Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal

Oncogene

Volumn 30, Issue 1, 2011, Pages 65-76

  Di Marcotullio, L ^a   Greco, A ^a   Mazza D ^a   Canettieri, G ^a   Pietrosanti, L ^a   Infante, P ^a   Coni, S ^a   Moretti, M ^b   De Smaele, E ^b   Ferretti, E ^b   Screpanti, I ^a,c   Gulino, A ^a,c,d  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d IRCCS NEUROMED   (Italy)

Author keywords

Gli1; Hedgehog; Itch; medulloblastoma; Numb; ubiquitination

Indexed keywords

ADAPTOR PROTEIN; PHOSPHOSERINE; PROLINE; TRANSCRIPTION FACTOR GLI1; UBIQUITIN PROTEIN LIGASE E3;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYST; CELL MIGRATION; GENE MUTATION; IN VITRO STUDY; MEDULLOBLASTOMA; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN STABILITY; PRURITUS; REGULATORY MECHANISM; TUMOR GROWTH; UBIQUITINATION;

ANIMALS; HEDGEHOG PROTEINS; HUMANS; MEMBRANE PROTEINS; MICE; NERVE TISSUE PROTEINS; NIH 3T3 CELLS; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

ERINACEIDAE;

EID: 78650983824     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2010.394     Document Type: Article

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