-
3
-
-
0042844744
-
Natural products as sources of new drugs over the period 1981-2002
-
Newman DJ, Cragg GM, Snader KM (2003) Natural products as sources of new drugs over the period 1981-2002. J Nat Prod 66: 1022-1037.
-
(2003)
J Nat Prod
, vol.66
, pp. 1022-1037
-
-
Newman, D.J.1
Cragg, G.M.2
Snader, K.M.3
-
5
-
-
27844474247
-
Drug discovery from medicinal plants
-
Balunas MJ, Kinghorn AD (2005) Drug discovery from medicinal plants. Life Sci 78: 431-441.
-
(2005)
Life Sci
, vol.78
, pp. 431-441
-
-
Balunas, M.J.1
Kinghorn, A.D.2
-
6
-
-
27144547510
-
The renaissance of natural products as drug candidates
-
Paterson I, Anderson EA (2005) The renaissance of natural products as drug candidates. Science 310: 451-453.
-
(2005)
Science
, vol.310
, pp. 451-453
-
-
Paterson, I.1
Anderson, E.A.2
-
8
-
-
84920038485
-
The history of traditional Chinese medicine of more than 2000 years
-
accessed November 2007
-
The history of traditional Chinese medicine of more than 2000 years. Further information available at: http://www.chinese-medicine-guide.org/History-of-traditional-Chinese-medicine.html (accessed November 2007).
-
Further Information
-
-
-
9
-
-
0035044430
-
The value of plants used in traditional medicine for drug discovery
-
Fabricant DS, Farnsworth NR (2001) The value of plants used in traditional medicine for drug discovery. Environ Health Perspect 109: 69-75.
-
(2001)
Environ Health Perspect
, vol.109
, pp. 69-75
-
-
Fabricant, D.S.1
Farnsworth, N.R.2
-
11
-
-
0035882369
-
Pure compound libraries: A new perspective for natural product based drug discovery
-
Bindseil KU, Jakupovic J, Wolf D, Lavayre J, Leboul J, van der Pyl D (2001) Pure compound libraries: A new perspective for natural product based drug discovery. Drug Discov Today 6: 840-847.
-
(2001)
Drug Discov Today
, vol.6
, pp. 840-847
-
-
Bindseil, K.U.1
Jakupovic, J.2
Wolf, D.3
Lavayre, J.4
Leboul, J.5
Van Der Pyl, D.6
-
12
-
-
11344292132
-
The role of natural product chemistry in drug discovery
-
Butler MS (2004) The role of natural product chemistry in drug discovery. J Nat Prod 67: 2141-2153.
-
(2004)
J Nat Prod
, vol.67
, pp. 2141-2153
-
-
Butler, M.S.1
-
13
-
-
2942566175
-
Natural products in the process of finding new drug candidates
-
Vuorelaa P, Leinonenb M, Saikkuc P, Tammelaa P, Rauhad JP, Wennberge T, Vuorela H (2004) Natural products in the process of finding new drug candidates. Curr Med Chem 11: 1375-1389.
-
(2004)
Curr Med Chem
, vol.11
, pp. 1375-1389
-
-
Vuorelaa, P.1
Leinonenb, M.2
Saikkuc, P.3
Tammelaa, P.4
Rauhad, J.P.5
Wennberge, T.6
Vuorela, H.7
-
14
-
-
14944383798
-
The evolving role of natural products in drug discovery
-
Koehn FE, Carter GT (2005) The evolving role of natural products in drug discovery. Nat Rev Drug Discov 4: 206-220.
-
(2005)
Nat Rev Drug Discov
, vol.4
, pp. 206-220
-
-
Koehn, F.E.1
Carter, G.T.2
-
15
-
-
0036589465
-
Chemoinformatics methods for systematic comparison of molecules from natural and synthetic sources and design of hybrid libraries
-
Bajorath J (2002) Chemoinformatics methods for systematic comparison of molecules from natural and synthetic sources and design of hybrid libraries. J Comput Aided Mol Des 16: 431-439.
-
(2002)
J Comput Aided Mol des
, vol.16
, pp. 431-439
-
-
Bajorath, J.1
-
16
-
-
0042975166
-
Natural products - A simple model to explain chemical diversity
-
Firn RD, Jones CG (2003) Natural products - A simple model to explain chemical diversity. Nat Prod Rep 20: 382-391.
-
(2003)
Nat Prod Rep
, vol.20
, pp. 382-391
-
-
Firn, R.D.1
Jones, C.G.2
-
17
-
-
0035347869
-
Scaffold architecture and pharmacophoric properties of natural products and trade drugs: Application in the design of natural product-based combinatorial libraries
-
Lee ML, Schneider G (2001) Scaffold architecture and pharmacophoric properties of natural products and trade drugs: Application in the design of natural product-based combinatorial libraries. J Comb Chem 3: 284-289.
-
(2001)
J Comb Chem
, vol.3
, pp. 284-289
-
-
Lee, M.L.1
Schneider, G.2
-
18
-
-
9244238653
-
Natural products as a hunting ground for combinatorial chemistry
-
Ganesan A (2004) Natural products as a hunting ground for combinatorial chemistry. Curr Opin Biotechnol 15: 584-590.
-
(2004)
Curr Opin Biotechnol
, vol.15
, pp. 584-590
-
-
Ganesan, A.1
-
19
-
-
2942565810
-
Natural products and combinatorial chemistry: Back to the future
-
Ortholand JY, Ganesan A (2004) Natural products and combinatorial chemistry: back to the future. Curr Opin Chem Biol 8: 271-280.
-
(2004)
Curr Opin Chem Biol
, vol.8
, pp. 271-280
-
-
Ortholand, J.Y.1
Ganesan, A.2
-
20
-
-
34247109045
-
Natural products as sources of new drugs over the last 25 years
-
Newman DJ, Cragg GM (2007) Natural products as sources of new drugs over the last 25 years. J Nat Prod 70: 461-477.
-
(2007)
J Nat Prod
, vol.70
, pp. 461-477
-
-
Newman, D.J.1
Cragg, G.M.2
-
21
-
-
0025818916
-
Natural products as probes for new drug target identification
-
Evans FJ (1991) Natural products as probes for new drug target identification. J Ethnopharmacol 32: 91-101.
-
(1991)
J Ethnopharmacol
, vol.32
, pp. 91-101
-
-
Evans, F.J.1
-
23
-
-
0036889051
-
Natural products and derivatives as leads to cell cycle pathway targets in cancer chemotherapy
-
Newman DJ, Cragg GM, Holbeck S, Sausville EA (2002) Natural products and derivatives as leads to cell cycle pathway targets in cancer chemotherapy. Curr Cancer Drug Targets 2: 279-308.
-
(2002)
Curr Cancer Drug Targets
, vol.2
, pp. 279-308
-
-
Newman, D.J.1
Cragg, G.M.2
Holbeck, S.3
Sausville, E.A.4
-
24
-
-
33751226567
-
Therapeutic potential of natural product signal transduction agents
-
Koehn FE (2006) Therapeutic potential of natural product signal transduction agents. Curr Opin Biotechnol 17: 631-637.
-
(2006)
Curr Opin Biotechnol
, vol.17
, pp. 631-637
-
-
Koehn, F.E.1
-
25
-
-
0035138232
-
Pharmacognosy in the 21st century
-
Kinghorn AD (2001) Pharmacognosy in the 21st century. J Pharm Pharmacol 53: 135-148.
-
(2001)
J Pharm Pharmacol
, vol.53
, pp. 135-148
-
-
Kinghorn, A.D.1
-
26
-
-
33645816334
-
The role of pharmacognosy in modern medicine and pharmacy
-
Jones WP, Chin YW, Kinghorn AD (2006) The role of pharmacognosy in modern medicine and pharmacy. Curr Drug Targets 7: 247-264.
-
(2006)
Curr Drug Targets
, vol.7
, pp. 247-264
-
-
Jones, W.P.1
Chin, Y.W.2
Kinghorn, A.D.3
-
27
-
-
0000343196
-
Tropane and related alkaloids
-
Hemscheidt T (2000) Tropane and related alkaloids. Topics Curr Chem 209: 175-206.
-
(2000)
Topics Curr Chem
, vol.209
, pp. 175-206
-
-
Hemscheidt, T.1
-
28
-
-
0036263186
-
Tropane alkaloids in pharmaceutical and phytochemical analysis
-
Gadzikowska M, Grynkiewicz G (2002) Tropane alkaloids in pharmaceutical and phytochemical analysis. Acta Pol Pharm 59: 149-160.
-
(2002)
Acta Pol Pharm
, vol.59
, pp. 149-160
-
-
Gadzikowska, M.1
Grynkiewicz, G.2
-
29
-
-
33644609505
-
Precessation treatment with nicotine skin patch facilitates smoking cessation
-
Rose JE, Behm, FM, Westman EC, Kukovich P (2006) Precessation treatment with nicotine skin patch facilitates smoking cessation. Nicot Tobacco Res 8: 89-101.
-
(2006)
Nicot Tobacco Res
, vol.8
, pp. 89-101
-
-
Rose, J.E.1
Behm, F.M.2
Westman, E.C.3
Kukovich, P.4
-
31
-
-
27844592673
-
Can herbs provide a new generation of drugs for treating Alzheimer's disease?
-
Anekonda TS, Reddy PH (2005) Can herbs provide a new generation of drugs for treating Alzheimer's disease? Brain Res Brain Res Rev 50: 361-376.
-
(2005)
Brain Res Brain Res Rev
, vol.50
, pp. 361-376
-
-
Anekonda, T.S.1
Reddy, P.H.2
-
33
-
-
0037125974
-
Nerve growth factor and galantamine ameliorate early signs of neurodegeneration in antinerve growth factor mice
-
Capsoni S, Giannotta S, Cattaneo A (2002) Nerve growth factor and galantamine ameliorate early signs of neurodegeneration in antinerve growth factor mice. Proc Natl Acad Sci USA 99: 12432-12437.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 12432-12437
-
-
Capsoni, S.1
Giannotta, S.2
Cattaneo, A.3
-
34
-
-
0037272674
-
Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders
-
Howes M-JR, Perry NSL, Houghton PJ (2003) Plants with traditional uses and activities, relevant to the management of Alzheimer's disease and other cognitive disorders. Phytother Res 17: 1-18.
-
(2003)
Phytother Res
, vol.17
, pp. 1-18
-
-
Howes, M.-J.R.1
Perry, N.S.L.2
Houghton, P.J.3
-
35
-
-
2342501400
-
Galanthamine from snowdrop - The development of a modern drug against Alzheimer's disease from local Caucasian knowledge
-
Heinrich M, Teoh HL (2004) Galanthamine from snowdrop - The development of a modern drug against Alzheimer's disease from local Caucasian knowledge. J Ethnopharmacol 92: 147-162.
-
(2004)
J Ethnopharmacol
, vol.92
, pp. 147-162
-
-
Heinrich, M.1
Teoh, H.L.2
-
36
-
-
31544471441
-
Synthesis and pharmacology of galantamine
-
Marco-Contelles J, Carreiras MdC, Rodriguez C, Villarroya M, Garcia AG (2006) Synthesis and pharmacology of galantamine. Chem Rev 106: 116-133.
-
(2006)
Chem Rev
, vol.106
, pp. 116-133
-
-
Marco-Contelles, J.1
Carreiras, M.2
Rodriguez, C.3
Villarroya, M.4
Garcia, A.G.5
-
37
-
-
34447132163
-
Scientists stir the pot for right to grow marijuana
-
Frood A (2007) Scientists stir the pot for right to grow marijuana. Nat Med 13: 764.
-
(2007)
Nat Med
, vol.13
, pp. 764
-
-
Frood, A.1
-
38
-
-
23444432920
-
The endocannabinoid system: Drug targets, lead compounds, and potential therapeutic applications
-
Lambert DM, Fowler CJ (2005) The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications. J Med Chem 48: 5059-5087.
-
(2005)
J Med Chem
, vol.48
, pp. 5059-5087
-
-
Lambert, D.M.1
Fowler, C.J.2
-
39
-
-
33645816506
-
Sativex ®: Clinical efficacy and tolerability in the treatment of symptoms of multiple sclerosis and neuropathic pain
-
Barnes MP (2006) Sativex ®: clinical efficacy and tolerability in the treatment of symptoms of multiple sclerosis and neuropathic pain. Exp Opin Pharmacother 7: 607-615.
-
(2006)
Exp Opin Pharmacother
, vol.7
, pp. 607-615
-
-
Barnes, M.P.1
-
40
-
-
33751431303
-
History of tropical medicine: William Ernest Cooke, FRCSI (1879-1967) and his Asian tour of 1929-1930
-
Cook GC (2006) History of tropical medicine: William Ernest Cooke, FRCSI (1879-1967) and his Asian tour of 1929-1930. Acta Trop 100: 1-10.
-
(2006)
Acta Trop
, vol.100
, pp. 1-10
-
-
Cook, G.C.1
-
42
-
-
0002776039
-
How Chinese scientists discovered qinghaosu (artemisinin) and developed its derivatives. What are the future perspectives?
-
Li Y, Wu YL (1998) How Chinese scientists discovered qinghaosu (artemisinin) and developed its derivatives. What are the future perspectives? Med Trop (Mars.) 58: 9-12.
-
(1998)
Med Trop (Mars.)
, vol.58
, pp. 9-12
-
-
Li, Y.1
Wu, Y.L.2
-
43
-
-
33751006146
-
Current perspectives on the mechanism of action of artemisinins
-
Golenser J, Waknine JH, Krugliak M, Hunt NH, Grau GE (2006) Current perspectives on the mechanism of action of artemisinins. Int J Parasitol 36: 1427-1441.
-
(2006)
Int J Parasitol
, vol.36
, pp. 1427-1441
-
-
Golenser, J.1
Waknine, J.H.2
Krugliak, M.3
Hunt, N.H.4
Grau, G.E.5
-
44
-
-
34347347791
-
Companies agree to withdraw artemisinin monotherapy
-
Kerr C (2006) Companies agree to withdraw artemisinin monotherapy. Lancet Infect Dis 6: 397.
-
(2006)
Lancet Infect Dis
, vol.6
, pp. 397
-
-
Kerr, C.1
-
45
-
-
33646685942
-
Lunar Society and the discovery of digitalis
-
Buchtel L, Ventura HO (2006) Lunar Society and the discovery of digitalis. J La State Med Soc 158: 26-30.
-
(2006)
J La State Med Soc
, vol.158
, pp. 26-30
-
-
Buchtel, L.1
Ventura, H.O.2
-
46
-
-
13844296680
-
Digitalis purpurea
-
Warren B (2005) Digitalis purpurea. Am J Cardiol 95: 544.
-
(2005)
Am J Cardiol
, vol.95
, pp. 544
-
-
Warren, B.1
-
47
-
-
0015211527
-
Plant antitumor agents. VI. The isolation and structure of taxol, A novel antileukemic and antitumor agent from Taxus brevifolia
-
Wani MC, Taylor HL, Wall ME, Coggon P, McPhail AT (1971) Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia. J Am Chem Soc 93: 2325-2327.
-
(1971)
J Am Chem Soc
, vol.93
, pp. 2325-2327
-
-
Wani, M.C.1
Taylor, H.L.2
Wall, M.E.3
Coggon, P.4
McPhail, A.T.5
-
48
-
-
1442310087
-
A tale of two tumor targets: Topoisomerase I and tubulin. The Wall and Wani contribution to cancer chemotherapy
-
Cragg GM, Newman DJ (2004) A tale of two tumor targets: Topoisomerase I and tubulin. The Wall and Wani contribution to cancer chemotherapy. J Nat Prod 67: 232-244.
-
(2004)
J Nat Prod
, vol.67
, pp. 232-244
-
-
Cragg, G.M.1
Newman, D.J.2
-
50
-
-
0016701089
-
Interaction of vinblastine with calf brain microtubule protein
-
Lee JC, Harrison D, Timasheff SN (1975) Interaction of vinblastine with calf brain microtubule protein. J Biol Chem 250: 9276-9282.
-
(1975)
J Biol Chem
, vol.250
, pp. 9276-9282
-
-
Lee, J.C.1
Harrison, D.2
Timasheff, S.N.3
-
51
-
-
1642263128
-
The Catharanthus alkaloids: Pharmacognosy and biotechnology
-
Van Der Heijden R, Jacobs DI, Snoeijer W, Hallard D, Verpoorte R (2004) The Catharanthus alkaloids: pharmacognosy and biotechnology. Curr Med Chem 11: 607-628.
-
(2004)
Curr Med Chem
, vol.11
, pp. 607-628
-
-
Van Der Heijden, R.1
Jacobs, D.I.2
Snoeijer, W.3
Hallard, D.4
Verpoorte, R.5
-
52
-
-
23044490704
-
Plants as a source of anti-cancer agents
-
Cragg GM, Newman DJ (2005) Plants as a source of anti-cancer agents. J Ethnopharmacol 100: 72-79.
-
(2005)
J Ethnopharmacol
, vol.100
, pp. 72-79
-
-
Cragg, G.M.1
Newman, D.J.2
-
53
-
-
0033035094
-
Artemisinin drugs in the treatment of malaria: From medicinal herb to registered medication
-
van Agtmael MA, Eggelte TA, van Boxtel CJ (1999) Artemisinin drugs in the treatment of malaria: from medicinal herb to registered medication. Trends Pharmacol Sci 20: 199-205.
-
(1999)
Trends Pharmacol Sci
, vol.20
, pp. 199-205
-
-
Van Agtmael, M.A.1
Eggelte, T.A.2
Van Boxtel, C.J.3
-
54
-
-
24344443742
-
The therapeutic potential of semi-synthetic artemisinin and synthetic endoperoxide antimalarial agents
-
O'Neill PM (2005) The therapeutic potential of semi-synthetic artemisinin and synthetic endoperoxide antimalarial agents. Expert Opin Investig Drugs 14: 1117-1128.
-
(2005)
Expert Opin Investig Drugs
, vol.14
, pp. 1117-1128
-
-
O'Neill, P.M.1
-
55
-
-
4644230441
-
Combination therapy counteracts the enhanced transmission of drug-resistant malaria parasites to mosquitoes
-
Hallett RL, Sutherland CJ, Alexander N, Ord R, Jawara M, Drakeley CJ, Pinder M, Walraven G, Targett GA, Alloueche A (2004) Combination therapy counteracts the enhanced transmission of drug-resistant malaria parasites to mosquitoes. Antimicrob Agents Chemother 48: 3940-3943.
-
(2004)
Antimicrob Agents Chemother
, vol.48
, pp. 3940-3943
-
-
Hallett, R.L.1
Sutherland, C.J.2
Alexander, N.3
Ord, R.4
Jawara, M.5
Drakeley, C.J.6
Pinder, M.7
Walraven, G.8
Targett, G.A.9
Alloueche, A.10
-
56
-
-
84920038484
-
Facts on acts (Artemisinin-based combination therapies)
-
accessed November 2007
-
Facts on acts (Artemisinin-based combination therapies). Further information available at: http://www.searo.who.int/LinkFiles/Drug-Policy-RBMInfosheet-9.pdf (accessed November 2007).
-
Further Information
-
-
-
57
-
-
0034041275
-
Recent advances in the chemistry of taxol
-
Kingston DGI (2000) Recent advances in the chemistry of taxol. J Nat Prod 63: 726-734.
-
(2000)
J Nat Prod
, vol.63
, pp. 726-734
-
-
Kingston, D.G.I.1
-
58
-
-
0028012837
-
Total synthesis of taxol
-
Nicolaou KC, Yang Z, Liu JJ, Ueno H, Nantermet PG, Guy RK, Claiborne CF, Renaud J, Couladouros EA, Paulvannan K, Sorensen EJ (1994) Total synthesis of taxol. Nature 367: 630-634.
-
(1994)
Nature
, vol.367
, pp. 630-634
-
-
Nicolaou, K.C.1
Yang, Z.2
Liu, J.J.3
Ueno, H.4
Nantermet, P.G.5
Guy, R.K.6
Claiborne, C.F.7
Renaud, J.8
Couladouros, E.A.9
Paulvannan, K.10
Sorensen, E.J.11
-
59
-
-
0028213668
-
First total synthesis of taxol. 1. Functionalization of the B ring
-
Holton RA, Somoza C, Kim HB, Liang F, Biediger RJ, Boatman PD, Shindo M, Smith CC, Kim SC, Nadizadeh H, Suzuki Y, Tao CL, Vu P, Tang S, Zhang P, Murthi KK, Gentile LN, Liu JH (1994) First total synthesis of taxol. 1. Functionalization of the B ring. J Am Chem Soc 116: 1597-1598.
-
(1994)
J Am Chem Soc
, vol.116
, pp. 1597-1598
-
-
Holton, R.A.1
Somoza, C.2
Kim, H.B.3
Liang, F.4
Biediger, R.J.5
Boatman, P.D.6
Shindo, M.7
Smith, C.C.8
Kim, S.C.9
Nadizadeh, H.10
Suzuki, Y.11
Tao, C.L.12
Vu, P.13
Tang, S.14
Zhang, P.15
Murthi, K.K.16
Gentile, L.N.17
Liu, J.H.18
-
60
-
-
0028353983
-
First total synthesis of taxol. 2. Completion of the C and D rings
-
Holton RA, Somoza C, Kim HB, Liang F, Biediger RJ, Boatman PD, Shindo M, Smith CC, Kim SC, Nadizadeh H, Suzuki Y, Tao CL, Vu P, Tang S, Zhang P, Murthi KK, Gentile LN, Liu JH (1994) First total synthesis of taxol. 2. Completion of the C and D rings. J Am Chem Soc 116: 1599-1600.
-
(1994)
J Am Chem Soc
, vol.116
, pp. 1599-1600
-
-
Holton, R.A.1
Somoza, C.2
Kim, H.B.3
Liang, F.4
Biediger, R.J.5
Boatman, P.D.6
Shindo, M.7
Smith, C.C.8
Kim, S.C.9
Nadizadeh, H.10
Suzuki, Y.11
Tao, C.L.12
Vu, P.13
Tang, S.14
Zhang, P.15
Murthi, K.K.16
Gentile, L.N.17
Liu, J.H.18
-
61
-
-
84886117962
-
Taxol and its analogs
-
Cragg GM, Kingston DGI, Newman DJ (eds), Taylor & Francis, Boca Raton, FL
-
Kingston DGI (2006) Taxol and its analogs. In: Cragg GM, Kingston DGI, Newman DJ (eds) Anticancer Agents from Natural Products. Taylor & Francis, Boca Raton, FL, pp 89-122.
-
(2006)
Anticancer Agents from Natural Products
, pp. 89-122
-
-
Kingston, D.G.I.1
-
62
-
-
0000052734
-
Taxol and Taxotere: Discovery, chemistry and structure-activity relationships
-
Guénard D, Guéritte-Voegelein F, Potier P (1993) Taxol and Taxotere: discovery, chemistry and structure-activity relationships. Acc Chem Res 26: 160-167.
-
(1993)
Acc Chem Res
, vol.26
, pp. 160-167
-
-
Guénard, D.1
Guéritte-Voegelein, F.2
Potier, P.3
-
63
-
-
33751517736
-
Antiviral agents active against influenza A viruses
-
De Clercq E (2006) Antiviral agents active against influenza A viruses. Nat Rev Drug Discov 5: 1015-1025.
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 1015-1025
-
-
De Clercq, E.1
-
64
-
-
40849150893
-
Antiviral drugs for influenza: Tamifluâ past, present and future
-
Laver G (2006) Antiviral drugs for influenza: Tamifluâ past, present and future. Future Virol 1: 577-586.
-
(2006)
Future Virol
, vol.1
, pp. 577-586
-
-
Laver, G.1
-
65
-
-
17244362180
-
Isolation of shikimic acid from star aniseed
-
Payne R, Edmonds M (2005) Isolation of shikimic acid from star aniseed. J Chem Ed 82: 599-600.
-
(2005)
J Chem Ed
, vol.82
, pp. 599-600
-
-
Payne, R.1
Edmonds, M.2
-
66
-
-
84920038483
-
Quantitative analysis and isolation of shikimic acid from Liquidambar styraciflua
-
Abstracts of Papers, Chicago, IL, March 25-29
-
Poon T, Enrich L, Mohadjer A (2007) Quantitative analysis and isolation of shikimic acid from Liquidambar styraciflua. Abstracts of Papers, 233rd American Chemical Society National Meeting, Chicago, IL, March 25-29.
-
(2007)
233rd American Chemical Society National Meeting
-
-
Poon, T.1
Enrich, L.2
Mohadjer, A.3
-
67
-
-
1642457254
-
Metabolic engineering for microbial production of shikimic acid
-
Krämer M, Bongaerts J, Bovenberg R, Kremer S, Müller U, Orf S, Wubbolts M, Raeven L (2003) Metabolic engineering for microbial production of shikimic acid. Metab Eng 5: 277-283.
-
(2003)
Metab Eng
, vol.5
, pp. 277-283
-
-
Krämer, M.1
Bongaerts, J.2
Bovenberg, R.3
Kremer, S.4
Müller, U.5
Orf, S.6
Wubbolts, M.7
Raeven, L.8
-
68
-
-
33646567839
-
A short enantioselective pathway for the synthesis of the anti-influenza neuramidase inhibitor oseltamivir from 1, 3-butadiene and acrylic acid
-
Yeung YY, Hong S, Corey EJ (2006) A short enantioselective pathway for the synthesis of the anti-influenza neuramidase inhibitor oseltamivir from 1, 3-butadiene and acrylic acid. J Am Chem Soc 128: 6310-6311.
-
(2006)
J Am Chem Soc
, vol.128
, pp. 6310-6311
-
-
Yeung, Y.Y.1
Hong, S.2
Corey, E.J.3
-
69
-
-
0033957078
-
Natural products as sources of herbicides: Current status and future trends
-
Duke SO, Dayan FE, Romagni JG, Rimando AM (2000) Natural products as sources of herbicides: current status and future trends. Weed Res 40: 99-111.
-
(2000)
Weed Res
, vol.40
, pp. 99-111
-
-
Duke, S.O.1
Dayan, F.E.2
Romagni, J.G.3
Rimando, A.M.4
-
70
-
-
33646766481
-
Nitisinone in the treatment of hereditary tyrosinaemia type 1
-
McKiernan PJ (2006) Nitisinone in the treatment of hereditary tyrosinaemia type 1. Drugs 66: 743-750.
-
(2006)
Drugs
, vol.66
, pp. 743-750
-
-
McKiernan, P.J.1
-
71
-
-
34248378313
-
Nitisinone: New drug. Type 1 tyrosinemia: An effective drug
-
Anonymous
-
Anonymous (2007) Nitisinone: new drug. Type 1 tyrosinemia: An effective drug. Prescrire Int 16: 56-58.
-
(2007)
Prescrire Int
, vol.16
, pp. 56-58
-
-
-
72
-
-
0004207821
-
-
St. Martin's Press, New York
-
Booth M (1984) Opium: A history. St. Martin's Press, New York.
-
(1984)
Opium: A History
-
-
Booth, M.1
-
73
-
-
84920038472
-
CDER new molecular entity (NME) drugs and new biologic approvals in calendar year 2004
-
accessed November 2007
-
US Food and Drug Administration. CDER new molecular entity (NME) drugs and new biologic approvals in calendar year 2004. Further information available at: http://www.fda.gov/cder/rdmt/nmecy2004.htm (accessed November 2007).
-
Further Information
-
-
-
74
-
-
2142716021
-
Analgesics for acute pain: Meeting the United States Food and Drug Administration's requirements for proof of efficacy
-
Ridgway D (2004) Analgesics for acute pain: meeting the United States Food and Drug Administration's requirements for proof of efficacy. Clin J Pain 20: 123-132.
-
(2004)
Clin J Pain
, vol.20
, pp. 123-132
-
-
Ridgway, D.1
-
75
-
-
33847735481
-
Naloxone treatment in opioid addiction: The risks and benefits
-
van Dorp ELA, Yassen A, Dahan A (2007) Naloxone treatment in opioid addiction: The risks and benefits. Expert Opin Drug Saf 6: 125-132.
-
(2007)
Expert Opin Drug Saf
, vol.6
, pp. 125-132
-
-
Van Dorp, E.L.A.1
Yassen, A.2
Dahan, A.3
-
76
-
-
33846096441
-
Sustainedrelease naltrexone formulations for the treatment of alcohol and opioid dependence
-
Volpicelli JR, Fenton M (2006) Sustainedrelease naltrexone formulations for the treatment of alcohol and opioid dependence. Future Neurol 1: 389-398.
-
(2006)
Future Neurol
, vol.1
, pp. 389-398
-
-
Volpicelli, J.R.1
Fenton, M.2
-
77
-
-
9644281924
-
Dose-response relationship with increasing doses of dextromethorphan for children with cough
-
Paul IM, Shaffer ML, Yoder KE, Sturgis SA, Baker MS, Berlin CM Jr (2004) Dose-response relationship with increasing doses of dextromethorphan for children with cough. Clin Ther 26: 1508-1514.
-
(2004)
Clin Ther
, vol.26
, pp. 1508-1514
-
-
Paul, I.M.1
Shaffer, M.L.2
Yoder, K.E.3
Sturgis, S.A.4
Baker, M.S.5
Berlin, C.M.6
-
79
-
-
25844502482
-
Plant-based anticancer molecules: A chemical and biological profile of some important leads
-
Srivastava V, Negi AS, Kumar JK, Gupta MM, Khanuja SPS (2005) Plant-based anticancer molecules: A chemical and biological profile of some important leads. Bioorg Med Chem 21: 5892-5908.
-
(2005)
Bioorg Med Chem
, vol.21
, pp. 5892-5908
-
-
Srivastava, V.1
Negi, A.S.2
Kumar, J.K.3
Gupta, M.M.4
Khanuja, S.P.S.5
-
81
-
-
2342638637
-
Bioactive isoflavone - genistein. Synthesis and prospective applications
-
Grynkiewicz G, Achmatowicz O, Pucko W (2000) Bioactive isoflavone - genistein. Synthesis and prospective applications. Herba Pol 46: 151-160.
-
(2000)
Herba Pol
, vol.46
, pp. 151-160
-
-
Grynkiewicz, G.1
Achmatowicz, O.2
Pucko, W.3
-
82
-
-
0034086058
-
Interactions of cyclic nucleotide-gated channel subunits and protein tyrosine kinase probed with genistein
-
Molokanova E, Savchenko A, Kramer RH (2000) Interactions of cyclic nucleotide-gated channel subunits and protein tyrosine kinase probed with genistein. J Gen Physiol 115: 685-696.
-
(2000)
J Gen Physiol
, vol.115
, pp. 685-696
-
-
Molokanova, E.1
Savchenko, A.2
Kramer, R.H.3
-
83
-
-
12144255588
-
Anticancer therapeutic potential of soy isoflavone, genistein
-
Ravindranath MH, Muthugounder S, Presser N, Viswanathan S (2004) Anticancer therapeutic potential of soy isoflavone, genistein. Adv Exp Med Biol 546: 121-165.
-
(2004)
Adv Exp Med Biol
, vol.546
, pp. 121-165
-
-
Ravindranath, M.H.1
Muthugounder, S.2
Presser, N.3
Viswanathan, S.4
-
84
-
-
0027351049
-
Forskolin and congeners
-
Bhat SV (1993) Forskolin and congeners. Prog Chem Org Nat Prod 62: 1-74.
-
(1993)
Prog Chem Org Nat Prod
, vol.62
, pp. 1-74
-
-
Bhat, S.V.1
-
85
-
-
0020503814
-
Forskolin: A labdane diterpenoid with antihypertensive, positive inotropic, platelet aggregation inhibitory, and adenylate cyclase activating properties
-
de Souza NJ, Dohadwalla AN, Reden J (1983) Forskolin: A labdane diterpenoid with antihypertensive, positive inotropic, platelet aggregation inhibitory, and adenylate cyclase activating properties. Med Res Rev 3: 201-219.
-
(1983)
Med Res Rev
, vol.3
, pp. 201-219
-
-
De Souza, N.J.1
Dohadwalla, A.N.2
Reden, J.3
-
86
-
-
0032412405
-
The structure, catalytic mechanism and regulation of adenylyl cyclase
-
Tesmer JJ, Sprang SR (1998) The structure, catalytic mechanism and regulation of adenylyl cyclase. Curr Opin Struct Biol 8: 713-719.
-
(1998)
Curr Opin Struct Biol
, vol.8
, pp. 713-719
-
-
Tesmer, J.J.1
Sprang, S.R.2
-
87
-
-
0031655330
-
Novel developments from natural products in cardiovascular research
-
Gilani AUH (1998) Novel developments from natural products in cardiovascular research. Phytother Res 12: S66-S69.
-
(1998)
Phytother Res
, vol.12
, pp. S66-S69
-
-
Gilani, A.U.H.1
-
89
-
-
0029610477
-
Review of the biology of quercetin and related bioflavonoids
-
Formica JV, Regelson W (1995) Review of the biology of quercetin and related bioflavonoids. Food Chem Toxicol 12: 1061-1080.
-
(1995)
Food Chem Toxicol
, vol.12
, pp. 1061-1080
-
-
Formica, J.V.1
Regelson, W.2
-
90
-
-
1842421154
-
Molecular imaging of the biological effects of quercetin and quercetin-rich foods
-
Moskaug JO, Carlsen H, Myhrstad M, Blomhoff R (2004) Molecular imaging of the biological effects of quercetin and quercetin-rich foods. Mech Ageing Dev 125: 315-324.
-
(2004)
Mech Ageing Dev
, vol.125
, pp. 315-324
-
-
Moskaug, J.O.1
Carlsen, H.2
Myhrstad, M.3
Blomhoff, R.4
-
91
-
-
67651141717
-
Quercetin: A versatile flavonoid
-
Further information, accessed December 2007
-
Lakhanpal P, Rai DK (2007) Quercetin: A versatile flavonoid. Internet J Med Update 2(2): Further information available at: http://www.geocities.com/agnihotrimed/paper05-juldec2007.htm (accessed December 2007).
-
(2007)
Internet J Med Update
, vol.2
, Issue.2
-
-
Lakhanpal, P.1
Rai, D.K.2
-
92
-
-
20844443677
-
Binding of selected phenolic compounds to proteins
-
Rawel HM, Meidtner K, Kroll J (2005) Binding of selected phenolic compounds to proteins. J Agric Food Chem 53: 4228-4235.
-
(2005)
J Agric Food Chem
, vol.53
, pp. 4228-4235
-
-
Rawel, H.M.1
Meidtner, K.2
Kroll, J.3
-
93
-
-
30644479887
-
Interactions of quercetin and its lanthane complex with double stranded DNA/RNA and single stranded RNA: Spectrophotometric sensing of poly G
-
Marinic M, Piantanida I, Rusak G, Zinic M (2006) Interactions of quercetin and its lanthane complex with double stranded DNA/RNA and single stranded RNA: Spectrophotometric sensing of poly G. J Inorg Biochem 100: 288-298.
-
(2006)
J Inorg Biochem
, vol.100
, pp. 288-298
-
-
Marinic, M.1
Piantanida, I.2
Rusak, G.3
Zinic, M.4
-
94
-
-
34247562656
-
Quercetin exhibits a specific fluorescence in cellular milieu: A valuable tool for the study of its intracellular distribution
-
Nifli AP, Theodoropoulos PA, Munier S, Castagnino C, Roussakis E, Katerinopoulos HE, Vercauteren J, Castanas E (2007) Quercetin exhibits a specific fluorescence in cellular milieu: A valuable tool for the study of its intracellular distribution. J Agric Food Chem 55: 2873-2878.
-
(2007)
J Agric Food Chem
, vol.55
, pp. 2873-2878
-
-
Nifli, A.P.1
Theodoropoulos, P.A.2
Munier, S.3
Castagnino, C.4
Roussakis, E.5
Katerinopoulos, H.E.6
Vercauteren, J.7
Castanas, E.8
-
95
-
-
0034670173
-
Pharmacology of the receptors for the phorbol ester tumor promoters: Multiple receptors with different biochemical properties
-
Kazanietz MG, Caloca MJ, Eroles P, Fujii T, Garcia-Bermejo ML, Reilly M, Wang H (2000) Pharmacology of the receptors for the phorbol ester tumor promoters: multiple receptors with different biochemical properties. Biochem Pharmacol 60: 1417-1424.
-
(2000)
Biochem Pharmacol
, vol.60
, pp. 1417-1424
-
-
Kazanietz, M.G.1
Caloca, M.J.2
Eroles, P.3
Fujii, T.4
Garcia-Bermejo, M.L.5
Reilly, M.6
Wang, H.7
-
96
-
-
34547472118
-
Phorbol esters: Structure, biological activity, and toxicity in animals
-
Gunjan G, Harinder PSM, George F, Klaus B (2007) Phorbol esters: structure, biological activity, and toxicity in animals. Int J Toxicol 26: 279-288.
-
(2007)
Int J Toxicol
, vol.26
, pp. 279-288
-
-
Gunjan, G.1
Harinder, P.S.M.2
George, F.3
Klaus, B.4
-
97
-
-
0022129496
-
Tumor-promoting phorbol esters induce angiogenesis in vitro
-
Montesano R, Orci L (1985) Tumor-promoting phorbol esters induce angiogenesis in vitro. Cell 42: 469-477.
-
(1985)
Cell
, vol.42
, pp. 469-477
-
-
Montesano, R.1
Orci, L.2
-
98
-
-
0016701089
-
Interaction of vinblastine with calf brain microtubule protein
-
Lee JC, Harrison D, Timasheff SN (1975) Interaction of vinblastine with calf brain microtubule protein. J Biol Chem 250: 9276-9282.
-
(1975)
J Biol Chem
, vol.250
, pp. 9276-9282
-
-
Lee, J.C.1
Harrison, D.2
Timasheff, S.N.3
-
99
-
-
0017344821
-
Podophyllotoxin as a probe for the colchicine binding site of tubulin
-
Cortese F, Bhattacharyya B, Wolff J (1977) Podophyllotoxin as a probe for the colchicine binding site of tubulin. J Biol Chem 252: 1134-1140.
-
(1977)
J Biol Chem
, vol.252
, pp. 1134-1140
-
-
Cortese, F.1
Bhattacharyya, B.2
Wolff, J.3
-
102
-
-
84891324458
-
Using small molecules to unravel biological mechanisms
-
Lampson MA, Kapoor TM (2007) Using small molecules to unravel biological mechanisms. Chem Biol 1: 71-94.
-
(2007)
Chem Biol
, vol.1
, pp. 71-94
-
-
Lampson, M.A.1
Kapoor, T.M.2
-
103
-
-
0025224503
-
Resiniferatoxin: An ultrapotent selective modulator of capsaicinsensitive primary afferent neurons
-
Szolcsanyi J, Szallasi A, Szallasi Z, Joo F, Blumberg PM (1990) Resiniferatoxin: An ultrapotent selective modulator of capsaicinsensitive primary afferent neurons. J Pharmacol Exp Ther 255: 923-928.
-
(1990)
J Pharmacol Exp Ther
, vol.255
, pp. 923-928
-
-
Szolcsanyi, J.1
Szallasi, A.2
Szallasi, Z.3
Joo, F.4
Blumberg, P.M.5
-
104
-
-
0030777012
-
The capsaicin receptor: A heat-activated ion channel in the pain pathway
-
Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D (1997) The capsaicin receptor: A heat-activated ion channel in the pain pathway. Nature 389: 816-824.
-
(1997)
Nature
, vol.389
, pp. 816-824
-
-
Caterina, M.J.1
Schumacher, M.A.2
Tominaga, M.3
Rosen, T.A.4
Levine, J.D.5
Julius, D.6
-
105
-
-
0023892725
-
Postherpetic neuralgia and topical capsaicin
-
Watson CP, Evans RJ, Watt VR (1988) Postherpetic neuralgia and topical capsaicin. Pain 33: 333-340.
-
(1988)
Pain
, vol.33
, pp. 333-340
-
-
Watson, C.P.1
Evans, R.J.2
Watt, V.R.3
-
106
-
-
84907806183
-
-
accessed November 2007
-
Anesiva, Inc. Further information available at: http://www.anesiva.com/wt/page/pipeline (accessed November 2007).
-
Further Information
-
-
-
107
-
-
17844399025
-
Natural products to drugs: Natural product compounds in clinical trials
-
Butler MS (2005) Natural products to drugs: natural product compounds in clinical trials. Nat Prod Rep 22: 162-195.
-
(2005)
Nat Prod Rep
, vol.22
, pp. 162-195
-
-
Butler, M.S.1
-
109
-
-
34548279788
-
Molecular understanding and modern application of traditional medicines: Triumphs and trials
-
Corson TW, Crews CM (2007) Molecular understanding and modern application of traditional medicines: Triumphs and trials. Cell 130: 769-774.
-
(2007)
Cell
, vol.130
, pp. 769-774
-
-
Corson, T.W.1
Crews, C.M.2
-
110
-
-
0013959835
-
Chemical studies on the oriental plant drugs. XVI. The stereochemistry of protopanaxadiol, a genuine sapogenin of ginseng
-
Tanaka O, Nagai M, Shibata S (1966) Chemical studies on the oriental plant drugs. XVI. The stereochemistry of protopanaxadiol, a genuine sapogenin of ginseng. Chem Pharm Bull 14: 1150-1156.
-
(1966)
Chem Pharm Bull
, vol.14
, pp. 1150-1156
-
-
Tanaka, O.1
Nagai, M.2
Shibata, S.3
-
111
-
-
0036403187
-
Structurefunction relationship exists for ginsenosides in reducing cell proliferation and inducing apoptosis in the human leukemia (THP-1) cell line
-
Popovich DG, Kitts DD (2002) Structurefunction relationship exists for ginsenosides in reducing cell proliferation and inducing apoptosis in the human leukemia (THP-1) cell line. Arch Biochem Biophys 406: 1-8.
-
(2002)
Arch Biochem Biophys
, vol.406
, pp. 1-8
-
-
Popovich, D.G.1
Kitts, D.D.2
-
112
-
-
33646734515
-
Ginsenoside 20( S )-protopanaxadiol inhibits the proliferation and invasion of human fibrosarcoma HT1080 cells
-
Li G, Wang ZH, Sun YX, Liu K, Wang Z (2006) Ginsenoside 20( S )-protopanaxadiol inhibits the proliferation and invasion of human fibrosarcoma HT1080 cells. Basic Clin Pharmacol Toxicol 98: 588-592.
-
(2006)
Basic Clin Pharmacol Toxicol
, vol.98
, pp. 588-592
-
-
Li, G.1
Wang, Z.H.2
Sun, Y.X.3
Liu, K.4
Wang, Z.5
-
113
-
-
33947394746
-
20 S - Protopanaxadiol-induced programmed cell death in glioma cells through caspase-dependent and -independent pathways
-
Liu GY, Bu X, Yan H, Jia WWG (2007) 20 S - Protopanaxadiol-induced programmed cell death in glioma cells through caspase-dependent and -independent pathways. J Nat Prod 70: 259-265.
-
(2007)
J Nat Prod
, vol.70
, pp. 259-265
-
-
Liu, G.Y.1
Bu, X.2
Yan, H.3
Jia, W.W.G.4
-
114
-
-
84907806183
-
-
accessed November 2007
-
PanaGin Pharmaceuticals, Inc. Further information available at: http://www.panagin.com (accessed November 2007).
-
Further Information
-
-
-
115
-
-
0017176632
-
The genus Cephalotaxus: Source of homoharringtonine and related anticancer alkaloids
-
Smith CR Jr, Powell RG, Mikolajczak KL (1976) The genus Cephalotaxus: source of homoharringtonine and related anticancer alkaloids. Cancer Treat Rep 60: 1157-1170.
-
(1976)
Cancer Treat Rep
, vol.60
, pp. 1157-1170
-
-
Smith, C.R.1
Powell, R.G.2
Mikolajczak, K.L.3
-
116
-
-
5444238462
-
Homoharringtonine: A new treatment option for myeloid leukemia
-
Luo CY, Tang JY, Wang YP (2004) Homoharringtonine: A new treatment option for myeloid leukemia. Hematology 9: 259-270.
-
(2004)
Hematology
, vol.9
, pp. 259-270
-
-
Luo, C.Y.1
Tang, J.Y.2
Wang, Y.P.3
-
117
-
-
33846261532
-
Phase I/II study of subcutaneous homoharringtonine in patients with chronic myeloid leukemia who have failed prior therapy
-
Quintas-Cardama A, Kantarjian H, Garcia-Manero G, O'Brien S, Faderl S, Estrov Z, Giles F, Murgo A, Ladie N, Verstovsek S, Cortes J (2007) Phase I/II study of subcutaneous homoharringtonine in patients with chronic myeloid leukemia who have failed prior therapy. Cancer 109: 248-255.
-
(2007)
Cancer
, vol.109
, pp. 248-255
-
-
Quintas-Cardama, A.1
Kantarjian, H.2
Garcia-Manero, G.3
O'Brien, S.4
Faderl, S.5
Estrov, Z.6
Giles, F.7
Murgo, A.8
Ladie, N.9
Verstovsek, S.10
Cortes, J.11
-
118
-
-
84920038471
-
The Rocky Mountain blood and marrow transplant program (RMBMTP), Initial patients treated in multinational phase 2/3 study of ceflatonin 09-20-2006
-
accessed January 2008
-
The Rocky Mountain blood and marrow transplant program (RMBMTP), Initial patients treated in multinational phase 2/3 study of ceflatonin 09-20-2006. Further information available at: http://www.rockymountainbmt.com/news/Initial-Patients-Treated-in-Multinational-Phase-23-Study-of-Ceflatonin-4682.html (accessed January 2008).
-
Further Information
-
-
-
120
-
-
84920038470
-
-
accessed November 2007
-
Further information for oxymatrine available at: http://www.sda.gov.cn/cmsweb/webportal (accessed November 2007).
-
Further Information for Oxymatrine
-
-
-
121
-
-
0032034585
-
Preliminary study on therapeutic effect of oxymatrine in treating patients with chronic hepatitis C
-
Li J, Li C, Zeng M (1998) Preliminary study on therapeutic effect of oxymatrine in treating patients with chronic hepatitis C. Chin J Integr Tradit West Med 18: 227-229.
-
(1998)
Chin J Integr Tradit West Med
, vol.18
, pp. 227-229
-
-
Li, J.1
Li, C.2
Zeng, M.3
-
122
-
-
0036106182
-
Effect of oxymatrine on murine fulminant hepatitis and hepatocyte apoptosis
-
Xiang XX, Wang GJ, Cai X, LI YL (2002) Effect of oxymatrine on murine fulminant hepatitis and hepatocyte apoptosis. Chin Med J 115: 593-596.
-
(2002)
Chin Med J
, vol.115
, pp. 593-596
-
-
Xiang, X.X.1
Wang, G.J.2
Cai, X.3
Li, Y.L.4
-
123
-
-
9744244198
-
Capsule oxymatrine in treatment of hepatic fibrosis due to chronic viral hepatitis: A randomized, double blind, placebo-controlled, multicenter clinical study
-
Mao YM, Zeng MD, Lu LG, Wan MB, Li CZ, Chen CW, Fu QC, Wang JY, She WM, Cai X, Ye J, Zhou XQ, Wang H, Wu SM, Tang MF, Zhu JS, Chen WX, Zhang HQ (2004) Capsule oxymatrine in treatment of hepatic fibrosis due to chronic viral hepatitis: A randomized, double blind, placebo-controlled, multicenter clinical study. World J Gastroenterol 10: 3269-3273.
-
(2004)
World J Gastroenterol
, vol.10
, pp. 3269-3273
-
-
Mao, Y.M.1
Zeng, M.D.2
Lu, L.G.3
Wan, M.B.4
Li, C.Z.5
Chen, C.W.6
Fu, Q.C.7
Wang, J.Y.8
She, W.M.9
Cai, X.10
Ye, J.11
Zhou, X.Q.12
Wang, H.13
Wu, S.M.14
Tang, M.F.15
Zhu, J.S.16
Chen, W.X.17
Zhang, H.Q.18
-
124
-
-
0036765911
-
Phenoxodiol [2H-1-benzopyran-7-ol, 3-(4-hydroxyphenyl)], a novel isoflavone derivative, inhibits DNA topoisomerase II by stabilizing the cleavable complex
-
Constantinou AI, Husband A (2002) Phenoxodiol [2H-1-benzopyran-7-ol, 3-(4-hydroxyphenyl)], a novel isoflavone derivative, inhibits DNA topoisomerase II by stabilizing the cleavable complex. Anticancer Res 22: 2581-2585.
-
(2002)
Anticancer Res
, vol.22
, pp. 2581-2585
-
-
Constantinou, A.I.1
Husband, A.2
-
125
-
-
33645547602
-
Phenoxodiol: Isoflavone analog with antineoplastic activity
-
Choueiri TK, Wesolowski R, Mekhail TM (2006) Phenoxodiol: isoflavone analog with antineoplastic activity. Curr Oncol Rep 8: 104-107.
-
(2006)
Curr Oncol Rep
, vol.8
, pp. 104-107
-
-
Choueiri, T.K.1
Wesolowski, R.2
Mekhail, T.M.3
-
126
-
-
0026586723
-
Identification in human urine of a natural growth inhibitor for cells derived from solid paediatric tumours
-
Schweigerer L, Christeleit K, Fleischmann G, Adlercreutz H, Wahala K, Hase T, Schwab M, Ludwig R, Fotsis T (1992) Identification in human urine of a natural growth inhibitor for cells derived from solid paediatric tumours. Eur J Clin Invest 22: 260-264.
-
(1992)
Eur J Clin Invest
, vol.22
, pp. 260-264
-
-
Schweigerer, L.1
Christeleit, K.2
Fleischmann, G.3
Adlercreutz, H.4
Wahala, K.5
Hase, T.6
Schwab, M.7
Ludwig, R.8
Fotsis, T.9
-
127
-
-
33745146190
-
Phenoxodiol, a novel approach for the treatment of ovarian cancer
-
Mor G, Fu HH, Alvero AB (2006) Phenoxodiol, a novel approach for the treatment of ovarian cancer. Curr Opin Investig Drugs 7: 542-548.
-
(2006)
Curr Opin Investig Drugs
, vol.7
, pp. 542-548
-
-
Mor, G.1
Fu, H.H.2
Alvero, A.B.3
-
128
-
-
84922342912
-
The structures of huperzine A and B, two new alkaloids exhibiting marked anticholinesterase activity
-
Liu JS, Zhu YL, Yu CM, Zhou YZ, Han YY, Wu FW, Qi BF (1986) The structures of huperzine A and B, two new alkaloids exhibiting marked anticholinesterase activity. Can J Chem 64: 837-839.
-
(1986)
Can J Chem
, vol.64
, pp. 837-839
-
-
Liu, J.S.1
Zhu, Y.L.2
Yu, C.M.3
Zhou, Y.Z.4
Han, Y.Y.5
Wu, F.W.6
Qi, B.F.7
-
129
-
-
0141953955
-
Progress in clinical, pharmacological, chemical and structural biological studies of huperzine A: A drug of traditional Chinese medicine origin for the treatment of Alzheimer's disease
-
Jiang HL, Luo XM, Bai DL (2003) Progress in clinical, pharmacological, chemical and structural biological studies of huperzine A: A drug of traditional Chinese medicine origin for the treatment of Alzheimer's disease. Curr Med Chem 10: 2231-2252.
-
(2003)
Curr Med Chem
, vol.10
, pp. 2231-2252
-
-
Jiang, H.L.1
Luo, X.M.2
Bai, D.L.3
-
130
-
-
34447578839
-
Huperzine A from Huperzia species - An ethnopharmacological review
-
Ma XQ, Tan CH, Zhu DY, Gang DR, Xiao PG (2007) Huperzine A from Huperzia species - An ethnopharmacological review. J Ethnopharmacol 113: 15-34.
-
(2007)
J Ethnopharmacol
, vol.113
, pp. 15-34
-
-
Ma, X.Q.1
Tan, C.H.2
Zhu, D.Y.3
Gang, D.R.4
Xiao, P.G.5
-
131
-
-
84920038469
-
Huperzine A in Alzheimer's disease
-
US National Institutes of Health. (accessed November 2007)
-
US National Institutes of Health. Huperzine A in Alzheimer's disease. Further information available at: http://www.clinicaltrials.gov/show/NCT00083590 (accessed November 2007).
-
Further Information
-
-
-
132
-
-
84920038468
-
Debio-9902 (formerly ZT-1) A novel treatment for Alzheimer's disease
-
accessed November 2007
-
Debiopharm. Debio-9902 (formerly ZT-1) A novel treatment for Alzheimer's disease. Further information available at: http://www.debio.com/e/pdf/zt-1-e.pdf (accessed November 2007).
-
Further Information
-
-
-
134
-
-
0346881254
-
Chemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection
-
Cichewicz RH, Kouzi SA (2004) Chemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection. Med Res Rev 24: 90-114.
-
(2004)
Med Res Rev
, vol.24
, pp. 90-114
-
-
Cichewicz, R.H.1
Kouzi, S.A.2
-
135
-
-
34447332823
-
Novel semisynthetic analogues of betulinic acid with diverse cytoprotective, antiproliferative, and proapoptotic activities
-
Liby K, Honda T, Williams CR, Risingsong R, Royce DB, Suh N, Dinkova-Kostova AT, Stephenson KK, Talalay P, Sundararajan C, Gribble GW, Sporn MB (2007) Novel semisynthetic analogues of betulinic acid with diverse cytoprotective, antiproliferative, and proapoptotic activities. Mol Cancer Ther 6: 2113-2119.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 2113-2119
-
-
Liby, K.1
Honda, T.2
Williams, C.R.3
Risingsong, R.4
Royce, D.B.5
Suh, N.6
Dinkova-Kostova, A.T.7
Stephenson, K.K.8
Talalay, P.9
Sundararajan, C.10
Gribble, G.W.11
Sporn, M.B.12
-
136
-
-
84920038467
-
Evaluation of 20% betulinic acid ointment for treatment of dysplastic nevi (moderate to severe dysplasia)
-
US National Institutes of Health. (accessed November 2007)
-
US National Institutes of Health. Evaluation of 20% betulinic acid ointment for treatment of dysplastic nevi (moderate to severe dysplasia). Further information available at: http://www.cancer.gov/search/ViewClinicalTrials.aspx?cdrid=494341&version=HealthProfessional&protocolsearchid=3664931 (accessed November 2007).
-
Further Information
-
-
-
137
-
-
33747601418
-
Drug evaluation: Bevirimat-HIV gag protein and viral maturation inhibitor
-
Temesgen Z, Feinberg JE (2006) Drug evaluation: bevirimat-HIV gag protein and viral maturation inhibitor. Curr Opin Invest Drugs 7: 759-765.
-
(2006)
Curr Opin Invest Drugs
, vol.7
, pp. 759-765
-
-
Temesgen, Z.1
Feinberg, J.E.2
-
138
-
-
33750695698
-
In vitro resistance to the human immunodeficiency virus type 1 maturation inhibitor PA-457 (bevirimat)
-
Adamson CS, Ablan SD, Boeras I, Goila-Gaur R, Soheilian Ferri, Nagashima K, Li F, Salzwedel K, Sakalian M, Wild CT, Freed EO (2006) In vitro resistance to the human immunodeficiency virus type 1 maturation inhibitor PA-457 (bevirimat). J Virol 80: 10957-10971.
-
(2006)
J Virol
, vol.80
, pp. 10957-10971
-
-
Adamson, C.S.1
Ablan, S.D.2
Boeras, I.3
Goila-Gaur, R.4
Soheilian, F.5
Nagashima, K.6
Li, F.7
Salzwedel, K.8
Sakalian, M.9
Wild, C.T.10
Freed, E.O.11
-
139
-
-
34948903088
-
Safety and pharmacokinetics of bevirimat (PA-457), A novel inhibitor of human immunodeficiency virus maturation, in healthy volunteers
-
Martin DE, Blum R, Wilton J, Doto J, Galbraith H, Burgess GL, Smith PC, Ballow C (2007) Safety and pharmacokinetics of bevirimat (PA-457), a novel inhibitor of human immunodeficiency virus maturation, in healthy volunteers. Antimicrob Agents Chemother 51: 3063-3066.
-
(2007)
Antimicrob Agents Chemother
, vol.51
, pp. 3063-3066
-
-
Martin, D.E.1
Blum, R.2
Wilton, J.3
Doto, J.4
Galbraith, H.5
Burgess, G.L.6
Smith, P.C.7
Ballow, C.8
-
140
-
-
34347370621
-
Multiple-dose pharmacokinetics and safety of bevirimat, a novel inhibitor of HIV maturation, in healthy volunteers
-
Martin DE, Blum R, Doto J, Galbraith H, Ballow C (2007) Multiple-dose pharmacokinetics and safety of bevirimat, a novel inhibitor of HIV maturation, in healthy volunteers. Clin Pharmacokinet 46: 589-598.
-
(2007)
Clin Pharmacokinet
, vol.46
, pp. 589-598
-
-
Martin, D.E.1
Blum, R.2
Doto, J.3
Galbraith, H.4
Ballow, C.5
-
141
-
-
4544277194
-
Combretastatin A4 phosphate: Background and current clinical status
-
Young SL, Chaplin DJ (2004) Combretastatin A4 phosphate: background and current clinical status. Expert Opin Investig Drugs 13: 1171-1182.
-
(2004)
Expert Opin Investig Drugs
, vol.13
, pp. 1171-1182
-
-
Young, S.L.1
Chaplin, D.J.2
-
142
-
-
2642571660
-
Vascular-targeting therapies for treatment of malignant disease
-
Siemann DW, Chaplin DJ, Horsman MR (2004) Vascular-targeting therapies for treatment of malignant disease. Cancer 100: 2491-2499.
-
(2004)
Cancer
, vol.100
, pp. 2491-2499
-
-
Siemann, D.W.1
Chaplin, D.J.2
Horsman, M.R.3
-
143
-
-
84920008357
-
-
Press releases June 5, 2006 and September 12, accessed November 2007
-
OXiGENE, Inc: Press releases June 5, 2006 and September 12, 2006. Further information available at: http://www.oxigene.com (accessed November 2007).
-
(2006)
Further Information
-
-
-
144
-
-
34548227773
-
From exotic spice to modern drug?
-
Singh S (2007) From exotic spice to modern drug? Cell 130: 765-768.
-
(2007)
Cell
, vol.130
, pp. 765-768
-
-
Singh, S.1
-
146
-
-
23144456197
-
Some thoughts on the future of ethnopharmacology
-
Cordell GA, Colvard MD (2005) Some thoughts on the future of ethnopharmacology. J Ethnopharmacol 100: 5-14.
-
(2005)
J Ethnopharmacol
, vol.100
, pp. 5-14
-
-
Cordell, G.A.1
Colvard, M.D.2
-
147
-
-
0033565471
-
HPLC-CD on-line coupling in combination with HPLCNMR and HPLC-MS/MS for the determination of the full absolute stereostructure of new metabolites in plant extracts
-
Bringmann G, Messer K, Wohlfarth M, Kraus J, Dumbuya K, Rückert M (1999) HPLC-CD on-line coupling in combination with HPLCNMR and HPLC-MS/MS for the determination of the full absolute stereostructure of new metabolites in plant extracts. Anal Chem 71: 2678-2686.
-
(1999)
Anal Chem
, vol.71
, pp. 2678-2686
-
-
Bringmann, G.1
Messer, K.2
Wohlfarth, M.3
Kraus, J.4
Dumbuya, K.5
Rückert, M.6
-
148
-
-
0037073083
-
Developing strategies for isolation of minor impurities with mass spectrometry-directed fractionation
-
Niessen WMA, Lin J, Bondoux GC (2002) Developing strategies for isolation of minor impurities with mass spectrometry-directed fractionation. J Chromatogr A 970: 131-140.
-
(2002)
J Chromatogr A
, vol.970
, pp. 131-140
-
-
Niessen, W.M.A.1
Lin, J.2
Bondoux, G.C.3
-
149
-
-
0038439687
-
Liquid chromatography with ultraviolet absorbance-mass spectrometric detection and with nuclear magnetic resonance spectrometry: A powerful combination for the on-line structural investigation of plant metabolites
-
Wolfender JL, Ndjoko K, Hostettmann K (2003) Liquid chromatography with ultraviolet absorbance-mass spectrometric detection and with nuclear magnetic resonance spectrometry: A powerful combination for the on-line structural investigation of plant metabolites. J Chromatogr A 1000: 437-455.
-
(2003)
J Chromatogr A
, vol.1000
, pp. 437-455
-
-
Wolfender, J.L.1
Ndjoko, K.2
Hostettmann, K.3
-
150
-
-
0036180639
-
Choosing the best pulse sequences, acquisition. Parameters, postacquisition processing strategies and probes for natural products structure elucidation by NMR spectroscopy
-
Reynolds WF, Enriquez RG (2002) Choosing the best pulse sequences, acquisition. parameters, postacquisition processing strategies and probes for natural products structure elucidation by NMR spectroscopy. J Nat Prod 65: 221-244.
-
(2002)
J Nat Prod
, vol.65
, pp. 221-244
-
-
Reynolds, W.F.1
Enriquez, R.G.2
-
151
-
-
23644445046
-
A comparison of capillary-scale LC-NMR with alternative techniques: Spectroscopic and practical considerations
-
Lewis RJ, Bernstein MA, Duncan SJ, Sleigh CJ (2005) A comparison of capillary-scale LC-NMR with alternative techniques: spectroscopic and practical considerations. Magn Reson Chem 43: 783-789.
-
(2005)
Magn Reson Chem
, vol.43
, pp. 783-789
-
-
Lewis, R.J.1
Bernstein, M.A.2
Duncan, S.J.3
Sleigh, C.J.4
-
153
-
-
28644441881
-
Small-volume and highsensitivity NMR probes
-
Martin GE (2005) Small-volume and highsensitivity NMR probes. Annu Rep NMR Spectrosc 56: 1-96.
-
(2005)
Annu Rep NMR Spectrosc
, vol.56
, pp. 1-96
-
-
Martin, G.E.1
-
154
-
-
84988044841
-
Assay development
-
Anonymous
-
Anonymous (2007) Assay development. Nat Rev Drug Disc 6: 681.
-
(2007)
Nat Rev Drug Disc
, vol.6
, pp. 681
-
-
-
155
-
-
33646499702
-
Natural products in drug discovery - concepts and approaches for tracking bioactivity
-
Potterat O, Hamburger M (2006). Natural products in drug discovery - concepts and approaches for tracking bioactivity. Curr Org Chem 10: 899-920.
-
(2006)
Curr Org Chem
, vol.10
, pp. 899-920
-
-
Potterat, O.1
Hamburger, M.2
-
156
-
-
35848962300
-
Mass spectrometric techniques for label-free high-throughput screening in drug discovery
-
Roddy TP, Horvath CR, Stout SJ, Kenney KL, Ho P-I, Zhang J-H, Vickers C, Kaushik V, Hubbard B, Wang YK (2007) Mass spectrometric techniques for label-free high-throughput screening in drug discovery. Anal Chem 79: 8207-8213.
-
(2007)
Anal Chem
, vol.79
, pp. 8207-8213
-
-
Roddy, T.P.1
Horvath, C.R.2
Stout, S.J.3
Kenney, K.L.4
Ho, P.-I.5
Zhang, J.-H.6
Vickers, C.7
Kaushik, V.8
Hubbard, B.9
Wang, Y.K.10
-
157
-
-
0028877010
-
Louis Pasteur (1822- 1895) - chance and the prepared mind
-
Manchester KL (1995) Louis Pasteur (1822- 1895) - chance and the prepared mind. Trends Biotechnol 13: 511-515.
-
(1995)
Trends Biotechnol
, vol.13
, pp. 511-515
-
-
Manchester, K.L.1
-
158
-
-
0029078695
-
Biocatalysis in organic chemistry (Part II): Present and future
-
Turner MK (1995) Biocatalysis in organic chemistry (Part II): present and future. Trends Biotechnol 13: 253-258.
-
(1995)
Trends Biotechnol
, vol.13
, pp. 253-258
-
-
Turner, M.K.1
-
159
-
-
0036275284
-
Plant cell cultures: Chemical factories of secondary metabolites
-
Rao SR, Ravishankar GA (2002) Plant cell cultures: chemical factories of secondary metabolites. Biotechnol Adv 20: 101-153.
-
(2002)
Biotechnol Adv
, vol.20
, pp. 101-153
-
-
Rao, S.R.1
Ravishankar, G.A.2
-
160
-
-
33750481245
-
Biochemistry: Directing biosynthesis
-
Fischbach MA, Walsh CT (2006) Biochemistry: directing biosynthesis. Science 314: 603-605.
-
(2006)
Science
, vol.314
, pp. 603-605
-
-
Fischbach, M.A.1
Walsh, C.T.2
-
161
-
-
3242878404
-
Green innovations
-
Ritter SK (2004) Green innovations. Chem Eng News 12: 25-30.
-
(2004)
Chem Eng News
, vol.12
, pp. 25-30
-
-
Ritter, S.K.1
-
162
-
-
0021848177
-
Methods for increasing diosgenin production by Dioscorea cells in suspension cultures
-
Rokem JS, Tal B, Goldberg I (1985) Methods for increasing diosgenin production by Dioscorea cells in suspension cultures. J Nat Prod 48: 210-220.
-
(1985)
J Nat Prod
, vol.48
, pp. 210-220
-
-
Rokem, J.S.1
Tal, B.2
Goldberg, I.3
-
163
-
-
1642263128
-
Catharanthus alkaloids: Pharmacognosy and biotechnology
-
van Der Heijden R, Jacobs DI, Snoeijer W, Hallard D, Verpoorte R (2004) Catharanthus alkaloids: pharmacognosy and biotechnology. Curr Med Chem 11: 607-628.
-
(2004)
Curr Med Chem
, vol.11
, pp. 607-628
-
-
Van Der Heijden, R.1
Jacobs, D.I.2
Snoeijer, W.3
Hallard, D.4
Verpoorte, R.5
-
164
-
-
84920038466
-
Bioproduction of triterpenes on plant cultures of Panax ginseng and Galphimia glauca
-
Pandalai SG (ed), Kerala, India
-
Moyano E, Osuna L, Bonfill M, Cusido RM, Palazon J, Tortoriello J, Pinol MT (2005) Bioproduction of triterpenes on plant cultures of Panax ginseng and Galphimia glauca. In: Pandalai SG (ed) Recent Research Developments in Plant Science, Vol. 3. Research Signpost, Kerala, India, p 195.
-
(2005)
Recent Research Developments in Plant Science, Vol. 3. Research Signpost
-
-
Moyano, E.1
Osuna, L.2
Bonfill, M.3
Cusido, R.M.4
Palazon, J.5
Tortoriello, J.6
Pinol, M.T.7
|