Effect of thymoquinone on mouse dendritic cells

Cellular Physiology and Biochemistry

Volumn 25, Issue 2-3, 2010, Pages 307-314

  Xuan, Nguyen Thi ^a   Shumilina, Ekaterina ^a   Qadri, Syed M ^a   Götz, Friedrich ^a   Lang, Florian ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Cytokines; LPS; Maturation; Phosphatidylserine

Indexed keywords

CD40 ANTIGEN; CD86 ANTIGEN; CYTOKINE; GLYCOPROTEIN P 15095; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 12P70; LIPOPOLYSACCHARIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; THYMOQUINONE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; BLACK CUMIN; CELL MATURATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; FLUORESCENCE ACTIVATED CELL SORTING; MOUSE; NONHUMAN; PRIORITY JOURNAL; WESTERN BLOTTING;

BACTERIA (MICROORGANISMS); NIGELLA SATIVA;

EID: 76249103767     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000276563     Document Type: Article

References (44)

1. Badary OA, Abd-Ellah MF, El Mahdy MA, Salama SA, Hamada FM: Anticlastogenic activity of thymoquinone against benzo(a)pyrene in mice. Food Chem Toxicol 2007;45:88-92.
2. Khader M, Bresgen N, Eckl PM: In vitro toxicological properties of thymoquinone. Food Chem Toxicol 2009;47:129-133.
3. Aggarwal BB, Kunnumakkara AB, Harikumar KB, Tharakan ST, Sung B, Anand P: Potential of spice-derived phytochemicals for cancer prevention. Planta Med 2008;74:1560-1569.
4. Ali BH, Blunden G: Pharmacological and toxicological properties of Nigella sativa. Phytother Res 2003;17:299-305.
5. Gali-Muhtasib H, Roessner A, Schneider-Stock R: Thymoquinone: a promising anti-cancer drug from natural sources. Int J Biochem Cell Biol 2006;38:1249-1253.
6. Gali-Muhtasib H, Ocker M, Kuester D, Krueger S, El Hajj Z, Diestel A, Evert M, El Najjar N, Peters B, Jurjus A, Roessner A, Schneider-Stock R: Thymoquinone reduces mouse colon tumor cell invasion and inhibits tumor growth in murine colon cancer models. J Cell Mol Med 2008;12:330-342.
7. Mohamed A, Shoker A, Bendjelloul F, Mare A, Alzrigh M, Benghuzzi H, Desin T: Improvement of experimental allergic encephalomyelitis (EAE) by thymoquinone; an oxidative stress inhibitor. Biomed Sci Instrum 2003;39:440-445.
8. Salem ML: Immunomodulatory and therapeutic properties of the Nigella sativa L. seed. Int Immunopharmacol 2005;5:1749-1770.
9. El Gazzar M, El Mezayen R, Marecki JC, Nicolls MR, Canastar A, Dreskin SC: Anti-inflammatory effect of thymoquinone in a mouse model of allergic lung inflammation. Int Immunopharmacol 2006;6:1135-1142.
10. El Gazzar M, El Mezayen R, Nicolls MR, Marecki JC, Dreskin SC: Downregulation of leukotriene biosynthesis by thymoquinone attenuates airway inflammation in a mouse model of allergic asthma. Biochim Biophys Acta 2006;1760:1088-1095. (Pubitemid 43867923)
11. El Gazzar MA: Thymoquinone suppressses in vitro production of IL-5 and IL-13 by mast cells in response to lipopolysaccharide stimulation. Inflamm Res 2007;56:345-351.
12. El Gazzar MA, El Mezayen R, Nicolls MR, Dreskin SC: Thymoquinone attenuates proinflammatory responses in li-popolysaccharide-activated mast cells by modulating NF-kappaB nuclear transactivation. Biochim Biophys Acta 2007;1770:556-564.
13. El Mezayen R, El Gazzar M, Nicolls MR, Marecki JC, Dreskin SC, Nomiyama H: Effect of thymoquinone on cyclooxygenase expression and prostag-landin production in a mouse model of allergic airway inflammation. Immunol Lett 2006;106:72-81. (Pubitemid 44093055)
14. Sethi G, Ahn KS, Aggarwal BB: Targeting nuclear factor-kappa B activation pathway by thymoquinone: role in suppression of antiapoptotic gene products and enhancement of apoptosis. Mol Cancer Res 2008;6:1059-1070.
15. Tekeoglu I, Dogan A, Ediz L, Budancamanak M, Demirel A: Effects of thymoquinone (volatile oil of black cumin) on rheumatoid arthritis in rat models. Phytother Res 2007;21:895-897.
16. Gali-Muhtasib H, Diab-Assaf M, Boltze C, Al Hmaira J, Hartig R, Roessner A, Schneider-Stock R: Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-dependent mechanism. Int J Oncol 2004;25:857-866.
17. Roepke M, Diestel A, Bajbouj K, Walluscheck D, Schonfeld P, Roessner A, Schneider-Stock R, Gali-Muhtasib H: Lack of p53 augments thymoquinone-induced apoptosis and caspase activation in human osteosarcoma cells. Cancer Biol Ther 2007;6:160-169.
18. Rooney S, Ryan MF: Effects of alpha-hederin and thymoquinone, constituents of Nigella sativa, on human cancer cell lines. Anticancer Res 2005;25:2199-2204. (Pubitemid 40904623)
19. Shoieb AM, Elgayyar M, Dudrick PS, Bell JL, Tithof PK: In vitro inhibition of growth and induction of apoptosis in cancer cell lines by thymoquinone. Int J Oncol 2003;22:107-113.
20. Yi T, Cho SG, Yi Z, Pang X, Rodriguez M, Wang Y, Sethi G, Aggarwal BB, Liu M: Thymoquinone inhibits tumor angiogen-esis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways. Mol Cancer Ther 2008;7:1789-1796.
21. Rooney S, Ryan MF: Modes of action of alpha-hederin and thymoquinone, active constituents of Nigella sativa, against HEp-2 cancer cells. Anticancer Res 2005;25:4255-4259.
22. El Mahdy MA, Zhu Q, Wang QE, Wani G, Wani AA: Thymoquinone induces apoptosis through activation of caspase-8 and mitochondrial events in p53-null myeloblastic leukemia HL-60 cells. Int J Cancer 2005;117:409-417.
23. Adler HS, Steinbrink K: Tolerogenic dendritic cells in health and disease: friend and foe! Eur J Dermatol 2007;17:476-491.
24. Banchereau J, Briere F, Caux C, Davoust J, Lebecque S, Liu YJ, Pulendran B, Palucka K: Immunobiology of dendritic cells. Annu Rev Immunol 2000;18:767-811.
25. van Duivenvoorde LM, Han WG, Bakker AM, Louis-Plence P, Charbonnier LM, Apparailly F, van der Voort EI, Jorgensen C, Huizinga TW, Toes RE: Immunomodulatory dendritic cells inhibit Th1 responses and arthritis via different mechanisms. J Immunol 2007;179:1506-1515.
26. Chorny A, Gonzalez-Rey E, Delgado M: Regulation of dendritic cell differentiation by vasoactive intestinal peptide: therapeutic applications on autoimmunity and transplantation. Ann N Y Acad Sci 2006;1088:187-194. (Pubitemid 47092026)
27. Gelin C, Sloma I, Charron D, Mooney N: Regulation of MHC II and CD1 antigen presentation: from ubiquity to security. J Leukoc Biol 2009;85:215-224.
28. Remondo C, Cereda V, Mostbock S, Sabzevari H, Franzusoff A, Schlom J, Tsang KY: Human dendritic cell maturation and activation by a heat-killed recombinant yeast (Saccharomyces cerevisiae) vector encoding carcinoembryonic antigen. Vaccine 2009;27:987-994.
29. Schuurhuis DH, Fu N, Ossendorp F, Melief CJ: Ins and outs of dendritic cells. Int Arch Allergy Immunol 2006;140:53-72.
30. Tarbell KV, Yamazaki S, Steinman RM: The interactions of dendritic cells with antigen-specific, regulatory T cells that suppress autoimmunity. Semin Immunol 2006;18:93-102.
31. Blanco P, Palucka AK, Pascual V, Banchereau J: Dendritic cells and cytokines in human inflammatory and autoimmune diseases. Cytokine Growth Factor Rev 2008;19:41-52.
32. Lehner T: Special regulatory T cell review: The resurgence of the concept of contrasuppression in immunoregulation. Immunology 2008;123:40-44.
33. Li MO, Flavell RA: Contextual regulation of inflammation: a duet by transforming growth factor-beta and interleukin-10. Immunity 2008;28:468-476.
34. Cerovic V, McDonald V, Nassar MA, Paulin SM, Macpherson G G, Milling SW: New insights into the roles of dendritic cells in intestinal immunity and tolerance. Int Rev Cell Mol Biol 2009;272:33-105.
35. Edelman SM, Kasper DL: Symbiotic commensal bacteria direct maturation of the host immune system. Curr Opin Gastroenterol 2008;24:720-724.
36. Rescigno M, Lopatin U, Chieppa M: Interactions among dendritic cells, macrophages, and epithelial cells in the gut: implications for immune tolerance. Curr Opin Immunol 2008;20:669-675.
37. Inaba K, Inaba M, Romani N, Aya H, Deguchi M, Ikehara S, Muramatsu S, Steinman RM: Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J Exp Med 1992;176:1693-1702.
38. Xuan NT, Shumilina E, Matzner N, Zemtsova IM, Biedermann T, Goetz F, Lang F: Ca2+-dependent functions in peptidoglycan-stimulated mouse dendritic cells. Cell Physiol Biochem 2009;24:167-176.
39. Wang K, Mahmud H, Foller M, Biswas R, Lang KS, Bohn E, Gotz F, Lang F: Lipopeptides in the triggering of eryth-rocyte cell membrane scrambling. Cell Physiol Biochem 2008;22:381-386.
40. Ardeshna KM, Pizzey AR, Devereux S, Khwaja A: The PI3 kinase, p38 SAP ki-nase, and NF-kappaB signal transduction pathways are involved in the survival and maturation of lipopolysaccharide-stimu-lated human monocyte-derived dendritic cells. Blood 2000;96:1039-1046.
41. Ji Y, Liu J, Wang Z, Liu N: Angiotensin II induces inflammatory response partly via toll-like receptor 4-dependent signaling pathway in vascular smooth muscle cells. Cell Physiol Biochem 2009;23:265-276.
42. Martins JO, Ferracini M, Ravanelli N, Landgraf RG, Jancar S: Insulin inhibits LPS-induced signaling pathways in alveolar macrophages. Cell Physiol Biochem 2008;21:297-304.
43. Martins JO, Ferracini M, Ravanelli N, Landgraf RG, Jancar S: Insulin suppresses LPS-induced iNOS and COX-2 expression and NF-kappaB activation in alveolar macrophages. Cell Physiol Biochem 2008;22:279-286.
44. Gali-Muhtasib HU, Abou Kheir W G, Kheir LA, Darwiche N, Crooks PA: Molecular pathway for thymoquinone-induced cell-cycle arrest and apoptosis in neoplastic keratinocytes. Anticancer Drugs 2004;15:389-399.