The connectivity map links iron regulatory protein-1-mediated inhibition of hypoxia-inducible factor-2a translation to the anti-inflammatory 15-deoxy-△12,14-prostaglandin J2

Cancer Research

Volumn 70, Issue 8, 2010, Pages 3071-3079

  Zimmer, Michael ^a,b   Lamb, Justin ^d   Ebert, Benjamin L ^c,d   Lynch, Mary ^a   Neil, Christopher ^a,b   Schmidt, Emmett ^a   Golub, Todd R ^d   Iliopoulos, Othon ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

15 DEOXY DELTA12,14 PROSTAGLANDIN J2; CYTOKINE; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 1BETA; HYPOXIA INDUCIBLE FACTOR 2; HYPOXIA INDUCIBLE FACTOR 2ALPHA; HYPOXIA INDUCIBLE FACTOR 2BETA; IRON REGULATORY PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; UNCLASSIFIED DRUG;

5' UNTRANSLATED REGION; ALPHA CHAIN; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; BETA CHAIN; CONTROLLED STUDY; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; HYPOXIA; INFLAMMATION; IRON RESPONSIVE ELEMENT; MESENCHYME CELL; NEOPLASM; PRIORITY JOURNAL; RNA TRANSLATION; TRANSLATION REGULATION;

ANTI-INFLAMMATORY AGENTS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL LINE, TUMOR; DIMERIZATION; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; IRON REGULATORY PROTEIN 1; MUTATION; PROSTAGLANDIN D2; PROTEIN BIOSYNTHESIS; PROTEIN-SERINE-THREONINE KINASES; RESPONSE ELEMENTS; TRANSCRIPTION, GENETIC;

EID: 77951082053     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-2877     Document Type: Article

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