Recombining germline-derived CDR sequences for creating diverse single-framework antibody libraries

Nature Biotechnology

Volumn 18, Issue 8, 2000, Pages 852-856

  Söderlind, Eskil ^a   Strandberg, Leif ^a   Jirholt, Pernilla ^b   Kobayashi, Norihiro ^b,c   Alexeiva, Vessela ^a   Åberg, Anna Maria ^a   Nilsson, Anna ^a   Jansson, Bo ^a   Ohlin, Mats ^b   Wingren, Christer ^b   Danielsson, Lena ^a   Carlsson, Roland ^a   Borrebaeck, Carl A K ^b  

^a BioInvent International AB   (Sweden)

^b LUND UNIVERSITY   (Sweden)

^c TOHOKU UNIVERSITY   (Japan)

Author keywords

Antibody engineering; Diversity; In vitro evolution; Recombination

Indexed keywords

ANTIBODY; CARBOHYDRATE; HAPTEN; IMMUNOGLOBULIN; M PROTEIN; PEPTIDE;

ARTICLE; COMPLEMENTARITY DETERMINING REGION; DISSOCIATION CONSTANT; GENE INSERTION; GENE LIBRARY; GENE SEQUENCE; GENETIC ENGINEERING; GENETIC RECOMBINATION; GENETIC TRANSFORMATION; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL;

GERM-LINE MUTATION; HUMANS; IMMUNOGLOBULIN FRAGMENTS; IMMUNOGLOBULIN VARIABLE REGION; RECOMBINANT PROTEINS; RECOMBINATION, GENETIC;

EID: 0033883409     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/78458     Document Type: Article

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