메뉴 건너뛰기




Volumn 8, Issue 1, 2013, Pages

Protective and antidiabetic effects of extract from Nigella sativa on blood glucose concentrations against streptozotocin (STZ)-induced diabetic in rats: An experimental study with histopathological evaluation

Author keywords

Hypoglycemic; Nigella Sativa; Rat; Streptozotocin

Indexed keywords

ANTIDIABETIC AGENT; BIOLOGICAL MARKER; GLYCOGEN; PLANT EXTRACT; STREPTOZOCIN;

EID: 84881402430     PISSN: None     EISSN: 17461596     Source Type: Journal    
DOI: 10.1186/1746-1596-8-137     Document Type: Article
Times cited : (67)

References (24)
  • 1
    • 0034108281 scopus 로고    scopus 로고
    • Cytotoxic and immunopotentiating effects of ethanolic extract of Nigella sativa L. seeds
    • 10.1016/S0378-8741(98)00241-4, 10720783
    • Swamy SMK, Tan BKH. Cytotoxic and immunopotentiating effects of ethanolic extract of Nigella sativa L. seeds. J Ethnopharmacol 2000, 70:1-7. 10.1016/S0378-8741(98)00241-4, 10720783.
    • (2000) J Ethnopharmacol , vol.70 , pp. 1-7
    • Swamy, S.M.K.1    Tan, B.K.H.2
  • 3
    • 0028852880 scopus 로고
    • Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation
    • 10.1055/s-2006-957994, 7700988
    • Houghton PJ, Zakara R, Heras B, Hoult JR. Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation. Planta Med 1995, 61:33-36. 10.1055/s-2006-957994, 7700988.
    • (1995) Planta Med , vol.61 , pp. 33-36
    • Houghton, P.J.1    Zakara, R.2    Heras, B.3    Hoult, J.R.4
  • 4
    • 0018611973 scopus 로고
    • Antimicrobial and anti-helminthic activities of the essential oil of Nigella sativa Linn
    • Agarwal R, Kharya MD, Shrivastava R. Antimicrobial and anti-helminthic activities of the essential oil of Nigella sativa Linn. Ind J Exp Biol 1979, 17:1264-1265.
    • (1979) Ind J Exp Biol , vol.17 , pp. 1264-1265
    • Agarwal, R.1    Kharya, M.D.2    Shrivastava, R.3
  • 5
    • 0027309568 scopus 로고
    • Hypoglycemic effect of the volatile oil of Nigella sativa seeds
    • Al-Hader A, Aqel M, Hasan Z. Hypoglycemic effect of the volatile oil of Nigella sativa seeds. Int J Pharmacog 1993, 31:96-100.
    • (1993) Int J Pharmacog , vol.31 , pp. 96-100
    • Al-Hader, A.1    Aqel, M.2    Hasan, Z.3
  • 6
    • 0033012875 scopus 로고    scopus 로고
    • Immunomodulatory effect of Nigella sativa proteins fractionated by ion exchange chromatography
    • 10.1016/S0192-0561(99)00010-7, 10408636
    • Haq A, Lobo PI, Al-Tufail M, Rama N, Al-Sedairy S. Immunomodulatory effect of Nigella sativa proteins fractionated by ion exchange chromatography. Int J Immunopharmacol 1999, 21:283-295. 10.1016/S0192-0561(99)00010-7, 10408636.
    • (1999) Int J Immunopharmacol , vol.21 , pp. 283-295
    • Haq, A.1    Lobo, P.I.2    Al-Tufail, M.3    Rama, N.4    Al-Sedairy, S.5
  • 7
    • 84888868856 scopus 로고    scopus 로고
    • Histopathological investigation of neuroprotective effects of Nigella sativa on motor neurons anterior horn spinal cord after sciatic nerve crush in rats
    • Javanbakht J, Hobbenaghi R, Hosseini E, Bahrami AM, Khadivar F, Fathi S, Hassan MA. Histopathological investigation of neuroprotective effects of Nigella sativa on motor neurons anterior horn spinal cord after sciatic nerve crush in rats. Pathol Biol (Paris) 2013,
    • (2013) Pathol Biol (Paris)
    • Javanbakht, J.1    Hobbenaghi, R.2    Hosseini, E.3    Bahrami, A.M.4    Khadivar, F.5    Fathi, S.6    Hassan, M.A.7
  • 8
    • 84873741147 scopus 로고    scopus 로고
    • Triggering receptor expressed on myeloid cells-1 (Trem-1) on blood neutrophils is associated with cytokine inducibility in human E. coli sepsis
    • 10.1186/1746-1596-8-24, 3584978, 23414215
    • Van Bremen T, Drömann D, Luitjens K, Dodt C, Dalhoff K, Goldmann T, Schaaf B. Triggering receptor expressed on myeloid cells-1 (Trem-1) on blood neutrophils is associated with cytokine inducibility in human E. coli sepsis. Diagn Pathol 2013, 8:24. 10.1186/1746-1596-8-24, 3584978, 23414215.
    • (2013) Diagn Pathol , vol.8 , pp. 24
    • Van Bremen, T.1    Drömann, D.2    Luitjens, K.3    Dodt, C.4    Dalhoff, K.5    Goldmann, T.6    Schaaf, B.7
  • 9
    • 34547813210 scopus 로고    scopus 로고
    • Evaluation of oxidative stress in Insulin Dependent Diabetes Mellitus (IDDM) patients
    • 10.1186/1746-1596-2-22, 1936413, 17603912
    • Ramakrishna V, Jailkhani R. Evaluation of oxidative stress in Insulin Dependent Diabetes Mellitus (IDDM) patients. Diagn Pathol 2007, 2:22. 10.1186/1746-1596-2-22, 1936413, 17603912.
    • (2007) Diagn Pathol , vol.2 , pp. 22
    • Ramakrishna, V.1    Jailkhani, R.2
  • 11
  • 12
    • 1842423094 scopus 로고    scopus 로고
    • The role of oxidative stress in diabetic complications
    • Baynes JW, Thorpe SR. The role of oxidative stress in diabetic complications. Curr Opin Endocrinol 1996, 3:277-84.
    • (1996) Curr Opin Endocrinol , vol.3 , pp. 277-284
    • Baynes, J.W.1    Thorpe, S.R.2
  • 13
    • 0025732948 scopus 로고
    • Role of oxidative stress in development of complications in diabetes
    • 10.2337/diabetes.40.4.405, 2010041
    • Baynes JW. Role of oxidative stress in development of complications in diabetes. Diabetes 1991, 40:405-12. 10.2337/diabetes.40.4.405, 2010041.
    • (1991) Diabetes , vol.40 , pp. 405-412
    • Baynes, J.W.1
  • 14
    • 0024523284 scopus 로고
    • Does oxygen free radical increased formation explain longterm complications of Diabetes mellitus?
    • 10.1016/0306-9877(89)90167-9, 2664434
    • Gillery P, Monboisse JC, Maquart FX, Borel JP. Does oxygen free radical increased formation explain longterm complications of Diabetes mellitus?. Med Hypotheses 1989, 29:47-50. 10.1016/0306-9877(89)90167-9, 2664434.
    • (1989) Med Hypotheses , vol.29 , pp. 47-50
    • Gillery, P.1    Monboisse, J.C.2    Maquart, F.X.3    Borel, J.P.4
  • 15
    • 0042672851 scopus 로고    scopus 로고
    • Nitric oxide synthase inhibition by L-NAME in streptozotocin induced diabetic rats: impacts on oxidative stress
    • Seven A, Guzel S, Seymen O, Civelek S, Bolayirli M, Yigit G. Nitric oxide synthase inhibition by L-NAME in streptozotocin induced diabetic rats: impacts on oxidative stress. Tohoku J Exp Med 2003, 99:205-10.
    • (2003) Tohoku J Exp Med , vol.99 , pp. 205-210
    • Seven, A.1    Guzel, S.2    Seymen, O.3    Civelek, S.4    Bolayirli, M.5    Yigit, G.6
  • 17
    • 3042776475 scopus 로고    scopus 로고
    • Effects of Nigella sativa on oxidative stress and β-cell damage in streptozotocin-induced diabetic rats
    • Kanter M, Coskun O, Korkmaz A. Effects of Nigella sativa on oxidative stress and β-cell damage in streptozotocin-induced diabetic rats. Anat Rec A Discov Mol Cell Evol Biol 2004, 279A(1):685-691.
    • (2004) Anat Rec A Discov Mol Cell Evol Biol , vol.279 A , Issue.1 , pp. 685-691
    • Kanter, M.1    Coskun, O.2    Korkmaz, A.3
  • 18
    • 0036901812 scopus 로고    scopus 로고
    • Isulinotropic properties of Nigella sativa oil in streptozotocin plus nicotinamide diabetic hamster
    • Fararh KM, Atoji Y, Shimizu Y. Isulinotropic properties of Nigella sativa oil in streptozotocin plus nicotinamide diabetic hamster. Research Veterinary Science 2002, 73:279-282.
    • (2002) Research Veterinary Science , vol.73 , pp. 279-282
    • Fararh, K.M.1    Atoji, Y.2    Shimizu, Y.3
  • 19
    • 53749091796 scopus 로고    scopus 로고
    • Effect of Nigella sativa oil on impaired glucose tolerance and insulin insensitivity induced by high-fat-diet and turpentine-induced trauma
    • Alsaif MA. Effect of Nigella sativa oil on impaired glucose tolerance and insulin insensitivity induced by high-fat-diet and turpentine-induced trauma. Pak J Biol Sci 2008, 11(8):1093-9.
    • (2008) Pak J Biol Sci , vol.11 , Issue.8 , pp. 1093-1099
    • Alsaif, M.A.1
  • 20
    • 0036273437 scopus 로고    scopus 로고
    • The hypoglycemic effect of Nigella sativa oil is mediated by extrapancreatic actions
    • El-Dakhakhny M, Mady N, Lembert N, Ammon HP. The hypoglycemic effect of Nigella sativa oil is mediated by extrapancreatic actions. Plant Med 2002, 68(5):465-6.
    • (2002) Plant Med , vol.68 , Issue.5 , pp. 465-466
    • El-Dakhakhny, M.1    Mady, N.2    Lembert, N.3    Ammon, H.P.4
  • 21
    • 78649673581 scopus 로고    scopus 로고
    • Effects of Nigella sativa and thymoquinone on biochemical and subcellular changes in pancreatic β-cells of streptozotocin-induced diabetic rats
    • Abdelmeguid NE, Fakhoury R, Kamal SM, Al Wafai RJ. Effects of Nigella sativa and thymoquinone on biochemical and subcellular changes in pancreatic β-cells of streptozotocin-induced diabetic rats. Diabetes 2010, 2(4):256-66.
    • (2010) Diabetes , vol.2 , Issue.4 , pp. 256-266
    • Abdelmeguid, N.E.1    Fakhoury, R.2    Kamal, S.M.3    Al Wafai, R.J.4
  • 22
    • 76649102383 scopus 로고    scopus 로고
    • Analysis on chemical components of volatile oil and determination of thymoquinone from seed of Nigella glandulifera
    • Geng D, Zhang S, Lan J. Analysis on chemical components of volatile oil and determination of thymoquinone from seed of Nigella glandulifera. Zhongguo Zhong Yao Za Zhi 2009, 34(22):2887-90.
    • (2009) Zhongguo Zhong Yao Za Zhi , vol.34 , Issue.22 , pp. 2887-2890
    • Geng, D.1    Zhang, S.2    Lan, J.3
  • 23
    • 70649088771 scopus 로고    scopus 로고
    • Beneficial effects of thymoquinone on hepatic key enzymes in streptozotocin-nicotinamide induced diabetic rats
    • Pari L, Sankaranarayanan C. Beneficial effects of thymoquinone on hepatic key enzymes in streptozotocin-nicotinamide induced diabetic rats. Life Sci 2009, 85(23-26):830-834.
    • (2009) Life Sci , vol.85 , Issue.23-26 , pp. 830-834
    • Pari, L.1    Sankaranarayanan, C.2
  • 24
    • 0036892408 scopus 로고    scopus 로고
    • Effect of feeding aqueous extract of Pterocarpus marsupium on glycogen content of tissues and the key enzymes of carbohydrate metabolism
    • 10.1023/A:1020870526014, 12482025
    • Grover J, Vats V, Yadav S. Effect of feeding aqueous extract of Pterocarpus marsupium on glycogen content of tissues and the key enzymes of carbohydrate metabolism. Mol Cell Biochem 2002, 241:53-59. 10.1023/A:1020870526014, 12482025.
    • (2002) Mol Cell Biochem , vol.241 , pp. 53-59
    • Grover, J.1    Vats, V.2    Yadav, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.