Synthesis and antitumor activities of naturally occurring oleanolic acid triterpenoid saponins and their derivatives

European Journal of Medicinal Chemistry

Volumn 64, Issue , 2013, Pages 1-15

  Liu, Qingchao ^a   Liu, Hongchun ^d   Zhang, Lei ^c   Guo, Tiantian ^c   Wang, Peng ^c   Geng, Meiyu ^d   Li, Yingxia ^b  

^a NORTHWEST UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

^c OCEAN UNIVERSITY OF CHINA   (China)

^d SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Cytotoxic activity; Glycosylation; IC50 value; Log P; Oleanolic acid triterpenoid saponins

Indexed keywords

1 (4 TOLYL) THIO 2,3 DI O BENZOYL 4 BETA DEXTRO XYLOPYRANOSIDE; 1 (4 TOLYL) THIO 2,3 DI O BENZOYL 4 O ACETYL BETA DEXTRO XYLOPYRANOSIDE; 1 (4 TOLYL) THIO 2,3 O ISOPROPYLIDENE 4 O (1 METHOXY 1 METHYLETHYL) BETA DEXTRO XYLOPYRANOSIDE; 1 (4 TOLYL) THIO 2,3 O ISOPROPYLIDENE BETA DEXTRO XYLOPYRANOSIDE; 1 (4 TOLYL) THIO 4 O ACETYL BETA DEXTRO XYLOPYRANOSIDE; 10 HYDROXYCAMPTOTHECIN; 2,3,4,6 TETRA O BENZOYL BETA DEXTRO GLUCOPYRANOSYL(1-4) 1 (4-TOLYL)THIO 2,3 DI O BENZOYL BETA DEXTRO XYLOPYRANOSIDE; 2,3,4,6 TETRA O BENZOYL BETA DEXTRO GLUCOPYRANOSYL(1-4) 2,3 DI O BENZOYL BETA DEXTRO XYLOPYRANOSIDE TRICHLOROACETIMIDATE; 28 O ALPHA LEVO RHAMNOPYRANOSYL(1-4)O BETA DEXTRO GLUCOPYRANOSYL(1-6)O BETA DEXTRO GLUCOPYRANOSYL OLEANATE; ANTINEOPLASTIC AGENT; BENZYL OLEANOLATE 2,3,4 TRI O BENZYL BETA LEVO 3 O BETA LEVO RHAMNOPYRANOSYL(1-2) 3,4 O ISOPROPYLIDENE ALPHA LEVO ARABINOPYRANOSIDE; BENZYL OLEANOLATE 2,4 DI O ACETYL 3 O LEVULINOYL ALPHA LEVO RHAMNOPYRANOSYL(1-2) 3,4 O ISOPROPYLID ENE ALPHA LEVO ARABINOPYRANOSIDE; BENZYL OLEANOLATE 3BETA O [2,3 DI O (2,3,4 TRI O BENZOYL ALPHA LEVO RHAMNOPYRANOSYL) 4,6 DI O BENZYLID ENE BETA DEXTRO GLUCOPYRANOSIDE]; BENZYL OLEANOLATE 3BETA O [3 O (2,3,4 TRI O BENZOYL ALPHA LEVO RHAMNOPYRANOSYL) 3,4 DI O BENZOYL BETA DEXTRO XYLO PYRANOSIDE]; DOXORUBICIN; OLEANOLATE 3BETA O BETA DEXTRO GLUCOPYRANOSYL (1-4) BETA DEXTRO XYLOPYRANOSYL (1-3) ALPHA LEVO RHAMNOPYRANOSYL (1-2) ALPHA LEVO ARABINOPYRANOSIDE; OLEANOLIC ACID; OLEANOLIC ACID 3 O 2,3 DI DI O (ALPHA LEVO RHAMNOPYRANOSYL) 4,6 DI O BENZYLIDENE BETA DEXTRO GALACTOPYRANOSIDE; OLEANOLIC ACID 3 O 2,3 DI O (ALPHA LEVO RHAMNOPYRANOSYL)BETA DEXTRO GLUCOPYRANOSIDE; OLEANOLIC ACID 3 O ALPHA LEVO RHAMNOPYRANOSYL(1-2) BETA DEXTRO GALACTOPYRANOSIDE; OLEANOLIC ACID 3 O ALPHA LEVO RHAMNOPYRANOSYL(1-2) BETA DEXTRO GLUCOPYRANOSIDE; OLEANOLIC ACID 3 O ALPHA LEVO RHAMNOPYRANOSYL(1-2) BETA DEXTRO XYLOPYRANOSID; OLEANOLIC ACID 3 O ALPHA LEVO RHAMNOPYRANOSYL(1-2)BETA DEXTRO GLUCOPYRANOSIDE; OLEANOLIC ACID 3 O ALPHA LEVO RHAMNOPYRANOSYL(1-3) BETA DEXTRO GALACTOPYRANOSIDE; OLEANOLIC ACID 3BETA O ALPHA LEVO RHAMNOPYRANOSYL(1-2) BETA LEVO ARABINOPYRANOSIDE; OLEANOLIC ACID 3BETA O ALPHA LEVO RHAMNOPYRANOSYL(1-3) ALPHA LEVO RHAMNOPYRANOSYL(1-2) BETA DEXTRO XYLOPYRANOSIDE; OLEANOLIC ACID 3BETA O BETA DEXTRO XYLOPYRANOSYL (1-3) ALPHA LEVO RHAMNOPYRANOSYL (1-2) BETA DEXTRO XYLOPYRANOSIDE; SAPONIN; TRITERPENOID; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ACETYLATION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CATALYSIS; CHEMICAL MODIFICATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; GLYCOSYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; LIPOPHILICITY; LUNG NON SMALL CELL CANCER; MELANOMA; ONE POT SYNTHESIS; PROMYELOCYTIC LEUKEMIA; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; THIN LAYER CHROMATOGRAPHY;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HL-60 CELLS; HUMANS; MOLECULAR CONFORMATION; OLEANOLIC ACID; SAPONINS; STRUCTURE-ACTIVITY RELATIONSHIP; TRITERPENES;

EID: 84877079384     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.04.016     Document Type: Article

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