Retinal and nonocular abnormalities in Cyp27a1-/-Cyp46a1 -/- mice with dysfunctional metabolism of cholesterol

American Journal of Pathology

Volumn 184, Issue 9, 2014, Pages 2403-2419

  Saadane, Aicha ^a   Mast, Natalia ^a   Charvet, Casey D ^a   Omarova, Saida ^a   Zheng, Wenchao ^a   Huang, Suber S ^a   Kern, Timothy S ^a   Peachey, Neal S ^b,c,d   Pikuleva, Irina A ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

^d LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

26 HYDROXYCHOLESTEROL; CELA3B PROTEIN; CHOLESTANETRIOL 26 MONOOXYGENASE; CHOLESTANOL; CHOLESTEROL; CHOLESTEROL ACYLTRANSFERASE; COMPLEMENT COMPONENT C3A; COMPLEMENT COMPONENT C9; CRUMBS HOMOLOG 1 PROTEIN; CXCL2 CHEMOKINE; CYTOCHROME P450; CYTOCHROME P450 46A1; DESMOSTEROL; ELASTASE; ELASTASE 3B; FIBROBLAST GROWTH FACTOR RECEPTOR 3; GLUCOSE; INTERLEUKIN 6; LANOSTEROL; LATHOSTEROL; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CHOLESTEROL 24-HYDROXYLASE; CYP27A1 PROTEIN, MOUSE; STEROID MONOOXYGENASE;

ANASTOMOSIS; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTERIOVENOUS SHUNT; ARTICLE; BASEMENT MEMBRANE; BLOOD VESSEL PERMEABILITY; BLOOD VESSEL WALL; BODY FAT; BROWN ADIPOSE TISSUE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL SYNTHESIS; CHOROID; COMPLEMENT ACTIVATION; CONTROLLED STUDY; DIABETIC RETINOPATHY; DISORDERS OF CHOLESTEROL METABOLISM; DOWN REGULATION; ELECTRORETINOGRAM; FEMALE; GENE EXPRESSION; GENE MUTATION; GENOTYPE; GLUCOSE BLOOD LEVEL; HETEROZYGOSITY; HISTOCHEMISTRY; HOMOZYGOSITY; IMMUNE RESPONSE; IMMUNOREACTIVITY; LEAN BODY WEIGHT; LEUKOCYTE ADHERENCE; LIMIT OF DETECTION; LIPID STORAGE; LIVER BLOOD VESSEL; LUNG BLOOD VESSEL; MACROPHAGE; MALE; MICROGLIA; MOUSE; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PHENOTYPE; PHOTORECEPTOR INNER SEGMENT; PIGMENT EPITHELIUM; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RETINA; RETINA BLOOD VESSEL; RETINA DISEASE; RETINA MACULA AGE RELATED DEGENERATION; RETINAL CHOROIDAL ANASTOMOSIS; SPLEEN; SPLEEN BLOOD VESSEL; SPLEEN WEIGHT; UPREGULATION; VASCULAR ENDOTHELIUM; VASCULARIZATION; WILD TYPE; XANTHOMA; ANIMAL; C57BL MOUSE; DEFICIENCY; KNOCKOUT MOUSE; LIVER; LUNG; METABOLISM; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; CHOLESTANETRIOL 26-MONOOXYGENASE; CHOLESTEROL; LIVER; LUNG; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RETINA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPLEEN; STEROID HYDROXYLASES;

EID: 84906241944     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2014.05.024     Document Type: Article

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