Engineering of stable bispecific antibodies targeting IL-17A and IL-23

Protein Engineering, Design and Selection

Volumn 23, Issue 3, 2010, Pages 115-127

  Mabry, Robert ^a   Lewis, Katherine E ^a   Moore, Margaret ^a   McKernan, Patricia A ^a   Bukowski, Thomas R ^a   Bontadelli, Kristen ^a   Brender, Ty ^a   Okada, Shannon ^a   Lum, Karen ^a   West, James ^a   Kuijper, Joseph L ^a   Ardourel, Dan ^a   Franke, Secil ^a   Lockwood, Luann ^a   Vu, Tuyen ^a   Frank, Amanda ^a   Appleby, Mark W ^a   Wolf, Anitra ^a   Reardon, Brian ^a   Hamacher, Nels B ^a   Stevens, Brenda ^a   Lewis, Patsy ^a   Lewis, Kenneth B ^a   Gilbertson, Debra G ^a   Lantry, Megan ^a   Julien, Susan H ^a   Ostrander, Craig ^a   Chan, Chung ^a   Byrnes Blake, Kelly ^a   Brody, Jennifer ^a   Presnell, Scott ^a   Meengs, Brent ^a   Levin, Steven D ^a   Snavely, Mark ^a   more..

^a ZYMOGENETICS INC   (United States)

Author keywords

Antibody; Bispecific; IL 17A; IL 23; ScFv

Indexed keywords

ANTIBODY FRAGMENT; BINDING AFFINITIES; BIOLOGICAL ACTIVITIES; CYTOKINES; ENGINEERING PROCESS; HALF LIVES; MONOCLONAL ANTIBODIES (MABS); PHAGE DISPLAY LIBRARIES; PHARMACOKINETIC ANALYSIS; RECOMBINANT MOLECULES; SIGNIFICANT IMPACTS; STRUCTURAL STABILITIES; STRUCTURE-RELATED; SYNERGISTIC EFFECT; THERAPEUTIC APPLICATION; THERAPEUTIC MOLECULES; VALENCIES; VARIABLE FRAGMENT;

BINDING ENERGY; BIOLOGY; GENE EXPRESSION; MONOCLONAL ANTIBODIES; STABILITY;

MOLECULES;

BISPECIFIC ANTIBODY; IMMUNOGLOBULIN G1; INTERLEUKIN 17; INTERLEUKIN 23; INTERLEUKIN 23P19; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY;

ANIMAL EXPERIMENT; ANTIBODY ENGINEERING; ARTICLE; BINDING AFFINITY; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DRUG STABILITY; DRUG TARGETING; FEMALE; HUMAN; ISOLATION PROCEDURE; MOLECULE; MOUSE; NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; PRODUCTIVITY;

ANIMALS; ANTIBODIES, BISPECIFIC; ANTIBODIES, MONOCLONAL; ANTIBODY AFFINITY; DATABASES, PROTEIN; ESCHERICHIA COLI; FEMALE; HALF-LIFE; HUMANS; INTERLEUKIN-17; INTERLEUKIN-23; KINETICS; MICE; PROTEIN ENGINEERING; PROTEIN STABILITY; SINGLE-CHAIN ANTIBODIES;

MUS;

EID: 76949084270     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzp073     Document Type: Article

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