The use of microdialysis in CNS drug delivery studies: Pharmacokinetic perspectives and results with analgesics and antiepileptics

Advanced Drug Delivery Reviews

Volumn 45, Issue 2-3, 2000, Pages 283-294

  Hammarlund Udenaes, Margareta ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Analgesics; Antiepileptics; Blood brain barrier permeability; CSF; Efflux clearance; Extent of drug delivery; Influx clearance; Opioids; Rate of drug delivery

Indexed keywords

BLOOD; BRAIN; CONTROLLED DRUG DELIVERY; DRUG INFUSION; DRUG PRODUCTS; NEUROPHYSIOLOGY; PHARMACOKINETICS;

ANALGESICS; ANTIEPILEPTICS; CENTRAL NERVOUS SYSTEM; MICRODIALYSIS;

DIALYSIS;

ANALGESIC AGENT; ANTICONVULSIVE AGENT; CARBAMAZEPINE; CARBAMAZEPINE 10,11 OXIDE; CODEINE; GABAPENTIN; MORPHINE; MORPHINE 3 GLUCURONIDE; MORPHINE 6 GLUCURONIDE; PARACETAMOL; PHENYTOIN; VALPROIC ACID;

AREA UNDER THE CURVE; BLOOD BRAIN BARRIER; BLOOD CEREBROSPINAL FLUID BARRIER; CENTRAL NERVOUS SYSTEM; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG PENETRATION; DRUG PROTEIN BINDING; DRUG TRANSPORT; EXTRACELLULAR FLUID; HUMAN; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; REVIEW;

EID: 0034672528     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(00)00109-5     Document Type: Article

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