Modelling the human immune response: Performance of a 1011 human antibody repertoire against a broad panel of therapeutically relevant antigens

Protein Engineering, Design and Selection

Volumn 22, Issue 3, 2009, Pages 159-168

  Lloyd, C ^a   Lowe, D ^a   Edwards, B ^a   Welsh, F ^a   Dilks, T ^a   Hardman, C ^a   Vaughan, T ^a  

^a MEDIMMUNE   (United States)

Author keywords

Antibody; Human; Library; Phage display; scFv

Indexed keywords

ANTIBODY FRAGMENTS; B-CELLS; BIOLOGICAL FUNCTIONS; GERMLINE; HUMAN; HUMAN ANTIBODIES; HUMAN IMMUNE SYSTEMS; IMMUNE RESPONSE; PHAGE DISPLAY; SCFV;

ANTIGENS; IMMUNOLOGY; TARGETS;

ANTIBODIES;

ANTIBODY; ANTIGEN; APRIL PROTEIN; B CELL ACTIVATING FACTOR; CD30 LIGAND; CXCL13 CHEMOKINE; DEATH RECEPTOR 4; DEATH RECEPTOR 5; GHRELIN; GLYCOPROTEIN GP 41; GROWTH HORMONE RECEPTOR; IMMUNOGLOBULIN E; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 15; INTERLEUKIN 21 RECEPTOR; INTERLEUKIN 22; INTERLEUKIN 4 RECEPTOR; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; MYOSTATIN; NERVE GROWTH FACTOR; P SELECTIN GLYCOPROTEIN LIGAND 1; PLACENTAL GROWTH FACTOR; PLACENTAL GROWTH FACTOR 1; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN LIGHT; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG; VASCULOTROPIN C;

AMINO ACID SUBSTITUTION; ANTIBODY LIBRARY; ANTIGEN SPECIFICITY; ARTICLE; GENE ISOLATION; GENETIC VARIABILITY; GERM LINE; HUMAN; HUMAN TISSUE; HUMORAL IMMUNITY; IMMUNOMODULATION; MEMBRANE REACTOR; MOLECULAR MODEL; MULTIGENE FAMILY; PRIORITY JOURNAL;

ANTIGENS; B-LYMPHOCYTES; BINDING SITES, ANTIBODY; CHI-SQUARE DISTRIBUTION; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; IMMUNOGLOBULIN VARIABLE REGION; PEPTIDE LIBRARY; SEQUENCE ANALYSIS, DNA;

EID: 60749123372     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzn058     Document Type: Article

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