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Volumn 56, Issue 1, 2015, Pages 81-97

Pathways of cholesterol homeostasis in mouse retina responsive to dietary and pharmacologic treatments

Author keywords

3 hydroxy 3 methyl glutaryl CoA reductase; Age related macular degeneration; Cytochrome P450; Liver X receptor; Posttranslational regulation; RPE65; Sterol regulatory element binding protein; Transcriptional regulation

Indexed keywords

APOLIPOPROTEIN D; CHOLESTEROL; LIVER X RECEPTOR; STEROL REGULATORY ELEMENT BINDING PROTEIN; CIS TRANS ISOMERASE; FLUORINATED HYDROCARBON; IDOL PROTEIN, MOUSE; ORPHAN NUCLEAR RECEPTOR; RETINOID ISOMEROHYDROLASE; SIMVASTATIN; SULFONAMIDE; TO-901317; UBIQUITIN PROTEIN LIGASE;

EID: 84920514857     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M053439     Document Type: Article
Times cited : (60)

References (81)
  • 1
    • 66349134748 scopus 로고    scopus 로고
    • Cholesterol feedback: From Schoenheimer's bottle to Scap's MELADL
    • Brown, M. S., and J. L. Goldstein. 2009. Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL. J. Lipid Res. 50 (Suppl.): S15-S27.
    • (2009) J. Lipid Res. , vol.50 , pp. S15-S27
    • Brown, M.S.1    Goldstein, J.L.2
  • 2
    • 0036251153 scopus 로고    scopus 로고
    • SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver
    • Horton, J. D., J. L. Goldstein, and M. S. Brown. 2002. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J. Clin. Invest. 109: 1125-1131.
    • (2002) J. Clin. Invest. , vol.109 , pp. 1125-1131
    • Horton, J.D.1    Goldstein, J.L.2    Brown, M.S.3
  • 3
    • 0034518420 scopus 로고    scopus 로고
    • The role of orphan nuclear receptors in the regulation of cholesterol homeostasis
    • Repa, J. J., and D. J. Mangelsdorf. 2000. The role of orphan nuclear receptors in the regulation of cholesterol homeostasis. Annu. Rev. Cell Dev. Biol. 16: 459-481.
    • (2000) Annu. Rev. Cell Dev. Biol. , vol.16 , pp. 459-481
    • Repa, J.J.1    Mangelsdorf, D.J.2
  • 6
    • 0027474282 scopus 로고
    • A method for the isolation of retinal pigment epithelial cells from adult rats
    • Wang, N., C. A. Koutz, and R. E. Anderson. 1993. A method for the isolation of retinal pigment epithelial cells from adult rats. Invest. Ophthalmol. Vis. Sci. 34: 101-107.
    • (1993) Invest. Ophthalmol. Vis. Sci. , vol.34 , pp. 101-107
    • Wang, N.1    Koutz, C.A.2    Anderson, R.E.3
  • 8
    • 0028991308 scopus 로고
    • Metabolism of [3H]farnesol to cholesterol and cholesterogenic intermediates in the living rat eye
    • Fliesler, S. J., and R. K. Keller. 1995. Metabolism of [3H]farnesol to cholesterol and cholesterogenic intermediates in the living rat eye. Biochem. Biophys. Res. Commun. 210: 695-702.
    • (1995) Biochem. Biophys. Res. Commun. , vol.210 , pp. 695-702
    • Fliesler, S.J.1    Keller, R.K.2
  • 9
    • 0036981659 scopus 로고    scopus 로고
    • Retinal pigment epithelial acid lipase activity and lipoprotein receptors: Effects of dietary omega-3 fatty acids
    • Elner, V. M. 2002. Retinal pigment epithelial acid lipase activity and lipoprotein receptors: effects of dietary omega-3 fatty acids. Trans. Am. Ophthalmol. Soc. 100: 301-338.
    • (2002) Trans. Am. Ophthalmol. Soc. , vol.100 , pp. 301-338
    • Elner, V.M.1
  • 13
    • 84925545770 scopus 로고    scopus 로고
    • Cholesterol in the retina: The best is yet to come
    • Pikuleva, I. A., and C. A. Curcio. 2014. Cholesterol in the retina: the best is yet to come. Prog. Retin. Eye Res. 41: 64-89.
    • (2014) Prog. Retin. Eye Res. , vol.41 , pp. 64-89
    • Pikuleva, I.A.1    Curcio, C.A.2
  • 14
    • 78650043089 scopus 로고    scopus 로고
    • The ins and outs of cholesterol in the vertebrate retina
    • Fliesler, S. J., and L. Bretillon. 2010. The ins and outs of cholesterol in the vertebrate retina. J. Lipid Res. 51: 3399-3413.
    • (2010) J. Lipid Res. , vol.51 , pp. 3399-3413
    • Fliesler, S.J.1    Bretillon, L.2
  • 15
    • 84899684795 scopus 로고    scopus 로고
    • Activation of liver X receptor alleviates ocular inflammation in experimental autoimmune uveitis. Invest. Ophthalmol
    • Yang, H., S. Zheng, Y. Qiu, Y. Yang, C. Wang, P. Yang, Q. Li, and B. Lei. 2014. Activation of liver X receptor alleviates ocular inflammation in experimental autoimmune uveitis. Invest. Ophthalmol. Vis. Sci. 55: 2795-2804.
    • (2014) Vis. Sci. , vol.55 , pp. 2795-2804
    • Yang, H.1    Zheng, S.2    Qiu, Y.3    Yang, Y.4    Wang, C.5    Yang, P.6    Li, Q.7    Lei, B.8
  • 17
    • 79951533845 scopus 로고    scopus 로고
    • Quantification of cholesterol-metabolizing P450s CYP27A1 and CYP46A1 in neural tissues reveals a lack of enzyme-product correlations in human retina but not human brain
    • Liao, W-L., G-Y. Heo, N. G. Dodder, R. E. Reem, N. Mast, S. Huang, P. L. DiPatre, I. V. Turko, and I. A. Pikuleva. 2011. Quantification of cholesterol-metabolizing P450s CYP27A1 and CYP46A1 in neural tissues reveals a lack of enzyme-product correlations in human retina but not human brain. J. Proteome Res. 10: 241-248.
    • (2011) J. Proteome Res. , vol.10 , pp. 241-248
    • Liao, W.-L.1    Heo, G.-Y.2    Dodder, N.G.3    Reem, R.E.4    Mast, N.5    Huang, S.6    DiPatre, P.L.7    Turko, I.V.8    Pikuleva, I.A.9
  • 18
    • 79952465940 scopus 로고    scopus 로고
    • Cholestenoic acid is an important elimination product of cholesterol in the retina: Comparison of retinal cholesterol metabolism with that in the brain
    • Mast, N., R. Reem, I. Bederman, S. Huang, P. L. DiPatre, I. Bjorkhem, and I. A. Pikuleva. 2011. Cholestenoic acid is an important elimination product of cholesterol in the retina: comparison of retinal cholesterol metabolism with that in the brain. Invest. Ophthalmol. Vis. Sci. 52: 594-603.
    • (2011) Invest. Ophthalmol. Vis. Sci. , vol.52 , pp. 594-603
    • Mast, N.1    Reem, R.2    Bederman, I.3    Huang, S.4    DiPatre, P.L.5    Bjorkhem, I.6    Pikuleva, I.A.7
  • 19
    • 84862534271 scopus 로고    scopus 로고
    • Sample prefractionation for mass spectrometry quantification of low-abundance membrane proteins
    • Wang, M., G. Y. Heo, S. Omarova, I. A. Pikuleva, and I. V. Turko. 2012. Sample prefractionation for mass spectrometry quantification of low-abundance membrane proteins. Anal. Chem. 84: 5186-5191.
    • (2012) Anal. Chem. , vol.84 , pp. 5186-5191
    • Wang, M.1    Heo, G.Y.2    Omarova, S.3    Pikuleva, I.A.4    Turko, I.V.5
  • 21
    • 0027242119 scopus 로고
    • Molecular cloning and expression of RPE65, a novel retinal pigment epithelium-specific microsomal protein that is post-transcriptionally regulated in vitro
    • Hamel, C. P., E. Tsilou, B. A. Pfeffer, J. J. Hooks, B. Detrick, and T. M. Redmond. 1993. Molecular cloning and expression of RPE65, a novel retinal pigment epithelium-specific microsomal protein that is post-transcriptionally regulated in vitro. J. Biol. Chem. 268: 15751-15757.
    • (1993) J. Biol. Chem. , vol.268 , pp. 15751-15757
    • Hamel, C.P.1    Tsilou, E.2    Pfeffer, B.A.3    Hooks, J.J.4    Detrick, B.5    Redmond, T.M.6
  • 22
    • 23744447355 scopus 로고    scopus 로고
    • Rpe65 is the retinoid isomerase in bovine retinal pigment epithelium
    • Jin, M., S. Li, W. N. Moghrabi, H. Sun, and G. H. Travis. 2005. Rpe65 is the retinoid isomerase in bovine retinal pigment epithelium. Cell. 122: 449-459.
    • (2005) Cell , vol.122 , pp. 449-459
    • Jin, M.1    Li, S.2    Moghrabi, W.N.3    Sun, H.4    Travis, G.H.5
  • 24
    • 26444596185 scopus 로고    scopus 로고
    • Mutation of key residues of RPE65 abolishes its enzymatic role as isomerohydrolase in the visual cycle
    • Redmond, T. M., E. Poliakov, S. Yu, J. Y. Tsai, Z. Lu, and S. Gentleman. 2005. Mutation of key residues of RPE65 abolishes its enzymatic role as isomerohydrolase in the visual cycle. Proc. Natl. Acad. Sci. USA. 102: 13658-13663.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 13658-13663
    • Redmond, T.M.1    Poliakov, E.2    Yu, S.3    Tsai, J.Y.4    Lu, Z.5    Gentleman, S.6
  • 25
    • 0032511035 scopus 로고    scopus 로고
    • Markedly reduced bile acid synthesis but maintained levels of cholesterol and vitamin D metabolites in mice with disrupted sterol 27-hydroxylase gene
    • Rosen, H., A. Reshef, N. Maeda, A. Lippoldt, S. Shpizen, L. Triger, G. Eggertsen, I. Bjorkhem, and E. Leitersdorf. 1998. Markedly reduced bile acid synthesis but maintained levels of cholesterol and vitamin D metabolites in mice with disrupted sterol 27-hydroxylase gene. J. Biol. Chem. 273: 14805-14812.
    • (1998) J. Biol. Chem. , vol.273 , pp. 14805-14812
    • Rosen, H.1    Reshef, A.2    Maeda, N.3    Lippoldt, A.4    Shpizen, S.5    Triger, L.6    Eggertsen, G.7    Bjorkhem, I.8    Leitersdorf, E.9
  • 26
    • 0034671509 scopus 로고    scopus 로고
    • Disruption of the sterol 27-hydroxylase gene in mice results in hepatomegaly and hypertriglyceridemia. Reversal by cholic acid feeding
    • Repa, J. J., E. G. Lund, J. D. Horton, E. Leitersdorf, D. W. Russell, J. M. Dietschy, and S. D. Turley. 2000. Disruption of the sterol 27-hydroxylase gene in mice results in hepatomegaly and hypertriglyceridemia. Reversal by cholic acid feeding. J. Biol. Chem. 275: 39685-39692.
    • (2000) J. Biol. Chem. , vol.275 , pp. 39685-39692
    • Repa, J.J.1    Lund, E.G.2    Horton, J.D.3    Leitersdorf, E.4    Russell, D.W.5    Dietschy, J.M.6    Turley, S.D.7
  • 28
    • 33645983221 scopus 로고    scopus 로고
    • LXRS and FXR: The yin and yang of cholesterol and fat metabolism
    • Kalaany, N. Y., and D. J. Mangelsdorf. 2006. LXRS and FXR: the yin and yang of cholesterol and fat metabolism. Annu. Rev. Physiol. 68: 159-191.
    • (2006) Annu. Rev. Physiol. , vol.68 , pp. 159-191
    • Kalaany, N.Y.1    Mangelsdorf, D.J.2
  • 29
    • 0036915379 scopus 로고    scopus 로고
    • Identification of PLTP as an LXR target gene and apoE as an FXR target gene reveals overlapping targets for the two nuclear receptors
    • Mak, P. A., H. R. Kast-Woelbern, A. M. Anisfeld, and P. A. Edwards. 2002. Identification of PLTP as an LXR target gene and apoE as an FXR target gene reveals overlapping targets for the two nuclear receptors. J. Lipid Res. 43: 2037-2041.
    • (2002) J. Lipid Res. , vol.43 , pp. 2037-2041
    • Mak, P.A.1    Kast-Woelbern, H.R.2    Anisfeld, A.M.3    Edwards, P.A.4
  • 30
    • 84894612360 scopus 로고    scopus 로고
    • Human FXR regulates SHP expression through direct binding to an LRH-1 binding site, independent of an IR-1 and LRH-1
    • Hoeke, M. O., J. Heegsma, M. Hoekstra, H. Moshage, and K. N. Faber. 2014. Human FXR regulates SHP expression through direct binding to an LRH-1 binding site, independent of an IR-1 and LRH-1. PLoS ONE. 9: e88011.
    • (2014) PLoS ONE , vol.9 , pp. e88011
    • Hoeke, M.O.1    Heegsma, J.2    Hoekstra, M.3    Moshage, H.4    Faber, K.N.5
  • 32
    • 84867763896 scopus 로고    scopus 로고
    • In silico and intuitive predictions of CYP46A1 inhibition by marketed drugs with subsequent enzyme crystallization in complex with fluvoxamine
    • Mast, N., M. Linger, M. Clark, J. Wiseman, C. D. Stout, and I. A. Pikuleva. 2012. In silico and intuitive predictions of CYP46A1 inhibition by marketed drugs with subsequent enzyme crystallization in complex with fluvoxamine. Mol. Pharmacol. 82: 824-834.
    • (2012) Mol. Pharmacol. , vol.82 , pp. 824-834
    • Mast, N.1    Linger, M.2    Clark, M.3    Wiseman, J.4    Stout, C.D.5    Pikuleva, I.A.6
  • 33
    • 84859225215 scopus 로고    scopus 로고
    • Features of the retinal environment which affect the activities and product profile of cholesterol-metabolizing cytochromes P450 CYP27A1 and CYP11A1
    • Heo, G. Y., W. L. Liao, I. V. Turko, and I. A. Pikuleva. 2012. Features of the retinal environment which affect the activities and product profile of cholesterol-metabolizing cytochromes P450 CYP27A1 and CYP11A1. Arch. Biochem. Biophys. 518: 119-126.
    • (2012) Arch. Biochem. Biophys. , vol.518 , pp. 119-126
    • Heo, G.Y.1    Liao, W.L.2    Turko, I.V.3    Pikuleva, I.A.4
  • 35
    • 68049097903 scopus 로고    scopus 로고
    • Expression of reverse cholesterol transport proteins ATP-binding cassette A1 (ABCA1) and scavenger receptor BI (SR-BI) in the retina and retinal pigment epithelium
    • Duncan, K. G., K. Hosseini, K. R. Bailey, H. Yang, R. J. Lowe, M. T. Matthes, J. P. Kane, M. M. LaVail, D. M. Schwartz, and J. L. Duncan. 2009. Expression of reverse cholesterol transport proteins ATP-binding cassette A1 (ABCA1) and scavenger receptor BI (SR-BI) in the retina and retinal pigment epithelium. Br. J. Ophthalmol. 93: 1116-1120.
    • (2009) Br. J. Ophthalmol. , vol.93 , pp. 1116-1120
    • Duncan, K.G.1    Hosseini, K.2    Bailey, K.R.3    Yang, H.4    Lowe, R.J.5    Matthes, M.T.6    Kane, J.P.7    LaVail, M.M.8    Schwartz, D.M.9    Duncan, J.L.10
  • 36
    • 79960459422 scopus 로고    scopus 로고
    • Cholesterol metabolism in neurons and astrocytes
    • Pfrieger, F. W., and N. Ungerer. 2011. Cholesterol metabolism in neurons and astrocytes. Prog. Lipid Res. 50: 357-371.
    • (2011) Prog. Lipid Res. , vol.50 , pp. 357-371
    • Pfrieger, F.W.1    Ungerer, N.2
  • 37
    • 44849131929 scopus 로고    scopus 로고
    • Feedback regulation of cholesterol synthesis: Sterol-accelerated ubiquitination and degradation of HMG CoA reductase
    • DeBose-Boyd, R. A. 2008. Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase. Cell Res. 18: 609-621.
    • (2008) Cell Res. , vol.18 , pp. 609-621
    • DeBose-Boyd, R.A.1
  • 38
    • 77952860536 scopus 로고    scopus 로고
    • Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductase
    • Jo, Y., and R. A. Debose-Boyd. 2010. Control of cholesterol synthesis through regulated ER-associated degradation of HMG CoA reductase. Crit. Rev. Biochem. Mol. Biol. 45: 185-198.
    • (2010) Crit. Rev. Biochem. Mol. Biol. , vol.45 , pp. 185-198
    • Jo, Y.1    Debose-Boyd, R.A.2
  • 39
    • 79961118496 scopus 로고    scopus 로고
    • Regulation of HMG-CoA reductase in mammals and yeast
    • Burg, J. S., and P. J. Espenshade. 2011. Regulation of HMG-CoA reductase in mammals and yeast. Prog. Lipid Res. 50: 403-410.
    • (2011) Prog. Lipid Res. , vol.50 , pp. 403-410
    • Burg, J.S.1    Espenshade, P.J.2
  • 41
    • 1642388321 scopus 로고    scopus 로고
    • Transcription of the vascular endothelial growth factor gene in macrophages is regulated by liver X receptors
    • Walczak, R., S. B. Joseph, B. A. Laffitte, A. Castrillo, L. Pei, and P. Tontonoz. 2004. Transcription of the vascular endothelial growth factor gene in macrophages is regulated by liver X receptors. J. Biol. Chem. 279: 9905-9911.
    • (2004) J. Biol. Chem. , vol.279 , pp. 9905-9911
    • Walczak, R.1    Joseph, S.B.2    Laffitte, B.A.3    Castrillo, A.4    Pei, L.5    Tontonoz, P.6
  • 43
    • 79960190061 scopus 로고    scopus 로고
    • Inflammation in diabetic retinopathy
    • Tang, J., and T. S. Kern. 2011. Inflammation in diabetic retinopathy. Prog. Retin. Eye Res. 30: 343-358.
    • (2011) Prog. Retin. Eye Res. , vol.30 , pp. 343-358
    • Tang, J.1    Kern, T.S.2
  • 44
    • 67650092919 scopus 로고    scopus 로고
    • LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor
    • Zelcer, N., C. Hong, R. Boyadjian, and P. Tontonoz. 2009. LXR regulates cholesterol uptake through Idol-dependent ubiquitination of the LDL receptor. Science. 325: 100-104.
    • (2009) Science , vol.325 , pp. 100-104
    • Zelcer, N.1    Hong, C.2    Boyadjian, R.3    Tontonoz, P.4
  • 47
    • 84876345363 scopus 로고    scopus 로고
    • IDOL stimulates clathrin-independent endocytosis and multivesicular body-mediated lysosomal degradation of the low-density lipoprotein receptor
    • Scotti, E., M. Calamai, C. N. Goulbourne, L. Zhang, C. Hong, R. R. Lin, J. Choi, P. F. Pilch, L. G. Fong, P. Zou, et al. 2013. IDOL stimulates clathrin-independent endocytosis and multivesicular body-mediated lysosomal degradation of the low-density lipoprotein receptor. Mol. Cell. Biol. 33: 1503-1514.
    • (2013) Mol. Cell. Biol. , vol.33 , pp. 1503-1514
    • Scotti, E.1    Calamai, M.2    Goulbourne, C.N.3    Zhang, L.4    Hong, C.5    Lin, R.R.6    Choi, J.7    Pilch, P.F.8    Fong, L.G.9    Zou, P.10
  • 48
    • 77952708884 scopus 로고    scopus 로고
    • Apolipoprotein D in lipid metabolism and its functional implication in atherosclerosis and aging
    • Perdomo, G., and H. Henry Dong. 2009. Apolipoprotein D in lipid metabolism and its functional implication in atherosclerosis and aging. Aging (Albany NY). 1: 17-27.
    • (2009) Aging (Albany NY) , vol.1 , pp. 17-27
    • Perdomo, G.1    Dong, H.H.2
  • 50
    • 0023639025 scopus 로고
    • Correlation between serum levels of some cholesterol precursors and activity of HMG-CoA reductase in human liver
    • Björkhem, I., T. Miettinen, E. Reihnér, S. Ewerth, B. Angelin, and K. Einarsson. 1987. Correlation between serum levels of some cholesterol precursors and activity of HMG-CoA reductase in human liver. J. Lipid Res. 28: 1137-1143.
    • (1987) J. Lipid Res. , vol.28 , pp. 1137-1143
    • Björkhem, I.1    Miettinen, T.2    Reihnér, E.3    Ewerth, S.4    Angelin, B.5    Einarsson, K.6
  • 51
    • 0023737126 scopus 로고
    • Serum lathosterol concentration is an indicator of whole-body cholesterol synthesis in humans
    • Kempen, H. J., J. F. Glatz, J. A. Gevers Leuven, H. A. van der Voort, and M. B. Katan. 1988. Serum lathosterol concentration is an indicator of whole-body cholesterol synthesis in humans. J. Lipid Res. 29: 1149-155.
    • (1988) J. Lipid Res. , vol.29 , pp. 1149-1155
    • Kempen, H.J.1    Glatz, J.F.2    Leuven, J.A.G.3    Van Der Voort, H.A.4    Katan, M.B.5
  • 52
    • 0024523769 scopus 로고
    • Determination of serum levels of unesterified lathosterol by isotope dilution-mass spectrometry
    • Lund, E., L. Sisfontes, E. Reihner, and I. Bjorkhem. 1989. Determination of serum levels of unesterified lathosterol by isotope dilution-mass spectrometry. Scand. J. Clin. Lab. Invest. 49: 165-171.
    • (1989) Scand. J. Clin. Lab. Invest. , vol.49 , pp. 165-171
    • Lund, E.1    Sisfontes, L.2    Reihner, E.3    Bjorkhem, I.4
  • 53
    • 79951567907 scopus 로고    scopus 로고
    • Statins as neuroprotectants: A comparative in vitro study of lipophilicity, blood-brain-barrier penetration, lowering of brain cholesterol, and decrease of neuron cell death
    • Sierra, S., M. C. Ramos, P. Molina, C. Esteo, J. A. Vazquez, and J. S. Burgos. 2011. Statins as neuroprotectants: a comparative in vitro study of lipophilicity, blood-brain-barrier penetration, lowering of brain cholesterol, and decrease of neuron cell death. J. Alzheimers Dis. 23: 307-318.
    • (2011) J. Alzheimers Dis. , vol.23 , pp. 307-318
    • Sierra, S.1    Ramos, M.C.2    Molina, P.3    Esteo, C.4    Vazquez, J.A.5    Burgos, J.S.6
  • 56
    • 84893122681 scopus 로고    scopus 로고
    • Effects of simvastatin on retinal structure and function of a high-fat atherogenic mouse model of thickened Bruch's membrane
    • Barathi, V. A., S. W. Yeo, R. H. Guymer, T. Y. Wong, and C. D. Luu. 2014. Effects of simvastatin on retinal structure and function of a high-fat atherogenic mouse model of thickened Bruch's membrane. Invest. Ophthalmol. Vis. Sci. 55: 460-468.
    • (2014) Invest. Ophthalmol. Vis. Sci. , vol.55 , pp. 460-468
    • Barathi, V.A.1    Yeo, S.W.2    Guymer, R.H.3    Wong, T.Y.4    Luu, C.D.5
  • 59
    • 27644468991 scopus 로고    scopus 로고
    • The pleiotropic effects of statins
    • Calabrò, P., and E. T. Yeh. 2005. The pleiotropic effects of statins. Curr. Opin. Cardiol. 20: 541-546.
    • (2005) Curr. Opin. Cardiol. , vol.20 , pp. 541-546
    • Calabrò, P.1    Yeh, E.T.2
  • 60
    • 3142654791 scopus 로고    scopus 로고
    • Ubiquitination of 3-hy-droxy-3-methylglutaryl-CoA reductase in permeabilized cells mediated by cytosolic E1 and a putative membrane-bound ubiquitin ligase
    • Song, B. L., and R. A. DeBose-Boyd. 2004. Ubiquitination of 3-hy-droxy-3-methylglutaryl-CoA reductase in permeabilized cells mediated by cytosolic E1 and a putative membrane-bound ubiquitin ligase. J. Biol. Chem. 279: 28798-28806.
    • (2004) J. Biol. Chem. , vol.279 , pp. 28798-28806
    • Song, B.L.1    DeBose-Boyd, R.A.2
  • 61
    • 0021320638 scopus 로고
    • Hydroxylations in biosynthesis of bile acids. Isolation of a cytochrome P-450 from rabbit liver mitochondria catalyzing 26-hydroxylation of C27-steroids
    • Wikvall, K. 1984. Hydroxylations in biosynthesis of bile acids. Isolation of a cytochrome P-450 from rabbit liver mitochondria catalyzing 26-hydroxylation of C27-steroids. J. Biol. Chem. 259: 3800-3804.
    • (1984) J. Biol. Chem. , vol.259 , pp. 3800-3804
    • Wikvall, K.1
  • 64
    • 77949905582 scopus 로고    scopus 로고
    • Liver X receptor modulators: A review of recently patented compounds (2007-2009)
    • Li, X., V. Yeh, and V. Molteni. 2010. Liver X receptor modulators: a review of recently patented compounds (2007-2009). Expert Opin. Ther. Pat. 20: 535-562.
    • (2010) Expert Opin. Ther. Pat. , vol.20 , pp. 535-562
    • Li, X.1    Yeh, V.2    Molteni, V.3
  • 65
    • 84862687669 scopus 로고    scopus 로고
    • Liver X receptor biology and pharmacology: New pathways, challenges and opportunities
    • Jakobsson, T., E. Treuter, J. A. Gustafsson, and K. R. Steffensen. 2012. Liver X receptor biology and pharmacology: new pathways, challenges and opportunities. Trends Pharmacol. Sci. 33: 394-404.
    • (2012) Trends Pharmacol. Sci. , vol.33 , pp. 394-404
    • Jakobsson, T.1    Treuter, E.2    Gustafsson, J.A.3    Steffensen, K.R.4
  • 67
    • 84893682384 scopus 로고    scopus 로고
    • Pharmacologic stimulation of cytochrome P450 46A1 and cerebral cholesterol turnover in mice
    • Mast, N., Y. Li, M. Linger, M. Clark, J. Wiseman, and I. A. Pikuleva. 2014. Pharmacologic stimulation of cytochrome P450 46A1 and cerebral cholesterol turnover in mice. J. Biol. Chem. 289: 3529-3538.
    • (2014) J. Biol. Chem. , vol.289 , pp. 3529-3538
    • Mast, N.1    Li, Y.2    Linger, M.3    Clark, M.4    Wiseman, J.5    Pikuleva, I.A.6
  • 68
    • 0033594903 scopus 로고    scopus 로고
    • cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain
    • Lund, E. G., J. M. Guileyardo, and D. W. Russell. 1999. cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain. Proc. Natl. Acad. Sci. USA. 96: 7238-7243.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 7238-7243
    • Lund, E.G.1    Guileyardo, J.M.2    Russell, D.W.3
  • 70
    • 0034684235 scopus 로고    scopus 로고
    • Lipocalins as a scaffold
    • Skerra, A. 2000. Lipocalins as a scaffold. Biochim. Biophys. Acta. 1482: 337-350.
    • (2000) Biochim. Biophys. Acta , vol.1482 , pp. 337-350
    • Skerra, A.1
  • 71
    • 35649024789 scopus 로고    scopus 로고
    • Structural insight into the dual ligand specificity and mode of high density lipoprotein association of apolipoprotein D
    • Eichinger, A., A. Nasreen, H. J. Kim, and A. Skerra. 2007. Structural insight into the dual ligand specificity and mode of high density lipoprotein association of apolipoprotein D. J. Biol. Chem. 282: 31068-31075.
    • (2007) J. Biol. Chem. , vol.282 , pp. 31068-31075
    • Eichinger, A.1    Nasreen, A.2    Kim, H.J.3    Skerra, A.4
  • 72
    • 0035218011 scopus 로고    scopus 로고
    • Immunocytochemical localization of apolipoprotein D in oligodendrocyte precursor-like cells, perivascular cells, and pericytes in the human cerebral cortex
    • Hu, C. Y., W. Y. Ong, R. K. Sundaram, C. Chan, and S. C. Patel. 2001. Immunocytochemical localization of apolipoprotein D in oligodendrocyte precursor-like cells, perivascular cells, and pericytes in the human cerebral cortex. J. Neurocytol. 30: 209-218.
    • (2001) J. Neurocytol. , vol.30 , pp. 209-218
    • Hu, C.Y.1    Ong, W.Y.2    Sundaram, R.K.3    Chan, C.4    Patel, S.C.5
  • 73
    • 70350495437 scopus 로고    scopus 로고
    • Absence of ApoE upregulates murine brain ApoD and ABCA1 levels, but does not affect brain sterol levels, while human ApoE3 and human ApoE4 upregulate brain cholesterol precursor levels
    • Jansen, P. J., D. Lutjohann, K. M. Thelen, K. von Bergmann, F. van Leuven, F. C. Ramaekers, and M. Monique. 2009. Absence of ApoE upregulates murine brain ApoD and ABCA1 levels, but does not affect brain sterol levels, while human ApoE3 and human ApoE4 upregulate brain cholesterol precursor levels. J. Alzheimers Dis. 18: 319-329.
    • (2009) J. Alzheimers Dis. , vol.18 , pp. 319-329
    • Jansen, P.J.1    Lutjohann, D.2    Thelen, K.M.3    Von Bergmann, K.4    Van Leuven, F.5    Ramaekers, F.C.6    Monique, M.7
  • 74
    • 0029917168 scopus 로고    scopus 로고
    • Apolipoprotein E is synthesized in the retina by Muller glial cells, secreted into the vitreous, and rapidly transported into the optic nerve by retinal ganglion cells
    • Amaratunga, A., C. R. Abraham, R. B. Edwards, J. H. Sandell, B. M. Schreiber, and R. E. Fine. 1996. Apolipoprotein E is synthesized in the retina by Muller glial cells, secreted into the vitreous, and rapidly transported into the optic nerve by retinal ganglion cells. J. Biol. Chem. 271: 5628-5632.
    • (1996) J. Biol. Chem. , vol.271 , pp. 5628-5632
    • Amaratunga, A.1    Abraham, C.R.2    Edwards, R.B.3    Sandell, J.H.4    Schreiber, B.M.5    Fine, R.E.6
  • 75
    • 0010355584 scopus 로고    scopus 로고
    • Changes in CD44 and ApoE immunoreactivities due to retinal pathology of man and rat
    • Kuhrt, H., W. Hartig, D. Grimm, F. Faude, M. Kasper, and A. Reichenbach. 1997. Changes in CD44 and ApoE immunoreactivities due to retinal pathology of man and rat. J. Hirnforsch. 38: 223-229.
    • (1997) J. Hirnforsch. , vol.38 , pp. 223-229
    • Kuhrt, H.1    Hartig, W.2    Grimm, D.3    Faude, F.4    Kasper, M.5    Reichenbach, A.6
  • 77
    • 0035008434 scopus 로고    scopus 로고
    • Local cellular sources of apolipoprotein E in the human retina and retinal pigmented epithelium: Implications for the process of drusen formation
    • Anderson, D. H., S. Ozaki, M. Nealon, J. Neitz, R. F. Mullins, G. S. Hageman, and L. V. Johnson. 2001. Local cellular sources of apolipoprotein E in the human retina and retinal pigmented epithelium: implications for the process of drusen formation. Am. J. Ophthalmol. 131: 767-781.
    • (2001) Am. J. Ophthalmol. , vol.131 , pp. 767-781
    • Anderson, D.H.1    Ozaki, S.2    Nealon, M.3    Neitz, J.4    Mullins, R.F.5    Hageman, G.S.6    Johnson, L.V.7
  • 78
    • 33750613413 scopus 로고    scopus 로고
    • Intraretinal lipid transport is dependent on high density lipoprotein-like particles and class B scavenger receptors
    • Tserentsoodol, N., N. V. Gordiyenko, I. Pascual, J. W. Lee, S. J. Fliesler, and I. R. Rodriguez. 2006. Intraretinal lipid transport is dependent on high density lipoprotein-like particles and class B scavenger receptors. Mol. Vis. 12: 1319-1333.
    • (2006) Mol. Vis. , vol.12 , pp. 1319-1333
    • Tserentsoodol, N.1    Gordiyenko, N.V.2    Pascual, I.3    Lee, J.W.4    Fliesler, S.J.5    Rodriguez, I.R.6
  • 79
    • 77954620409 scopus 로고    scopus 로고
    • Membrane-binding and enzymatic properties of RPE65
    • Kiser, P. D., and K. Palczewski. 2010. Membrane-binding and enzymatic properties of RPE65. Prog. Retin. Eye Res. 29: 428-442.
    • (2010) Prog. Retin. Eye Res. , vol.29 , pp. 428-442
    • Kiser, P.D.1    Palczewski, K.2
  • 80
    • 19544385387 scopus 로고    scopus 로고
    • The role of cholesterol in rod outer segment membranes
    • Albert, A. D., and K. Boesze-Battaglia. 2005. The role of cholesterol in rod outer segment membranes. Prog. Lipid Res. 44: 99-124.
    • (2005) Prog. Lipid Res. , vol.44 , pp. 99-124
    • Albert, A.D.1    Boesze-Battaglia, K.2
  • 81
    • 84902144481 scopus 로고    scopus 로고
    • Constitutively active rhodopsin and retinal disease
    • Park, P. S. 2014. Constitutively active rhodopsin and retinal disease. Adv. Pharmacol. 70: 1-36.
    • (2014) Adv. Pharmacol. , vol.70 , pp. 1-36
    • Park, P.S.1


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