-
1
-
-
84881296154
-
Trial watch: Phase II and phase III attrition rates 2011-2012
-
Arrowsmith J, Miller P. Trial watch: phase II and phase III attrition rates 2011-2012. Nat Rev Drug Discov 2013;12:569
-
(2013)
Nat Rev Drug Discov
, vol.12
, pp. 569
-
-
Arrowsmith, J.1
Miller, P.2
-
4
-
-
13244271912
-
Prediction of blood-brain barrier permeation in drug discovery from in vivo, in vitro and in silico models
-
Abbott NJ. Prediction of blood-brain barrier permeation in drug discovery from in vivo, in vitro and in silico models. Drug Discov Today Technol 2004;1:407-16
-
(2004)
Drug Discov Today Technol
, vol.1
, pp. 407-416
-
-
Abbott, N.J.1
-
5
-
-
79951922143
-
Engaging neuroscience to advance translational research in brain barrier biology
-
Neuwelt EA, Bauer B, Fahlke C, et al. Engaging neuroscience to advance translational research in brain barrier biology. Nat Rev Neurosci 2011;12:169-82
-
(2011)
Nat Rev Neurosci
, vol.12
, pp. 169-182
-
-
Neuwelt, E.A.1
Bauer, B.2
Fahlke, C.3
-
6
-
-
84887403996
-
Sealing off the CNS: Cellular and molecular regulation of blood-brain barriergenesis
-
Siegenthaler JA, Sohet F, Daneman R. "Sealing off the CNS": cellular and molecular regulation of blood-brain barriergenesis. Curr Opin Neurobiol 2013;23:1057-64
-
(2013)
Curr Opin Neurobiol
, vol.23
, pp. 1057-1064
-
-
Siegenthaler, J.A.1
Sohet, F.2
Daneman, R.3
-
7
-
-
84889872057
-
Development, maintenance and disruption of the blood-brain barrier
-
Obermeier B, Daneman R, Ransohoff RM. Development, maintenance and disruption of the blood-brain barrier. Nat Med 2013;19:1584-96
-
(2013)
Nat Med
, vol.19
, pp. 1584-1596
-
-
Obermeier, B.1
Daneman, R.2
Ransohoff, R.M.3
-
8
-
-
29244463365
-
Astrocyte-endothelial interactions at the blood-brain barrier
-
Abbott NJ, Rönnbäck L, Hansson E. Astrocyte-endothelial interactions at the blood-brain barrier. Nat Rev Neurosci 2006;7:41-53
-
(2006)
Nat Rev Neurosci
, vol.7
, pp. 41-53
-
-
Abbott, N.J.1
Rönnbäck, L.2
Hansson, E.3
-
9
-
-
80053548451
-
In vitro modeling of the blood-brain barrier: Simplicity versus complexity
-
Ogunshola OO. In vitro modeling of the blood-brain barrier: simplicity versus complexity. Curr Pharm Des 2011;17:2755-61
-
(2011)
Curr Pharm des
, vol.17
, pp. 2755-2761
-
-
Ogunshola, O.O.1
-
10
-
-
0033526177
-
In vitro model for evaluating drug transport across the blood-brain barrier
-
Cecchelli R, Dehouck B, Descamps L, et al. In vitro model for evaluating drug transport across the blood-brain barrier. Adv Drug Deliv Rev 1999;36:165-78
-
(1999)
Adv Drug Deliv Rev
, vol.36
, pp. 165-178
-
-
Cecchelli, R.1
Dehouck, B.2
Descamps, L.3
-
11
-
-
79959337016
-
Patented in vitro blood-brain barrier models in CNS drug discovery
-
Tóth A, Veszelka S, Nakagawa S, et al. Patented in vitro blood-brain barrier models in CNS drug discovery. Recent Pat CNS Drug Discov 2011;6:107-18
-
(2011)
Recent Pat CNS Drug Discov
, vol.6
, pp. 107-118
-
-
Tóth, A.1
Veszelka, S.2
Nakagawa, S.3
-
12
-
-
60949110463
-
A new blood-brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes
-
Nakagawa S, Deli MA, Kawaguchi H, et al. A new blood-brain barrier model using primary rat brain endothelial cells, pericytes and astrocytes. Neurochem Int 2009;54:253-63
-
(2009)
Neurochem Int
, vol.54
, pp. 253-263
-
-
Nakagawa, S.1
Deli, M.A.2
Kawaguchi, H.3
-
13
-
-
40249118217
-
An in vitro blood-brain barrier model for high throughput (HTS) toxicological screening
-
Culot M, Lundquist S, Vanuxeem D, et al. An in vitro blood-brain barrier model for high throughput (HTS) toxicological screening. Toxicol Vitr 2008;22:799-811
-
(2008)
Toxicol Vitr
, vol.22
, pp. 799-811
-
-
Culot, M.1
Lundquist, S.2
Vanuxeem, D.3
-
14
-
-
84860366574
-
Characterization of a microfluidic in vitro model of the bloodbrain barrier (μBBB)
-
Booth R, Kim H. Characterization of a microfluidic in vitro model of the bloodbrain barrier (μBBB). Lab Chip 2012;12:1784-92
-
(2012)
Lab Chip
, vol.12
, pp. 1784-1792
-
-
Booth, R.1
Kim, H.2
-
15
-
-
84872610509
-
BBB on chip: Microfluidic platform to mechanically and biochemically modulate blood-brain barrier function
-
Griep LM, Wolbers F, de Wagenaar B, et al. BBB on chip: microfluidic platform to mechanically and biochemically modulate blood-brain barrier function. Biomed Microdevices 2013;15:145-50
-
(2013)
Biomed Microdevices
, vol.15
, pp. 145-150
-
-
Griep, L.M.1
Wolbers, F.2
De Wagenaar, B.3
-
16
-
-
84873255363
-
A new dynamic in vitro modular capillaries-venules modular system: Cerebrovascular physiology in a box
-
Cucullo L, Hossain M, Tierney W, Janigro D. A new dynamic in vitro modular capillaries-venules modular system: cerebrovascular physiology in a box. BMC Neurosci 2013;14:18
-
(2013)
BMC Neurosci
, vol.14
, pp. 18
-
-
Cucullo, L.1
Hossain, M.2
Tierney, W.3
Janigro, D.4
-
17
-
-
38549096764
-
Immortalized human brain endothelial cells and flow-based vascular modeling: A marriage of convenience for rational neurovascular studies
-
Cucullo L, Couraud P-O, Weksler B, et al. Immortalized human brain endothelial cells and flow-based vascular modeling: a marriage of convenience for rational neurovascular studies. J Cereb Blood Flow Metab 2008;28:312-28
-
(2008)
J Cereb Blood Flow Metab
, vol.28
, pp. 312-328
-
-
Cucullo, L.1
Couraud, P.-O.2
Weksler, B.3
-
18
-
-
84867848663
-
Comparison of brain capillary endothelial cell-based and epithelial (MDCKMDR1, Caco-2, and VB-Caco-2) cellbased surrogate blood-brain barrier penetration models
-
Hellinger E, Veszelka S, Tóth AE, et al. Comparison of brain capillary endothelial cell-based and epithelial (MDCKMDR1, Caco-2, and VB-Caco-2) cellbased surrogate blood-brain barrier penetration models. Eur J Pharm Biopharm 2012;82:340-51
-
(2012)
Eur J Pharm Biopharm
, vol.82
, pp. 340-351
-
-
Hellinger, E.1
Veszelka, S.2
Tóth, A.E.3
-
19
-
-
13844299532
-
In vitro models for the blood-brain barrier
-
Garberg P, Ball M, Borg N, et al. In vitro models for the blood-brain barrier. Toxicol Vitr 2005;19:299-334
-
(2005)
Toxicol Vitr
, vol.19
, pp. 299-334
-
-
Garberg, P.1
Ball, M.2
Borg, N.3
-
20
-
-
34748815589
-
Pericytes from brain microvessels strengthen the barrier integrity in primary cultures of rat brain endothelial cells
-
Nakagawa S, Deli MA, Nakao S, et al. Pericytes from brain microvessels strengthen the barrier integrity in primary cultures of rat brain endothelial cells. Cell Mol Neurobiol 2007;27:687-94
-
(2007)
Cell Mol Neurobiol
, vol.27
, pp. 687-694
-
-
Nakagawa, S.1
Deli, M.A.2
Nakao, S.3
-
21
-
-
84879047058
-
Modelling the endothelial blood-CNS barriers: A method for the production of robust in vitro models of the rat blood-brain barrier and bloodspinal cord barrier
-
Watson PMD, Paterson JC, Thom G, et al. Modelling the endothelial blood-CNS barriers: a method for the production of robust in vitro models of the rat blood-brain barrier and bloodspinal cord barrier. BMC Neurosci 2013;14:59
-
(2013)
BMC Neurosci
, vol.14
, pp. 59
-
-
Watson, P.M.D.1
Paterson, J.C.2
Thom, G.3
-
22
-
-
20444415354
-
Mouse syngenic in vitro blood-brain barrier model: A new tool to examine inflammatory events in cerebral endothelium
-
Coisne C, Dehouck L, Faveeuw C, et al. Mouse syngenic in vitro blood-brain barrier model: a new tool to examine inflammatory events in cerebral endothelium. Lab Investig 2005;85:734-46
-
(2005)
Lab Investig
, vol.85
, pp. 734-746
-
-
Coisne, C.1
Dehouck, L.2
Faveeuw, C.3
-
23
-
-
84879317981
-
Establishment of a simplified in vitro porcine blood-brain barrier model with high transendothelial electrical resistance
-
Patabendige A, Skinner RA, Abbott NJ. Establishment of a simplified in vitro porcine blood-brain barrier model with high transendothelial electrical resistance. Brain Res 2013;1521:1-15
-
(2013)
Brain Res
, vol.1521
, pp. 1-15
-
-
Patabendige, A.1
Skinner, R.A.2
Abbott, N.J.3
-
24
-
-
84899917684
-
T-PA, but not desmoteplase, induces plasmin-dependent opening of a blood-brain barrier model under normoxic and ischaemic conditions
-
Freeman R, Niego B, R Croucher D, et al. t-PA, but not desmoteplase, induces plasmin-dependent opening of a blood-brain barrier model under normoxic and ischaemic conditions. Brain Res 2014;1565:63-73
-
(2014)
Brain Res
, vol.1565
, pp. 63-73
-
-
Freeman, R.1
Niego, B.2
Croucher, D.3
-
25
-
-
0036480118
-
Selection of phagedisplayed llama single-domain antibodies that transmigrate across human bloodbrain barrier endothelium
-
Muruganandam A, Tanha J, Narang S, Stanimirovic D. Selection of phagedisplayed llama single-domain antibodies that transmigrate across human bloodbrain barrier endothelium. FASEB J 2002;16:240-2
-
(2002)
FASEB J
, vol.16
, pp. 240-242
-
-
Muruganandam, A.1
Tanha, J.2
Narang, S.3
Stanimirovic, D.4
-
26
-
-
84887444174
-
GRL-04810 and GRL-05010, difluoride-containing nonpeptidic HIV-1 protease inhibitors (PIs) that inhibit the replication of multi-PI-resistant HIV-1 in vitro and possess favorable lipophilicity that may allow blood-brain barrier penetration
-
Salcedo Gómez PM, Amano M, Yashchuk S, et al. GRL-04810 and GRL-05010, difluoride-containing nonpeptidic HIV-1 protease inhibitors (PIs) that inhibit the replication of multi-PI-resistant HIV-1 in vitro and possess favorable lipophilicity that may allow blood-brain barrier penetration. Antimicrob Agents Chemother 2013;57:6110-21
-
(2013)
Antimicrob Agents Chemother
, vol.57
, pp. 6110-6121
-
-
Salcedo Gómez, P.M.1
Amano, M.2
Yashchuk, S.3
-
27
-
-
0025063772
-
Increased proteolytic activity is responsible for the aberrant morphogenetic behavior of endothelial cells expressing the middle T oncogene
-
Montesano R, Pepper MS, Möhle-Steinlein U, et al. Increased proteolytic activity is responsible for the aberrant morphogenetic behavior of endothelial cells expressing the middle T oncogene. Cell 1990;62:435-45
-
(1990)
Cell
, vol.62
, pp. 435-445
-
-
Montesano, R.1
Pepper, M.S.2
Möhle-Steinlein, U.3
-
28
-
-
0028024646
-
Regulation of gammaglutamyl transpeptidase and alkaline phosphatase activities in immortalized rat brain microvessel endothelial cells
-
Roux F, Durieu-Trautmann O, Chaverot N, et al. Regulation of gammaglutamyl transpeptidase and alkaline phosphatase activities in immortalized rat brain microvessel endothelial cells. J Cell Physiol 1994;159:101-13
-
(1994)
J Cell Physiol
, vol.159
, pp. 101-113
-
-
Roux, F.1
Durieu-Trautmann, O.2
Chaverot, N.3
-
29
-
-
0030726926
-
Development of immortalized human cerebromicrovascular endothelial cell line as an in vitro model of the human blood-brain barrier
-
Muruganandam A, Herx LM, Monette R, et al. Development of immortalized human cerebromicrovascular endothelial cell line as an in vitro model of the human blood-brain barrier. FASEB J 1997;11:1187-97
-
(1997)
FASEB J
, vol.11
, pp. 1187-1197
-
-
Muruganandam, A.1
Herx, L.M.2
Monette, R.3
-
30
-
-
27744460321
-
Blood-brain barrier-specific properties of a human adult brain endothelial cell line
-
Weksler BB, Subileau EA, Perrière N, et al. Blood-brain barrier-specific properties of a human adult brain endothelial cell line. FASEB J 2005;19:1872-4
-
(2005)
FASEB J
, vol.19
, pp. 1872-1874
-
-
Weksler, B.B.1
Subileau, E.A.2
Perrière, N.3
-
31
-
-
84876161205
-
The hCMEC/D3 cell line as a model of the human blood brain barrier
-
Weksler B, Romero IA, Couraud PO. The hCMEC/D3 cell line as a model of the human blood brain barrier. Fluids Barriers CNS 2013;10:16
-
(2013)
Fluids Barriers CNS
, vol.10
, pp. 16
-
-
Weksler, B.1
Romero, I.A.2
Couraud, P.O.3
-
32
-
-
84872178048
-
Laminin isoforms in endothelial and perivascular basement membranes
-
Yousif LF, Di Russo J, Sorokin L. Laminin isoforms in endothelial and perivascular basement membranes. Cell Adh Migr 2013;7:101-10
-
(2013)
Cell Adh Migr
, vol.7
, pp. 101-110
-
-
Yousif, L.F.1
Di Russo, J.2
Sorokin, L.3
-
33
-
-
33947723274
-
The impact of glia-derived extracellular matrices on the barrier function of cerebral endothelial cells: An in vitro study
-
Hartmann C, Zozulya A, Wegener J, Galla HJ. The impact of glia-derived extracellular matrices on the barrier function of cerebral endothelial cells: an in vitro study. Exp Cell Res 2007;313:1318-25
-
(2007)
Exp Cell Res
, vol.313
, pp. 1318-1325
-
-
Hartmann, C.1
Zozulya, A.2
Wegener, J.3
Galla, H.J.4
-
34
-
-
67249117305
-
Control of the blood-brain barrier by glucocorticoids and the cells of the neurovascular unit
-
Kröll S, El-Gindi J, Thanabalasundaram G, et al. Control of the blood-brain barrier by glucocorticoids and the cells of the neurovascular unit. Ann N Y Acad Sci 2009;1165:228-39
-
(2009)
Ann N y Acad Sci
, vol.1165
, pp. 228-239
-
-
Kröll, S.1
El-Gindi, J.2
Thanabalasundaram, G.3
-
35
-
-
27844518332
-
The critical component to establish in vitro BBB model: Pericyte
-
Lai CH, Kuo KH, The critical component to establish in vitro BBB model: pericyte. Brain Res Brain Res Rev 2005;50:258-65
-
(2005)
Brain Res Brain Res Rev
, vol.50
, pp. 258-265
-
-
Lai, C.H.1
Kuo, K.H.2
-
36
-
-
17644364388
-
Dynamics of CNS barriers: Evolution, differentiation, and modulation
-
Abbott NJ. Dynamics of CNS barriers: evolution, differentiation, and modulation. Cell Mol Neurobiol 2005;25:5-23
-
(2005)
Cell Mol Neurobiol
, vol.25
, pp. 5-23
-
-
Abbott, N.J.1
-
37
-
-
84881180266
-
Wnt activation of immortalized brain endothelial cells as a tool for generating a standardized model of the blood brain barrier in vitro
-
Paolinelli R, Corada M, Ferrarini L, et al. Wnt activation of immortalized brain endothelial cells as a tool for generating a standardized model of the blood brain barrier in vitro. PLoS One 2013;8:e70233
-
(2013)
PLoS One
, vol.8
, pp. e70233
-
-
Paolinelli, R.1
Corada, M.2
Ferrarini, L.3
-
38
-
-
84872734009
-
Retinoic acid induces blood-brain barrier development
-
Mizee MR, Wooldrik D, Lakeman KAM, et al. Retinoic acid induces blood-brain barrier development. J Neurosci 2013;33:1660-71
-
(2013)
J Neurosci
, vol.33
, pp. 1660-1671
-
-
Mizee, M.R.1
Wooldrik, D.2
Lakeman, K.A.M.3
-
39
-
-
79953686193
-
Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors
-
Uchida Y, Ohtsuki S, Katsukura Y, et al. Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors. J Neurochem 2011;117:333-45
-
(2011)
J Neurochem
, vol.117
, pp. 333-345
-
-
Uchida, Y.1
Ohtsuki, S.2
Katsukura, Y.3
-
40
-
-
84901056306
-
Quantitative targeted proteomics for understanding the blood-brain barrier: Towards pharmacoproteomics
-
Ohtsuki S, Hirayama M, Ito S, et al. Quantitative targeted proteomics for understanding the blood-brain barrier: towards pharmacoproteomics. Expert Rev Proteomics 2014;11:303-13
-
(2014)
Expert Rev Proteomics
, vol.11
, pp. 303-313
-
-
Ohtsuki, S.1
Hirayama, M.2
Ito, S.3
-
41
-
-
79957439772
-
Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target
-
Yu YJ, Zhang Y, Kenrick M, et al. Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target. Sci Transl Med 2011;3:84ra44
-
(2011)
Sci Transl Med
, vol.3
, pp. 84ra44
-
-
Yu, Y.J.1
Zhang, Y.2
Kenrick, M.3
-
42
-
-
84878276906
-
Addressing safety liabilities of TfR bispecific antibodies that cross the bloodbrain barrier
-
Couch JA, Yu YJ, Zhang Y, et al. Addressing safety liabilities of TfR bispecific antibodies that cross the bloodbrain barrier. Sci Transl Med 2013;5(183):183ra571
-
(2013)
Sci Transl Med
, vol.5
, Issue.183
, pp. 183ra571
-
-
Couch, J.A.1
Yu, Y.J.2
Zhang, Y.3
-
43
-
-
0025837039
-
Immortalization of brain capillary endothelial cells with maintenance of structural characteristics of the bloodbrain barrier endothelium
-
Durieu-Trautmann O, Foignant-Chaverot N, Perdomo J, et al. Immortalization of brain capillary endothelial cells with maintenance of structural characteristics of the bloodbrain barrier endothelium. Vitr Cell Dev Biol 1991;27A:771-8
-
(1991)
Vitr Cell Dev Biol
, vol.27 A
, pp. 771-778
-
-
Durieu-Trautmann, O.1
Foignant-Chaverot, N.2
Perdomo, J.3
-
44
-
-
0035154799
-
Bacterial invasion and transcytosis in transfected human brain microvascular endothelial cells
-
Stins MF, Badger J, Sik Kim K. Bacterial invasion and transcytosis in transfected human brain microvascular endothelial cells. Microb Pathog 2001;30:19-28
-
(2001)
Microb Pathog
, vol.30
, pp. 19-28
-
-
Stins, M.F.1
Badger, J.2
Sik Kim, K.3
-
45
-
-
84887987425
-
Comparative study of four immortalized human brain capillary endothelial cell lines, hCMEC/D3, hBMEC, TY10, and BB19, and optimization of culture conditions, for an in vitro blood-brain barrier model for drug permeability studies
-
Eigenmann DE, Xue G, Kim KS, et al. Comparative study of four immortalized human brain capillary endothelial cell lines, hCMEC/D3, hBMEC, TY10, and BB19, and optimization of culture conditions, for an in vitro blood-brain barrier model for drug permeability studies. Fluids Barriers CNS 2013;10:33
-
(2013)
Fluids Barriers CNS
, vol.10
, pp. 33
-
-
Eigenmann, D.E.1
Xue, G.2
Kim, K.S.3
-
46
-
-
0030175172
-
Studies of Plasmodium falciparum cytoadherence using immortalized human brain capillary endothelial cells
-
Prudhomme JG, Sherman IW, Land KM, et al. Studies of Plasmodium falciparum cytoadherence using immortalized human brain capillary endothelial cells. Int J Parasitol 1996;26:647-55
-
(1996)
Int J Parasitol
, vol.26
, pp. 647-655
-
-
Prudhomme, J.G.1
Sherman, I.W.2
Land, K.M.3
-
47
-
-
3242656233
-
Establishment of a line of human fetal glial cells that supports JC virus multiplication
-
Major EO, Miller AE, Mourrain P, et al. Establishment of a line of human fetal glial cells that supports JC virus multiplication. Proc Natl Acad Sci USA 1985;82:1257-61
-
(1985)
Proc Natl Acad Sci USA
, vol.82
, pp. 1257-1261
-
-
Major, E.O.1
Miller, A.E.2
Mourrain, P.3
-
48
-
-
78049231404
-
Peripheral nerve pericytes modify the blood-nerve barrier function and tight junctional molecules through the secretion of various soluble factors
-
Shimizu F, Sano Y, Abe M-A, et al. Peripheral nerve pericytes modify the blood-nerve barrier function and tight junctional molecules through the secretion of various soluble factors. J Cell Physiol 2011;226:255-66
-
(2011)
J Cell Physiol
, vol.226
, pp. 255-266
-
-
Shimizu, F.1
Sano, Y.2
Abe, M.-A.3
-
49
-
-
84861684871
-
Transcriptional profiling of human brain endothelial cells reveals key properties crucial for predictive in vitro blood-brain barrier models
-
Arai K, editor
-
Urich E, Lazic SE, Molnos J, et al. Transcriptional profiling of human brain endothelial cells reveals key properties crucial for predictive in vitro blood-brain barrier models. In: Arai K, editor. PLoS One 2012;7:e38149
-
(2012)
PLoS One
, vol.7
, pp. e38149
-
-
Urich, E.1
Lazic, S.E.2
Molnos, J.3
-
50
-
-
84864874302
-
Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells
-
Lippmann ES, Azarin SM, Kay JE, et al. Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells. Nat Biotechnol 2012;30:783-91
-
(2012)
Nat Biotechnol
, vol.30
, pp. 783-791
-
-
Lippmann, E.S.1
Azarin, S.M.2
Kay, J.E.3
-
51
-
-
84894641836
-
A retinoic acid-enhanced, multicellular human blood-brain barrier model derived from stem cell sources
-
Lippmann ES, Al-Ahmad A, Azarin SM, et al. A retinoic acid-enhanced, multicellular human blood-brain barrier model derived from stem cell sources. Sci Rep 2014;4:4160
-
(2014)
Sci Rep
, vol.4
, pp. 4160
-
-
Lippmann, E.S.1
Al-Ahmad, A.2
Azarin, S.M.3
-
52
-
-
0020081135
-
Electrical resistance of brain microvascular endothelium
-
Crone C, Olesen SP. Electrical resistance of brain microvascular endothelium. Brain Res 1982;241:49-55
-
(1982)
Brain Res
, vol.241
, pp. 49-55
-
-
Crone, C.1
Olesen, S.P.2
-
53
-
-
0025048342
-
Electrical resistance across the bloodbrain barrier in anaesthetized rats: A developmental study
-
Butt AM, Jones HC, Abbott NJ. Electrical resistance across the bloodbrain barrier in anaesthetized rats: a developmental study. J Physiol 1990;429:47-62
-
(1990)
J Physiol
, vol.429
, pp. 47-62
-
-
Butt, A.M.1
Jones, H.C.2
Abbott, N.J.3
-
54
-
-
84903316132
-
A stable and reproducible human bloodbrain barrier model derived from hematopoietic stem cells
-
Cecchelli R, Aday S, Sevin E, et al. A stable and reproducible human bloodbrain barrier model derived from hematopoietic stem cells. PLoS One 2014;9:e99733
-
(2014)
PLoS One
, vol.9
, pp. e99733
-
-
Cecchelli, R.1
Aday, S.2
Sevin, E.3
-
55
-
-
84894243243
-
Instruction of circulating endothelial progenitors in vitro towards specialized blood-brain barrier and arterial phenotypes
-
Boyer-Di Ponio J, El-Ayoubi F, Glacial F, et al. Instruction of circulating endothelial progenitors in vitro towards specialized blood-brain barrier and arterial phenotypes. PLoS One 2014;9:e84179
-
(2014)
PLoS One
, vol.9
, pp. e84179
-
-
Boyer-Di Ponio, J.1
El-Ayoubi, F.2
Glacial, F.3
-
56
-
-
79959952037
-
Physiologic and anatomic characterization of the brain surface glia barrier of Drosophila
-
DeSalvo MK, Mayer N, Mayer F, Bainton RJ. Physiologic and anatomic characterization of the brain surface glia barrier of Drosophila. Glia 2011;59:1322-40
-
(2011)
Glia
, vol.59
, pp. 1322-1340
-
-
Desalvo, M.K.1
Mayer, N.2
Mayer, F.3
Bainton, R.J.4
-
57
-
-
84895072784
-
Zebrafish approaches enhance the translational research tackle box
-
Pickart MA, Klee EW. Zebrafish approaches enhance the translational research tackle box. Transl Res 2014;163:65-78
-
(2014)
Transl Res
, vol.163
, pp. 65-78
-
-
Pickart, M.A.1
Klee, E.W.2
-
58
-
-
77956674943
-
Claudin-5a in developing zebrafish brain barriers: Another brick in the wall
-
Abdelilah-Seyfried S. Claudin-5a in developing zebrafish brain barriers: another brick in the wall. Bioessays 2010;32:768-76
-
(2010)
Bioessays
, vol.32
, pp. 768-776
-
-
Abdelilah-Seyfried, S.1
-
59
-
-
79951882202
-
Zebrafish model of the blood-brain barrier: Morphological and permeability studies
-
Eliceiri BP, Gonzalez AM, Baird A. Zebrafish model of the blood-brain barrier: morphological and permeability studies. Methods Mol Biol 2011;686:371-8
-
(2011)
Methods Mol Biol
, vol.686
, pp. 371-378
-
-
Eliceiri, B.P.1
Gonzalez, A.M.2
Baird, A.3
-
60
-
-
84863376198
-
Galanin transgenic mice with elevated circulating galanin levels alleviate demyelination in a cuprizone-induced MS mouse model
-
Zhang L, Yu W, Schroedter I, et al. Galanin transgenic mice with elevated circulating galanin levels alleviate demyelination in a cuprizone-induced MS mouse model. PLoS One 2012;7:e33901
-
(2012)
PLoS One
, vol.7
, pp. e33901
-
-
Zhang, L.1
Yu, W.2
Schroedter, I.3
-
61
-
-
84867874859
-
Zebrafish as a model to study drug transporters at the blood-brain barrier
-
Umans RA, Taylor MR. Zebrafish as a model to study drug transporters at the blood-brain barrier. Clin Pharmacol Ther 2012;92:567-70
-
(2012)
Clin Pharmacol Ther
, vol.92
, pp. 567-570
-
-
Umans, R.A.1
Taylor, M.R.2
-
62
-
-
84885739130
-
Functional characterisation of the maturation of the blood-brain barrier in larval zebrafish
-
Fleming A, Diekmann H, Goldsmith P. Functional characterisation of the maturation of the blood-brain barrier in larval zebrafish. PLoS One 2013;8:e77548
-
(2013)
PLoS One
, vol.8
, pp. e77548
-
-
Fleming, A.1
Diekmann, H.2
Goldsmith, P.3
-
63
-
-
84899909435
-
Zebrafish models for translational neuroscience research: From tank to bedside
-
Stewart AM, Braubach O, Spitsbergen J, et al. Zebrafish models for translational neuroscience research: from tank to bedside. Trends Neurosci 2014;37:264-78
-
(2014)
Trends Neurosci
, vol.37
, pp. 264-278
-
-
Stewart, A.M.1
Braubach, O.2
Spitsbergen, J.3
-
64
-
-
84864948753
-
In vivo assessment of the permeability of the blood-brain barrier and blood-retinal barrier to fluorescent indoline derivatives in zebrafish
-
Watanabe K, Nishimura Y, Nomoto T, et al. In vivo assessment of the permeability of the blood-brain barrier and blood-retinal barrier to fluorescent indoline derivatives in zebrafish. BMC Neurosci 2012;13:101
-
(2012)
BMC Neurosci
, vol.13
, pp. 101
-
-
Watanabe, K.1
Nishimura, Y.2
Nomoto, T.3
-
65
-
-
84904264611
-
Blood-brain barrier models and their relevance for a successful development of CNS drug delivery systems: A review
-
Bicker J, Alves G, Fortuna A, Falcão A. Blood-brain barrier models and their relevance for a successful development of CNS drug delivery systems: a review. Eur J Pharm Biopharm 2014;87:409-32
-
(2014)
Eur J Pharm Biopharm
, vol.87
, pp. 409-432
-
-
Bicker, J.1
Alves, G.2
Fortuna, A.3
Falcão, A.4
-
66
-
-
0000545811
-
An in situ brain perfusion technique to study cerebrovascular transport in the rat
-
Takasato Y, Rapoport SI, Smith QR. An in situ brain perfusion technique to study cerebrovascular transport in the rat. Am J Physiol 1984;247:H484-93
-
(1984)
Am J Physiol
, vol.247
, pp. H484-H493
-
-
Takasato, Y.1
Rapoport, S.I.2
Smith, Q.R.3
-
67
-
-
0642311330
-
In situ brain perfusion technique
-
Smith QR, Allen DD. In situ brain perfusion technique. Methods Mol Med 2003;89:209-18
-
(2003)
Methods Mol Med
, vol.89
, pp. 209-218
-
-
Smith, Q.R.1
Allen, D.D.2
-
68
-
-
12344321374
-
Involvement of P-glycoprotein in bloodbrain barrier transport of pentazocine in rats using brain uptake index method
-
Moriki Y, Suzuki T, Fukami T, et al. Involvement of P-glycoprotein in bloodbrain barrier transport of pentazocine in rats using brain uptake index method. Biol Pharm Bull 2004;27:932-5
-
(2004)
Biol Pharm Bull
, vol.27
, pp. 932-935
-
-
Moriki, Y.1
Suzuki, T.2
Fukami, T.3
-
69
-
-
26844558032
-
Quantitation and localization of blood-to-brain influx by magnetic resonance imaging and quantitative autoradiography in a model of transient focal ischemia
-
Knight RA, Nagaraja TN, Ewing JR, et al. Quantitation and localization of blood-to-brain influx by magnetic resonance imaging and quantitative autoradiography in a model of transient focal ischemia. Magn Reson Med 2005;54:813-21
-
(2005)
Magn Reson Med
, vol.54
, pp. 813-821
-
-
Knight, R.A.1
Nagaraja, T.N.2
Ewing, J.R.3
-
70
-
-
0030806636
-
Methodological considerations of intracerebral microdialysis in pharmacokinetic studies on drug transport across the blood-brain barrier
-
De Lange EC, Danhof M, de Boer AG, Breimer DD. Methodological considerations of intracerebral microdialysis in pharmacokinetic studies on drug transport across the blood-brain barrier. Brain Res Brain Res Rev 1997;25:27-49
-
(1997)
Brain Res Brain Res Rev
, vol.25
, pp. 27-49
-
-
De Lange, E.C.1
Danhof, M.2
De Boer, A.G.3
Breimer, D.D.4
-
71
-
-
0034672528
-
The use of microdialysis in CNS drug delivery studies. Pharmacokinetic perspectives and results with analgesics and antiepileptics
-
Hammarlund-Udenaes M. The use of microdialysis in CNS drug delivery studies. Pharmacokinetic perspectives and results with analgesics and antiepileptics. Adv Drug Deliv Rev 2000;45:283-94
-
(2000)
Adv Drug Deliv Rev
, vol.45
, pp. 283-294
-
-
Hammarlund-Udenaes, M.1
-
72
-
-
38849136513
-
CSF as a surrogate for assessing CNS exposure: An industrial perspective
-
Lin JH. CSF as a surrogate for assessing CNS exposure: an industrial perspective. Curr Drug Metab 2008;9:46-59
-
(2008)
Curr Drug Metab
, vol.9
, pp. 46-59
-
-
Lin, J.H.1
-
73
-
-
0036349375
-
Considerations in the use of cerebrospinal fluid pharmacokinetics to predict brain target concentrations in the clinical setting: Implications of the barriers between blood and brain
-
De Lange ECM, Danhof M. Considerations in the use of cerebrospinal fluid pharmacokinetics to predict brain target concentrations in the clinical setting: implications of the barriers between blood and brain. Clin Pharmacokinet 2002;41:691-703
-
(2002)
Clin Pharmacokinet
, vol.41
, pp. 691-703
-
-
De Lange, E.C.M.1
Danhof, M.2
-
74
-
-
65249143425
-
Dynamic analysis of the blood-brain barrier disruption in experimental stroke using time domain in vivo fluorescence imaging
-
Abulrob A, Brunette E, Slinn J, et al. Dynamic analysis of the blood-brain barrier disruption in experimental stroke using time domain in vivo fluorescence imaging. Mol Imaging 2008;7:248-62
-
(2008)
Mol Imaging
, vol.7
, pp. 248-262
-
-
Abulrob, A.1
Brunette, E.2
Slinn, J.3
-
75
-
-
33644758151
-
Methods to assess drug permeability across the blood-brain barrier
-
Nicolazzo JA, Charman SA, Charman WN. Methods to assess drug permeability across the blood-brain barrier. J Pharm Pharmacol 2006;58:281-93
-
(2006)
J Pharm Pharmacol
, vol.58
, pp. 281-293
-
-
Nicolazzo, J.A.1
Charman, S.A.2
Charman, W.N.3
-
76
-
-
84872193339
-
Imaging bloodbrain barrier dysfunction in animal disease models
-
Wunder A, Schoknecht K, Stanimirovic DB, et al. Imaging bloodbrain barrier dysfunction in animal disease models. Epilepsia 2012;53(Suppl 6):14-21
-
(2012)
Epilepsia
, vol.53
, pp. 14-21
-
-
Wunder, A.1
Schoknecht, K.2
Stanimirovic, D.B.3
-
79
-
-
79956337554
-
How well can in vitro brain microcapillary endothelial cell models predict rodent in vivo blood-brain barrier permeability?
-
Avdeef A. How well can in vitro brain microcapillary endothelial cell models predict rodent in vivo blood-brain barrier permeability? Eur J Pharm Sci 2011;43:109-24
-
(2011)
Eur J Pharm Sci
, vol.43
, pp. 109-124
-
-
Avdeef, A.1
-
80
-
-
77957736634
-
Validation of in vitro cell-based human blood-brain barrier model using clinical positron emission tomography radioligands to predict in vivo human brain penetration
-
Mabondzo A, Bottlaender M, Guyot A-C, et al. Validation of in vitro cell-based human blood-brain barrier model using clinical positron emission tomography radioligands to predict in vivo human brain penetration. Mol Pharm 2010;7:1805-15
-
(2010)
Mol Pharm
, vol.7
, pp. 1805-1815
-
-
Mabondzo, A.1
Bottlaender, M.2
Guyot, A.-C.3
-
81
-
-
84895778441
-
Mechanistic understanding of brain drug disposition to optimize the selection of potential neurotherapeutics in drug discovery
-
Loryan I, Sinha V, Mackie C, et al. Mechanistic understanding of brain drug disposition to optimize the selection of potential neurotherapeutics in drug discovery. Pharm Res 2014;31(8):2203-19
-
(2014)
Pharm Res
, vol.31
, Issue.8
, pp. 2203-2219
-
-
Loryan, I.1
Sinha, V.2
MacKie, C.3
-
82
-
-
84855597543
-
Reengineering biopharmaceuticals for targeted delivery across the blood-brain barrier
-
1st edition. Elsevier Inc.
-
Pardridge WM, Boado RJ. Reengineering biopharmaceuticals for targeted delivery across the blood-brain barrier. Methods Enzymol. 1st edition. Elsevier Inc; 2012. pp 269-92
-
(2012)
Methods Enzymol
, pp. 269-292
-
-
Pardridge, W.M.1
Boado, R.J.2
-
83
-
-
84877292573
-
Diffusion of macromolecules in the brain: Implications for drug delivery
-
Wolak DJ, Thorne RG. Diffusion of macromolecules in the brain: implications for drug delivery. Mol Pharm 2013;10:1492-504
-
(2013)
Mol Pharm
, vol.10
, pp. 1492-1504
-
-
Wolak, D.J.1
Thorne, R.G.2
-
84
-
-
84908002106
-
A novel platform for engineering blood-brain barrier-crossing bispecific biologics
-
Farrington GK, Caram-Salas N, Haqqani AS, et al. A novel platform for engineering blood-brain barrier-crossing bispecific biologics. FASEB J 2014;doi:10.1096/fj.14-253369
-
(2014)
FASEB J
-
-
Farrington, G.K.1
Caram-Salas, N.2
Haqqani, A.S.3
-
85
-
-
34547642139
-
Blood-brain barrier transport of therapeutics via receptor-mediation
-
Jones AR, Shusta E V. Blood-brain barrier transport of therapeutics via receptor-mediation. Pharm Res 2007;24:1759-71
-
(2007)
Pharm Res
, vol.24
, pp. 1759-1771
-
-
Jones, A.R.1
Shusta, E.V.2
-
86
-
-
34547637590
-
Drug targeting to the brain
-
Pardridge WM. Drug targeting to the brain. Pharm Res 2007;24:1733-44
-
(2007)
Pharm Res
, vol.24
, pp. 1733-1744
-
-
Pardridge, W.M.1
-
87
-
-
0642342122
-
Phage display technology for identifying specific antigens on brain endothelial cells
-
Tanha J, Muruganandam A, Stanimirovic D. Phage display technology for identifying specific antigens on brain endothelial cells. Methods Mol Med 2003;89:435-49
-
(2003)
Methods Mol Med
, vol.89
, pp. 435-449
-
-
Tanha, J.1
Muruganandam, A.2
Stanimirovic, D.3
-
88
-
-
28244432240
-
The blood-brain barrier transmigrating single domain antibody: Mechanisms of transport and antigenic epitopes in human brain endothelial cells
-
Abulrob A, Sprong H, Van Bergen en Henegouwen P, Stanimirovic D. The blood-brain barrier transmigrating single domain antibody: mechanisms of transport and antigenic epitopes in human brain endothelial cells. J Neurochem 2005;95:1201-14
-
(2005)
J Neurochem
, vol.95
, pp. 1201-1214
-
-
Abulrob, A.1
Sprong, H.2
Van Bergen-En-Henegouwen, P.3
Stanimirovic, D.4
-
89
-
-
84877255599
-
Multiplexed evaluation of serum and CSF pharmacokinetics of braintargeting single-domain antibodies using a NanoLC-SRM-ILIS method
-
Haqqani AS, Caram-Salas N, Ding W, et al. Multiplexed evaluation of serum and CSF pharmacokinetics of braintargeting single-domain antibodies using a NanoLC-SRM-ILIS method. Mol Pharm 2013;10:1542-56
-
(2013)
Mol Pharm
, vol.10
, pp. 1542-1556
-
-
Haqqani, A.S.1
Caram-Salas, N.2
Ding, W.3
-
90
-
-
0035997330
-
Prediction of drug transport through the blood-brain barrier in vivo: A comparison between two in vitro cell models
-
Lundquist S, Renftel M, Brillault J, et al. Prediction of drug transport through the blood-brain barrier in vivo: a comparison between two in vitro cell models. Pharm Res 2002;19:976-81
-
(2002)
Pharm Res
, vol.19
, pp. 976-981
-
-
Lundquist, S.1
Renftel, M.2
Brillault, J.3
-
91
-
-
2942623871
-
Evidence for bulk flow of brain interstitial fluid: Significance for physiology and pathology
-
Abbott NJ. Evidence for bulk flow of brain interstitial fluid: significance for physiology and pathology. Neurochem Int 2004;45:545-52
-
(2004)
Neurochem Int
, vol.45
, pp. 545-552
-
-
Abbott, N.J.1
-
92
-
-
84898433336
-
Neonatal Fc receptor (FcRn): A novel target for therapeutic antibodies and antibody engineering
-
Wang Y, Tian Z, Thirumalai D, Zhang X. Neonatal Fc receptor (FcRn): a novel target for therapeutic antibodies and antibody engineering. J Drug Target 2014;22:269-78
-
(2014)
J Drug Target
, vol.22
, pp. 269-278
-
-
Wang, Y.1
Tian, Z.2
Thirumalai, D.3
Zhang, X.4
-
93
-
-
34347403252
-
Drug development for CNS disorders: Strategies for balancing risk and reducing attrition
-
Pangalos MN, Schechter LE, Hurko O. Drug development for CNS disorders: strategies for balancing risk and reducing attrition. Nat Rev Drug Discov 2007;6:521-32
-
(2007)
Nat Rev Drug Discov
, vol.6
, pp. 521-532
-
-
Pangalos, M.N.1
Schechter, L.E.2
Hurko, O.3
|