-
1
-
-
78049485263
-
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
-
Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010;127:2893-917.
-
(2010)
Int J Cancer
, vol.127
, pp. 2893-2917
-
-
Ferlay, J.1
Shin, H.R.2
Bray, F.3
Forman, D.4
Mathers, C.5
Parkin, D.M.6
-
2
-
-
77952263737
-
The genetic basis of kidney cancer: A metabolic disease
-
Linehan WM, Srinivasan R, Schmidt LS. The genetic basis of kidney cancer: a metabolic disease. Nat Rev Urol 2010;7:277-85.
-
(2010)
Nat Rev Urol
, vol.7
, pp. 277-285
-
-
Linehan, W.M.1
Srinivasan, R.2
Schmidt, L.S.3
-
3
-
-
84868309625
-
Genetic basis of kidney cancer: Role of genomics for the development of disease-based therapeutics
-
Linehan WM. Genetic basis of kidney cancer: role of genomics for the development of disease-based therapeutics. Genome Res 2012;22:2089-100.
-
(2012)
Genome Res
, vol.22
, pp. 2089-2100
-
-
Linehan, W.M.1
-
4
-
-
84863195746
-
Ten years of progress in renal cell carcinoma
-
Jonasch E, Motzer RJ. Ten years of progress in renal cell carcinoma. J Natl Compr Canc Netw 2012;10:690-3.
-
(2012)
J Natl Compr Canc Netw
, vol.10
, pp. 690-693
-
-
Jonasch, E.1
Motzer, R.J.2
-
5
-
-
0027240519
-
Identification of the von Hippel-Lindau disease tumor suppressor gene
-
Latif F, Tory K, Gnarra JR, Yao M, Duh F-M, Orcutt ML, et al. Identification of the von Hippel-Lindau disease tumor suppressor gene. Science 1993;260:1317-20.
-
(1993)
Science
, vol.260
, pp. 1317-1320
-
-
Latif, F.1
Tory, K.2
Gnarra, J.R.3
Yao, M.4
Duh, F.-M.5
Orcutt, M.L.6
-
6
-
-
51049084870
-
Improved identification of von Hippel-Lindau gene alterations in clear cell renal tumors
-
Nickerson ML, Jaeger E, Shi Y, Durocher JA, Mahurkar S, Zaridze D, et al. Improved identification of von Hippel-Lindau gene alterations in clear cell renal tumors. Clin Cancer Res 2008;14:4726-34.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 4726-4734
-
-
Nickerson, M.L.1
Jaeger, E.2
Shi, Y.3
Durocher, J.A.4
Mahurkar, S.5
Zaridze, D.6
-
7
-
-
84880967722
-
Integrated molecular analysis of clear-cell renal cell carcinoma
-
Sato Y, Yoshizato T, Shiraishi Y, Maekawa S, Okuno Y, Kamura T, et al. Integrated molecular analysis of clear-cell renal cell carcinoma. Nat Genet 2013;45:860-7.
-
(2013)
Nat Genet
, vol.45
, pp. 860-867
-
-
Sato, Y.1
Yoshizato, T.2
Shiraishi, Y.3
Maekawa, S.4
Okuno, Y.5
Kamura, T.6
-
8
-
-
0029126892
-
Inhibition of transcription elongation by the VHL tumor suppressor protein
-
Duan DR, Pause A, Burgess WH, Aso T, Chen DY, Garrett KP, et al. Inhibition of transcription elongation by the VHL tumor suppressor protein. Science 1995;269:1402-6.
-
(1995)
Science
, vol.269
, pp. 1402-1406
-
-
Duan, D.R.1
Pause, A.2
Burgess, W.H.3
Aso, T.4
Chen, D.Y.5
Garrett Kp.6
-
9
-
-
0035917313
-
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing
-
Ivan M, Kondo K, Yang H, Kim W, Valiando J, Ohh M, et al. HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 2001;292:464-8.
-
(2001)
Science
, vol.292
, pp. 464-468
-
-
Ivan, M.1
Kondo, K.2
Yang, H.3
Kim, W.4
Valiando, J.5
Ohh, M.6
-
10
-
-
0035917808
-
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
-
Jaakkola P, Mole DR, Tian YM, Wilson MI, Gielbert J, Gaskell SJ, et al. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 2001;292:468-72.
-
(2001)
Science
, vol.292
, pp. 468-472
-
-
Jaakkola, P.1
Mole, D.R.2
Tian, Y.M.3
Wilson, M.I.4
Gielbert, J.5
Gaskell, S.J.6
-
11
-
-
84880942539
-
Novel approaches targeting the vascular endothelial growth factor axis in renal cell carcinoma
-
Voss MH, Hsieh JJ, Motzer RJ. Novel approaches targeting the vascular endothelial growth factor axis in renal cell carcinoma. Cancer J 2013;19:299-306.
-
(2013)
Cancer J
, vol.19
, pp. 299-306
-
-
Voss, M.H.1
Hsieh, J.J.2
Motzer, R.J.3
-
12
-
-
84883167443
-
Non-clear cell renal cancer: Disease-based management and opportunities for targeted therapeutic approaches
-
Linehan WM, Srinivasan R, Garcia JA. Non-clear cell renal cancer: disease-based management and opportunities for targeted therapeutic approaches. Semin Oncol 2013;40:511-20.
-
(2013)
Semin Oncol
, vol.40
, pp. 511-520
-
-
Linehan, W.M.1
Srinivasan, R.2
Garcia, J.A.3
-
13
-
-
0036527785
-
The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma
-
Maranchie JK, Vasselli JR, Riss J, Bonifacino JS, Linehan WM, Klausner RD. The contribution of VHL substrate binding and HIF1-alpha to the phenotype of VHL loss in renal cell carcinoma. Cancer Cell 2002;1:247-55.
-
(2002)
Cancer Cell
, vol.1
, pp. 247-255
-
-
Maranchie, J.K.1
Vasselli, J.R.2
Riss, J.3
Bonifacino, J.S.4
Linehan, W.M.5
Klausner, R.D.6
-
14
-
-
0036528246
-
Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein
-
Kondo K, Klco J, Nakamura E, Lechpammer M, Kaelin WG Jr. Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Cancer Cell 2002;1:237-46.
-
(2002)
Cancer Cell
, vol.1
, pp. 237-246
-
-
Kondo, K.1
Klco, J.2
Nakamura, E.3
Lechpammer, M.4
Kaelin, W.G.5
-
15
-
-
2342597973
-
Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth
-
Kondo K, Kim WY, Lechpammer M, Kaelin WG Jr. Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth. PLoS Biol 2003;1:E83.
-
(2003)
PLoS Biol
, vol.1
, pp. E83
-
-
Kondo, K.1
Kim, W.Y.2
Lechpammer, M.3
Kaelin, W.G.4
-
17
-
-
78651257523
-
Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3
-
Purdue MP, Johansson M, Zelenika D, Toro JR, Scelo G, Moore LE, et al. Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3. Nat Genet 2011;43:60-5.
-
(2011)
Nat Genet
, vol.43
, pp. 60-65
-
-
Purdue, M.P.1
Johansson, M.2
Zelenika, D.3
Toro, J.R.4
Scelo, G.5
Moore, L.E.6
-
18
-
-
84873091765
-
The VHL/HIF axis in clear cell renal carcinoma
-
Shen C, Kaelin WG Jr. The VHL/HIF axis in clear cell renal carcinoma. Semin Cancer Biol 2013;23:18-25.
-
(2013)
Semin Cancer Biol
, vol.23
, pp. 18-25
-
-
Shen, C.1
Kaelin, W.G.2
-
19
-
-
80054771537
-
Genetic and functional studies implicate HIF1a as a 14q kidney cancer suppressor gene
-
Shen C, Beroukhim R, Schumacher SE, Zhou J, Chang M, Signoretti S, et al. Genetic and functional studies implicate HIF1a as a 14q kidney cancer suppressor gene. Cancer Discov 2011;1:223-35.
-
(2011)
Cancer Discov
, vol.1
, pp. 223-235
-
-
Shen, C.1
Beroukhim, R.2
Schumacher, S.E.3
Zhou, J.4
Chang, M.5
Signoretti, S.6
-
20
-
-
80455174760
-
Chromosome 14q loss defines a molecular subtype of clear-cell renal cell carcinoma associated with poor prognosis
-
Monzon FA, Alvarez K, Peterson L, Truong L, Amato RJ, Hernandez-McClain J, et al. Chromosome 14q loss defines a molecular subtype of clear-cell renal cell carcinoma associated with poor prognosis. Mod Pathol 2011;24:1470-9.
-
(2011)
Mod Pathol
, vol.24
, pp. 1470-1479
-
-
Monzon, F.A.1
Alvarez, K.2
Peterson, L.3
Truong, L.4
Amato, R.J.5
Hernandez-McClain, J.6
-
21
-
-
33748194210
-
Development of a cell-based reporter assay for screening of inhibitors of hypoxia-inducible factor 2-induced gene expression
-
Woldemichael GM, Vasselli JR, Gardella RS, McKee TC, Linehan WM, McMahon JB. Development of a cell-based reporter assay for screening of inhibitors of hypoxia-inducible factor 2-induced gene expression. J Biomol Screen 2006;11:678-87.
-
(2006)
J Biomol Screen
, vol.11
, pp. 678-687
-
-
Woldemichael, G.M.1
Vasselli, J.R.2
Gardella, R.S.3
McKee, T.C.4
Linehan, W.M.5
McMahon, J.B.6
-
22
-
-
80052282526
-
A new hypoxia inducible factor-2 inhibitory pyrrolinone alkaloid from roots and stems of Piper sarmentosum
-
Bokesch HR, Gardella RS, Rabe DC, Bottaro DP, Linehan WM, McMahon JB, et al. A new hypoxia inducible factor-2 inhibitory pyrrolinone alkaloid from roots and stems of Piper sarmentosum. Chem Pharm Bull 2011;59:1178-9.
-
(2011)
Chem Pharm Bull
, vol.59
, pp. 1178-1179
-
-
Bokesch, H.R.1
Gardella, R.S.2
Rabe, D.C.3
Bottaro, D.P.4
Linehan, W.M.5
McMahon, J.B.6
-
23
-
-
79952483977
-
Identification and evaluation of soft coral diterpenes as inhibitors of HIF-2alpha induced gene expression
-
Grkovic T, Whitson EL, Rabe DC, Gardella RS, Bottaro DP, Linehan WM, et al. Identification and evaluation of soft coral diterpenes as inhibitors of HIF-2alpha induced gene expression. Bioorg Med Chem Lett 2011;21:2113-5.
-
(2011)
Bioorg Med Chem Lett
, vol.21
, pp. 2113-2115
-
-
Grkovic, T.1
Whitson, E.L.2
Rabe, D.C.3
Gardella, R.S.4
Bottaro, D.P.5
Linehan, W.M.6
-
24
-
-
84866984541
-
Inhibition of hypoxia inducible factor-2 transcription: Isolation of active modulators from marine sponges
-
McKee TC, Rabe D, Bokesch HR, Grkovic T, Whitson EL, Diyabalanage T, et al. Inhibition of hypoxia inducible factor-2 transcription: isolation of active modulators from marine sponges. J Nat Prod 2012;75:1632-6.
-
(2012)
J Nat Prod
, vol.75
, pp. 1632-1636
-
-
McKee, T.C.1
Rabe, D.2
Bokesch, H.R.3
Grkovic, T.4
Whitson, E.L.5
Diyabalanage, T.6
-
25
-
-
57849147670
-
Small-molecule inhibitors of HIF-2a translation link its 5'UTR ironresponsive element to oxygen sensing
-
Zimmer M, Ebert BL, Neil C, Brenner K, Papaioannou I, Melas A, et al. Small-molecule inhibitors of HIF-2a translation link its 5'UTR ironresponsive element to oxygen sensing. Mol Cell 2008;32:838-48.
-
(2008)
Mol Cell
, vol.32
, pp. 838-848
-
-
Zimmer, M.1
Ebert, B.L.2
Neil, C.3
Brenner, K.4
Papaioannou, I.5
Melas, A.6
-
26
-
-
77951082053
-
The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2
-
Zimmer M, Lamb J, Ebert BL, Lynch M, Neil C, Schmidt E, et al. The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-delta12,14-prostaglandin J2. Cancer Res 2010;70:3071-9.
-
(2010)
Cancer Res
, vol.70
, pp. 3071-3079
-
-
Zimmer, M.1
Lamb, J.2
Ebert, B.L.3
Lynch, M.4
Neil, C.5
Schmidt, E.6
-
27
-
-
84872813122
-
Targeting HIF2α translation with Tempol in VHL-deficient clear cell renal cell carcinoma
-
Sourbier C, Srivastava G, Ghosh MC, Ghosh S, Yang Y, Gupta G, et al. Targeting HIF2α translation with Tempol in VHL-deficient clear cell renal cell carcinoma. Oncotarget 2012;3:1472-82.
-
(2012)
Oncotarget
, vol.3
, pp. 1472-1482
-
-
Sourbier, C.1
Srivastava, G.2
Ghosh, M.C.3
Ghosh, S.4
Yang, Y.5
Gupta, G.6
-
28
-
-
84920679463
-
Autophagy mediates HIF2α degradation and suppresses renal tumorigenesis
-
Jul 7. [Epub ahead of print]
-
Liu XD, Yao J, Tripathi DN, Ding Z, Xu Y, Sun M, et al. Autophagy mediates HIF2α degradation and suppresses renal tumorigenesis. Oncogene 2014 Jul 7. [Epub ahead of print].
-
(2014)
Oncogene
-
-
Liu, X.D.1
Yao, J.2
Tripathi, D.N.3
Ding, Z.4
Xu, Y.5
Sun, M.6
-
29
-
-
84902170698
-
Genetic and pharmacological strategies to refunctionalize the von Hippel Lindau R167Q mutant protein
-
Ding Z, German P, Bai S, Reddy AS, Liu XD, Sun M, et al. Genetic and pharmacological strategies to refunctionalize the von Hippel Lindau R167Q mutant protein. Cancer Res 2014;74:3127-36.
-
(2014)
Cancer Res
, vol.74
, pp. 3127-3136
-
-
Ding, Z.1
German, P.2
Bai, S.3
Reddy, A.S.4
Liu, X.D.5
Sun, M.6
-
30
-
-
57349136768
-
Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1alpha, leading to its oxygen-independent degradation
-
Koh MY, Darnay BG, Powis G. Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1alpha, leading to its oxygen-independent degradation. Mol Cell Biol 2008;28:7081-95.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 7081-7095
-
-
Koh, M.Y.1
Darnay, B.G.2
Powis, G.3
-
31
-
-
79957440998
-
The hypoxia-associated factor switches cells from HIF-1alpha- to HIF-2alpha-dependent signaling promoting stem cell characteristics, aggressive tumor growth and invasion
-
Koh MY, Lemos R Jr, Liu X, Powis G. The hypoxia-associated factor switches cells from HIF-1alpha- to HIF-2alpha-dependent signaling promoting stem cell characteristics, aggressive tumor growth and invasion. Cancer Res 2011;71:4015-27.
-
(2011)
Cancer Res
, vol.71
, pp. 4015-4027
-
-
Koh, M.Y.1
Lemos, R.2
Liu, X.3
Powis, G.4
-
32
-
-
75149188170
-
Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
-
Dalgliesh GL, Furge K, Greenman C, Chen L, Bignell G, Butler A, et al. Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes. Nature 2010;463:360-3.
-
(2010)
Nature
, vol.463
, pp. 360-363
-
-
Dalgliesh, G.L.1
Furge, K.2
Greenman, C.3
Chen, L.4
Bignell, G.5
Butler, A.6
-
33
-
-
79251635938
-
Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma
-
Varela I, Tarpey P, Raine K, Huang D, Ong CK, Stephens P, et al. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. Nature 2011;469:539-42.
-
(2011)
Nature
, vol.469
, pp. 539-542
-
-
Varela, I.1
Tarpey, P.2
Raine, K.3
Huang, D.4
Ong, C.K.5
Stephens, P.6
-
34
-
-
84920653450
-
Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma
-
Guo G, Gui Y, Gao S, Tang A, Hu X, Huang Y, et al. Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma. Nat Genet 2011;12:1-3.
-
(2011)
Nat Genet
, vol.12
, pp. 1-3
-
-
Guo, G.1
Gui, Y.2
Gao, S.3
Tang, A.4
Hu, X.5
Huang, Y.6
-
35
-
-
84879890360
-
Comprehensive molecular characterization of clear cell renal cell carcinoma
-
Cancer Genome Atlas Research Network. Comprehensive molecular characterization of clear cell renal cell carcinoma. Nature 2013;499:43-9.
-
(2013)
Nature
, vol.499
, pp. 43-49
-
-
Cancer Genome Atlas Research Network1
-
36
-
-
84879466482
-
Adverse outcomes in clear cell renal cell carcinomawith mutations of 3p21 epigenetic regulators BAP1 and SETD2: A report by MSKCC and the KIRC TCGA research network
-
Hakimi AA, Ostrovnaya I, Reva B, Schultz N, Chen YB, Gonen M, et al. Adverse outcomes in clear cell renal cell carcinomawith mutations of 3p21 epigenetic regulators BAP1 and SETD2: a report by MSKCC and the KIRC TCGA research network. Clin Cancer Res 2013;19:3259-67.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 3259-3267
-
-
Hakimi, A.A.1
Ostrovnaya, I.2
Reva, B.3
Schultz, N.4
Chen, Y.B.5
Gonen, M.6
-
37
-
-
84862988411
-
BAP1 loss defines a new class of renal cell carcinoma
-
Pena-Llopis S, Vega-Rubin-de-Celis S, Liao A, Leng N, Pavia-Jimenez A, Wang S, et al. BAP1 loss defines a new class of renal cell carcinoma. Nat Genet 2012;44:751-9.
-
(2012)
Nat Genet
, vol.44
, pp. 751-759
-
-
Pena-Llopis, S.1
Vega-Rubin-de-Celis, S.2
Liao, A.3
Leng, N.4
Pavia-Jimenez, A.5
Wang, S.6
-
38
-
-
84899421896
-
Loss of BAP1 protein expression is an independent marker of poor prognosis in patients with low-risk clear cell renal cell carcinoma
-
Joseph RW, Kapur P, Serie DJ, Eckel-Passow JE, Parasramka M, Ho T, et al. Loss of BAP1 protein expression is an independent marker of poor prognosis in patients with low-risk clear cell renal cell carcinoma. Cancer 2014;120:1059-67.
-
(2014)
Cancer
, vol.120
, pp. 1059-1067
-
-
Joseph, R.W.1
Kapur, P.2
Serie, D.J.3
Eckel-Passow, J.E.4
Parasramka, M.5
Ho, T.6
-
39
-
-
84884497841
-
A novel germline mutation in BAP1 predisposes to familial clearcell renal cell carcinoma
-
Farley MN, Schmidt LS, Mester JL, Pena-Llopis S, Pavia-Jimenez A, Christie A, et al. A novel germline mutation in BAP1 predisposes to familial clearcell renal cell carcinoma. Mol Cancer Res 2013;11:1061-71.
-
(2013)
Mol Cancer Res
, vol.11
, pp. 1061-1071
-
-
Farley, M.N.1
Schmidt, L.S.2
Mester, J.L.3
Pena-Llopis, S.4
Pavia-Jimenez, A.5
Christie, A.6
-
40
-
-
84878846119
-
Germline BAP1 mutations predispose to renal cell carcinomas
-
Popova T, Hebert L, Jacquemin V, Gad S, Caux-Moncoutier V, Duboisd'Enghien C, et al. Germline BAP1 mutations predispose to renal cell carcinomas. Am J Hum Genet 2013;92:974-80.
-
(2013)
Am J Hum Genet
, vol.92
, pp. 974-980
-
-
Popova, T.1
Hebert, L.2
Jacquemin, V.3
Gad, S.4
Caux-Moncoutier, V.5
Duboisd'Enghien, C.6
-
41
-
-
84893664978
-
Variation in chromatin accessibility in human kidney cancer links H3K36 methyltransferase loss with widespread RNA processing defects
-
Simon JM, Hacker KE, Singh D, Brannon AR, Parker JS, Weiser M, et al. Variation in chromatin accessibility in human kidney cancer links H3K36 methyltransferase loss with widespread RNA processing defects. Genome Res 2014;24:241-50.
-
(2014)
Genome Res
, vol.24
, pp. 241-250
-
-
Simon, J.M.1
Hacker, K.E.2
Singh, D.3
Brannon, A.R.4
Parker, J.S.5
Weiser, M.6
-
42
-
-
84899849011
-
SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint
-
Carvalho S, Vitor AC, Sridhara SC, Martins FB, Raposo AC, Desterro JM, et al. SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint. Elife 2014;3:e02482.
-
(2014)
Elife
, vol.3
, pp. e02482
-
-
Carvalho, S.1
Vitor, A.C.2
Sridhara, S.C.3
Martins, F.B.4
Raposo, A.C.5
Desterro, J.M.6
-
43
-
-
84903451450
-
SETD2-dependent histone H3K36 trimethylation is required for homologous recombination repair and genome stability
-
Pfister SX, Ahrabi S, Zalmas LP, Sarkar S, Aymard F, Bachrati CZ, et al. SETD2-dependent histone H3K36 trimethylation is required for homologous recombination repair and genome stability. Cell Rep 2014;7:2006-18.
-
(2014)
Cell Rep
, vol.7
, pp. 2006-2018
-
-
Pfister, S.X.1
Ahrabi, S.2
Zalmas, L.P.3
Sarkar, S.4
Aymard, F.5
Bachrati, C.Z.6
-
44
-
-
84876943255
-
The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSalpha
-
Li F, Mao G, Tong D, Huang J, Gu L, Yang W, et al. The histone mark H3K36me3 regulates human DNA mismatch repair through its interaction with MutSalpha. Cell 2013;153:590-600.
-
(2013)
Cell
, vol.153
, pp. 590-600
-
-
Li, F.1
Mao, G.2
Tong, D.3
Huang, J.4
Gu, L.5
Yang, W.6
-
45
-
-
84863393080
-
Intratumor heterogeneity and branched evolution revealed bymultiregion sequencing
-
Gerlinger M, Rowan AJ, Horswell S, Larkin J, Endesfelder D, Gronroos E, et al. Intratumor heterogeneity and branched evolution revealed bymultiregion sequencing. N Engl J Med 2012;366:883-92.
-
(2012)
N Engl J Med
, vol.366
, pp. 883-892
-
-
Gerlinger, M.1
Rowan, A.J.2
Horswell, S.3
Larkin, J.4
Endesfelder, D.5
Gronroos, E.6
-
46
-
-
84895876130
-
Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing
-
Gerlinger M, Horswell S, Larkin J, Rowan AJ, Salm MP, Varela I, et al. Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing. Nat Genet 2014;46:225-33.
-
(2014)
Nat Genet
, vol.46
, pp. 225-233
-
-
Gerlinger, M.1
Horswell, S.2
Larkin, J.3
Rowan, A.J.4
Salm, M.P.5
Varela, I.6
-
47
-
-
84895865038
-
Intratumoral heterogeneity in kidney cancer
-
Ricketts CJ, Linehan WM. Intratumoral heterogeneity in kidney cancer. Nat Genet 2014;46:214-5.
-
(2014)
Nat Genet
, vol.46
, pp. 214-215
-
-
Ricketts, C.J.1
Linehan, W.M.2
-
48
-
-
84856014884
-
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
-
Metallo CM, Gameiro PA, Bell EL, Mattaini KR, Yang J, Hiller K, et al. Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia. Nature 2011;481:380-4.
-
(2011)
Nature
, vol.481
, pp. 380-384
-
-
Metallo, C.M.1
Gameiro, P.A.2
Bell, E.L.3
Mattaini, K.R.4
Yang, J.5
Hiller, K.6
-
49
-
-
84875354450
-
In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation
-
Gameiro PA, Yang J, Metelo AM, Perez-Carro R, Baker R, Wang Z, et al. In vivo HIF-mediated reductive carboxylation is regulated by citrate levels and sensitizes VHL-deficient cells to glutamine deprivation. Cell Metab 2013;17:372-85.
-
(2013)
Cell Metab
, vol.17
, pp. 372-385
-
-
Gameiro, P.A.1
Yang, J.2
Metelo, A.M.3
Perez-Carro, R.4
Baker, R.5
Wang, Z.6
-
50
-
-
84877109282
-
Cofactor balance by nicotinamide nucleotide transhydrogenase (NNT) coordinates reductive carboxylation and glucose catabolism in the tricarboxylic acid (TCA) cycle
-
Gameiro PA, Laviolette LA, Kelleher JK, Iliopoulos O, Stephanopoulos G. Cofactor balance by nicotinamide nucleotide transhydrogenase (NNT) coordinates reductive carboxylation and glucose catabolism in the tricarboxylic acid (TCA) cycle. J Biol Chem 2013;288:12967-77.
-
(2013)
J Biol Chem
, vol.288
, pp. 12967-12977
-
-
Gameiro, P.A.1
Laviolette, L.A.2
Kelleher, J.K.3
Iliopoulos, O.4
Stephanopoulos, G.5
-
51
-
-
80052572942
-
The glycolytic shift in fumarate-hydratase-deficient kidney cancer lowers AMPK levels, increases anabolic propensities and lowers cellular iron levels
-
Tong WH, Sourbier C, Kovtunovych G, Jeong SY, Vira M, Ghosh M, et al. The glycolytic shift in fumarate-hydratase-deficient kidney cancer lowers AMPK levels, increases anabolic propensities and lowers cellular iron levels. Cancer Cell 2011;20:315-27.
-
(2011)
Cancer Cell
, vol.20
, pp. 315-327
-
-
Tong, W.H.1
Sourbier, C.2
Kovtunovych, G.3
Jeong, S.Y.4
Vira, M.5
Ghosh, M.6
-
52
-
-
78649858143
-
AMPK as a therapeutic target in renal cell carcinoma
-
Woodard J, Joshi S, Viollet B, Hay N, Platanias LC. AMPK as a therapeutic target in renal cell carcinoma. Cancer Biol Ther 2010;10:1168-77.
-
(2010)
Cancer Biol Ther
, vol.10
, pp. 1168-1177
-
-
Woodard, J.1
Joshi, S.2
Viollet, B.3
Hay, N.4
Platanias, L.C.5
-
53
-
-
0028157342
-
Hereditary papillary renal cell carcinoma
-
Zbar B, Tory K, Merino MJ, Schmidt LS, Glenn GM, Choyke P, et al. Hereditary papillary renal cell carcinoma. J Urol 1994;151:561-6.
-
(1994)
J Urol
, vol.151
, pp. 561-566
-
-
Zbar, B.1
Tory, K.2
Merino, M.J.3
Schmidt, L.S.4
Glenn, G.M.5
Choyke, P.6
-
54
-
-
17344381429
-
Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas
-
Schmidt LS, Duh FM, Chen F, Kishida T, Glenn GM, Choyke P, et al. Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas. Nat Genet 1997;16:68-73.
-
(1997)
Nat Genet
, vol.16
, pp. 68-73
-
-
Schmidt, L.S.1
Duh, F.M.2
Chen, F.3
Kishida, T.4
Glenn, G.M.5
Choyke, P.6
-
55
-
-
0032522486
-
Two North American families with hereditary papillary renal carcinoma and identical novel mutations in the MET proto-oncogene
-
Schmidt LS, Junker K, Weirich G, Glenn G, Choyke P, Lubensky I, et al. Two North American families with hereditary papillary renal carcinoma and identical novel mutations in the MET proto-oncogene. Cancer Res 1998;58:1719-22.
-
(1998)
Cancer Res
, vol.58
, pp. 1719-1722
-
-
Schmidt, L.S.1
Junker, K.2
Weirich, G.3
Glenn, G.4
Choyke, P.5
Lubensky, I.6
-
56
-
-
17344373892
-
Trisomy 7 - harboring non-random duplication of the mutant MET allele in hereditary papillary renal carcinomas
-
Zhuang Z, Park WS, Pack S, Schmidt LS, Pak E, Pham T, et al. Trisomy 7 - harboring non-random duplication of the mutant MET allele in hereditary papillary renal carcinomas. Nat Genet 1998;20:66-9.
-
(1998)
Nat Genet
, vol.20
, pp. 66-69
-
-
Zhuang, Z.1
Park, W.S.2
Pack, S.3
Schmidt, L.S.4
Pak, E.5
Pham, T.6
-
57
-
-
0032813906
-
Hereditary and sporadic papillary renal carcinomas with c-met mutations share a distinctmorphological phenotype
-
Lubensky IA, Schmidt LS, Zhuang Z, Weirich G, Pack S, Zambrano N, et al. Hereditary and sporadic papillary renal carcinomas with c-met mutations share a distinctmorphological phenotype. Am J Pathol 1999;155:517-26.
-
(1999)
Am J Pathol
, vol.155
, pp. 517-526
-
-
Lubensky, I.A.1
Schmidt, L.S.2
Zhuang, Z.3
Weirich, G.4
Pack, S.5
Zambrano, N.6
-
58
-
-
84872548337
-
Phase II and biomarker study of the dual MET/VEGFR2 inhibitor foretinib in patients with papillary renal cell carcinoma
-
Choueiri TK, Vaishampayan U, Rosenberg JE, Logan TF, Harzstark AL, Bukowski RM, et al. Phase II and biomarker study of the dual MET/VEGFR2 inhibitor foretinib in patients with papillary renal cell carcinoma. J Clin Oncol 2013;31:181-6.
-
(2013)
J Clin Oncol
, vol.31
, pp. 181-186
-
-
Choueiri, T.K.1
Vaishampayan, U.2
Rosenberg, J.E.3
Logan, T.F.4
Harzstark, A.L.5
Bukowski, R.M.6
-
59
-
-
0035853166
-
Inherited susceptibility to uterine leiomyomas and renal cell cancer
-
Launonen V, Vierimaa O, Kiuru M, Isola J, Roth S, Pukkala E, et al. Inherited susceptibility to uterine leiomyomas and renal cell cancer. Proc Natl Acad Sci U S A 2001;98:3387-2.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 3387-3392
-
-
Launonen, V.1
Vierimaa, O.2
Kiuru, M.3
Isola, J.4
Roth, S.5
Pukkala, E.6
-
60
-
-
33846882602
-
Hereditary leiomyomatosis and renal cell carcinoma syndrome (HLRCC): Clinical, histopathological and molecular features of the first American families described
-
Merino MJ, Torres-Cabala CA, Zbar B, Chian-Garcia CA, Linehan WM. Hereditary leiomyomatosis and renal cell carcinoma syndrome (HLRCC): clinical, histopathological and molecular features of the first American families described. Mod Pathol 2003;16:739.
-
(2003)
Mod Pathol
, vol.16
, pp. 739
-
-
Merino, M.J.1
Torres-Cabala, C.A.2
Zbar, B.3
Chian-Garcia, C.A.4
Linehan, W.M.5
-
61
-
-
34248336258
-
Hereditary leiomyomatosis and renal cell cancer: A syndrome associated with an aggressive form of inherited renal cancer
-
Grubb RL III, Franks ME, Toro J, Middelton L, Choyke L, Fowler S, et al. Hereditary leiomyomatosis and renal cell cancer: a syndrome associated with an aggressive form of inherited renal cancer. J Urol 2007;177:2074-80.
-
(2007)
J Urol
, vol.177
, pp. 2074-2080
-
-
Grubb, R.L.1
Franks, M.E.2
Toro, J.3
Middelton, L.4
Choyke, L.5
Fowler, S.6
-
62
-
-
18544365990
-
Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer
-
Tomlinson IP, Alam NA, Rowan AJ, Barclay E, Jaeger EE, Kelsell D, et al. Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer. NatGenet 2002;30:406-10.
-
(2002)
NatGenet
, vol.30
, pp. 406-410
-
-
Tomlinson, I.P.1
Alam, N.A.2
Rowan, A.J.3
Barclay, E.4
Jaeger, E.E.5
Kelsell, D.6
-
64
-
-
12444279265
-
On the origin of cancer cells
-
Warburg O. On the origin of cancer cells. Science 1956;123:309-14.
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
65
-
-
70949105507
-
UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: In vitro and in vivo model of an aberrant energy metabolic pathway in human cancer
-
Yang Y, Valera VA, Padilla-Nash HM, Sourbier C, Vocke CD, Vira MA, et al. UOK 262 cell line, fumarate hydratase deficient (FH-/FH-) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer. Cancer Genet Cytogenet 2010;196:45-55.
-
(2010)
Cancer Genet Cytogenet
, vol.196
, pp. 45-55
-
-
Yang, Y.1
Valera, V.A.2
Padilla-Nash, H.M.3
Sourbier, C.4
Vocke, C.D.5
Vira Ma.6
-
66
-
-
23644448721
-
HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability
-
Isaacs JS, Jung YJ, Mole DR, Lee S, Torres-Cabala C, Chung YL, et al. HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability. Cancer Cell 2005;8:143-53.
-
(2005)
Cancer Cell
, vol.8
, pp. 143-153
-
-
Isaacs, J.S.1
Jung, Y.J.2
Mole, D.R.3
Lee, S.4
Torres-Cabala, C.5
Chung, Y.L.6
-
67
-
-
84879875481
-
Molecular pathways: Fumarate hydratase-deficient kidney cancer-targeting the Warburg effect in cancer
-
Linehan WM, Rouault TA. Molecular pathways: fumarate hydratase-deficient kidney cancer-targeting the Warburg effect in cancer. Clin Cancer Res 2013;19:3345-52.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 3345-3352
-
-
Linehan, W.M.1
Rouault, T.A.2
-
68
-
-
84855987831
-
Reductive carboxylation supports growth in tumour cells with defective mitochondria
-
Mullen AR, Wheaton WW, Jin ES, Chen PH, Sullivan LB, Cheng T, et al. Reductive carboxylation supports growth in tumour cells with defective mitochondria. Nature 2011;481:385-8.
-
(2011)
Nature
, vol.481
, pp. 385-388
-
-
Mullen, A.R.1
Wheaton, W.W.2
Jin, E.S.3
Chen, P.H.4
Sullivan, L.B.5
Cheng, T.6
-
69
-
-
67651204610
-
Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and HIF-1 alpha stabilization by glucose-dependent generation of reactive oxygen species
-
Sudarshan S, Sourbier C, Kong HS, Block K, Romero VV, Yang Y, et al. Fumarate hydratase deficiency in renal cancer induces glycolytic addiction and HIF-1 alpha stabilization by glucose-dependent generation of reactive oxygen species. Mol Cell Biol 2009;15:4080-90.
-
(2009)
Mol Cell Biol
, vol.15
, pp. 4080-4090
-
-
Sudarshan, S.1
Sourbier, C.2
Kong, H.S.3
Block, K.4
Romero, V.V.5
Yang, Y.6
-
70
-
-
80054767730
-
Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: Roles for fumarate in KEAP1 succination and Nrf2 signaling
-
Adam J, Hatipoglu E, O'Flaherty L, Ternette N, Sahgal N, Lockstone H, et al. Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling. Cancer Cell 2011;20:524-37.
-
(2011)
Cancer Cell
, vol.20
, pp. 524-537
-
-
Adam, J.1
Hatipoglu, E.2
O'Flaherty, L.3
Ternette, N.4
Sahgal, N.5
Lockstone, H.6
-
71
-
-
80054772589
-
An antioxidant response phenotype shared between hereditary and sporadic type 2 papillary renal cell carcinoma
-
Ooi A, Wong JC, Petillo D, Roossien D, Perrier-Trudova V, Whitten D, et al. An antioxidant response phenotype shared between hereditary and sporadic type 2 papillary renal cell carcinoma. Cancer Cell 2011;20:511-23.
-
(2011)
Cancer Cell
, vol.20
, pp. 511-523
-
-
Ooi, A.1
Wong, J.C.2
Petillo, D.3
Roossien, D.4
Perrier-Trudova, V.5
Whitten, D.6
-
72
-
-
84876005313
-
CUL3 and NRF2 mutations confer an NRF2 activation phenotype in a sporadic form of papillary renal cell carcinoma
-
Ooi A, Dykema K, Ansari A, Petillo D, Snider J, Kahnoski R, et al. CUL3 and NRF2 mutations confer an NRF2 activation phenotype in a sporadic form of papillary renal cell carcinoma. Cancer Res 2013;73:2044-51.
-
(2013)
Cancer Res
, vol.73
, pp. 2044-2051
-
-
Ooi, A.1
Dykema, K.2
Ansari, A.3
Petillo, D.4
Snider, J.5
Kahnoski, R.6
-
73
-
-
66449103009
-
LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer
-
Xie H, Valera VA, Merino MJ, Amato AM, Signoretti S, Linehan WM, et al. LDH-A inhibition, a therapeutic strategy for treatment of hereditary leiomyomatosis and renal cell cancer. Mol Cancer Ther 2009;8:626-35.
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 626-635
-
-
Xie, H.1
Valera, V.A.2
Merino, M.J.3
Amato, A.M.4
Signoretti, S.5
Linehan, W.M.6
-
74
-
-
42949117343
-
A sweet new role for EGFR in cancer
-
Engelman JA, Cantley LC. A sweet new role for EGFR in cancer. Cancer Cell 2008;13:375-6.
-
(2008)
Cancer Cell
, vol.13
, pp. 375-376
-
-
Engelman, J.A.1
Cantley, L.C.2
|