-
1
-
-
67650751079
-
Cholesterol 24-hydroxylase: An enzyme of cholesterol turnover in the brain
-
Russell, D. W., Halford, R. W., Ramirez, D. M., Shah, R., and Kotti, T. (2009) Cholesterol 24-hydroxylase: an enzyme of cholesterol turnover in the brain. Annu. Rev. Biochem. 78, 1017-1040
-
(2009)
Annu. Rev. Biochem.
, vol.78
, pp. 1017-1040
-
-
Russell, D.W.1
Halford, R.W.2
Ramirez, D.M.3
Shah, R.4
Kotti, T.5
-
2
-
-
41549141257
-
Neuronal expression and subcellular localization of cholesterol 24-hydroxylase in the mouse brain
-
Ramirez, D. M., Andersson, S., and Russell, D. W. (2008) Neuronal expression and subcellular localization of cholesterol 24-hydroxylase in the mouse brain. J. Comp. Neurol. 507, 1676-1693
-
(2008)
J. Comp. Neurol.
, vol.507
, pp. 1676-1693
-
-
Ramirez, D.M.1
Andersson, S.2
Russell, D.W.3
-
3
-
-
33751096969
-
Crossing the barrier: Oxysterols as cholesterol transporters and metabolic modulators in the brain
-
Björkhem, I. (2006) Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain. J. Intern. Med. 260, 493-508
-
(2006)
J. Intern. Med.
, vol.260
, pp. 493-508
-
-
Björkhem, I.1
-
4
-
-
0036916491
-
On the rate of translocation in vitro and kinetics in vivo of the major oxysterols in human circulation: Critical importance of the position of the oxygen function
-
Meaney, S., Bodin, K., Diczfalusy, U., and Björkhem, I. (2002) On the rate of translocation in vitro and kinetics in vivo of the major oxysterols in human circulation: critical importance of the position of the oxygen function. J. Lipid Res. 43, 2130-2135
-
(2002)
J. Lipid Res.
, vol.43
, pp. 2130-2135
-
-
Meaney, S.1
Bodin, K.2
Diczfalusy, U.3
Björkhem, I.4
-
5
-
-
0031860570
-
Transport of side-chain oxidized oxysterols in the human circulation
-
Babiker, A., and Diczfalusy, U. (1998) Transport of side-chain oxidized oxysterols in the human circulation. Biochim. Biophys. Acta 1392, 333-339
-
(1998)
Biochim. Biophys. Acta
, vol.1392
, pp. 333-339
-
-
Babiker, A.1
Diczfalusy, U.2
-
6
-
-
0031848338
-
Cholesterol homeostasis in human brain: Turnover of 24s- hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation
-
Björkhem, I., Lütjohann, D., Diczfalusy, U., Stahle, L., Ahlborg, G., and Wahren, J. (1998) Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation. J. Lipid Res. 39, 1594-1600
-
(1998)
J. Lipid Res.
, vol.39
, pp. 1594-1600
-
-
Björkhem, I.1
Lütjohann, D.2
Diczfalusy, U.3
Stahle, L.4
Ahlborg, G.5
Wahren, J.6
-
7
-
-
0038265008
-
Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover
-
Lund, E. G., Xie, C., Kotti, T., Turley, S. D., Dietschy, J. M., and Russell, D. W. (2003) Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover. J. Biol. Chem. 278, 22980-22988
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 22980-22988
-
-
Lund, E.G.1
Xie, C.2
Kotti, T.3
Turley, S.D.4
Dietschy, J.M.5
Russell, D.W.6
-
8
-
-
33644868456
-
Brain cholesterol turnover required for geranylgeraniol production and learning in mice
-
Kotti, T. J., Ramirez, D. M., Pfeiffer, B. E., Huber, K. M., and Russell, D. W. (2006) Brain cholesterol turnover required for geranylgeraniol production and learning in mice. Proc. Natl. Acad. Sci. U.S.A. 103, 3869-3874
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, pp. 3869-3874
-
-
Kotti, T.J.1
Ramirez, D.M.2
Pfeiffer, B.E.3
Huber, K.M.4
Russell, D.W.5
-
9
-
-
80052965098
-
Enhanced production of 24s-hydroxycholesterol is not sufficient to drive liver x receptor target genes in vivo
-
Shafaati, M., Olin, M., Bavner, A., Pettersson, H., Rozell, B., Meaney, S., Parini, P., and Björkhem, I. (2011) Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo. J. Intern. Med. 270, 377-387
-
(2011)
J. Intern. Med.
, vol.270
, pp. 377-387
-
-
Shafaati, M.1
Olin, M.2
Bavner, A.3
Pettersson, H.4
Rozell, B.5
Meaney, S.6
Parini, P.7
Björkhem, I.8
-
10
-
-
84880499466
-
Is it possible to improve memory function by upregulation of the cholesterol 24s-hydroxylase (cyp46a1) in the brain?
-
Maioli, S., Bavner, A., Ali, Z., Heverin, M., Ismail, M. A., Puerta, E., Olin, M., Saeed, A., Shafaati, M., Parini, P., Cedazo-Minguez, A., and Björkhem, I. (2013) Is it possible to improve memory function by upregulation of the cholesterol 24S-hydroxylase (CYP46A1) in the brain? PLoS ONE 8, e68534
-
(2013)
PLoS ONE
, vol.8
-
-
Maioli, S.1
Bavner, A.2
Ali, Z.3
Heverin, M.4
Ismail, M.A.5
Puerta, E.6
Olin, M.7
Saeed, A.8
Shafaati, M.9
Parini, P.10
Cedazo-Minguez, A.11
Björkhem, I.12
-
11
-
-
74149083432
-
Adeno-Associated virus gene therapy with cholesterol 24-hydroxylase reduces the amyloid pathology before or after the onset of amyloid plaques in mouse models of alzheimer's disease
-
Hudry, E., Van Dam, D., Kulik, W., De Deyn, P. P., Stet, F. S., Ahouansou, O., Benraiss, A., Delacourte, A., Bougnéres, P., Aubourg, P., and Cartier, N. (2010) Adeno-Associated virus gene therapy with cholesterol 24-hydroxylase reduces the amyloid pathology before or after the onset of amyloid plaques in mouse models of Alzheimer's disease. Mol. Ther. 18, 44-53
-
(2010)
Mol. Ther.
, vol.18
, pp. 44-53
-
-
Hudry, E.1
Van Dam, D.2
Kulik, W.3
De Deyn, P.P.4
Stet, F.S.5
Ahouansou, O.6
Benraiss, A.7
Delacourte, A.8
Bougnéres, P.9
Aubourg, P.10
Cartier, N.11
-
12
-
-
77649259094
-
Acat1 gene ablation increases 24(s)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with ad
-
Bryleva, E. Y., Rogers, M. A., Chang, C. C., Buen, F., Harris, B. T., Rousselet, E., Seidah, N. G., Oddo, S., LaFerla, F. M., Spencer, T. A., Hickey, W. F., and Chang, T. Y. (2010) ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD. Proc. Natl. Acad. Sci. U.S.A. 107, 3081-3086
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, pp. 3081-3086
-
-
Bryleva, E.Y.1
Rogers, M.A.2
Chang, C.C.3
Buen, F.4
Harris, B.T.5
Rousselet, E.6
Seidah, N.G.7
Oddo, S.8
LaFerla, F.M.9
Spencer, T.A.10
Hickey, W.F.11
Chang, T.Y.12
-
13
-
-
0033594903
-
Cdna cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain
-
Lund, E. G., Guileyardo, J. M., and Russell, D. W. (1999) cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain. Proc. Natl. Acad. Sci. U.S.A. 96, 7238-7243
-
(1999)
Proc. Natl. Acad. Sci. U.S.A.
, vol.96
, pp. 7238-7243
-
-
Lund, E.G.1
Guileyardo, J.M.2
Russell, D.W.3
-
14
-
-
47749117627
-
Crystal structures of substrate-bound and substratefree cytochrome p450 46a1, the principal cholesterol hydroxylase in the brain
-
Mast, N., White, M. A., Björkhem, I., Johnson, E. F., Stout, C. D., and Pikuleva, I. A. (2008) Crystal structures of substrate-bound and substratefree cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain. Proc. Natl. Acad. Sci. U.S.A. 105, 9546-9551
-
(2008)
Proc. Natl. Acad. Sci. U.S.A.
, vol.105
, pp. 9546-9551
-
-
Mast, N.1
White, M.A.2
Björkhem, I.3
Johnson, E.F.4
Stout, C.D.5
Pikuleva, I.A.6
-
15
-
-
77957791628
-
Structural basis of drug binding to cyp46a1, an enzyme that controls cholesterol turnover in the brain
-
Mast, N., Charvet, C., Pikuleva, I. A., and Stout, C. D. (2010) Structural basis of drug binding to CYP46A1, an enzyme that controls cholesterol turnover in the brain. J. Biol. Chem. 285, 31783-31795
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 31783-31795
-
-
Mast, N.1
Charvet, C.2
Pikuleva, I.A.3
Stout, C.D.4
-
16
-
-
84867763896
-
In silico and intuitive predictions of cyp46a1 inhibition by marketed drugs with subsequent enzyme crystallization in complex with fluvoxamine
-
Mast, N., Linger, M., Clark, M., Wiseman, J., Stout, C. D., and Pikuleva, I. A. (2012) In silico and intuitive predictions of CYP46A1 inhibition by marketed drugs with subsequent enzyme crystallization in complex with fluvoxamine. Mol. Pharmacol. 82, 824-834
-
(2012)
Mol. Pharmacol.
, vol.82
, pp. 824-834
-
-
Mast, N.1
Linger, M.2
Clark, M.3
Wiseman, J.4
Stout, C.D.5
Pikuleva, I.A.6
-
17
-
-
43249093431
-
Use of complementary cation and anion heavy-Atom salt derivatives to solve the structure of cytochrome p450 46a1
-
White, M. A., Mast, N., Björkhem, I., Johnson, E. F., Stout, C. D., and Pikuleva, I. A. (2008) Use of complementary cation and anion heavy-Atom salt derivatives to solve the structure of cytochrome P450 46A1. Acta Crystallogr. D. Biol. Crystallogr. 64, 487-495
-
(2008)
Acta Crystallogr. D. Biol. Crystallogr.
, vol.64
, pp. 487-495
-
-
White, M.A.1
Mast, N.2
Björkhem, I.3
Johnson, E.F.4
Stout, C.D.5
Pikuleva, I.A.6
-
18
-
-
79952465940
-
Cholestenoic acid is an important elimination product of cholesterol in the retina: Comparison of retinal cholesterol metabolism with that in the brain
-
Mast, N., Reem, R., Bederman, I., Huang, S., DiPatre, P. L., Björkhem, I., and Pikuleva, I. A. (2011) Cholestenoic acid is an important elimination product of cholesterol in the retina: comparison of retinal cholesterol metabolism with that in the brain. Invest. Ophthalmol. Vis. Sci. 52, 594-603
-
(2011)
Invest. Ophthalmol. Vis. Sci.
, vol.52
, pp. 594-603
-
-
Mast, N.1
Reem, R.2
Bederman, I.3
Huang, S.4
DiPatre, P.L.5
Björkhem, I.6
Pikuleva, I.A.7
-
19
-
-
3042683304
-
Expression of human cytochrome p450 46a1 in escherichia coli: Effects of n-And c-terminal modifications
-
Mast, N., Andersson, U., Nakayama, K., Björkhem, I., and Pikuleva, I. A. (2004) Expression of human cytochrome P450 46A1 in Escherichia coli: effects of N-And C-terminal modifications. Arch. Biochem. Biophys. 428, 99-108
-
(2004)
Arch. Biochem. Biophys.
, vol.428
, pp. 99-108
-
-
Mast, N.1
Andersson, U.2
Nakayama, K.3
Björkhem, I.4
Pikuleva, I.A.5
-
20
-
-
84874036519
-
Binding of a cyano-And fluoro-containing drug bicalutamide to cytochrome p45046a1: Unusual features and spectral response
-
Mast, N., Zheng, W., Stout, C. D., and Pikuleva, I. A. (2013) Binding of a cyano-And fluoro-containing drug bicalutamide to cytochrome P450 46A1: unusual features and spectral response. J. Biol. Chem. 288, 4613-4624
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 4613-4624
-
-
Mast, N.1
Zheng, W.2
Stout, C.D.3
Pikuleva, I.A.4
-
21
-
-
69549135452
-
Fragment-based computation of binding free energies by systematic sampling
-
Clark, M., Meshkat, S., Talbot, G. T., Carnevali, P., and Wiseman, J. S. (2009) Fragment-based computation of binding free energies by systematic sampling. J. Chem. Inf. Model. 49, 1901-1913
-
(2009)
J. Chem. Inf. Model.
, vol.49
, pp. 1901-1913
-
-
Clark, M.1
Meshkat, S.2
Talbot, G.T.3
Carnevali, P.4
Wiseman, J.S.5
-
22
-
-
77950629442
-
Marked variability in hepatic expression of cytochromes cyp7a1 and cyp27a1 as compared to cerebral cyp46a1. Lessons from a dietary study with omega 3 fatty acids in hamsters
-
Mast, N., Shafaati, M., Zaman, W., Zheng, W., Prusak, D., Wood, T., Ansari, G. A., Lövgren-Sandblom, A., Olin, M., Björkhem, I., and Pikuleva, I. (2010) Marked variability in hepatic expression of cytochromes CYP7A1 and CYP27A1 as compared to cerebral CYP46A1. Lessons from a dietary study with omega 3 fatty acids in hamsters. Biochim. Biophys. Acta 1801, 674-681
-
(2010)
Biochim. Biophys. Acta
, vol.1801
, pp. 674-681
-
-
Mast, N.1
Shafaati, M.2
Zaman, W.3
Zheng, W.4
Prusak, D.5
Wood, T.6
Ansari, G.A.7
Lövgren-Sandblom, A.8
Olin, M.9
Björkhem, I.10
Pikuleva, I.11
-
23
-
-
0028816863
-
Determination of cholesterol oxidation products in human plasma by isotope dilution-mass spectrometry
-
Dzeletovic, S., Breuer, O., Lund, E., and Diczfalusy, U. (1995) Determination of cholesterol oxidation products in human plasma by isotope dilution-mass spectrometry. Anal. Biochem. 225, 73-80
-
(1995)
Anal. Biochem.
, vol.225
, pp. 73-80
-
-
Dzeletovic, S.1
Breuer, O.2
Lund, E.3
Diczfalusy, U.4
-
24
-
-
84862534271
-
Sample prefractionation for mass spectrometry quantification of low-Abundance membrane proteins
-
Wang, M., Heo, G.-Y., Omarova, S., Pikuleva, I. A., and Turko, I. V. (2012) Sample prefractionation for mass spectrometry quantification of low-Abundance membrane proteins. Anal. Chem. 84, 5186-5191
-
(2012)
Anal. Chem.
, vol.84
, pp. 5186-5191
-
-
Wang, M.1
Heo, G.-Y.2
Omarova, S.3
Pikuleva, I.A.4
Turko, I.V.5
-
25
-
-
33745125951
-
Spectral analyses of cytochromes p450
-
Schenkman, J. B., and Jansson, I. (2006) Spectral analyses of cytochromes P450. Methods Mol. Biol. 320, 11-18
-
(2006)
Methods Mol. Biol.
, vol.320
, pp. 11-18
-
-
Schenkman, J.B.1
Jansson, I.2
-
26
-
-
0013891410
-
Drug interaction with hepatic microsomal cytochrome
-
Remmer, H., Schenkman, J., Estabrook, R. W., Sasame, H., Gillette, J., Narasimhulu, S., Cooper, D. Y., and Rosenthal, O. (1966) Drug interaction with hepatic microsomal cytochrome. Mol. Pharmacol. 2, 187-190
-
(1966)
Mol. Pharmacol.
, vol.2
, pp. 187-190
-
-
Remmer, H.1
Schenkman, J.2
Estabrook, R.W.3
Sasame, H.4
Gillette, J.5
Narasimhulu, S.6
Cooper, D.Y.7
Rosenthal, O.8
-
27
-
-
0014059179
-
Spectral studies of drug interaction with hepatic microsomal cytochrome
-
Schenkman, J. B., Remmer, H., and Estabrook, R. W. (1967) Spectral studies of drug interaction with hepatic microsomal cytochrome. Mol. Pharmacol. 3, 113-123
-
(1967)
Mol. Pharmacol.
, vol.3
, pp. 113-123
-
-
Schenkman, J.B.1
Remmer, H.2
Estabrook, R.W.3
-
28
-
-
0023645035
-
High-resolution crystal structure of cytochrome p450cam
-
Poulos, T. L., Finzel, B. C., and Howard, A. J. (1987) High-resolution crystal structure of cytochrome P450cam. J. Mol. Biol. 195, 687-700
-
(1987)
J. Mol. Biol.
, vol.195
, pp. 687-700
-
-
Poulos, T.L.1
Finzel, B.C.2
Howard, A.J.3
-
29
-
-
0020478791
-
Spectroscopic investigations of ferric cytochrome p-450-cam ligand complexes. Identification of the ligand trans to cysteinate in the native enzyme
-
Dawson, J. H., Andersson, L. A., and Sono, M. (1982) Spectroscopic investigations of ferric cytochrome P-450-CAM ligand complexes. Identification of the ligand trans to cysteinate in the native enzyme. J. Biol. Chem. 257, 3606-3617
-
(1982)
J. Biol. Chem.
, vol.257
, pp. 3606-3617
-
-
Dawson, J.H.1
Andersson, L.A.2
Sono, M.3
-
30
-
-
0023583624
-
Crystal structures of metyraponeand phenylimidazole-inhibited complexes of cytochrome p-450cam
-
Poulos, T. L., and Howard, A. J. (1987) Crystal structures of metyraponeand phenylimidazole-inhibited complexes of cytochrome P-450cam. Biochemistry 26, 8165-8174
-
(1987)
Biochemistry
, vol.26
, pp. 8165-8174
-
-
Poulos, T.L.1
Howard, A.J.2
-
31
-
-
0014427423
-
Effect of drug substrates on the reduction of hepatic microsomal cytochrome p-450 by nadph
-
Gigon, P. L., Gram, T. E., and Gillette, J. R. (1968) Effect of drug substrates on the reduction of hepatic microsomal cytochrome P-450 by NADPH. Biochem. Biophys. Res. Commun. 31, 558-562
-
(1968)
Biochem. Biophys. Res. Commun.
, vol.31
, pp. 558-562
-
-
Gigon, P.L.1
Gram, T.E.2
Gillette, J.R.3
-
32
-
-
0030768931
-
The hill equation revisited: Uses and misuses
-
Weiss, J. N. (1997) The Hill equation revisited: uses and misuses. FASEB J. 11, 835-841
-
(1997)
FASEB J.
, vol.11
, pp. 835-841
-
-
Weiss, J.N.1
-
33
-
-
0024523769
-
Determination of serum levels of unesterified lathosterol by isotope dilution-mass spectrometry
-
Lund, E., Sisfontes, L., Reihner, E., and Björkhem, I. (1989) Determination of serum levels of unesterified lathosterol by isotope dilution-mass spectrometry. Scand. J. Clin. Lab. Invest. 49, 165-171
-
(1989)
Scand. J. Clin. Lab. Invest.
, vol.49
, pp. 165-171
-
-
Lund, E.1
Sisfontes, L.2
Reihner, E.3
Björkhem, I.4
-
34
-
-
84862076431
-
Role of carglumic acid in the treatment of acute hyperammonemia due to n-Acetylglutamate synthase deficiency
-
Häberle, J. (2011) Role of carglumic acid in the treatment of acute hyperammonemia due to N-Acetylglutamate synthase deficiency. Ther. Clin. Risk Manag. 7, 327-332
-
(2011)
Ther. Clin. Risk Manag.
, vol.7
, pp. 327-332
-
-
Häberle, J.1
-
35
-
-
79955605398
-
Research and development of glucokinase activators for diabetes therapy: Theoretical and practical aspects
-
Matschinsky, F. M., Zelent, B., Doliba, N. M., Kaestner, K. H., Vanderkooi, J. M., Grimsby, J., Berthel, S. J., and Sarabu, R. (2011) Research and development of glucokinase activators for diabetes therapy: theoretical and practical aspects. Handb. Exp. Pharmacol. 203, 357-401
-
(2011)
Handb. Exp. Pharmacol.
, vol.203
, pp. 357-401
-
-
Matschinsky, F.M.1
Zelent, B.2
Doliba, N.M.3
Kaestner, K.H.4
Vanderkooi, J.M.5
Grimsby, J.6
Berthel, S.J.7
Sarabu, R.8
-
36
-
-
78751663378
-
Sirt1 modulation as a novel approach to the treatment of diseases of aging
-
Blum, C. A., Ellis, J. L., Loh, C., Ng, P. Y., Perni, R. B., and Stein, R. L. (2011) SIRT1 modulation as a novel approach to the treatment of diseases of aging. J. Med. Chem. 54, 417-432
-
(2011)
J. Med. Chem.
, vol.54
, pp. 417-432
-
-
Blum, C.A.1
Ellis, J.L.2
Loh, C.3
Ng, P.Y.4
Perni, R.B.5
Stein, R.L.6
-
37
-
-
0037076706
-
Neurologic and psychiatric complications of antiretroviral agents
-
Treisman, G. J., and Kaplin, A. I. (2002) Neurologic and psychiatric complications of antiretroviral agents. AIDS 16, 1201-1215
-
(2002)
AIDS
, vol.16
, pp. 1201-1215
-
-
Treisman, G.J.1
Kaplin, A.I.2
-
38
-
-
3543104951
-
Thematic review series: Brain lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal
-
Dietschy, J. M., and Turley, S. D. (2004) Thematic review series: brain lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal. J. Lipid Res. 45, 1375-1397
-
(2004)
J. Lipid Res.
, vol.45
, pp. 1375-1397
-
-
Dietschy, J.M.1
Turley, S.D.2
-
39
-
-
37549037886
-
Liver x receptor activation enhances cholesterol loss from the brain, decreases neuroinflammation, and increases survival of the npc1 mouse
-
Repa, J. J., Li, H., Frank-Cannon, T. C., Valasek, M. A., Turley, S. D., Tansey, M. G., and Dietschy, J. M. (2007) Liver X receptor activation enhances cholesterol loss from the brain, decreases neuroinflammation, and increases survival of the NPC1 mouse. J. Neurosci. 27, 14470-14480
-
(2007)
J. Neurosci.
, vol.27
, pp. 14470-14480
-
-
Repa, J.J.1
Li, H.2
Frank-Cannon, T.C.3
Valasek, M.A.4
Turley, S.D.5
Tansey, M.G.6
Dietschy, J.M.7
-
40
-
-
79958773215
-
Liver x receptor activation restores memory in aged ad mice without reducing amyloid
-
Vanmierlo, T., Rutten, K., Dederen, J., Bloks, V. W., van Vark-Van der Zee, L. C., Kuipers, F., Kiliaan, A., Blokland, A., Sijbrands, E. J., Steinbusch, H., Prickaerts, J., Lütjohann, D., and Mulder, M. (2011) Liver X receptor activation restores memory in aged AD mice without reducing amyloid. Neurobiol. Aging 32, 1262-1272
-
(2011)
Neurobiol. Aging
, vol.32
, pp. 1262-1272
-
-
Vanmierlo, T.1
Rutten, K.2
Dederen, J.3
Bloks, V.W.4
Van Vark-Van Der Zee, L.C.5
Kuipers, F.6
Kiliaan, A.7
Blokland, A.8
Sijbrands, E.J.9
Steinbusch, H.10
Prickaerts, J.11
Lütjohann, D.12
Mulder, M.13
-
41
-
-
1842424448
-
Liver x receptors as potential therapeutic targets for multiple diseases
-
Cao, G., Liang, Y., Jiang, X. C., and Eacho, P. I. (2004) Liver X receptors as potential therapeutic targets for multiple diseases. Drug News Perspect. 17, 35-41
-
(2004)
Drug News Perspect.
, vol.17
, pp. 35-41
-
-
Cao, G.1
Liang, Y.2
Jiang, X.C.3
Eacho, P.I.4
-
42
-
-
33645240965
-
Studies on the transcriptional regulation of cholesterol 24-hydroxylase (cyp46a1). Marked insensitivity toward different regulatory axes
-
Ohyama, Y., Meaney, S., Heverin, M., Ekström, L., Brafman, A., Shafir, M., Andersson, U., Olin, M., Eggertsen, G., Diczfalusy, U., Feinstein, E., and Björkhem, I. (2006) Studies on the transcriptional regulation of cholesterol 24-hydroxylase (CYP46A1). Marked insensitivity toward different regulatory axes. J. Biol. Chem. 281, 3810-3820
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 3810-3820
-
-
Ohyama, Y.1
Meaney, S.2
Heverin, M.3
Ekström, L.4
Brafman, A.5
Shafir, M.6
Andersson, U.7
Olin, M.8
Eggertsen, G.9
Diczfalusy, U.10
Feinstein, E.11
Björkhem, I.12
-
43
-
-
79951533845
-
Quantification of cholesterol-metabolizing p450s cyp27a1 and cyp46a1 in neural tissues reveals a lack of enzyme-product correlations in human retina but not human brain
-
Liao, W.-L., Heo, G.-Y., Dodder, N. G., Reem, R. E., Mast, N., Huang, S., DiPatre, P. L., Turko, I. V., and Pikuleva, I. A. (2011) Quantification of cholesterol-metabolizing P450s CYP27A1 and CYP46A1 in neural tissues reveals a lack of enzyme-product correlations in human retina but not human brain. J. Proteome Res. 10, 241-248
-
(2011)
J. Proteome Res.
, vol.10
, pp. 241-248
-
-
Liao, W.-L.1
Heo, G.-Y.2
Dodder, N.G.3
Reem, R.E.4
Mast, N.5
Huang, S.6
DiPatre, P.L.7
Turko, I.V.8
Pikuleva, I.A.9
-
44
-
-
75149179231
-
Alterations in brain cholesterol metabolism in the appslxps1mut mouse, a model for alzheimer's disease
-
Vanmierlo, T., Bloks, V. W., van Vark-van der Zee, L. C., Rutten, K., Kerksiek, A., Friedrichs, S., Sijbrands, E., Steinbusch, H. W., Kuipers, F., Lütjohann, D., and Mulder, M. (2010) Alterations in brain cholesterol metabolism in the APPSLxPS1mut mouse, a model for Alzheimer's disease. J. Alzheimers Dis. 19, 117-127
-
(2010)
J. Alzheimers Dis.
, vol.19
, pp. 117-127
-
-
Vanmierlo, T.1
Bloks, V.W.2
Van Vark-Van Der Zee, L.C.3
Rutten, K.4
Kerksiek, A.5
Friedrichs, S.6
Sijbrands, E.7
Steinbusch, H.W.8
Kuipers, F.9
Lütjohann, D.10
Mulder, M.11
-
45
-
-
3042598691
-
Pxr and the regulation of apoa1 and hdl-cholesterol in rodents
-
Bachmann, K., Patel, H., Batayneh, Z., Slama, J., White, D., Posey, J., Ekins, S., Gold, D., and Sambucetti, L. (2004) PXR and the regulation of apoA1 and HDL-cholesterol in rodents. Pharmacol. Res. 50, 237-246
-
(2004)
Pharmacol. Res.
, vol.50
, pp. 237-246
-
-
Bachmann, K.1
Patel, H.2
Batayneh, Z.3
Slama, J.4
White, D.5
Posey, J.6
Ekins, S.7
Gold, D.8
Sambucetti, L.9
-
46
-
-
33845881481
-
Relative activation of human pregnane x receptor versus constitutive androstane receptor defines distinct classes of cyp2b6 and cyp3a4 inducers
-
Faucette, S. R., Zhang, T. C., Moore, R., Sueyoshi, T., Omiecinski, C. J., LeCluyse, E. L., Negishi, M., and Wang, H. (2007) Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers. J. Pharmacol. Exp. Ther. 320, 72-80
-
(2007)
J. Pharmacol. Exp. Ther.
, vol.320
, pp. 72-80
-
-
Faucette, S.R.1
Zhang, T.C.2
Moore, R.3
Sueyoshi, T.4
Omiecinski, C.J.5
LeCluyse, E.L.6
Negishi, M.7
Wang, H.8
-
47
-
-
67349213582
-
Effects of nevirapine and efavirenz on hdl cholesterol levels and reverse cholesterol transport in mice
-
Tohyama, J., Billheimer, J. T., Fuki, I. V., Rothblat, G. H., Rader, D. J., and Millar, J. S. (2009) Effects of nevirapine and efavirenz on HDL cholesterol levels and reverse cholesterol transport in mice. Atherosclerosis 204, 418-423
-
(2009)
Atherosclerosis
, vol.204
, pp. 418-423
-
-
Tohyama, J.1
Billheimer, J.T.2
Fuki, I.V.3
Rothblat, G.H.4
Rader, D.J.5
Millar, J.S.6
-
48
-
-
84868695746
-
Increase in standard cholesterol and large hdl particle subclasses in antiretroviral-naive patients prescribed efavirenz compared to atazanavir/ritonavir
-
Gotti, D., Cesana, B. M., Albini, L., Calabresi, A., Izzo, I., Focá, E., Motta, D., Bellagamba, R., Fezza, R., Narciso, P., Sighinolfi, L., Maggi, P., Brianese, N., Quiros-Roldan, E., Guaraldi, G., and Torti, C. (2012) Increase in standard cholesterol and large HDL particle subclasses in antiretroviral-naive patients prescribed efavirenz compared to atazanavir/ritonavir. HIV Clin. Trials 13, 245-255
-
(2012)
HIV Clin. Trials
, vol.13
, pp. 245-255
-
-
Gotti, D.1
Cesana, B.M.2
Albini, L.3
Calabresi, A.4
Izzo, I.5
Focá, E.6
Motta, D.7
Bellagamba, R.8
Fezza, R.9
Narciso, P.10
Sighinolfi, L.11
Maggi, P.12
Brianese, N.13
Quiros-Roldan, E.14
Guaraldi, G.15
Torti, C.16
-
49
-
-
59849110382
-
Combined use of mass spectrometry and heterologous expression for identification of membrane-interacting peptides in cytochrome p450 46a1 and nadphcytochrome p450 oxidoreductase
-
Mast, N., Liao, W.-L., Pikuleva, I. A., and Turko, I. V. (2009) Combined use of mass spectrometry and heterologous expression for identification of membrane-interacting peptides in cytochrome P450 46A1 and NADPHcytochrome P450 oxidoreductase. Arch. Biochem. Biophys. 483, 81-89
-
(2009)
Arch. Biochem. Biophys.
, vol.483
, pp. 81-89
-
-
Mast, N.1
Liao, W.-L.2
Pikuleva, I.A.3
Turko, I.V.4
-
50
-
-
84879070955
-
Antifungal azoles: Structural insights into undesired tight binding to cholesterol-metabolizing cyp46a1
-
Mast, N., Zheng, W., Stout, C. D., and Pikuleva, I. A. (2013) Antifungal azoles: structural insights into undesired tight binding to cholesterol- metabolizing CYP46A1. Mol. Pharmacol. 84, 86-94
-
(2013)
Mol. Pharmacol.
, vol.84
, pp. 86-94
-
-
Mast, N.1
Zheng, W.2
Stout, C.D.3
Pikuleva, I.A.4
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