The chemical and biological potential of C ring modified triterpenoids

European Journal of Medicinal Chemistry

Volumn 72, Issue , 2014, Pages 84-101

  Siewert, Bianka ^a   Wiemann, Jana ^a   Köwitsch, Alexander ^a   Csuk, René ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Antitumor activity; Apoptosis; Oleanolic acid acid; Structure activity relationships; Triterpenoids; Ursolic acid

Indexed keywords

(2ALPHA, 3BETA) METHYL 3,12 DIHYDROXY 11 OXO OLEAN 12 EN 28 OATE; (2ALPHA,3BETA) METHYL 2,3 DIACETYL OLEAN 12 EN 28 OATE; (2ALPHA,3BETA) METHYL 3 ACETOXY 11 OXO OLEAN 12 EN 28 OATE; (3BETA) 3 ACETOXY OLEAN 11 EN 28 ACID; (3BETA) 3 ACETOXY URS 11 EN 28 ACID; (3BETA) BENZYL 3 ACETOXY 11 OXO 12 HYDROXY OLEAN DELTA 12,13 EN 28 OATE; (3BETA) BENZYL 3 ACETOXY 12 OXO OLEAN 28 OATE; (3BETA) BENZYL 3 ACETOXY OLEAN 11 EN 28 OATE; (3BETA) BENZYL 3 ACETOXY URS 11 EN 28 OATE; (3BETA) BENZYL 3 HYDROXY 12 OXO OLEAN 28 OATE; (3BETA) BENZYL 3 HYDROXY OLEAN 12 EN 28 OATE; (3BETA) BENZYL 3 HYDROXY URS 12 EN 28 OATE; (3BETA) BUT 3 ENYL 3 HYDROXY 12 OXO OLEAN 28 OATE; (3BETA) BUT 3 ENYL 3 HYDROXY OLEAN 12 EN 28 OATE; (3BETA) METHYL 3 ACETOXY 11 OXO OLEAN 12 EN 28 OATE; (3BETA) METHYL 3 ACETOXY 12 HYDROXY 11 OXO OLEAN DELTA 12,13 EN 28 OATE; (3BETA) METHYL 3 ACETOXY 12 OXO OLEAN 28 OATE; (3BETA) METHYL 3 ACETOXY OLEAN 11 EN 28 OATE; (3BETA) METHYL 3 ACETOXY URS 11 EN 28 OATE; (3BETA) METHYL 3 HYDROXY 11 OXO OLEAN 12 EN 28 OATE; (3BETA) METHYL 3 HYDROXY 12 OXO OLEAN 28 OATE; (3BETA) METHYL 3 HYDROXY OLEAN 11 EN 28 OATE; (3BETA) METHYL 3 HYDROXY URS 11 EN 28 OATE; (3BETA, 12ALPHA) 3 ACETYL 12 HYDROXY 18BETA OLEAN 28 OIC ACID 28,13 LACTONE; (3BETA, 12ALPHA) 3,12 DIACETOXY OLEAN 28 OIC ACID 28,13 LACTONE; (3BETA, 12ALPHA) 3,12 DIHYDROXY 18BETA OLEAN 28 OIC ACID 28,13 LACTONE; METHYL (2ALPHA,3BETA)2,3 DI O ACETYL 12 OXO OLEAN 28 OATE; TRITERPENOID; UNCLASSIFIED DRUG; UNINDEXED DRUG; URSOLIC ACID; ANTINEOPLASTIC AGENT; OLEANOLIC ACID; TRITERPENE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BIOLOGICAL ACTIVITY; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL MODIFICATION; COMPARATIVE STUDY; CONTROLLED STUDY; CRYSTALLIZATION; CYTOTOXICITY; DRUG DESIGN; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; HUMAN CELL; IC 50; MTT ASSAY; NUCLEOPHILICITY; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; 3T3 CELL LINE; ANIMAL; CELL PROLIFERATION; CHEMISTRY; CONFORMATION; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; HT 29 CELL LINE; MCF 7 CELL LINE; MOUSE; SYNTHESIS; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HT29 CELLS; HUMANS; MCF-7 CELLS; MICE; MOLECULAR CONFORMATION; NIH 3T3 CELLS; OLEANOLIC ACID; STRUCTURE-ACTIVITY RELATIONSHIP; TRITERPENES;

EID: 84890816801     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.11.025     Document Type: Article

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