Novel dammarane-type sapogenins from Panax ginseng berry and their biological activities

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 3, 2011, Pages 1027-1031

  Zhao, Jun Ming ^a,b   Li, Ning ^c   Zhang, Hong ^c   Wu, Chun Fu ^c   Piao, Hu Ri ^a   Zhao, Yu Qing ^c  

^a YANBIAN UNIVERSITY   (China)

^b Liaoning Xinzhong Modern Medicine Co Ltd   (China)

^c SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Antitumor effects; Novel dammarane type sapogenins; Panax ginseng berry

Indexed keywords

20 METHOXYLDAMMARANE 3BETA,12BETA,25 TRIOL; 20,25 DIMETHOXYLDAMMARANE 3BETA,12BETA DIOL; 24 DIEPOXYDAMMARANE 3BETA OL; 25 METHOXYLDAMMARANE 3BETA,12BETA,20 TRIOL; 25 METHOXYLDAMMARANE 3BETA,6ALPHA,12BETA,20 TETROL; AGLYCONE; DAMMARANE DERIVATIVE; GINSENG EXTRACT; GINSENOSIDE; SAPOGENIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BERRY; CANCER CELL CULTURE; CELL STRAIN HEPG2; CELL STRAIN HL 60; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG ISOLATION; DRUG STRUCTURE; GINSENG; HUMAN; HUMAN CELL; IC 50; ISOMER; STRUCTURE ANALYSIS;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; PANAX; PLANT ROOTS; SAPOGENINS; STRUCTURE-ACTIVITY RELATIONSHIP; TRITERPENES;

PANAX GINSENG;

EID: 78751646573     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.12.035     Document Type: Article

References (33)

1. J.T. Coon, and E. Emst Drug Saf. 25 2002 322
2. M. Zhu, K.W. Chan, L.S. Ng, Q. Chang, S. Chang, and R.C. Li J. Pharm. Pharmacol. 5 1999 175
3. S. Helms Altern. Med. Rev. 9 2004 259
4. A. Sparreboom, M.C. Cox, M.R. Acharya, and W.D. Figg J. Clin. Oncol. 22 2004 2489
5. A.S. Attele, J.A. Wu, and C.S. Yuan Biochem. Pharmacol. 58 1999 1685
6. C.N. Gillis Pharmacology 54 1997 1
7. L. Jia, and Y.Q. Zhao Curr. Med. Chem. 16 2009 2475
8. L. Jia, Y.Q. Zhao, and X.J. Liang Curr. Med. Chem. 16 2009 2924
9. D.G. Popovich, and D.D. Kitts Arch. Biochem. Biophys. 406 2002 1
10. S.J. Shibata Korean Med. Sci. 16 2001 28
11. Y.Q. Zhao, C. Yuan, and H. Lu Zhongguo Zhong Yao Za Zhi 16 1991 678
12. Y.Q. Zhao, and C.L. Yuan Zhongguo Zhong Yao Za Zhi 18 1993 296
13. M. Yu, and Y.Q. Zhao Chin. Tradit. Herb. Drugs 33 2002 404
14. M. Yu, and Y.Q. Zhao Chin. Tradit. Herb. Drugs 35 2004 869
15. D. Wang, R.H. Chui, and Y.Q. Zhao Mod. Chin. Med. 10 2008 12
16. X.F. Fei, B.X. Wang, S. Tashiro, T.J. Li, J.S. Ma, and T. Ikejima Acta Pharmacol. Sin. 23 2002 315
17. Q. Tran, Y. Tezuka, A.H. Banskota, and Q.K. Tran J. Nat. Prod. 64 2001 1127
18. H. Nakata, Y. Kikuchi, and T. Tode Jpn. J. Cancer Res. 89 1998 733
19. C.C. Cheng, S.M. Yang, C.Y. Huang, J.C. Chen, W.M. Chang, and S.L. Hsu Cancer Chemother. Pharmacol. 55 2005 531
20. H. Jiang, and G.H. Fan Chin. J. Clin. Oncol. Rehabil. 11 2004 289
21. M. Oh, Y.H. Choi, and S. Choi Int. J. Oncol. 14 1999 869
22. W.K. Liu, S.X. Xu, and C.T. Che Life Sci. 67 2000 1297
23. X. Li, Y.S. Guan, and X.P. Zhou Sichuan Da Xue Xue Bao Yi Xue Ban 36 2005 217
24. T.M. Xu, Y. Xin, M.H. Cui, X. Jiang, and L.P. Gu Chin. Med. J. 120 2007 584
25. J.X. Chen, H.M. Peng, S.P. Pu, and Y.P. Guo Zhongguo Zhong Yao Za Zhi 32 2007 1680
26. L.W. Liu, and G.C. Ye Chin. J. Cancer Prev. Treat. 11 2004 957
27. W. Wang, Y.Q. Zhao, E. Rayburn, D.L. Hill, H. Wang, and R.W. Zhang Cancer Chemother. Pharmacol. 59 2007 589
28. Y.Q. Zhao, W. Wang, L. Han, E.R. Rayburn, D.L. Hill, H. Wang, and R.W. Zhang Med. Chem. 3 2007 51
29. Hydrolysis and isolation: the total saponins (100 g) were hydrolyzed with 18% HCl (500 mL). The hydrolyzed preparation was then extracted with EtOAc (500 mL) three times and the extract was subjected to chromatography on a silica gel column (400 g). Elution was stepwise with a petroleum-EtOAc gradient (petroleum-EtOAc, 10:1, 5:1, 2:1, 1:1, 1:2, 1:3, 1:4) to afford compounds 1, 2, 3, 4, and 5.
30. 4Na, 515.4076).
31. 4Na, 515.4076).
32. 3Na, 481.3658).
33. 50). DMSO and MTT were purchased from Sigma Chemical Co., Ltd, USA.