Inhibition of Wnt/b-catenin signaling mediates ursolic acid-induced apoptosis in PC-3 prostate cancer cells

Pharmacological Reports

Volumn 65, Issue 5, 2013, Pages 1366-1374

  Park, Ji Hyuk ^a   Kwon, Hee Young ^a   Sohn, Eun Jung ^a   Kim, Kyung A ^a   Kim, Bonglee ^a   Jeong, Soo Jin ^a   Song, Jun Ho ^a   Koo, Jin Suk ^b   Kim, Sung Hoon ^a  

^a Kyung Hee University   (South Korea)

^b Andong National University   (South Korea)

Author keywords

Apoptosis; Caspase; Ursolic acid; Wnt GSK3b b catenin signaling

Indexed keywords

2 (2,4 DICHLOROPHENYL) 3 (1 METHYL 3 INDOLYL)MALEIMIDE; BETA CATENIN; CASPASE 3; CASPASE 9; GLYCOGEN SYNTHASE KINASE 3BETA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN MCL 1; URSOLIC ACID; WNT PROTEIN; WNT5A PROTEIN; WNT5B PROTEIN; ANTINEOPLASTIC AGENT; APOPTOSIS REGULATORY PROTEIN; CTNNB1 PROTEIN, HUMAN; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; ONCOPROTEIN; PROTEIN KINASE INHIBITOR; TRITERPENE; WNT3A PROTEIN; WNT3A PROTEIN, HUMAN; WNT5A PROTEIN, HUMAN; WNT5B PROTEIN, HUMAN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL STRAIN DU145; CELL STRAIN LNCAP; CELL STRAIN PC 3; CONTROLLED STUDY; CYTOTOXICITY ASSAY; DRUG CYTOTOXICITY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; IMMUNOFLUORESCENCE; PROSTATE CANCER; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; CELL SURVIVAL; CULTURE MEDIUM; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; G1 PHASE CELL CYCLE CHECKPOINT; HEK293 CELL LINE; MALE; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PROSTATE TUMOR; TUMOR CELL LINE; WNT SIGNALING PATHWAY;

ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BETA CATENIN; CELL LINE, TUMOR; CELL SURVIVAL; CULTURE MEDIA, CONDITIONED; DOSE-RESPONSE RELATIONSHIP, DRUG; G1 PHASE CELL CYCLE CHECKPOINTS; GLYCOGEN SYNTHASE KINASE 3; HEK293 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; MALE; PHOSPHORYLATION; PROSTATIC NEOPLASMS; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS; TRITERPENES; WNT PROTEINS; WNT SIGNALING PATHWAY; WNT3A PROTEIN;

EID: 84894118193     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: 10.1016/S1734-1140(13)71495-6     Document Type: Article

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