NUMBL interacts with TRAF6 and promotes the degradation of TRAF6

Biochemical and Biophysical Research Communications

Volumn 392, Issue 3, 2010, Pages 409-414

  Zhou, Li ^a   Ma, Qi ^a   Shi, Huili ^a   Huo, Keke ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

NF B signaling pathway; NUMBL; TRAF6; Ubiquitination

Indexed keywords

CYTOPLASM PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NUMBL PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BRAIN CELL; CELL CULTURE; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN INTERACTION; RAT; UBIQUITINATION;

CELL LINE; CEREBRAL CORTEX; GENE KNOCKDOWN TECHNIQUES; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NEURONS; NF-KAPPA B; PROTEIN STRUCTURE, TERTIARY; TNF RECEPTOR-ASSOCIATED FACTOR 6; UBIQUITINATION;

EID: 76349083124     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.01.037     Document Type: Article

References (26)

1. Yoshimura A., Mori H., Ohishi M., Aki D., and Hanada T. Negative regulation of cytokine signaling influences inflammation. Curr. Opin. Immunol. 15 (2003) 704-707
2. Barnes P.J., and Karin M. Nuclear factor-κB - a pivotal transcription factor in chronic inflammatory diseases. N. Engl. J. Med. 336 (1997) 1066-1071
3. Pikarsky E., Porat R.M., Stein I., Abramovitch R., Amit S., Kasem S., Pyest E.G., Shoval S.U., Galun E., and Neriah Y.B. NF-κB functions as a tumour promoter in inflammation-associated cancer. Nature 431 (2004) 461-466
4. Arch R.H., Gedrich R.W., and Thompson C.B. Tumor necrosis factor receptor-associated factors (TRAFs)-a family of adapter proteins that regulates life and death. Genes Dev. 12 (1998) 2821-2830 10.1101/gad.12.18.2821
5. Aggarwal B.B. Signalling pathways of the TNF superfamily: a double-edged sword. Nat. Rev. Immunol. 3 (2003) 745-756
6. Deng L., Wang C., Spencer E., Pickart C., and Chen Z.J. Activation of the IκB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell 103 (2000) 351-361
7. Hofmann R.M., and Pickart C.M. Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair. Cell 96 (1999) 645-653
8. Ea C.K., Deng L., Xia Z.P., Pineda G., and Chen Z.J. Activation of IKK by TNFα requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Mol. Cell 22 (2006) 245-257
9. Li H., Kobayashi M., Blonska M., You Y., and Lin X. Ubiquitination of RIP is required for tumor necrosis factor-induced NF-κB activation. J. Biol. Chem. 281 (2006) 13636-13643
10. Lamothe B., Besse A., Campos A.D., Webster W.K., Wu H., and Darnay B.G. Site-specific K63-linked TRAF6 auto-ubiquitination is a critical determinant of IKK activation. J. Biol. Chem. 282 (2006) 4102-4112
11. Chen Z.J. Ubiquitin signalling in the NF-κB pathway. Nat. Cell Biol. 7 (2005) 758-766
12. Li H.S., Wang D., Shen Q., Schonemann M.D., Gorski J.A., Jones K.R., Temple S., Jan L.Y., and Jan Y.N. Inactivation of Numb and Numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis. Neuron 40 (2003) 1105-1118
13. Petersen P.H., Zou K., Krauss S., and Zhong W. Continuing role for mouse Numb and Numbl in maintaining progenitor cells during cortical neurogenesis. Nat. Neurosci. 7 (2004) 803-811
14. Zhong W., Feder J.N., Jiang M., Jan L.Y., and Jan Y.N. Asymmetric localization of a mammalian Numb homolog during mouse cortical neurogenesis. Neuron 17 (1996) 43-53
15. Zhong W., Jiang M., Weinmaster G., Jan L.Y., and Jan Y.N. Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis. Development 124 (1997) 1887-1897
16. Ma Q., Zhou L., Shi H., and Huo K. NUMBL interacts with TAB2 and inhibits TNF-α and IL-1β induced NF-κB activation. Cell. Signal. 20 (2008) 1044-1051
17. Lois C., Hong E.J., Pease S.S., Brown E.J., and Baltimore D. Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors. Science 295 (2002) 868-872
18. Kanayama A., Seth R.B., Deng L., and Chen Z.J. TAB2 and TAB3 activate the NF-κB pathway through binding to polyubiquitin chains. Mol. Cell 15 (2004) 535-548
19. Wertz I.E., O'Rourke K.M., Zhou H., Eby M., Aravind L., Seshagiri S., Wu P., Wiesmann C., Baker R., Boone D.L., Ma A., Koonin E.V., and Dixit V.M. De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signaling. Nature 430 (2004) 694-699
20. Trompouki E., Hatzivassiliou E., Tsichritzis T., Farmer H., Ashworth A., and Mosialos G. CYLD is a deubiquitinating enzyme that negatively regulates NF-κB activation by TNFR family members. Nature 424 (2003) 793-796
21. Hong S., Lim S., Li A.G., Lee C., Lee Y.S., Lee E.K., Park S.H., Wang X.J., and Kim S.J. Smad7 binds to the adaptors TAB2 and TAB3 to block recruitment of the kinase TAK1 to the adaptor TRAF2. Nat. Immunol. 8 (2007) 504-513
22. Wang Y., Tang Y., Teng L., Wu Y., Zhao X., and Pei G. Association of β-arrestin and TRAF6 negatively regulates toll-like receptor-interlukin 1 receptor signaling. Nat. Immunol. 7 (2006) 139-147
23. O'Neill L.A.J., and Kaltschmidt C. NF-κB: a crucial transcription factor for glial and neuronal cell function. Trends Neurosci. 20 (1997) 252-258
24. Boersma M.C., and Meffert M.K. Novel roles for the NF-κB signaling pathway in regulating neuronal function. Sci. Signal. 1 6 (2008) pe7
25. Huang E.J., Li H., Tang A.A., Wiggins A.K., Neve R.L., Zhong W., Jan L.Y., and Jan Y. Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization. Genes Dev. 19 (2005) 138-151
26. Kuo C.T., Mirzadeh Z., Soriano-Navarro M., Rasin M., Wang D., Shen J., Sěstan N., Garcia-Verdugo J., Alvarez-Buylla A., Jan L.Y., and Jan Y. Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche. Cell 127 (2006) 1253-1264