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Volumn 413, Issue 1, 2011, Pages 261-278

HuCAL PLATINUM, a synthetic fab library optimized for sequence diversity and superior performance in mammalian expression systems

Author keywords

antibody expression; CDR H3 design; HuCAL PLATINUM; human combinatorial antibody libraries; trinucleotide mutagenesis

Indexed keywords

IMMUNOGLOBULIN F(AB) FRAGMENT;

EID: 80053303946     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2011.08.012     Document Type: Article
Times cited : (127)

References (53)
  • 3
    • 0026841383 scopus 로고
    • An artificial immune system for making antibodies
    • Marks J.D., and Winter G. An artificial immune system for making antibodies Behring Inst. Mitt. 1992 6 12
    • (1992) Behring Inst. Mitt. , pp. 6-12
    • Marks, J.D.1    Winter, G.2
  • 4
    • 9344223986 scopus 로고    scopus 로고
    • Human antibodies with sub-nanomolar affinities isolated from a large non-immunized phage display library
    • Vaughan T.J., Williams A.J., Pritchard K., Osbourn J.K., Pope A.R., and Earnshaw J.C. Human antibodies with sub-nanomolar affinities isolated from a large non-immunized phage display library Nat. Biotechnol. 14 1996 309 314
    • (1996) Nat. Biotechnol. , vol.14 , pp. 309-314
    • Vaughan, T.J.1    Williams, A.J.2    Pritchard, K.3    Osbourn, J.K.4    Pope, A.R.5    Earnshaw, J.C.6
  • 6
    • 60749123372 scopus 로고    scopus 로고
    • Modelling the human immune response: Performance of a 1011 human antibody repertoire against a broad panel of therapeutically relevant antigens
    • Lloyd C., Lowe D., Edwards B., Welsh F., Dilks T., Hardman C., and Vaughan T. Modelling the human immune response: performance of a 1011 human antibody repertoire against a broad panel of therapeutically relevant antigens Protein Eng. Des. Sel. 22 2009 159 168
    • (2009) Protein Eng. Des. Sel. , vol.22 , pp. 159-168
    • Lloyd, C.1    Lowe, D.2    Edwards, B.3    Welsh, F.4    Dilks, T.5    Hardman, C.6    Vaughan, T.7
  • 7
    • 0028926814 scopus 로고
    • Selection and application of human single chain Fv antibody fragments from a semi-synthetic phage antibody display library with designed CDR3 regions
    • de Kruif J., Boel E., and Logtenberg T. Selection and application of human single chain Fv antibody fragments from a semi-synthetic phage antibody display library with designed CDR3 regions J. Mol. Biol. 248 1995 97 105
    • (1995) J. Mol. Biol. , vol.248 , pp. 97-105
    • De Kruif, J.1    Boel, E.2    Logtenberg, T.3
  • 10
    • 0028006072 scopus 로고
    • Antibody fragments from a 'single pot' phage display library as immunochemical reagents
    • Nissim A., Hoogenboom H.R., Tomlinson I.M., Flynn G., Midgley C., Lane D., and Winter G. Antibody fragments from a "single pot" phage display library as immunochemical reagents EMBO J. 13 1994 692 698 (Pubitemid 24050684)
    • (1994) EMBO Journal , vol.13 , Issue.3 , pp. 692-698
    • Nissim, A.1    Hoogenboom, H.R.2    Tomlinson, I.M.3    Flynn, G.4    Midgley, C.5    Lane, D.6    Winter, G.7
  • 11
    • 0035558749 scopus 로고    scopus 로고
    • n-CoDeR concept: Unique types of antibodies for diagnostic use and therapy
    • Carlsson R., and Soderlind E. n-CoDeR concept: unique types of antibodies for diagnostic use and therapy Expert Rev. Mol. Diagn. 1 2001 102 108 (Pubitemid 34654452)
    • (2001) Expert Review of Molecular Diagnostics , vol.1 , Issue.1 , pp. 102-108
    • Carlsson, R.1    Soderlind, E.2
  • 14
    • 0034635335 scopus 로고    scopus 로고
    • Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides
    • Knappik A., Ge L., Honegger A., Pack P., Fischer M., and Wellnhofer G. Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides J. Mol. Biol. 296 2000 57 86
    • (2000) J. Mol. Biol. , vol.296 , pp. 57-86
    • Knappik, A.1    Ge, L.2    Honegger, A.3    Pack, P.4    Fischer, M.5    Wellnhofer, G.6
  • 15
    • 39149087988 scopus 로고    scopus 로고
    • The human combinatorial antibody library HuCAL GOLD combines diversification of all six CDRs according to the natural immune system with a novel display method for efficient selection of high-affinity antibodies
    • Rothe C., Urlinger S., Lohning C., Prassler J., Stark Y., and Jager U. The human combinatorial antibody library HuCAL GOLD combines diversification of all six CDRs according to the natural immune system with a novel display method for efficient selection of high-affinity antibodies J. Mol. Biol. 376 2008 1182 1200
    • (2008) J. Mol. Biol. , vol.376 , pp. 1182-1200
    • Rothe, C.1    Urlinger, S.2    Lohning, C.3    Prassler, J.4    Stark, Y.5    Jager, U.6
  • 16
    • 77349120461 scopus 로고    scopus 로고
    • De novo selection of high-affinity antibodies from synthetic Fab libraries displayed on phage as pIX fusion proteins
    • Shi L., Wheeler J.C., Sweet R.W., Lu J., Luo J., and Tornetta M. De novo selection of high-affinity antibodies from synthetic Fab libraries displayed on phage as pIX fusion proteins J. Mol. Biol. 397 2010 385 396
    • (2010) J. Mol. Biol. , vol.397 , pp. 385-396
    • Shi, L.1    Wheeler, J.C.2    Sweet, R.W.3    Lu, J.4    Luo, J.5    Tornetta, M.6
  • 18
    • 0028559783 scopus 로고
    • Trinucleotide phosphoramidites: Ideal reagents for the synthesis of mixed oligonucleotides for random mutagenesis
    • Virnekas B., Ge L., Pluckthun A., Schneider K.C., Wellnhofer G., and Moroney S.E. Trinucleotide phosphoramidites: ideal reagents for the synthesis of mixed oligonucleotides for random mutagenesis Nucleic Acids Res. 22 1994 5600 5607
    • (1994) Nucleic Acids Res. , vol.22 , pp. 5600-5607
    • Virnekas, B.1    Ge, L.2    Pluckthun, A.3    Schneider, K.C.4    Wellnhofer, G.5    Moroney, S.E.6
  • 19
    • 3242760800 scopus 로고    scopus 로고
    • High-affinity human antibodies from phage-displayed synthetic Fab libraries with a single framework scaffold
    • DOI 10.1016/j.jmb.2004.05.051, PII S0022283604006333
    • Lee C.V., Liang W.C., Dennis M.S., Eigenbrot C., Sidhu S.S., and Fuh G. High-affinity human antibodies from phage-displayed synthetic Fab libraries with a single framework scaffold J. Mol. Biol. 340 2004 1073 1093 (Pubitemid 38976491)
    • (2004) Journal of Molecular Biology , vol.340 , Issue.5 , pp. 1073-1093
    • Lee, C.V.1    Liang, W.-C.2    Dennis, M.S.3    Eigenbrot, C.4    Sidhu, S.S.5    Fuh, G.6
  • 21
    • 73949116413 scopus 로고    scopus 로고
    • Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire
    • Glanville J., Zhai W., Berka J., Telman D., Huerta G., and Mehta G.R. Precise determination of the diversity of a combinatorial antibody library gives insight into the human immunoglobulin repertoire Proc. Natl Acad. Sci. USA 106 2009 20216 20221
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 20216-20221
    • Glanville, J.1    Zhai, W.2    Berka, J.3    Telman, D.4    Huerta, G.5    Mehta, G.R.6
  • 23
    • 0026785856 scopus 로고
    • The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops
    • Tomlinson I.M., Walter G., Marks J.D., Llewelyn M.B., and Winter G. The repertoire of human germline VH sequences reveals about fifty groups of VH segments with different hypervariable loops J. Mol. Biol. 227 1992 776 798
    • (1992) J. Mol. Biol. , vol.227 , pp. 776-798
    • Tomlinson, I.M.1    Walter, G.2    Marks, J.D.3    Llewelyn, M.B.4    Winter, G.5
  • 25
    • 0026563253 scopus 로고
    • Semisynthetic combinatorial antibody libraries: A chemical solution to the diversity problem
    • Barbas C.F. III, Bain J.D., Hoekstra D.M., and Lerner R.A. Semisynthetic combinatorial antibody libraries: a chemical solution to the diversity problem Proc. Natl Acad. Sci. USA 89 1992 4457 4461
    • (1992) Proc. Natl Acad. Sci. USA , vol.89 , pp. 4457-4461
    • Barbas Iii, C.F.1    Bain, J.D.2    Hoekstra, D.M.3    Lerner, R.A.4
  • 26
    • 0027759586 scopus 로고
    • Selection of human anti-hapten antibodies from semisynthetic libraries
    • DOI 10.1016/0378-1119(93)90251-W
    • Barbas C.F. III, Amberg W., Simoncsits A., Jones T.M., and Lerner R.A. Selection of human anti-hapten antibodies from semisynthetic libraries Gene 137 1993 57 62 (Pubitemid 24053732)
    • (1993) Gene , vol.137 , Issue.1 , pp. 57-62
    • Barbas III, C.F.1    Amberg, W.2    Simonesits, A.3    Jones, T.M.4    Lerner, R.A.5
  • 27
    • 0031558798 scopus 로고    scopus 로고
    • Standard conformations for the canonical structures of immunoglobulins
    • DOI 10.1006/jmbi.1997.1354
    • Al Lazikani B., Lesk A.M., and Chothia C. Standard conformations for the canonical structures of immunoglobulins J. Mol. Biol. 273 1997 927 948 (Pubitemid 27493729)
    • (1997) Journal of Molecular Biology , vol.273 , Issue.4 , pp. 927-948
    • Al-Lazikani, B.1    Lesk, A.M.2    Chothia, C.3
  • 28
    • 0023278330 scopus 로고
    • Canonical structures for the hypervariable regions of immunoglobulins
    • Chothia C., and Lesk A.M. Canonical structures for the hypervariable regions of immunoglobulins J. Mol. Biol. 196 1987 901 917 (Pubitemid 17127946)
    • (1987) Journal of Molecular Biology , vol.196 , Issue.4 , pp. 901-917
    • Chothia, C.1    Lesk, A.M.2
  • 30
    • 0031586002 scopus 로고    scopus 로고
    • The creation of diversity in the human immunoglobulin V(λ) repertoire
    • DOI 10.1006/jmbi.1997.0956
    • Ignatovich O., Tomlinson I.M., Jones P.T., and Winter G. The creation of diversity in the human immunoglobulin V(lambda) repertoire J. Mol. Biol. 268 1997 69 77 (Pubitemid 27192679)
    • (1997) Journal of Molecular Biology , vol.268 , Issue.1 , pp. 69-77
    • Ignatovich, O.1    Tomlinson, I.M.2    Jones, P.T.3    Winter, G.4
  • 33
    • 0242551578 scopus 로고    scopus 로고
    • Expressed murine and human CDR-H3 intervals of equal length exhibit distinct repertoires that differ in their amino acid composition and predicted range of structures
    • DOI 10.1016/j.jmb.2003.10.007
    • Zemlin M., Klinger M., Link j., Zemlin C., Bauer K., and Engler J.A. Expressed murine and human CDR-H3 intervals of equal length exhibit distinct repertoires that differ in their amino acid composition and predicted range of structures J. Mol. Biol. 334 2003 733 749 (Pubitemid 37433888)
    • (2003) Journal of Molecular Biology , vol.334 , Issue.4 , pp. 733-749
    • Zemlin, M.1    Klinger, M.2    Link, J.3    Zemlin, C.4    Bauer, K.5    Engler, J.A.6    Schroeder Jr., H.W.7    Kirkham, P.M.8
  • 34
    • 0025922273 scopus 로고
    • Comparison of D, JH, and junctional diversity in the fetal, adult, and aged B cell repertoires
    • Bangs L.A., Sanz I.E., and Teale J.M. Comparison of D, JH, and junctional diversity in the fetal, adult, and aged B cell repertoires J. Immunol. 146 1991 1996 2004
    • (1991) J. Immunol. , vol.146 , pp. 1996-2004
    • Bangs, L.A.1    Sanz, I.E.2    Teale, J.M.3
  • 35
    • 0020534965 scopus 로고
    • Somatic generation of antibody diversity
    • Tonegawa S. Somatic generation of antibody diversity Nature 302 1983 575 581
    • (1983) Nature , vol.302 , pp. 575-581
    • Tonegawa, S.1
  • 36
    • 0036240127 scopus 로고    scopus 로고
    • The mechanism and regulation of chromosomal V(D)J recombination
    • Bassing C.H., Swat W., and Alt F.W. The mechanism and regulation of chromosomal V(D)J recombination Cell 109 2002 S45 S55
    • (2002) Cell , vol.109
    • Bassing, C.H.1    Swat, W.2    Alt, F.W.3
  • 37
    • 0031647621 scopus 로고    scopus 로고
    • Preferred CDRH3 lengths for antibodies with defined specificities
    • Johnson G., and Wu T.T. Preferred CDRH3 lengths for antibodies with defined specificities Int. Immunol. 10 1998 1801 1805 (Pubitemid 28566041)
    • (1998) International Immunology , vol.10 , Issue.12 , pp. 1801-1805
    • Johnson, G.1    Wu, T.T.2
  • 38
    • 0037227422 scopus 로고    scopus 로고
    • Analysis of the antigen combining site: Correlations between length and sequence composition of the hypervariable loops and the nature of the antigen
    • DOI 10.1016/S0022-2836(02)01222-6
    • Collis A.V., Brouwer A.P., and Martin A.C. Analysis of the antigen combining site: correlations between length and sequence composition of the hypervariable loops and the nature of the antigen J. Mol. Biol. 325 2003 337 354 (Pubitemid 36062692)
    • (2003) Journal of Molecular Biology , vol.325 , Issue.2 , pp. 337-354
    • Collis, A.V.J.1    Brouwer, A.P.2    Martin, A.C.R.3
  • 39
    • 0026592314 scopus 로고
    • Immunoglobulin VH clan and family identity predicts variable domain structure and may influence antigen binding
    • Kirkham P.M., Mortari F., Newton J.A., and Schroeder H.W. Jr Immunoglobulin VH clan and family identity predicts variable domain structure and may influence antigen binding EMBO J. 11 1992 603 609
    • (1992) EMBO J. , vol.11 , pp. 603-609
    • Kirkham, P.M.1    Mortari, F.2    Newton, J.A.3    Schroeder, Jr.H.W.4
  • 42
    • 1842609526 scopus 로고    scopus 로고
    • Phage-displayed antibody libraries of synthetic heavy chain complementarity determining regions
    • DOI 10.1016/j.jmb.2004.02.050, PII S002228360400230X
    • Sidhu S.S., Li B., Chen Y., Fellouse F.A., Eigenbrot C., and Fuh G. Phage-displayed antibody libraries of synthetic heavy chain complementarity determining regions J. Mol. Biol. 338 2004 299 310 (Pubitemid 38447087)
    • (2004) Journal of Molecular Biology , vol.338 , Issue.2 , pp. 299-310
    • Sidhu, S.S.1    Li, B.2    Chen, Y.3    Fellouse, F.A.4    Eigenbrot, C.5    Fuh, G.6
  • 43
    • 0037160031 scopus 로고    scopus 로고
    • Functional consequences of insertions and deletions in the complementarity-determining regions of human antibodies
    • DOI 10.1074/jbc.M208401200
    • Lantto J., and Ohlin M. Functional consequences of insertions and deletions in the complementarity-determining regions of human antibodies J. Biol. Chem. 277 2002 45108 45114 (Pubitemid 36159112)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.47 , pp. 45108-45114
    • Lantto, J.1    Ohlin, M.2
  • 47
    • 14844321929 scopus 로고    scopus 로고
    • Characterization of high-affinity antibodies by electrochemiluminescence- based equilibrium titration
    • DOI 10.1016/j.ab.2004.12.032
    • Haenel C., Satzger M., Ducata D.D., Ostendorp R., and Brocks B. Characterization of high-affinity antibodies by electrochemiluminescence-based equilibrium titration Anal. Biochem. 339 2005 182 184 (Pubitemid 40342695)
    • (2005) Analytical Biochemistry , vol.339 , Issue.1 , pp. 182-184
    • Haenel, C.1    Satzger, M.2    Ducata, D.D.3    Ostendorp, R.4    Brocks, B.5
  • 48
    • 0035745388 scopus 로고    scopus 로고
    • An oriP expression vector containing the HIV-1 Tat/TAR transactivation axis produces high levels of protein expression in mammalian cells
    • DOI 10.1023/A:1016124911071
    • Cho M.S., Yee H., Brown C., Jeang K.T., and Chan S. An oriP expression vector containing the HIV-1 Tat/TAR transactivation axis produces high levels of protein expression in mammalian cells Cytotechnology 37 2001 23 30 (Pubitemid 34816967)
    • (2001) Cytotechnology , vol.37 , Issue.1 , pp. 23-30
    • Cho, M.-S.1    Yee, H.2    Brown, C.3    Jeang, K.-T.4    Chan, S.5
  • 49
    • 0013261473 scopus 로고    scopus 로고
    • Establishment of a human somatic hybrid cell line for recombinant protein production
    • Cho M.S., Yee H., and Chan S. Establishment of a human somatic hybrid cell line for recombinant protein production J. Biomed. Sci. 9 2002 631 638
    • (2002) J. Biomed. Sci. , vol.9 , pp. 631-638
    • Cho, M.S.1    Yee, H.2    Chan, S.3
  • 52
    • 0029810446 scopus 로고    scopus 로고
    • A convenient approach to the synthesis of trinucleotide phosphoramidites-synthons for the generation of oligonucleotide/peptide libraries
    • DOI 10.1093/nar/24.19.3748
    • Kayushin A.L., Korosteleva M.D., Miroshnikov A.I., Kosch W., Zubov D., and Piel N. A convenient approach to the synthesis of trinucleotide phosphoramidites-synthons for the generation of oligonucleotide/peptide libraries Nucleic Acids Res. 24 1996 3748 3755 (Pubitemid 26335384)
    • (1996) Nucleic Acids Research , vol.24 , Issue.19 , pp. 3748-3755
    • Kayushin, A.L.1    Korosteleva, M.D.2    Miroshnikov, A.I.3    Kosch, W.4    Zubov, D.5    Piel, N.6
  • 53
    • 52949093147 scopus 로고    scopus 로고
    • In vitro affinity maturation of human GM-CSF antibodies by targeted CDR-diversification
    • Steidl S., Ratsch O., Brocks B., Durr M., and Thomassen-Wolf E. In vitro affinity maturation of human GM-CSF antibodies by targeted CDR-diversification Mol. Immunol. 46 2008 135 144
    • (2008) Mol. Immunol. , vol.46 , pp. 135-144
    • Steidl, S.1    Ratsch, O.2    Brocks, B.3    Durr, M.4    Thomassen-Wolf, E.5


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