Osteopetrosis in TAK1-deficient mice owing to defective NF-κB and NOTCH signaling

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 1, 2015, Pages 154-159

  Swarnkar, Gaurav ^a   Karuppaiah, Kannan ^a   Mbalaviele, Gabriel ^a   Chen, Tim ^a   Abu Amer, Yousef ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

NUMBL; Osteoclast; Osteopetrosis; RBPJ; TAK1

Indexed keywords

BETA ACTIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NOTCH RECEPTOR; NUMBL PROTEIN; OSTEOCLAST DIFFERENTIATION FACTOR; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; UNCLASSIFIED DRUG; IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE BINDING PROTEIN; MAP KINASE KINASE KINASE 7; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; NERVE PROTEIN; NUMBL PROTEIN, MOUSE; RBPJ PROTEIN, MOUSE;

ALBERS SCHOENBERG DISEASE; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL SURVIVAL; CONTROLLED STUDY; DOWN REGULATION; GENE DELETION; GENE EXPRESSION; MACROPHAGE; MICRO-COMPUTED TOMOGRAPHY; MOUSE; MYELOID PROGENITOR CELL; NONHUMAN; OSTEOCLASTOGENESIS; PHENOTYPE; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION; SYSTEMATIC REVIEW; ANIMAL; BONE DEVELOPMENT; BONE MARROW CELL; C57BL MOUSE; DEFICIENCY; ENZYMOLOGY; METABOLISM; OSTEOCLAST; PATHOLOGY; STEM CELL;

MUS;

ANIMALS; CELL DIFFERENTIATION; GENE DELETION; IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE-BINDING PROTEIN; MAP KINASE KINASE KINASES; MICE, INBRED C57BL; MYELOID CELLS; NERVE TISSUE PROTEINS; NF-KAPPA B; OSTEOCLASTS; OSTEOGENESIS; OSTEOPETROSIS; PHENOTYPE; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; STEM CELLS;

EID: 84920497871     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1415213112     Document Type: Article

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