Anti-tumor activity of three novel derivatives of ginsenoside on colorectal cancer cells

Steroids

Volumn 80, Issue , 2014, Pages 24-29

  Xia, Xichun ^a   Jiang, Bowen ^a   Liu, Wei ^a   Wang, Peng ^b,c   Mou, Yanhua ^b   Liu, Yafei ^b   Zhao, Yuqing ^b,c   Bi, Xiuli ^a  

^a LIAONING UNIVERSITY   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^c YANBIAN UNIVERSITY   (China)

Author keywords

Anti tumor activity; Apoptosis; Chemotherapeutic; Derivatives of 25 OH PPD

Indexed keywords

12BETA O (LEVO CHLOARCETYL) DAMMARANE 3BETA, 20, 25 TRIOL; 3BETA O (LEVO ALANYL) DAMMARANE 12BETA, 20, 25 TRIOL; 3BETA O (TERT BUTYLOXYCARBONYL LEVO ARGINYL) DAMMARANE 12BETA, 20, 25 TRIOL; ANTINEOPLASTIC AGENT; CASPASE; GINSENOSIDE; UNCLASSIFIED DRUG; 25-HYDROXYPROTOPANAXADIOL;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL GROWTH; CELL STRAIN HCT116; CELL VIABILITY ASSAY; COLORECTAL CANCER; CONTROLLED STUDY; DNA FRAGMENTATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; LYMPHOCYTE; MUSCLE CELL; CELL PROLIFERATION; CELL SURVIVAL; CHEMISTRY; COLORECTAL NEOPLASMS; CONFORMATION; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; HCT116 CELL LINE; HT 29 CELL LINE; ISOLATION AND PURIFICATION; PANAX; PATHOLOGY; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; TUMOR CELL CULTURE;

PANAX GINSENG;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL PROLIFERATION; CELL SURVIVAL; COLORECTAL NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; GINSENOSIDES; HCT116 CELLS; HT29 CELLS; HUMANS; MOLECULAR CONFORMATION; PANAX; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 84890445132     PISSN: 0039128X     EISSN: 18785867     Source Type: Journal    
DOI: 10.1016/j.steroids.2013.11.018     Document Type: Article

References (30)

1. R. Siegel, D. Naishadham, and A. Jemal Cancer statistics CA Cancer J Clin 62 2012 10 29
2. S. Shibata Chemistry and cancer preventing activities of ginseng saponins and some related triterpenoid compounds J Korean Med Sci 16 2001 28 37
3. K.W. Leung, K.K. Yung, N.K. Mak, P.Y. Yue, H.B. Luo, and Y.K. Chen Angiomodulatory and neurological effects of ginsenosides Curr Med Chem 14 2007 1371 1380 (Pubitemid 46758853)
4. K. Sato, M. Mochizuki, I. Saiki, Y.C. Yoo, K. Samaukawa, and I. Azuma Inhibition of tumor angiogenesis and metastasis by a saponin of Panax ginseng, ginsenoside-Rb2 Biol Pharm Bull 17 1994 635 639 (Pubitemid 24186106)
5. T.K. Yun, and S.Y. Choi Preventive effect of ginseng intake against various human cancers: a case-control study on 1987 pairs Cancer Epidemiol Biomarkers Prev 4 1995 401 408
6. W. Wang, Y. Zhao, E.R. Rayburn, D.L. Hill, H. Wang, and R. Zhang In vitro anti-cancer activity and structure-activity relationships of natural products isolated from fruits of Panax ginseng Cancer Chemother Pharmacol 59 2007 589 601 (Pubitemid 46295123)
7. Y. Zhao, W. Wang, L. Han, E.R. Rayburn, D.L. Hill, and H. Wang Isolation, structural determination, and evaluation of the biological activity of 20(S)-25-methoxyl-dammarane-3beta, 12beta, 20-triol [20(S)-25-OCH3-PPD], a novel natural product from Panax notoginseng Med Chem 3 2007 51 60 (Pubitemid 46062342)
8. 3-PPD as experimental therapy for pancreatic cancer: anticancer activity and mechanisms of action Cancer Lett 278 2009 241 248
9. J. Hou, D. Wang, R. Zhang, and H. Wang Experimental therapy of hepatoma with artemisinin and its derivatives: in vitro and in vivo activity, chemosensitization, and mechanisms of action Clin Cancer Res 14 2008 5519 5530
10. M. Hao, Y. Zhao, P. Chen, H. Huang, H. Liu, and H. Jiang Structure-activity relationship and substrate-dependent phenomena in effects of ginsenosides on activities of drug-metabolizing P450 enzymes PLoS One 3 2008 e2697
11. P. Wang, X.L. Bi, J. Xu, H.N. Yuan, H.R. Piao, and Y.Q. Zhao Synthesis and anti-tumor evaluation of novel 25-hydroxyprotopanaxadiol analogs incorporating natural amino acids Steroids 78 2013 203 209
12. Zhao YQ, Wang P, Sun BS, inventor; Liaoning Xinzhong Modern Medicine Co., Ltd., assignee. Derivatives of 20(S) and 20(R)-dammarane-3β, 12β, 20, 25-tetrol and its preparation method and application. China patent CN 201210061033.8. 2012 Jul 11.
13. H. Li, Y.Y. Zhang, X.Y. Huang, Y.N. Sun, Y.F. Jia, and D. Li Beneficial effect of tripterine on systemic lupus erythematosus induced by active chromatin in BALB/c mice Eur J Pharmacol 512 2005 231 237 (Pubitemid 40544358)
14. J. Wang, X.W. Lv, and Y.G. Du Potential mechanisms involved in ceramide-induced apoptosis in human colon cancer HT29 cells Biomed Environ Sci 22 2009 76 85
15. S. Ramasamy, N. Abdul Wahab, N. Zainal Abidin, and S. Manickam Effect of extracts from Phyllanthus watsonii Airy Shaw on cell apoptosis in cultured human breast cancer MCF-7 cells Exp Toxicol Pathol 65 2013 341 349
16. X.L. Bi, Y.Q. Zhao, W.F. Fang, and W.C. Yang Anticancer activity of Panax notoginseng extract 20(S)-25-OCH3-PPD: targetting beta-catenin signaling Clin Exp Pharmacol Physiol 36 2009 1074 1078
17. X.L. Bi, N.M. Pohl, Z. Qian, G.R. Yang, Y. Gou, and G. Guzman Decorin-mediated inhibition of colorectal cancer growth and migration is associated with E-cadherin in vitro and in mice Carcinogenesis 33 2012 326 330
18. Y.Z. Xiang, H.C. Shang, X.M. Gao, and B.L. Zhang A comparison of the ancient use of ginseng in traditional Chinese medicine with modern pharmacological experiments and clinical trials Phytother Res 22 2008 851 858
19. L.J. Hofseth, and M.J. Wargovich Inflammation, cancer, and targets of ginseng J Nutr 137 2007 183 185
20. S. Helms Cancer prevention and therapeutics: Panax ginseng Altern Med Rev 9 2004 259 274 (Pubitemid 39299200)
21. Y.S. Chang, E.K. Seo, C. Gyllenhaal, and K.I. Block Panax ginseng: a role in cancer therapy? Integr Cancer Ther 2 2003 13 33 (Pubitemid 37101984)
22. A.S. Attele, J.A. Wu, and C.S. Yuan Ginseng pharmacology: multiple constituents and multiple actions Biochem Pharmacol 58 1999 1685 1693 (Pubitemid 29505408)
23. S.C.L. Thomas Asian and American ginseng: a review Hort Technol 5 1995 27 34
24. D. Kitts, and C. Hu Efficacy and safety of ginseng Public Health Nutr 4 2000 473 485 (Pubitemid 32095585)
25. J.T. Xie, S.R. Mehendale, X. Li, R. Quigg, X. Wang, and C.Z. Wang Anti-diabetic effect of ginsenoside Re in ob/ob mice Biochim Biophys Acta 1740 2005 319 325 (Pubitemid 40804743)
26. W. Wang, H. Wang, E.R. Rayburn, Y. Zhao, D.L. Hill, and R. Zhang 20(S)-25-methoxyl-dammarane-3beta, 12beta, 20-triol, a novel natural product for prostate cancer therapy: activity in vitro and in vivo and mechanisms of action Br J Cancer 98 2008 792 802 (Pubitemid 351272613)
27. W. Wang, E.R. Rayburn, M. Hao, Y. Zhao, D.L. Hill, and R. Zhang Experimental therapy of prostate cancer with novel natural product anti-cancer ginsenosides Prostate 68 2008 809 819 (Pubitemid 351845212)
28. A. Gross, J.M. McDonnell, and S.J. Korsmeyer BCL-2 family members and the mitochondria in apoptosis Genes Dev 13 1999 1899 1911 (Pubitemid 29407357)
29. P. Li, D. Nijhawan, and X.D. Wang Mitochondrial activation of apoptosis Cell 116 2004 57 59
30. X.J. Jiang, and X.D. Wang Cytochrome C-mediated apoptosis Annu Rev Biochem 73 2004 87 106