Identification of optimal protein binders through the use of large genetically encoded display libraries

Current Opinion in Chemical Biology

Volumn 26, Issue , 2015, Pages 16-24

  McCafferty, John ^a   Schofield, Darren ^b  

^a IONTAS LTD   (United Kingdom)

^b MEDIMMUNE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; EPITOPE; MOLECULAR LIBRARY; MOLECULAR PROBE; PEPTIDE LIBRARY; PROTEIN BINDING; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY;

ANTIBODY COMBINING SITE; ANTIGEN SPECIFICITY; EUKARYOTE; EUKARYOTIC CELL; FLOW CYTOMETRY; GENE LIBRARY; GENETIC TRANSFECTION; GENETICALLY ENCODED LIBRARY; HUMAN; MAMMAL CELL; NONHUMAN; PHAGE DISPLAY; PROTEIN BINDING; PROTEIN ENGINEERING; REVIEW; YEAST CELL; BACTERIUM TRANSFORMATION; BINDING SITE; BIOSYNTHESIS; CHEMISTRY; DRUG DEVELOPMENT; ESCHERICHIA COLI; GENE EXPRESSION; GENETICS; METABOLISM; MOLECULAR LIBRARY; MOLECULAR PROBE; PEPTIDE LIBRARY; SYNTHESIS;

EUKARYOTA; MAMMALIA;

BINDING SITES; DRUG DISCOVERY; ESCHERICHIA COLI; GENE EXPRESSION; GENE LIBRARY; MOLECULAR PROBES; PEPTIDE LIBRARY; PROTEIN BINDING; PROTEIN ENGINEERING; SINGLE-CHAIN ANTIBODIES; SMALL MOLECULE LIBRARIES; TRANSFORMATION, BACTERIAL;

EID: 84921503892     PISSN: 13675931     EISSN: 18790402     Source Type: Journal    
DOI: 10.1016/j.cbpa.2015.01.003     Document Type: Review

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