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Volumn 25, Issue 6, 2010, Pages 1282-1294

IKKβ activation is sufficient for RANK-independent osteoclast differentiation and osteolysis

Author keywords

IKK ; NF B; Osteoclast; Osteolysis; Rank

Indexed keywords

I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; TUMOR NECROSIS FACTOR ALPHA; CHUK PROTEIN, MOUSE; I KAPPA B KINASE; IKBKB PROTEIN, MOUSE; NEMO PROTEIN, MOUSE; OSTEOCLAST DIFFERENTIATION FACTOR; SIGNAL PEPTIDE;

EID: 77953527361     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbmr.4     Document Type: Article
Times cited : (55)

References (44)
  • 1
    • 33947497852 scopus 로고    scopus 로고
    • Osteoclasts: What do they do and how do they do it?
    • Teitelbaum SL. Osteoclasts: what do they do and how do they do it? Amer J Pathol. 2007;170:427-435.
    • (2007) Amer J Pathol , vol.170 , pp. 427-435
    • Teitelbaum, S.L.1
  • 2
    • 23644455507 scopus 로고    scopus 로고
    • Advances in osteoclast differentiation and function. Current drug targets
    • Abu-Amer Y. Advances in osteoclast differentiation and function. Current drug targets. Immune, endo and metab dis. 2005;5:347-355.
    • (2005) Immune, Endo and Metab Dis , vol.5 , pp. 347-355
    • Abu-Amer, Y.1
  • 3
    • 0043267732 scopus 로고    scopus 로고
    • Genetic regulation of osteoclast development and function
    • Teitelbaum SL, Ross FP. Genetic regulation of osteoclast development and function. Nat Rev Genet. 2003;4:638-649.
    • (2003) Nat Rev Genet , vol.4 , pp. 638-649
    • Teitelbaum, S.L.1    Ross, F.P.2
  • 4
    • 16844377831 scopus 로고    scopus 로고
    • Mechanistic insight into osteoclast differentiation in osteoimmunology
    • Berlin, Germany
    • Takayanagi H. Mechanistic insight into osteoclast differentiation in osteoimmunology. J Mol Med (Berlin, Germany). 2005;83:170-179.
    • (2005) J Mol Med , vol.83 , pp. 170-179
    • Takayanagi, H.1
  • 5
    • 38749128376 scopus 로고    scopus 로고
    • The tyrosine kinase activity of c-Src regulates actin dynamics and organization of podosomes in osteoclasts
    • Destaing O, Sanjay A, Itzstein C, et al. The tyrosine kinase activity of c-Src regulates actin dynamics and organization of podosomes in osteoclasts. Mol Biol Cell. 2008;19:394-404.
    • (2008) Mol Biol Cell , vol.19 , pp. 394-404
    • Destaing, O.1    Sanjay, A.2    Itzstein, C.3
  • 7
    • 33947240223 scopus 로고    scopus 로고
    • 3-integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption
    • 3-integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption. J Cell Biol. 2007;176:877-888.
    • (2007) J Cell Biol , vol.176 , pp. 877-888
    • Zou, W.1    Kitaura, H.2    Reeve, J.3
  • 8
    • 48349105543 scopus 로고    scopus 로고
    • DAP12 couples c-Fms activation to the osteoclast cytoskeleton by recruitment of Syk
    • Zou W, Reeve JL, Liu Y, Teitelbaum SL, Ross FP. DAP12 couples c-Fms activation to the osteoclast cytoskeleton by recruitment of Syk. Mol cell. 2008;31:422-431.
    • (2008) Mol Cell , vol.31 , pp. 422-431
    • Zou, W.1    Reeve, J.L.2    Liu, Y.3    Teitelbaum, S.L.4    Ross, F.P.5
  • 10
    • 0034284970 scopus 로고    scopus 로고
    • Bone resorption by osteoclasts
    • New York
    • Teitelbaum SL. Bone resorption by osteoclasts. Science (New York). 2000;289:1504-1508.
    • (2000) Science , vol.289 , pp. 1504-1508
    • Teitelbaum, S.L.1
  • 12
    • 45749124735 scopus 로고    scopus 로고
    • RelA/p65 promotes osteoclast differentiation by blocking a RANKL-induced apoptotic JNK pathway in mice
    • Vaira S, Alhawagri M, Anwisye I, Kitaura H, Faccio R, Novack DV. RelA/p65 promotes osteoclast differentiation by blocking a RANKL-induced apoptotic JNK pathway in mice. J Clin Invest. 2008;118:2088-2097.
    • (2008) J Clin Invest , vol.118 , pp. 2088-2097
    • Vaira, S.1    Alhawagri, M.2    Anwisye, I.3    Kitaura, H.4    Faccio, R.5    Novack, D.V.6
  • 13
    • 41649089360 scopus 로고    scopus 로고
    • RelB is the NF-κB subunit downstream of NIK responsible for osteoclast differentiation
    • Vaira S, Johnson T, Hirbe AC, et al. RelB is the NF-κB subunit downstream of NIK responsible for osteoclast differentiation. Proc Natl Acad Sci USA. 2008;105:3897-3902.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 3897-3902
    • Vaira, S.1    Johnson, T.2    Hirbe, A.C.3
  • 14
    • 0033607313 scopus 로고    scopus 로고
    • The NF-κB activation pathway: A paradigm in information transfer from membrane to nucleus
    • Rothwarf DM, Karin M. The NF-κB activation pathway: a paradigm in information transfer from membrane to nucleus. Science's STKE. 1999;1999:RE1.
    • (1999) Science's STKE , vol.1999
    • Rothwarf, D.M.1    Karin, M.2
  • 15
    • 39049183044 scopus 로고    scopus 로고
    • Regulation and function of IKK and IKK-related kinases
    • Hèacker H, Karin M. Regulation and function of IKK and IKK-related kinases. Science's STKE. 2006;2006:re13.
    • (2006) Science's STKE , vol.2006
    • Hèacker, H.1    Karin, M.2
  • 16
    • 0034610759 scopus 로고    scopus 로고
    • Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase
    • Rossi A, Kapahi P, Natoli G, et al. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IκB kinase. Nature. 2000;403:103-118.
    • (2000) Nature , vol.403 , pp. 103-118
    • Rossi, A.1    Kapahi, P.2    Natoli, G.3
  • 17
    • 4444306858 scopus 로고    scopus 로고
    • The IκB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks osteoclastogenesis and bone erosion in inflammatory arthritis
    • Dai S, Hirayama T, Abbas S, Abu-Amer Y. The IκB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks osteoclastogenesis and bone erosion in inflammatory arthritis. J Biol Chem. 2004;279:37219-37222.
    • (2004) J Biol Chem , vol.279 , pp. 37219-37222
    • Dai, S.1    Hirayama, T.2    Abbas, S.3    Abu-Amer, Y.4
  • 18
    • 2942703810 scopus 로고    scopus 로고
    • Selective inhibition of NF-kappa B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo
    • Jimi E, Aoki K, Saito H, et al. Selective inhibition of NF-kappa B blocks osteoclastogenesis and prevents inflammatory bone destruction in vivo. Nat Med. 2004;10:617-624.
    • (2004) Nat Med , vol.10 , pp. 617-624
    • Jimi, E.1    Aoki, K.2    Saito, H.3
  • 19
    • 11144242115 scopus 로고    scopus 로고
    • Osteoclast differentiation is impaired in the absence of IκB kinase-α
    • Chaisson ML, Branstetter DG, Derry JM, et al. Osteoclast differentiation is impaired in the absence of IκB kinase-α. J Biol Chem. 2004;279:54841-54848.
    • (2004) J Biol Chem , vol.279 , pp. 54841-54848
    • Chaisson, M.L.1    Branstetter, D.G.2    Derry, J.M.3
  • 20
    • 19344374949 scopus 로고    scopus 로고
    • IκB kinase-β, but not IκK-α, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss
    • Ruocco MG, Maeda S, Park JM, et al. IκB kinase-β, but not IκK-α, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss. J. Exp. Med. 2005;201:1677-1687.
    • (2005) J. Exp. Med. , vol.201 , pp. 1677-1687
    • Ruocco, M.G.1    Maeda, S.2    Park, J.M.3
  • 21
    • 54049088603 scopus 로고    scopus 로고
    • Defective osteoclastogenesis by IKKβ null precursors is a result of receptor activator of NF-κB ligand (RANKL)-induced JNK-dependent apoptosis and impaired differentiation
    • Otero JE, Dai S, Foglia D, et al. Defective osteoclastogenesis by IKKβ null precursors is a result of receptor activator of NF-κB ligand (RANKL)-induced JNK-dependent apoptosis and impaired differentiation. J Biol Chem. 2008;283:24546-24553.
    • (2008) J Biol Chem , vol.283 , pp. 24546-24553
    • Otero, J.E.1    Dai, S.2    Foglia, D.3
  • 23
    • 0037142027 scopus 로고    scopus 로고
    • TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2
    • Pasparakis M, Courtois G, Hafner M, et al. TNF-mediated inflammatory skin disease in mice with epidermis-specific deletion of IKK2. Nature. 2002;417:861-866.
    • (2002) Nature , vol.417 , pp. 861-866
    • Pasparakis, M.1    Courtois, G.2    Hafner, M.3
  • 24
    • 11144242115 scopus 로고    scopus 로고
    • Osteoclast differentiation is impaired in the absence of IkB kinase-α
    • Chaisson ML, Branstetter DG, Derry JM, et al. Osteoclast differentiation is impaired in the absence of IkB kinase-α. J Biol Chem. 2004;279:54841-54848.
    • (2004) J Biol Chem , vol.279 , pp. 54841-54848
    • Chaisson, M.L.1    Branstetter, D.G.2    Derry, J.M.3
  • 25
    • 41649089360 scopus 로고    scopus 로고
    • RelB is the NF-κB subunit downstream of NIK responsible for osteoclast differentiation
    • USA
    • Vaira S, Johnson T, Hirbe AC, et al. RelB is the NF-κB subunit downstream of NIK responsible for osteoclast differentiation. Proc Natl Acad Sci (USA). 2008;105:3897-3902.
    • (2008) Proc Natl Acad Sci , vol.105 , pp. 3897-3902
    • Vaira, S.1    Johnson, T.2    Hirbe, A.C.3
  • 26
    • 13044316551 scopus 로고    scopus 로고
    • Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand
    • USA
    • Hsu H, Lacey DL, Dunstan CR, et al. Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. Proc Natl Acad Sci (USA). 1999;96:3540-3545.
    • (1999) Proc Natl Acad Sci , vol.96 , pp. 3540-3545
    • Hsu, H.1    Lacey, D.L.2    Dunstan, C.R.3
  • 27
    • 34547124586 scopus 로고    scopus 로고
    • NF-κB p50 and p52 regulate receptor activator of NF-κB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1
    • Yamashita T, Yao Z, Li F, et al. NF-κB p50 and p52 regulate receptor activator of NF-κB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1. J Biol Chem. 2007;282:18245-18253.
    • (2007) J Biol Chem , vol.282 , pp. 18245-18253
    • Yamashita, T.1    Yao, Z.2    Li, F.3
  • 28
    • 0030685825 scopus 로고    scopus 로고
    • IKK-1 and IKK-2: Cytokine-activated IκB kinases essential for NF-κB activation
    • New York, N.Y.
    • Mercurio F, Zhu H, Murray BW, et al. IKK-1 and IKK-2: cytokine-activated IκB kinases essential for NF-κB activation. Science (New York, N.Y.). 1997;278:860-866.
    • (1997) Science , vol.278 , pp. 860-866
    • Mercurio, F.1    Zhu, H.2    Murray, B.W.3
  • 29
    • 0033537719 scopus 로고    scopus 로고
    • Positive and negative regulation of IκB kinase activity through IKKβ subunit phosphorylation
    • New York, N.Y.
    • Delhase M, Hayakawa M, Chen Y, Karin M. Positive and negative regulation of IκB kinase activity through IKKβ subunit phosphorylation. Science (New York, N.Y.). 1999;284:309-313.
    • (1999) Science , vol.284 , pp. 309-313
    • Delhase, M.1    Hayakawa, M.2    Chen, Y.3    Karin, M.4
  • 30
    • 0034046944 scopus 로고    scopus 로고
    • Plat-E: An efficient and stable system for transient packaging of retroviruses
    • Morita S, Kojima T, Kitamura T. Plat-E: an efficient and stable system for transient packaging of retroviruses. Gene therapy. 2000;7:1063-1066.
    • (2000) Gene Therapy , vol.7 , pp. 1063-1066
    • Morita, S.1    Kojima, T.2    Kitamura, T.3
  • 32
    • 0028173214 scopus 로고
    • C-Fos: A key regulator of osteoclast-macrophage lineage determination and bone remodeling
    • New York, N.Y.
    • Grigoriadis AE, Wang ZQ, Cecchini MG, et al. c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling. Science (New York, N.Y.). 1994;266:443-448.
    • (1994) Science , vol.266 , pp. 443-448
    • Grigoriadis, A.E.1    Wang, Z.Q.2    Cecchini, M.G.3
  • 33
    • 0032506007 scopus 로고    scopus 로고
    • Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice
    • Saftig P, Hunziker E, Wehmeyer O, et al. Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice. Proc Natl Acad Sci U S A. 1998;95:13453-13458.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 13453-13458
    • Saftig, P.1    Hunziker, E.2    Wehmeyer, O.3
  • 34
    • 0035206443 scopus 로고    scopus 로고
    • Minireview: The OPG/RANKL/RANK system
    • Khosla S. Minireview: the OPG/RANKL/RANK system. Endocrinology. 2001;142:5050-5055.
    • (2001) Endocrinology , vol.142 , pp. 5050-5055
    • Khosla, S.1
  • 35
    • 0034175632 scopus 로고    scopus 로고
    • Severe liver degeneration and lack of NF-κB activation in NEMO/IKKgamma-deficient mice
    • Rudolph D, Yeh WC, Wakeham A, et al. Severe liver degeneration and lack of NF-κB activation in NEMO/IKKgamma-deficient mice. Genes & development. 2000;14:854-862.
    • (2000) Genes & Development , vol.14 , pp. 854-862
    • Rudolph, D.1    Yeh, W.C.2    Wakeham, A.3
  • 36
    • 0037195419 scopus 로고    scopus 로고
    • Characterization of the IκB-kinase NEMO binding domain
    • May MJ, Marienfeld RB, Ghosh S. Characterization of the IκB-kinase NEMO binding domain. J Biol Chem. 2002;277:45992-46000.
    • (2002) J Biol Chem , vol.277 , pp. 45992-46000
    • May, M.J.1    Marienfeld, R.B.2    Ghosh, S.3
  • 37
    • 0029020282 scopus 로고
    • Protein kinases 6. The eukaryotic protein kinase superfamily: Kinase (catalytic) domain structure and classification
    • Hanks SK, Hunter T. Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. FASEB J. 1995;9:576-596.
    • (1995) FASEB J , vol.9 , pp. 576-596
    • Hanks, S.K.1    Hunter, T.2
  • 38
    • 17944378526 scopus 로고    scopus 로고
    • Activation by IKKα of a second, evolutionary conserved, NF-κB signaling pathway
    • Senftleben U, Cao Y, Xiao G, et al. Activation by IKKα of a second, evolutionary conserved, NF-κB signaling pathway. Science. 2001;293:1495-1499.
    • (2001) Science , vol.293 , pp. 1495-1499
    • Senftleben, U.1    Cao, Y.2    Xiao, G.3
  • 39
    • 18744366041 scopus 로고    scopus 로고
    • Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts
    • Takayanagi H, Kim S, Koga T, et al. Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev Cell. 2002;3:889-901.
    • (2002) Dev Cell , vol.3 , pp. 889-901
    • Takayanagi, H.1    Kim, S.2    Koga, T.3
  • 40
    • 2342464085 scopus 로고    scopus 로고
    • The two NF-κB activation pathways and their role in innate and adaptive immunity
    • Bonizzi G, Karin M. The two NF-κB activation pathways and their role in innate and adaptive immunity. Trends Immunol. 2004; 25:280-288.
    • (2004) Trends Immunol , vol.25 , pp. 280-288
    • Bonizzi, G.1    Karin, M.2
  • 41
    • 0036839607 scopus 로고    scopus 로고
    • Tumor necrosis factor superfamily cytokines and the pathogenesis of inflammatory osteolysis
    • Lam J, Abu-Amer Y, Nelson C, Fermont D, Ross F, Teitelbaum S. Tumor necrosis factor superfamily cytokines and the pathogenesis of inflammatory osteolysis. Ann Rheu Dis. 2002;61:82-83.
    • (2002) Ann Rheu Dis , vol.61 , pp. 82-83
    • Lam, J.1    Abu-Amer, Y.2    Nelson, C.3    Fermont, D.4    Ross, F.5    Teitelbaum, S.6
  • 43
    • 24344433524 scopus 로고    scopus 로고
    • Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis
    • Kim N, Kadono Y, Takami M, et al. Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis. J Exp Med. 2005;202:589-595.
    • (2005) J Exp Med , vol.202 , pp. 589-595
    • Kim, N.1    Kadono, Y.2    Takami, M.3
  • 44
    • 34249860937 scopus 로고    scopus 로고
    • Sporadic hyperphosphatasia syndrome featuring periostitis and accelerated skeletal turnover without receptor activator of nuclear factor-κB, osteoprotegerin or sequestosome-1 gene defects
    • Simsek S, Basoski NM, Bravenboer N, et al. Sporadic hyperphosphatasia syndrome featuring periostitis and accelerated skeletal turnover without receptor activator of nuclear factor-κB, osteoprotegerin, or sequestosome-1 gene defects. J Clin Endo Metab. 2007;92:1897-1901.
    • (2007) J Clin Endo Metab , vol.92 , pp. 1897-1901
    • Simsek, S.1    Basoski, N.M.2    Bravenboer, N.3


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