship to MDR1, MnSOD, and TNF gene expression. Cancer Res 1994; 54: 825-831.
    • (1994) Cancer Res , vol.54 , pp. 825-831
    • Zyad, A.1    Benard, J.2    Tursz, T.3    Clarke, R.4    Chouaib, S.5
  • 20
    • 0029616208 scopus 로고
    • In vivo effect of the combination of TNF and adriamycin against a human breast cell line expressing the MDR-phenotype
    • Zyad A, Cai Z, Modzet J, Legres LG, Benard J, Chouaib S. In vivo effect of the combination of TNF and adriamycin against a human breast cell line expressing the MDR-phenotype. Int J Oncol 1995; 7: 1067.
    • (1995) Int J Oncol , vol.7 , pp. 1067
    • Zyad, A.1    Cai, Z.2    Modzet, J.3    Legres, L.G.4    Benard, J.5    Chouaib, S.6
  • 22
    • 0034108281 scopus 로고    scopus 로고
    • Cytotoxic and immunopotentiating effects of ethanolic extract of Nigella sativa L. seeds
    • Swamy SM, Tan BK. Cytotoxic and immunopotentiating effects of ethanolic extract of Nigella sativa L. seeds. J Ethnopharmacol 2000; 70:1-7.
    • (2000) J Ethnopharmacol , vol.70 , pp. 1-7
    • Swamy, S.M.1    Tan, B.K.2
  • 23
    • 0034664936 scopus 로고    scopus 로고
    • Novel triterpenoids inhibit both DNA polymerase and DNA topoisomerase
    • Mizushina Y, Iida A, Ohta K, Sugawara F, Sakaguchi K. Novel triterpenoids inhibit both DNA polymerase and DNA topoisomerase. Biochem J 2000; 350 (Part 3): 757-763.
    • (2000) Biochem J , vol.350 , Issue.PART 3 , pp. 757-763
    • Mizushina, Y.1    Iida, A.2    Ohta, K.3    Sugawara, F.4    Sakaguchi, K.5
  • 24
    • 18444367100 scopus 로고    scopus 로고
    • Anti-cancer potential of sesquiterpene lactones: Bioactivity and molecular mechanisms
    • Zhang S, Won YK, Ong CN, Shen HM. Anti-cancer potential of sesquiterpene lactones: bioactivity and molecular mechanisms. Curr Med Chem Anticancer Agents 2005; 5: 239-249.
    • (2005) Curr Med Chem Anticancer Agents , vol.5 , pp. 239-249
    • Zhang, S.1    Won, Y.K.2    Ong, C.N.3    Shen, H.M.4
  • 25
    • 16344372465 scopus 로고    scopus 로고
    • A sesquiterpenelactone from Inula britannica induces anti-tumor effects dependent on Bcl-2 phosphorylation
    • Rafi MM, Bai NS, Chi TH, Rosen RT, White E, Perez D, et al. A sesquiterpenelactone from Inula britannica induces anti-tumor effects dependent on Bcl-2 phosphorylation. Anticancer Res 2005; 25: 313-318.
    • (2005) Anticancer Res , vol.25 , pp. 313-318
    • Rafi, M.M.1    Bai, N.S.2    Chi, T.H.3    Rosen, R.T.4    White, E.5    Perez, D.6
  • 26
    • 10044245898 scopus 로고    scopus 로고
    • Iddoid glucosides and p-coumaroyl iridoids from Vibumum luzonicum and their cytotoxicity
    • Fukuyama Y, Minoshima Y, Kishimoto Y, Chen IS, Takahashi H, Esumi T. Iddoid glucosides and p-coumaroyl iridoids from Vibumum luzonicum and their cytotoxicity. J Nat Prod 2004; 67:1833-1838.
    • (2004) J Nat Prod , vol.67 , pp. 1833-1838
    • Fukuyama, Y.1    Minoshima, Y.2    Kishimoto, Y.3    Chen, I.S.4    Takahashi, H.5    Esumi, T.6
  • 27
    • 0035237915 scopus 로고    scopus 로고
    • Inhibitory effects of thymoquinone against 20-methylcholanthrene-induced fibrosarcoma tumorigenesis
    • Badary OA, Gamal El-Din AM. Inhibitory effects of thymoquinone against 20-methylcholanthrene-induced fibrosarcoma tumorigenesis. Cancer Detect Prev 2001; 25: 362-368.
    • (2001) Cancer Detect Prev , vol.25 , pp. 362-368
    • Badary, O.A.1    Gamal El-Din, A.M.2
  • 28
    • 0032876393 scopus 로고    scopus 로고
    • Thymoquinone attenuates ifosfamide-induced Fanconi syndrome in rats and enhances its antitumor activity in mice
    • Badary OA. Thymoquinone attenuates ifosfamide-induced Fanconi syndrome in rats and enhances its antitumor activity in mice. J Ethnopharmacol 1999; 67: 135-142.
    • (1999) J Ethnopharmacol , vol.67 , pp. 135-142
    • Badary, O.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.