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Volumn 7, Issue 4, 2008, Pages 283-290

In vitro challenge using thymoquinone on hepatocellular carcinoma (HepG2) cell line

Author keywords

Apoptosis; Black seed; Cell cycle; Flowcytometry; Thymoquinone

Indexed keywords

CASPASE 3; CASPASE 9; THYMOQUINONE;

EID: 67549099839     PISSN: 17350328     EISSN: 17266890     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (25)

References (39)
  • 1
    • 0025769731 scopus 로고
    • Recent nutrition research: Implications for foods of the future
    • Gruddy SM. Recent nutrition research: implications for foods of the future. Ann. Med. (1991) 23: 187-93
    • (1991) Ann. Med , vol.23 , pp. 187-193
    • Gruddy, S.M.1
  • 3
    • 0024273970 scopus 로고
    • Chemoprevention of N-nitrosomethyl benzyllamine-induced oesophageal cancer in rats by the naturally cancer thiother, sulphide
    • Wargovich MJ, Woods C and Eng VWS. Chemoprevention of N-nitrosomethyl benzyllamine-induced oesophageal cancer in rats by the naturally cancer thiother, sulphide. Cancer Res. (1988) 48: 6872-875
    • (1988) Cancer Res , vol.48 , pp. 6872-6875
    • Wargovich, M.J.1    Woods, C.2    Eng, V.W.S.3
  • 4
    • 0037049882 scopus 로고    scopus 로고
    • Mechanism(s) of turmeric-mediated protective effects against benzo(a)pyrene-derived adducts
    • Thapliyal R, Deshpande SS and Maru GB. Mechanism(s) of turmeric-mediated protective effects against benzo(a)pyrene-derived adducts. Cancer Lett. (2002) 175: 79-88
    • (2002) Cancer Lett , vol.175 , pp. 79-88
    • Thapliyal, R.1    Deshpande, S.S.2    Maru, G.B.3
  • 5
    • 2942547469 scopus 로고    scopus 로고
    • Protection against diethylnitrosoamine-induced hepatocarcinogenesis by an indigenous medicine comprised of Nigella sativa, Hemidesmus indicus and smilax glabra: A preliminary study
    • Iddamaldeniya SS, Wickramasinghe N, Thabrew I, Ratnatunge N and Thammitiyagodage MG. Protection against diethylnitrosoamine-induced hepatocarcinogenesis by an indigenous medicine comprised of Nigella sativa, Hemidesmus indicus and smilax glabra: a preliminary study. J. Carcinog. (2003) 2: 6-18
    • (2003) J. Carcinog , vol.2 , pp. 6-18
    • Iddamaldeniya, S.S.1    Wickramasinghe, N.2    Thabrew, I.3    Ratnatunge, N.4    Thammitiyagodage, M.G.5
  • 6
    • 13244285843 scopus 로고    scopus 로고
    • Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-depenelent mechanism
    • Gali-Muhtasib H, Diab-Assaf M, Boltze C, Al-Hmaira J, Hartig R, Roessner A and Schneider-Stock R. Thymoquinone extracted from black seed triggers apoptotic cell death in human colorectal cancer cells via a p53-depenelent mechanism. Int. J. Oncol. (2004) 25: 857-66
    • (2004) Int. J. Oncol , vol.25 , pp. 857-866
    • Gali-Muhtasib, H.1    Diab-Assaf, M.2    Boltze, C.3    Al-Hmaira, J.4    Hartig, R.5    Roessner, A.6    Schneider-Stock, R.7
  • 7
    • 0028852880 scopus 로고
    • Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leucocytes and membrane lipid peroxidation
    • Houghton PJ, Zarka R, de las Heras B and Hoult JR. Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leucocytes and membrane lipid peroxidation. Planta Med. (1995) 61: 33-6
    • (1995) Planta Med , vol.61 , pp. 33-36
    • Houghton, P.J.1    Zarka, R.2    de las Heras, B.3    Hoult, J.R.4
  • 8
    • 67549114851 scopus 로고    scopus 로고
    • Keuk I, Michalska T, Lichszteld K, Kaldna A and Aboul-Enein HY. The effect of thymol and its derivatives on reaction generating reactive oxygen
    • Keuk I, Michalska T, Lichszteld K, Kaldna A and Aboul-Enein HY. The effect of thymol and its derivatives on reaction generating reactive oxygen
  • 10
    • 0012980550 scopus 로고    scopus 로고
    • In vitro inhibition of growth and induction of apoptosis in cancer cell lines by thymoquinone
    • Shoieb AM, Elgayyar M, Dudrick PS, Bell JL and Tithof PK. In vitro inhibition of growth and induction of apoptosis in cancer cell lines by thymoquinone. Int. J. Oncol. (2003) 22: 107-13
    • (2003) Int. J. Oncol , vol.22 , pp. 107-113
    • Shoieb, A.M.1    Elgayyar, M.2    Dudrick, P.S.3    Bell, J.L.4    Tithof, P.K.5
  • 11
    • 26444457920 scopus 로고    scopus 로고
    • Thymoquinone induces apoptosis through activation of caspase-8 and mitochondrial events in p53-null myeloblastic leukemia HL-60 cells
    • El-Mahdy MA, Zhu Q, Wang QE, Wani G and Wani AA. Thymoquinone induces apoptosis through activation of caspase-8 and mitochondrial events in p53-null myeloblastic leukemia HL-60 cells. Int. J. Cancer (2005) 117: 409-17
    • (2005) Int. J. Cancer , vol.117 , pp. 409-417
    • El-Mahdy, M.A.1    Zhu, Q.2    Wang, Q.E.3    Wani, G.4    Wani, A.A.5
  • 12
    • 0033524857 scopus 로고    scopus 로고
    • A comparative study of apoptosis and necrosis in HepG2 cells: Oxidant-induced caspase inactivation leads to necrosis
    • Samali A, Nordgren H, Zhivotovsky B, Peterson E and Orrenius S. A comparative study of apoptosis and necrosis in HepG2 cells: oxidant-induced caspase inactivation leads to necrosis. Biochem. Biophys. Res. Commun. (1999) 255: 6-11
    • (1999) Biochem. Biophys. Res. Commun , vol.255 , pp. 6-11
    • Samali, A.1    Nordgren, H.2    Zhivotovsky, B.3    Peterson, E.4    Orrenius, S.5
  • 17
    • 0025738516 scopus 로고
    • Tetrazolium-based assays for cellular viability: A critical examination of selected parameters affecting formazan production
    • Vistica DT, Skehan P, Scudiero D, Monks A, Pittman A and Boyd MR. Tetrazolium-based assays for cellular viability: a critical examination of selected parameters affecting formazan production. Cancer Research (1991) 51: 2515-520
    • (1991) Cancer Research , vol.51 , pp. 2515-2520
    • Vistica, D.T.1    Skehan, P.2    Scudiero, D.3    Monks, A.4    Pittman, A.5    Boyd, M.R.6
  • 18
    • 34247110303 scopus 로고    scopus 로고
    • Antitumor activity and in vivo antioxidant status of Mucuna Pruiens (Fabaceae) seeds against Ehrlich ascites carcinoma in swiss albino mice
    • Rajeshwar Y, Gupta M and Mazumder UK. Antitumor activity and in vivo antioxidant status of Mucuna Pruiens (Fabaceae) seeds against Ehrlich ascites carcinoma in swiss albino mice. Iranian Journal of pharmacology and Therapeutics (2005) 4: 46-53
    • (2005) Iranian Journal of pharmacology and Therapeutics , vol.4 , pp. 46-53
    • Rajeshwar, Y.1    Gupta, M.2    Mazumder, U.K.3
  • 20
    • 67549106642 scopus 로고    scopus 로고
    • Methods of cell cycle analysis and detection of apoptosis of teleost cells
    • Donald LE, Reid BG and Liliana JF. Methods of cell cycle analysis and detection of apoptosis of teleost cells. J. Metho. Cell Science (2000) 22: 2-3
    • (2000) J. Metho. Cell Science , vol.22 , pp. 2-3
    • Donald, L.E.1    Reid, B.G.2    Liliana, J.F.3
  • 21
    • 0029890823 scopus 로고    scopus 로고
    • Casciola-Rosen LA. Apopain/CPP32 cleave proteins that are essential for cellular repair. A fundamental principle of apoptotic death. Journal of Experimental Medicine (1996) 138: 1957-964
    • Casciola-Rosen LA. Apopain/CPP32 cleave proteins that are essential for cellular repair. A fundamental principle of apoptotic death. Journal of Experimental Medicine (1996) 138: 1957-964
  • 22
    • 0032875149 scopus 로고    scopus 로고
    • Herbal Products for liver diseases: A therapeutic challenge for the new millennium
    • Schuppan D, Jia JD, Brinkhaus B and Hahn EG. Herbal Products for liver diseases: A therapeutic challenge for the new millennium. Hepatology Clinical Challenge (1999) 30: 1099-104
    • (1999) Hepatology Clinical Challenge , vol.30 , pp. 1099-1104
    • Schuppan, D.1    Jia, J.D.2    Brinkhaus, B.3    Hahn, E.G.4
  • 23
    • 0032575705 scopus 로고    scopus 로고
    • A matter of life and cell death
    • Evan G and Littlewood T. A matter of life and cell death. Science (1998) 281: 1317-322
    • (1998) Science , vol.281 , pp. 1317-1322
    • Evan, G.1    Littlewood, T.2
  • 24
    • 27944477663 scopus 로고    scopus 로고
    • Modes of action of alphahederin and thymoquinone, active constituents of Nigella sativa, against HEp-2 cancer cells
    • Rooney S and Ryan MF. Modes of action of alphahederin and thymoquinone, active constituents of Nigella sativa, against HEp-2 cancer cells. Anticancer Research (2005) 25: 4255-259
    • (2005) Anticancer Research , vol.25 , pp. 4255-4259
    • Rooney, S.1    Ryan, M.F.2
  • 25
    • 21344452084 scopus 로고    scopus 로고
    • Effects of alpha-hederin and thymoquinone, constituents of Nigella sativa, on human cancer cell lines
    • Rooney S and Ryan MF. Effects of alpha-hederin and thymoquinone, constituents of Nigella sativa, on human cancer cell lines. Anticancer Research (2005) 25: 2199-204
    • (2005) Anticancer Research , vol.25 , pp. 2199-2204
    • Rooney, S.1    Ryan, M.F.2
  • 28
    • 0030865646 scopus 로고    scopus 로고
    • Hydrogen peroxide suppress both the activation and activity of caspases
    • Hampton MB and Orrenius S. Hydrogen peroxide suppress both the activation and activity of caspases. FEBS Letter Journal (1997) 414: 552-56
    • (1997) FEBS Letter Journal , vol.414 , pp. 552-556
    • Hampton, M.B.1    Orrenius, S.2
  • 29
    • 0031445356 scopus 로고    scopus 로고
    • The oxidation of dithiocarbamates to dithiocarmamate disulphates has been shown to inhibit apoptosis through binding to active site of the caspases and inhibition of their enzymatic activity
    • Nobil CS, Kamland M, Nicholson DW, Orrenius S and Slater AF. The oxidation of dithiocarbamates to dithiocarmamate disulphates has been shown to inhibit apoptosis through binding to active site of the caspases and inhibition of their enzymatic activity. Chemical Research and Toxicology (1997) 10: 1319-324
    • (1997) Chemical Research and Toxicology , vol.10 , pp. 1319-1324
    • Nobil, C.S.1    Kamland, M.2    Nicholson, D.W.3    Orrenius, S.4    Slater, A.F.5
  • 30
    • 0032571567 scopus 로고    scopus 로고
    • Caspases contain an active site cysteine nucleophile which is prone to oxidation or thiol alkylation
    • Lemaire C, Andreau K, Souvannavong V and Adam A. Caspases contain an active site cysteine nucleophile which is prone to oxidation or thiol alkylation. FEBS Letter Journal (1998) 425: 266-70
    • (1998) FEBS Letter Journal , vol.425 , pp. 266-270
    • Lemaire, C.1    Andreau, K.2    Souvannavong, V.3    Adam, A.4
  • 31
    • 0028568315 scopus 로고
    • Cell cycle control and cancer
    • Hartwell LH and Kastan MB. Cell cycle control and cancer. Science (1994) 266: 1821-828
    • (1994) Science , vol.266 , pp. 1821-1828
    • Hartwell, L.H.1    Kastan, M.B.2
  • 32
    • 0028915222 scopus 로고
    • Molecular foundation of cancer, new targets for intervention
    • Karp JE and Broder S. Molecular foundation of cancer, new targets for intervention. International Medical Journal (1995) 1: 309-20
    • (1995) International Medical Journal , vol.1 , pp. 309-320
    • Karp, J.E.1    Broder, S.2
  • 34
    • 0025302864 scopus 로고
    • Activity of quinone alkylating agents in quinine-resistant cells
    • Begleiter A and Leith MK. Activity of quinone alkylating agents in quinine-resistant cells. Cancer Research (1990) 50: 2872-876
    • (1990) Cancer Research , vol.50 , pp. 2872-2876
    • Begleiter, A.1    Leith, M.K.2
  • 35
    • 0026766364 scopus 로고    scopus 로고
    • Quinoneinduced DNA single strand breaks in rat hepatocytes and human chronic myelogenous leukemia K562 cells
    • Morgan WA, Hartley JA and Cohen GM. Quinoneinduced DNA single strand breaks in rat hepatocytes and human chronic myelogenous leukemia K562 cells. Biochemistry and Pharmacology Research Journal (1997) 44: 215-21
    • (1997) Biochemistry and Pharmacology Research Journal , vol.44 , pp. 215-221
    • Morgan, W.A.1    Hartley, J.A.2    Cohen, G.M.3
  • 37
    • 0029730636 scopus 로고    scopus 로고
    • Induction of p21 mediated by reactive Oxygen species formed during the metabolism of aziridinylbenzoquinones by HCT116 cells
    • Qiu X, Forman HJ and Cadenas E. Induction of p21 mediated by reactive Oxygen species formed during the metabolism of aziridinylbenzoquinones by HCT116 cells. J. Biol. Chem. (1996) 271: 31915-1921
    • (1996) J. Biol. Chem , vol.271 , pp. 31915-31921
    • Qiu, X.1    Forman, H.J.2    Cadenas, E.3
  • 39
    • 0033965801 scopus 로고    scopus 로고
    • The influence of thymoquinone on doxorubicin-induced hyperlipidemic nephropathy in rats
    • Badary OA, Abdel-Naim AB, Abdel-Wahab MH and Hamada FM. The influence of thymoquinone on doxorubicin-induced hyperlipidemic nephropathy in rats. Toxicology (2000) 143: 219-26
    • (2000) Toxicology , vol.143 , pp. 219-226
    • Badary, O.A.1    Abdel-Naim, A.B.2    Abdel-Wahab, M.H.3    Hamada, F.M.4


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