LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation

EMBO Journal

Volumn 21, Issue 1-2, 2002, Pages 93-102

  Nie, Jing ^a   McGill, Melanie A ^a   Dermer, Matt ^a   Dho, Sascha E ^a   Wolting, Cheryl D ^a   McGlade, C Jane ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

LNX; Numb; PDZ domain; RING finger; Ubiquitin ligase

Indexed keywords

CYSTEINE; NOTCH RECEPTOR; PROTEASOME; PROTEIN; PROTEIN LNX; UBIQUITIN; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL DIVISION; CELL FATE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ANIMALS; BINDING SITES; CARRIER PROTEINS; CELL LINE; CHO CELLS; CRICETINAE; DOGS; HUMANS; LIGASES; MEMBRANE PROTEINS; MICE; MUTAGENESIS, SITE-DIRECTED; NERVE TISSUE PROTEINS; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; SUBSTRATE SPECIFICITY; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

ANIMALIA; MAMMALIA;

EID: 0037080811     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/21.1.93     Document Type: Article

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