Cytotoxic and apoptosis-inducing activities of triterpene acids from Poria cocos

Journal of Natural Products

Volumn 74, Issue 2, 2011, Pages 137-144

  Kikuchi, Takashi ^a   Uchiyama, Emiko ^a   Ukiya, Motohiko ^a   Tabata, Keiichi ^a   Kimura, Yumiko ^a   Suzuki, Takashi ^a   Akihisa, Toshihiro ^a  

^a NIHON UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXY 3 EPIDEHYDROTUMULOSIC ACID; 25 HYDROXY 3 EPIDEHYDROTUMULOSOL [(2') 3,4 SECO 24 METHYLLANOSTA 4(28),8, 24(241) TRIENE 3,16ALPHA,21 TRIOL]; ANTINEOPLASTIC AGENT; APOPTOSIS INDUCING FACTOR; CASPASE 3; CASPASE 8; CASPASE 9; CISPLATIN; DEHYDROEBURICOL [(2') 24 METHYLLANOSTA 7,9(11),24 (241) TRIENE 3BETA,21 DIOL]; DEHYDROEBURICONIC ACID; DIMETHYL PORICOATE A; DIMETHYL PORICOATE C; DIMETHYL PORICOATE G; DIMETHYL PORICOATE H; FLUOROURACIL; METHYL 25 HYDROXY 3 EPIDEHYDROTUMULOSATE [METHYL (2') 3ALPHA,16ALPHA DIHYDROXY 24 METHYLLANOSTA 7,9(11),24(241) TRIENE 21 OATE]; METHYL DEHYDROEBURICONATE [METHYL (2') 3 OXO 24 METHYLLANOSTA 8,24(241) DIENE 21 OATE]; PORICOIC ACID A; PORICOIC ACID C; PORICOIC ACID G; PORICOIC ACID H; PORICOTRIOL A; PORICOTRIOL C; PORICOTRIOL G; PORICOTRIOL H; PROTEIN BAX; PROTEIN BCL 2; TRITERPENE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL DEATH; CELL STRAIN HL 60; CYTOTOXICITY; DRUG ISOLATION; DRUG SCREENING; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IC 50; LEUKEMIA CELL; MITOCHONDRION; WESTERN BLOTTING;

PORIA COCOS;

EID: 79952290238     PISSN: 01633864     EISSN: 15206025     Source Type: Journal    
DOI: 10.1021/np100402b     Document Type: Article

References (32)

1. Shan, Z.; Yuan, Y. X., Eds. Zhong Shan Medical College, Clinical Application of Chinese Medicine; Guang Dong People's Publisher: Guang Dong, 1975; p 136.
2. Namba, T. The Encyclopedia of Wakan-Yaku (Traditional Sino-Japanese Medicines) with Color Pictures, revised ed.; Hoikusya: Osaka, 1994; Vol. II, pp 241-243.
3. Tai, T.; Akahori, A.; Shingu, T. Phytochemistry 1993, 32, 1239-1244.
4. Tai, T.; Shingu, T.; Kikuchi, T.; Tezuka, Y.; Akahori, A. Phytochemistry 1995, 40, 225-231.
5. Yasukawa, K.; Kaminaga, T.; Kitanaka, S.; Tai, T.; Nunoura, Y.; Natori, S.; Takido, M. Phytochemistry 1998, 48, 1357-1360.
6. Ukiya, M.; Akihisa, T.; Tokuda, H.; Hirano, M.; Oshikubo, M.; Nobukuni, Y.; Kimura, Y.; Tai, T.; Kondo, S.; Nishino, H. J. Nat. Prod. 2002, 65, 462-465.
7. Tai, T.; Akahori, A.; Shingu, T. Phytochemistry 1991, 30, 2796-2797.
8. Tai, T.; Shingu, T.; Kikuchi, T.; Tezuka, Y.; Akahori, A. Phytochemistry 1995, 39, 1165-1169.
9. Akihisa, T.; Nakamura, Y.; Tokuda, H.; Uchiyama, E.; Suzuki, T.; Kimura, Y.; Uchikura, K.; Nishino, H. J. Nat. Prod. 2007, 70, 948-953.
10. Akihisa, T.; Uchiyama, E.; Kikuchi, T.; Tokuda, H.; Suzuki, T.; Kimura, Y. J. Nat. Prod. 2009, 72, 1786-1792.
11. Kaminaga, T.; Yasukawa, K.; Takido, M.; Tai, T.; Nunoura, Y. Phytother. Res. 1996, 10, 581-584.
12. Kaminaga, T.; Yasukawa, K.; Kanno, H.; Tai, T.; Nunoura, Y.; Takido, M. Oncology 1996, 53, 382-385.
13. Gapter, L.; Wang, Z.; Glinski, J.; Ng., K.-y. Biochem. Biophys. Res. Commun. 2005, 332, 1153-1161.
14. Kang, H.-M.; Lee, S.-K.; Shin, D.-S.; Lee, M.-Y.; Han, D. C.; Baek, N.-I.; Son, K.-H.; Kwon, B.-M. Life Sci. 2006, 78, 607-613.
15. Akihisa, T.; Mizushina, Y.; Ukiya, M.; Oshikubo, M.; Kondo, S.; Kimura, Y.; Suzuki, T.; Tai, T. Biosci. Biotechnol. Biochem. 2004, 68, 448-450.
16. Mizushina, Y.; Akihisa, T.; Ukiya, M.; Murakami, C.; Kuriyama, I.; Xu, X.; Yoshida, H.; Sakaguchi, K. Cancer Sci. 2004, 95, 354-360.
17. Drawings correspond to energy-minimized conformation of the (20R)-epimers of 1b and 1c. Calculation was performed using CAChe CONFLEX with the MM2 force field (CAChe version 5.5; Fujitsu Co., Tokyo, Japan).
18. Darzynkiewicz, Z.; Bruno, S.; Del Bino, G.; Gorczyca, W.; Hotz, M. A.; Lassota, P.; Traganose, F. Cytometry 1992, 13, 795-808.
19. Martin, S. J.; Reutelingsperger, C. P.; McGahon, A. J.; Rader, J. A.; van Schie, R. C. A. A.; LaFace, D. M.; Green, D. R. J. Exp. Med. 1995, 182, 1545-15556.
20. Salvesen, G. S.; Dixit, V. M. Cell 1997, 91, 443-446.
21. Thornberry, N. A.; Lazebnik, Y. Science 1998, 281, 1312-1316.
22. Kluck, R. M.; Bossy-Wetzel, E.; Green, D. R.; Newmeyer, D. D. Science 1997, 275, 1132-1137.
23. Kluck, R. M.; Esposti, M. D.; Perkins, G.; Renken, C.; Kuwana, T.; Bossy-Wetzel, E.; Goldberg, M.; Allen, T.; Barber, M. J.; Green, D. R.; Newmeyer, D. D. J. Cell Biol. 1999, 147, 809-822.
24. Bcl-2 band was quantified with CS Analyzer Ver. 3.00 (ATTO&Rise Corporation, Tokyo, Japan). The level of bcl-2 decreased from 1.00 to 0.81±0.11 after 24 h and 0.69±0.07 after 48 h (means ± standard error) (n = 3).
25. Oltvai, Z. N.; Milliman, C. L.; Korameyer, S. J. Cell 1993, 74, 609-619.
26. Cregan, S. P.; Dawson, V. L.; Slack, R. S. Oncogene 2004, 23, 2785-2796.
27. Norberg, E.; Orrenius, S.; Zhivotovsky, B. Biochem. Biophys. Res. Commun. 2010, 396, 95-100.
28. Pati, H. N.; Das, U.; Kawase, M.; Sakagami, H.; Balzarini, J.; De Clercq, E.; Dimmock, J. R. Bioorg. Med. Chem. 2008, 16, 5747-5753.
29. Pan, L.;Chai, H.;Kinghorn, A.D. Phytochem. Lett. 2009, 2, 15-18.
30. Tabata, K.; Motani, K.; Takayanagi, N.; Nishimura, R.; Asami, S.; Kimura, Y.; Ukiya, M.; Hasegawa, D.; Akihisa, T.; Suzuki, T. Biol. Pharm. Bull. 2009, 28, 1404-1407.
31. Kikuchi, T.; Nihei, M.; Nagai, H.; Fukushi, H.; Tabata, K.; Suzuki, T.; Akihisa, T. Chem. Pharm. Bull. 2010, 58, 568-571.
32. Motani, K.; Tabata, K.; Kimura, Y.; Okano, S.; Shibata, Y.; Nagai, H.; Akihisa, T.; Suzuki, T. Biol. Pharm. Bull. 2008, 31, 618-626.