Mammalian cell display for the discovery and optimization of antibody therapeutics

Methods

Volumn 65, Issue 1, 2014, Pages 44-56

  Bowers, Peter M ^a   Horlick, Robert A ^a   Kehry, Marilyn R ^a   Neben, Tamlyn Y ^a   Tomlinson, Geoffery L ^a   Altobell, Larry ^a   Zhang, Xue ^a   Macomber, John L ^a   Krapf, Irina P ^a   Wu, Betty F ^a   McConnell, Audrey D ^a   Chau, Betty ^a   Berkebile, Ashley D ^a   Hare, Eric ^a   Verdino, Petra ^a   King, David J ^a  

^a AnaptysBio Inc   (United States)

Author keywords

AID; Antibody; Mammalian cell display; Somatic hypermutation

Indexed keywords

ACTIVATION INDUCED CYTIDINE DEAMINASE; ANTIBODY; B CELL MATURATION ANTIGEN;

ADAPTIVE IMMUNITY; ANTIBODY SCREENING; ANTIGEN SPECIFICITY; ARTICLE; BACTERIOPHAGE; CELL MATURATION; CELL POPULATION; CELL SURFACE; CELL SURFACE DISPLAY; COLD; DISPLAY SYSTEM; DNA SEQUENCE; FLUORESCENCE ACTIVATED CELL SORTING; GENOTYPE; HUMAN; IMMUNIZATION; IN VITRO STUDY; IN VIVO STUDY; MAMMAL CELL; PHENOTYPE; PRIORITY JOURNAL; SECRETION (PROCESS); SOMATIC HYPERMUTATION;

MAMMALIA;

AID; ANTIBODY; MAMMALIAN CELL DISPLAY; SOMATIC HYPERMUTATION;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY AFFINITY; ANTIGENS; BASE SEQUENCE; CELL SEPARATION; DIRECTED MOLECULAR EVOLUTION; DNA PRIMERS; DRUG DISCOVERY; FLOW CYTOMETRY; GENE LIBRARY; HEK293 CELLS; HUMANS; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN ENGINEERING;

EID: 84891629425     PISSN: 10462023     EISSN: 10959130     Source Type: Journal    
DOI: 10.1016/j.ymeth.2013.06.010     Document Type: Article

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