T-PA, but not desmoteplase, induces plasmin-dependent opening of a blood-brain barrier model under normoxic and ischaemic conditions

Brain Research

Volumn 1565, Issue , 2014, Pages 63-73

  Freeman, Roxann ^a   Niego, Beeri ^a   Croucher, David R ^b,d   Pedersen, Lars O ^c   Medcalf, Robert L ^a  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF WOLLONGONG   (Australia)

^c H LUNDBECK A S   (Denmark)

^d GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

Blood brain barrier; Desmoteplase; ICH; Oxygen glucose deprivation; Plasmin; Stroke; Tissue type plasminogen activator

Indexed keywords

APROTININ; DESMOTEPLASE; PLASMIN; PLASMINOGEN; TIGHT JUNCTION PROTEIN; TISSUE PLASMINOGEN ACTIVATOR; FIBRINOLYTIC AGENT; GLUCOSE; OXYGEN; PLASMINOGEN ACTIVATOR; SALIVARY PLASMINOGEN ACTIVATOR ALPHA 1, DESMODUS ROTUNDUS;

ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER; CELL STIMULATION; CELL STRUCTURE; COCULTURE; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; PRIORITY JOURNAL; TIGHT JUNCTION; BRAIN; CELL CULTURE; DRUG EFFECTS; METABOLISM; PERMEABILITY;

BLOOD-BRAIN BARRIER; BRAIN; CELLS, CULTURED; ENDOTHELIAL CELLS; FIBRINOLYTIC AGENTS; GLUCOSE; HUMANS; OXYGEN; PERMEABILITY; PLASMINOGEN; PLASMINOGEN ACTIVATORS; TISSUE PLASMINOGEN ACTIVATOR;

EID: 84899917684     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2014.03.027     Document Type: Article

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