Erratum: RBP-J imposes a requirement for ITAM-mediated costimulation of osteoclastogenesis (Journal of Clinical Investigation (2014) 124:11 (5057-5073) DOI: 10.1172/JCI71882);RBP-J imposes a requirement for ITAM-mediated costimulation of osteoclastogenesis

Journal of Clinical Investigation

Volumn 124, Issue 11, 2014, Pages 5057-5073

  Li, Susan ^a   Miller, Christine H ^a   Giannopoulou, Eugenia ^a,b   Hu, Xiaoyu ^a,c   Ivashkiv, Lionel B ^a,c   Zhao, Baohong ^a,c  

^a HOSPITAL FOR SPECIAL SURGERY   (United States)

^b NEW YORK CITY COLLEGE OF TECHNOLOGY   (United States)

^c Weill Cornell Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE BINDING PROTEIN; KILLER CELL ACTIVATING RECEPTOR ASSOCIATED PROTEIN; OSTEOCLAST DIFFERENTIATION FACTOR; PROTEIN PRECURSOR; SIGNAL PEPTIDE; TUMOR NECROSIS FACTOR ALPHA; FC RECEPTOR; NFATC1 PROTEIN, MOUSE; PHOSPHOLIPASE C GAMMA; PRDM1 PROTEIN, MOUSE; PROTEIN C FOS; RBPJ PROTEIN, MOUSE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NFAT; TYROBP PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE DISEASE; BONE REMODELING; CALCIUM SIGNALING; CELL DIFFERENTIATION; CONTROLLED STUDY; DISEASE SEVERITY; ELECTROSTIMULATION; GENE DELETION; GENE EXPRESSION PROFILING; GENE TARGETING; HIGH THROUGHPUT SEQUENCING; HOMEOSTASIS; IMMUNORECEPTOR TYROSINEBASED ACTIVATION MOTIF; MALE; MOUSE; NONHUMAN; OSTEOCLASTOGENESIS; OSTEOLYSIS; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SEQUENCE; SIGNAL TRANSDUCTION; ANIMAL; CELL CULTURE; KNOCKOUT MOUSE; METABOLISM; OSTEOCLAST; PHYSIOLOGY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BONE RESORPTION; CALCIUM SIGNALING; CELL DIFFERENTIATION; CELLS, CULTURED; IMMUNOGLOBULIN J RECOMBINATION SIGNAL SEQUENCE-BINDING PROTEIN; MICE, KNOCKOUT; NFATC TRANSCRIPTION FACTORS; OSTEOCLASTS; PHOSPHOLIPASE C GAMMA; PROTO-ONCOGENE PROTEINS C-FOS; RECEPTORS, IGG; TRANSCRIPTION FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84908626290     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI161196     Document Type: Erratum

References (66)

1. Novack DV, Teitelbaum SL. The osteoclast: friend or foe? Annu Rev Pathol. 2008;3:457-484.
2. Nakashima T, Takayanagi H. New regulation mechanisms of osteoclast differentiation. Ann N Y Acad Sci. 2011;1240:E13-E18.
3. Boyce BF, et al. New roles for osteoclasts in bone. Ann N Y Acad Sci. 2007;1116:245-254.
4. Teitelbaum SL. Osteoclasts; culprits in inflammatory osteolysis. Arthritis Res Ther. 2006;8(1):201.
5. Schett G, Gravallese E. Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment. Nat Rev Rheumatol. 2012;8(11):656-664.
6. Schett G, Teitelbaum SL. Osteoclasts and arthritis. J Bone Miner Res. 2009;24(7):1142-1146.
7. Asagiri M, Takayanagi H. The molecular understanding of osteoclast differentiation. Bone. 2007;40(2):251-264.
8. Zhao B, Ivashkiv LB. Negative regulation of osteoclastogenesis and bone resorption by cytokines and transcriptional repressors. Arthritis Res Ther. 2011;13(4):234.
9. Humphrey MB, Lanier LL, Nakamura MC. Role of ITAM-containing adapter proteins and their receptors in the immune system and bone. Immunol Rev. 2005;208:50-65.
10. Faccio R, Takeshita S, Zallone A, Ross FP, Teitelbaum SL. c-Fms and the alphavbeta3 integrin collaborate during osteoclast differentiation. J Clin Invest. 2003;111(5):749-758.
11. Wu Y, et al. Bone microenvironment specific roles of ITAM adapter signaling during bone remodeling induced by acute estrogen-deficiency. PLoS One. 2007;2(7):e586.
12. Ivashkiv LB. A signal-switch hypothesis for crossregulation of cytokine and TLR signalling pathways. Nat Rev Immunol. 2008;8(10):816-822.
13. Ivashkiv LB. Cross-regulation of signaling by ITAM-associated receptors. Nat Immunol. 2009;10(4):340-347.
14. Bezbradica JS, Medzhitov R. Role of ITAM signaling module in signal integration. Curr Opin Immunol. 2012;24(1):58-66.
15. Zou W, Teitelbaum SL. Integrins, growth factors, and the osteoclast cytoskeleton. Ann N Y Acad Sci. 2010;1192:27-31.
16. 2+-NFATc1 signaling is an essential axis of osteoclast differentiation. Immunol Rev. 2009;231(1):241-256.
17. Park-Min KH, et al. IL-10 suppresses calciummediated costimulation of receptor activator NF-κB signaling during human osteoclast differentiation by inhibiting TREM-2 expression. J Immunol. 2009;183(4):2444-2455.
18. Koga T, et al. Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis. Nature. 2004;428(6984):758-763.
19. Mao D, Epple H, Uthgenannt B, Novack DV, Faccio R. PLCgamma2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2. J Clin Invest. 2006;116(11):2869-2879.
20. Shinohara M, et al. Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals. Cell. 2008;132(5):794-806.
21. Tassiulas I, et al. Amplification of IFN-α-induced STAT1 activation and inflammatory function by Syk and ITAM-containing adaptors. Nat Immunol. 2004;5(11):1181-1189.
22. Wang L, et al. 'Tuning' of type I interferoninduced Jak-STAT1 signaling by calcium-dependent kinases in macrophages. Nat Immunol. 2008;9(2):186-193.
23. Kang YJ, et al. Calcineurin negatively regulates TLR-mediated activation pathways. J Immunol. 2007;179(7):4598-4607.
24. Mocsai A, et al. The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRγ) regulate development of functional osteoclasts through the Syk tyrosine kinase. Proc Natl Acad Sci U S A. 2004;101(16):6158-6163.
25. Kopan R, Ilagan MX. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell. 2009;137(2):216-233.
26. Shimizu T, et al. Stabilized β-catenin functions through TCF/LEF proteins and the Notch/RBPJκ complex to promote proliferation and suppress differentiation of neural precursor cells. Mol Cell Biol. 2008;28(24):7427-7441.
27. Izumiya Y, Izumiya C, Hsia D, Ellison TJ, Luciw PA, Kung HJ. NF-κB serves as a cellular sensor of Kaposi's sarcoma-associated herpesvirus latency and negatively regulates K-Rta by antagonizing the RBP-Jκ coactivator. J Virol. 2009;83(9):4435-4446.
28. Hu X, et al. Integrated regulation of Toll-like receptor responses by Notch and interferon-γ pathways. Immunity. 2008;29(5):691-703.
29. Zhao B, Grimes SN, Li S, Hu X, Ivashkiv LB. TNF induced osteoclasto genesis and inflammatory bone resorption are inhibited by transcription factor RBP-J. J Exp Med. 2012;209(2):319-334.
30. Xu H, et al. Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization. Nat Immunol. 2012;13(7):642-650.
31. Engin F, Lee B. NOTCHing the bone: insights into multi-functionality. Bone. 2010;46(2):274-280.
32. Zou W, et al. Syk, c-Src, the alphavbeta3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption. J Cell Biol. 2007;176(6):877-888.
33. Kaifu T, et al. Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12- deficient mice. J Clin Invest. 2003;111(3):323-332.
34. Zou W, Reeve JL, Liu Y, Teitelbaum SL, Ross FP. DAP12 couples c-Fms activation to the osteoclast cytoskeleton by recruitment of Syk. Mol Cell. 2008;31(3):422-431.
35. Nishikawa K, et al. Blimp1-mediated repression of negative regulators is required for osteoclast differentiation. Proc Natl Acad Sci U S A. 2010;107(7):3117-3122.
36. Miyauchi Y, et al. The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis. J Exp Med. 2010;207(4):751-762.
37. Bai S, et al. NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells. J Biol Chem. 2008;283(10):6509-6518.
38. Castel D, Mourikis P, Bartels SJ, Brinkman AB, Tajbakhsh S, Stunnenberg HG. Dynamic binding of RBPJ is determined by Notch signaling status. Genes Dev. 2013;27(9):1059-1071.
39. Li Y, Hibbs MA, Gard AL, Shylo NA, Yun K. Genome-wide analysis of N1ICD/RBPJ targets in vivo reveals direct transcriptional regulation of Wnt, SHH, and hippo pathway effectors by Notch1. Stem Cells. 2012;30(4):741-752.
40. Hamidi H, Gustafason D, Pellegrini M, Gasson J. Identification of novel targets of CSL-dependent Notch signaling in hematopoiesis. PLoS One. 2011;6(5):e20022.
41. Kim N, et al. Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis. J Exp Med. 2005;202(5):589-595.
42. Yasui T, et al. Regulation of RANKL-induced osteoclastogenesis by TGF-β through molecular interaction between Smad3 and Traf6. J Bone Miner Res. 2011;26(7):1447-1456.
43. Zavadil J, Cermak L, Soto-Nieves N, Bottinger EP. Integration of TGF-β/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition. EMBO J. 2004;23(5):1155-1165.
44. Niranjan T, et al. The Notch pathway in podocytes plays a role in the development of glomerular disease. Nat Med. 2008;14(3):290-298.
45. Sassoli C, et al. Relaxin prevents cardiac fibroblast- myofibroblast transition via notch-1-mediated inhibition of TGF-β/Smad3 signaling. PLoS One. 2013;8(5):e63896.
46. Misra K, Luo H, Li S, Matise M, Xiang M. Asymmetric activation of Dll4-Notch signaling by Foxn4 and proneural factors activates BMP/TGFβ signaling to specify V2b interneurons in the spinal cord. Development. 2014; 141(1):187-198.
47. 2+ waves and enhances gene expression in human pulmonary fibroblasts. Am J Respir Cell Mol Biol. 2012;46(6):757-764.
48. Alevizopoulos A, Dusserre Y, Ruegg U, Mermod N. Regulation of the transforming growth factor β-responsive transcription factor CTF-1 by calcineurin and calcium/calmodulindependent protein kinase IV. J Biol Chem. 1997;272(38):23597-23605.
49. Chow JY, Dong H, Quach KT, Van Nguyen PN, Chen K, Carethers JM. TGF-β mediates PTEN suppression and cell motility through calciumdependent PKC-alpha activation in pancreatic cancer cells. Am J Physiol Gastrointest Liver Physiol. 2008;294(4):G899-G905.
50. Mullen AC, et al. Master transcription factors determine cell-type-specific responses to TGF-β signaling. Cell. 2011;147(3):565-576.
51. Yarilina A, Xu K, Chen J, Ivashkiv LB. TNF activates calcium-nuclear factor of activated T cells (NFAT)c1 signaling pathways in human macrophages. Proc Natl Acad Sci U S A. 2011;108(4):1573-1578.
52. Kitaura H, Zhou P, Kim HJ, Novack DV, Ross FP, Teitelbaum SL. M-CSF mediates TNFinduced inflammatory osteolysis. J Clin Invest. 2005;115(12):3418-3427.
53. Stahl EA, et al. Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. Nat Genet. 2010;42(6):508-514.
54. Eyre S, et al. High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. Nat Genet. 2012;44(12):1336-1340.
55. Orozco G, et al. Novel RA susceptibility locus at 22q12 identified in an extended UK genome wide association study. Arthritis Rheum. 2014;66(1):24-30.
56. Barrow AD, et al. OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice. J Clin Invest. 2011;121(9):3505-3516.
57. Aliprantis AO, Glimcher LH. NFATc1 in inflammatory and musculoskeletal conditions. Adv Exp Med Biol. 2010;658:69-75.
58. Ochi S, et al. Pathological role of osteoclast costimulation in arthritis-induced bone loss. Proc Natl Acad Sci U S A. 2007;104(27):11394-11399.
59. Feng X, et al. A Glanzmann's mutation in β3 integrin specifically impairs osteoclast function. J Clin Invest. 2001;107(9):1137-1144.
60. Zhao B, et al. Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis. Nat Med. 2009;15(9):1066-1071.
61. Takeshita S, Kaji K, Kudo A. Identification and characterization of the new osteoclast progenitor with macrophage phenotypes being able to differentiate into mature osteoclasts. J Bone Miner Res. 2000;15(8):1477-1488.
62. 2+]i oscillations in T lymphocytes. J Gen Physiol. 1994;103(3):365-388.
63. R Core Team. R: A Language And Environment For Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing; 2013.
64. Rogatsky I, Zarember KA, Yamamoto KR. Factor recruitment and TIF2/GRIP1 corepressor activity at a collagenase-3 response element that mediates regulation by phorbol esters and hormones. EMBO J. 2001;20(21):6071-6083.
65. Trapnell C, Pachter L, Salzberg SL. TopHat: discovering splice junctions with RNA-Seq. Bioinformatics. 2009;25(9):1105-1111.
66. Trapnell C, et al. Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Nat Biotechnol. 2010;28(5):511-515.