Triterpenoid saponin augmention of saporin-based immunotoxin cytotoxicity for human leukaemia and lymphoma cells is partially immunospecific and target molecule dependent

Immunopharmacology and Immunotoxicology

Volumn 37, Issue 1, 2015, Pages 42-55

  Holmes, Suzanne E ^a   Bachran, Christopher ^b,e   Fuchs, Hendrik ^c   Weng, Alexander ^c   Melzig, Matthias F ^d   Flavell, Sopsamorn U ^a   Flavell, David J ^a  

^a SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d FREIE UNIVERSITÄT BERLIN   (Germany)

^e BioMed X Innovation Center   (Germany)

Author keywords

Augmentation; Immunotoxin; Leukemia; Lymphoma; Saponins

Indexed keywords

ANTIBODY; BLOCKING ANTIBODY; CD19 ANTIGEN; CD22 ANTIGEN; CD38 ANTIGEN; CD7 ANTIGEN; CD71 ANTIGEN; IMMUNOTOXIN; LIPOCORTIN 5; LYMPHOCYTE ANTIGEN; OKT10 ANTIBODY; SAPONIN DERIVATIVE; SAPONINUM ALBUM; SAPORIN; TRITERPENOID; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; MONOCLONAL ANTIBODY; RIBOSOME INACTIVATING PROTEIN 1; SAPONIN; T LYMPHOCYTE ANTIGEN; TRITERPENE;

APOPTOSIS; APOPTOSIS ASSAY; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CELL SURFACE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DAUDI CELL LINE; DOSE RESPONSE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC50; LEUKEMIA CELL; LYMPHOMA CELL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; TARGET CELL; XTT ASSAY; ACUTE LYMPHOBLASTIC LEUKEMIA; BURKITT LYMPHOMA; DRUG ADMINISTRATION; DRUG EFFECTS; IMMUNOLOGY; ISOLATION AND PURIFICATION; MOLECULARLY TARGETED THERAPY; PATHOLOGY; TUMOR CELL LINE;

ANTIBODIES, MONOCLONAL, MURINE-DERIVED; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; BURKITT LYMPHOMA; CELL LINE, TUMOR; CYTOTOXICITY, IMMUNOLOGIC; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; FLOW CYTOMETRY; HUMANS; MOLECULAR TARGETED THERAPY; PRECURSOR T-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; RIBOSOME INACTIVATING PROTEINS, TYPE 1; SAPONINS; TRITERPENES;

EID: 84918787825     PISSN: 08923973     EISSN: 15322513     Source Type: Journal    
DOI: 10.3109/08923973.2014.971964     Document Type: Article

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