Lys63-linked polyubiquitin chains: Linking more than just ubiquitin

Cancer Biology and Therapy

Volumn 5, Issue 10, 2006, Pages 1273-1274

  Kawadler, Holli ^a   Yang, Xiaolu ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

IKK; Lys48; Lys63; NEMO; RIP1; Ubiquitin chain; Ubiquitination

Indexed keywords

I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LYSINE; NUCLEAR PROTEIN; POLYUBIQUITIN; PROTEIN RIP1; PROTEIN SUBUNIT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN MODIFICATION; PROTEIN STRUCTURE; PROTEIN TARGETING; SHORT SURVEY; SIGNAL TRANSDUCTION;

EID: 33751072638     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.5.10.3289     Document Type: Short Survey

References (12)

1. Ciechanover A. The ubiquitin-proteasome pathway: On protein death and cell life. Embo J 1998; 17:7151-60.
2. Ben-Neriah Y. Regulatory functions of ubiquitination in the immune system. Nat Immunol 2002; 3:20-6.
3. Hayden MS, Ghosh S. Signaling to NF-kappaB. Genes Dev 2004; 18:2195-224.
4. Wertz IE, O'Rourke KM, Zhou H, Eby M, Aravind L, Seshagiri S, Wu P, Wiesmann C, Baker R, Boone DL, Ma A, Koonin EV, Dixit VM. De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling. Nature 2004; 430:694-9.
5. Ea CK, Deng L, Xia ZP, Pineda G, Chen ZJ. Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Mol Cell 2006; 22:245-57.
6. Wu CJ, Conze DB, Li T, Srinivasula SM, Ashwell JD. NEMO is a sensor of Lys 63-linked polyubiquitination and functions in NF-kappaB activation. Nat Cell Biol 2006; 8:398-406.
7. Tenno T, Fujiwara K, Tochio H, Iwai K, Morita EH, Hayashi H, Murata S, Hiroaki H, Sato M, Tanaka K, Shirakawa M. Structural basis for distinct roles of Lys63- and Lys48-linked polyubiquitin chains. Genes Cells 2004; 9:865-75.
8. Varadan R, Assfalg M, Haririnia A, Raasi S, Pickart C, Fushman D. Solution conformation of Lys63-linked di-ubiquitin chain provides clues to functional diversity of polyubiquitin signaling. J Biol Chem 2004; 279:7055-63.
9. Hicke L, Schubert HL, Hill CP. Ubiquitin-binding domains. Nat Rev Mol Cell Biol 2005; 6:610-21.
10. Meylan E, Burns K, Hofmann K, Blancheteau V, Martinon F, Kelliher M, Tschopp J. RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation. Nat Immunol 2004; 5:503-7.
11. Kovalenko A, Chable-Bessia C, Cantarella G, Israel A, Wallach D, Courtois G. The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination. Nature 2003; 424:801-5.
12. Brummelkamp TR, Nijman SM, Dirac AM, Bernards R. Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB. Nature 2003; 424:797-801.