-
1
-
-
33144479546
-
Cancer therapies targeted to the epidermal growth factor receptor and its family members
-
Kane S.E. Cancer therapies targeted to the epidermal growth factor receptor and its family members. Expert Opinion on Therapeutic Patents 16 (2006) 147-164
-
(2006)
Expert Opinion on Therapeutic Patents
, vol.16
, pp. 147-164
-
-
Kane, S.E.1
-
2
-
-
28544444712
-
Type I insulin-like growth factor receptor as a therapeutic target in cancer
-
Miller B.S., and Yee D. Type I insulin-like growth factor receptor as a therapeutic target in cancer. Cancer Res 65 (2005) 10123-10127
-
(2005)
Cancer Res
, vol.65
, pp. 10123-10127
-
-
Miller, B.S.1
Yee, D.2
-
3
-
-
21344435775
-
Mechanisms of disease: insights into the emerging role of signal transducers and activators of transcription in cancer
-
Haura E.B., Turkson J., and Jove R. Mechanisms of disease: insights into the emerging role of signal transducers and activators of transcription in cancer. Nat Clin Pract Oncol 2 (2005) 315-324
-
(2005)
Nat Clin Pract Oncol
, vol.2
, pp. 315-324
-
-
Haura, E.B.1
Turkson, J.2
Jove, R.3
-
4
-
-
14044279871
-
Signal transduction pathways and transcription factors as therapeutic targets in inflammatory disease: towards innovative antirheumatic therapy
-
Tas S.W., Remans P.H.J., Reedquist K.A., and Tak P.P. Signal transduction pathways and transcription factors as therapeutic targets in inflammatory disease: towards innovative antirheumatic therapy. Curr Pharm Des 11 (2005) 581-611
-
(2005)
Curr Pharm Des
, vol.11
, pp. 581-611
-
-
Tas, S.W.1
Remans, P.H.J.2
Reedquist, K.A.3
Tak, P.P.4
-
5
-
-
25144469688
-
Cell signaling in the cardiovascular system: an overview
-
Wheeler-Jones C.P.D. Cell signaling in the cardiovascular system: an overview. Heart 91 (2005) 1366-1374
-
(2005)
Heart
, vol.91
, pp. 1366-1374
-
-
Wheeler-Jones, C.P.D.1
-
6
-
-
24144498411
-
Rho-kinase is an important therapeutic target in cardiovascular medicine
-
Shimokawa H., and Takeshita A. Rho-kinase is an important therapeutic target in cardiovascular medicine. Arterioscler Thromb Vasc Biol 25 (2005) 1767-1775
-
(2005)
Arterioscler Thromb Vasc Biol
, vol.25
, pp. 1767-1775
-
-
Shimokawa, H.1
Takeshita, A.2
-
9
-
-
10044253102
-
Compound library development guided by protein structure similarity clustering and natural product structure
-
A conceptual rationale for the high hit rates of natural product structures against multiple protein targets, and a demonstration of the principle of privileged natural product structures in library design.
-
Koch M.A., Wittenberg L.-O., Basu S., Jeyaraj D.A., Gourzoulidou E., Reinecke K., Odermatt A., and Waldmann H. Compound library development guided by protein structure similarity clustering and natural product structure. Proc Natl Acad Sci USA 101 (2004) 16721-16726. A conceptual rationale for the high hit rates of natural product structures against multiple protein targets, and a demonstration of the principle of privileged natural product structures in library design.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 16721-16726
-
-
Koch, M.A.1
Wittenberg, L.-O.2
Basu, S.3
Jeyaraj, D.A.4
Gourzoulidou, E.5
Reinecke, K.6
Odermatt, A.7
Waldmann, H.8
-
10
-
-
14944383798
-
The evolving role of natural products in drug discovery
-
A review describing the history, challenges and enabling technologies in natural product based drug discovery.
-
Koehn F.E., and Carter G.T. The evolving role of natural products in drug discovery. Nat Rev Drug Discov 4 (2005) 206-220. A review describing the history, challenges and enabling technologies in natural product based drug discovery.
-
(2005)
Nat Rev Drug Discov
, vol.4
, pp. 206-220
-
-
Koehn, F.E.1
Carter, G.T.2
-
11
-
-
33744994317
-
Platensimycin is a selective FabF inhibitor with potent antibiotic properties
-
Strong example of a new structural class of natural product with a unique mechanism of action discovered by high-throughput screening.
-
Wang J., Soisson S.M., Young K., Shoop W., Kodali S., Galgoci A., Painter R., Parthasarathy G., Tang Y.S., Cummings R., et al. Platensimycin is a selective FabF inhibitor with potent antibiotic properties. Nature 441 (2006) 358-361. Strong example of a new structural class of natural product with a unique mechanism of action discovered by high-throughput screening.
-
(2006)
Nature
, vol.441
, pp. 358-361
-
-
Wang, J.1
Soisson, S.M.2
Young, K.3
Shoop, W.4
Kodali, S.5
Galgoci, A.6
Painter, R.7
Parthasarathy, G.8
Tang, Y.S.9
Cummings, R.10
-
12
-
-
33645730786
-
The efficacy and safety of daptomycin: first in a new class of antibiotics for Gram-positive bacteria
-
Rybak M.J. The efficacy and safety of daptomycin: first in a new class of antibiotics for Gram-positive bacteria. Clin Microbiol Infect 12 (2006) 24-32
-
(2006)
Clin Microbiol Infect
, vol.12
, pp. 24-32
-
-
Rybak, M.J.1
-
13
-
-
0037623521
-
The Rapamune era of immunosuppression 2003: the journey from the laboratory to clinical transplantation
-
Camardo J. The Rapamune era of immunosuppression 2003: the journey from the laboratory to clinical transplantation. Transplant Proc 35 (2003) 18S-24S
-
(2003)
Transplant Proc
, vol.35
-
-
Camardo, J.1
-
14
-
-
3142781225
-
Small-molecule inhibitors of protein-protein interactions: progressing towards the dream
-
Arkin M.R., and Wells J.A. Small-molecule inhibitors of protein-protein interactions: progressing towards the dream. Nat Rev Drug Discov 3 (2004) 301-317
-
(2004)
Nat Rev Drug Discov
, vol.3
, pp. 301-317
-
-
Arkin, M.R.1
Wells, J.A.2
-
17
-
-
24944532876
-
Identification and comparative analysis of the peptidyl-prolyl cis/trans isomerase repertoires of H. sapiens, D. melanogaster, C. elegans, S. cerevisiae and Sz. pombe
-
Pemberton T.J., and Kay J.E. Identification and comparative analysis of the peptidyl-prolyl cis/trans isomerase repertoires of H. sapiens, D. melanogaster, C. elegans, S. cerevisiae and Sz. pombe. Comp Funct Genomics 6 (2005) 277-300
-
(2005)
Comp Funct Genomics
, vol.6
, pp. 277-300
-
-
Pemberton, T.J.1
Kay, J.E.2
-
18
-
-
32044465506
-
TOR signaling in growth and metabolism
-
A thorough review of the multiple, intricate cellular functions of the TOR signalling pathway.
-
Wullschleger S., Loewith R., and Hall Michael N. TOR signaling in growth and metabolism. Cell 124 (2006) 471-484. A thorough review of the multiple, intricate cellular functions of the TOR signalling pathway.
-
(2006)
Cell
, vol.124
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall Michael, N.3
-
19
-
-
23944481410
-
Phase II trial of single-agent temsirolimus (CCI-779) for relapsed mantle cell lymphoma
-
Witzig T.E., Geyer S.M., Ghobrial I., Inwards D.J., Fonseca R., Kurtin P., Ansell S.M., Luyun R., Flynn P.J., Morton R.F., et al. Phase II trial of single-agent temsirolimus (CCI-779) for relapsed mantle cell lymphoma. J Clin Oncol 23 (2005) 5347-5356
-
(2005)
J Clin Oncol
, vol.23
, pp. 5347-5356
-
-
Witzig, T.E.1
Geyer, S.M.2
Ghobrial, I.3
Inwards, D.J.4
Fonseca, R.5
Kurtin, P.6
Ansell, S.M.7
Luyun, R.8
Flynn, P.J.9
Morton, R.F.10
-
20
-
-
18144399578
-
mTOR-targeted therapy of cancer with rapamycin derivatives
-
Vignot S., Faivre S., Aguirre D., and Raymond E. mTOR-targeted therapy of cancer with rapamycin derivatives. Ann oncol 16 (2005) 525-537
-
(2005)
Ann oncol
, vol.16
, pp. 525-537
-
-
Vignot, S.1
Faivre, S.2
Aguirre, D.3
Raymond, E.4
-
21
-
-
33748194240
-
Recent developments in targeting the mammalian target of rapamycin (mTOR) kinase pathway
-
Smolewski P. Recent developments in targeting the mammalian target of rapamycin (mTOR) kinase pathway. Anticancer Drugs 17 (2006) 487-494
-
(2006)
Anticancer Drugs
, vol.17
, pp. 487-494
-
-
Smolewski, P.1
-
23
-
-
33645462236
-
Zotarolimus-eluting stents reduce experimental coronary artery neointimal hyperplasia after 4 weeks
-
Garcia-Touchard A., Burke Sandra E., Toner John L., Cromack K., and Schwartz Robert S. Zotarolimus-eluting stents reduce experimental coronary artery neointimal hyperplasia after 4 weeks. Eur Heart J 27 (2006) 988-993
-
(2006)
Eur Heart J
, vol.27
, pp. 988-993
-
-
Garcia-Touchard, A.1
Burke Sandra, E.2
Toner John, L.3
Cromack, K.4
Schwartz Robert, S.5
-
24
-
-
31944439065
-
Atrophic remodeling of the transplanted rat heart
-
Sharma S., Ying J., Razeghi P., Stepkowski S., and Taegtmeyer H. Atrophic remodeling of the transplanted rat heart. Cardiology 105 (2006) 128-136
-
(2006)
Cardiology
, vol.105
, pp. 128-136
-
-
Sharma, S.1
Ying, J.2
Razeghi, P.3
Stepkowski, S.4
Taegtmeyer, H.5
-
25
-
-
33646352217
-
Mammalian target of rapamycin pathway blockade slows progression of diabetic kidney disease in rats
-
Lloberas N., Cruzado J.M., Franquesa M., Herrero-Fresneda I., Torras J., Alperovich G., Rama I., Vidal A., and Grinyo J.M. Mammalian target of rapamycin pathway blockade slows progression of diabetic kidney disease in rats. J Am Soc Nephrol 17 (2006) 1395-1404
-
(2006)
J Am Soc Nephrol
, vol.17
, pp. 1395-1404
-
-
Lloberas, N.1
Cruzado, J.M.2
Franquesa, M.3
Herrero-Fresneda, I.4
Torras, J.5
Alperovich, G.6
Rama, I.7
Vidal, A.8
Grinyo, J.M.9
-
26
-
-
29144443463
-
Sirolimus: its role in nephrology
-
Lee V.W.S., and Chapman J.R. Sirolimus: its role in nephrology. Nephrology 10 (2005) 606-614
-
(2005)
Nephrology
, vol.10
, pp. 606-614
-
-
Lee, V.W.S.1
Chapman, J.R.2
-
27
-
-
1542395816
-
Therapeutic implications for immunophilin ligands in the treatment of neurodegenerative diseases
-
Pong K., and Zaleska M.M. Therapeutic implications for immunophilin ligands in the treatment of neurodegenerative diseases. Curr Drug Target CNS Neurol Disord 2 (2003) 349-356
-
(2003)
Curr Drug Target CNS Neurol Disord
, vol.2
, pp. 349-356
-
-
Pong, K.1
Zaleska, M.M.2
-
29
-
-
33646344249
-
3-Normeridamycin: a potent non-immunosuppressive immunophilin ligand is neuroprotective in dopaminergic neurons
-
A solid example of the isolation, structure elucidation and biological activity of a neuroprotective immunophilin ligand.
-
Summers M.Y., Leighton M., Liu D., Pong K., and Graziani E.I. 3-Normeridamycin: a potent non-immunosuppressive immunophilin ligand is neuroprotective in dopaminergic neurons. J Antibiot (Tokyo) 59 (2006) 184-189. A solid example of the isolation, structure elucidation and biological activity of a neuroprotective immunophilin ligand.
-
(2006)
J Antibiot (Tokyo)
, vol.59
, pp. 184-189
-
-
Summers, M.Y.1
Leighton, M.2
Liu, D.3
Pong, K.4
Graziani, E.I.5
-
32
-
-
0141854979
-
Novel sulfur-containing rapamycin analogs prepared by precursor-directed biosynthesis
-
Graziani E.I., Ritacco F.V., Summers M.Y., Zabriskie T.M., Yu K., Bernan V.S., Greenstein M., and Carter G.T. Novel sulfur-containing rapamycin analogs prepared by precursor-directed biosynthesis. Org Lett 5 (2003) 2385-2388
-
(2003)
Org Lett
, vol.5
, pp. 2385-2388
-
-
Graziani, E.I.1
Ritacco, F.V.2
Summers, M.Y.3
Zabriskie, T.M.4
Yu, K.5
Bernan, V.S.6
Greenstein, M.7
Carter, G.T.8
-
33
-
-
23444460405
-
Mutational biosynthesis: a tool for the generation of structural diversity in the biosynthesis of antibiotics
-
Weist S., and Suessmuth R.D. Mutational biosynthesis: a tool for the generation of structural diversity in the biosynthesis of antibiotics. Appl Microbiol Biotechnol 68 (2005) 141-150
-
(2005)
Appl Microbiol Biotechnol
, vol.68
, pp. 141-150
-
-
Weist, S.1
Suessmuth, R.D.2
-
34
-
-
30544434619
-
Combinatorial biosynthesis of reduced polyketides
-
A thorough review of the principles, strategies and technical challenges involved in the genetic manipulation of natural product biosynthetic gene clusters to produce new molecules.
-
Weissman K.J., and Leadlay P.F. Combinatorial biosynthesis of reduced polyketides. Nat Rev Microbiol 3 (2005) 925-936. A thorough review of the principles, strategies and technical challenges involved in the genetic manipulation of natural product biosynthetic gene clusters to produce new molecules.
-
(2005)
Nat Rev Microbiol
, vol.3
, pp. 925-936
-
-
Weissman, K.J.1
Leadlay, P.F.2
-
35
-
-
33751252895
-
Anti-tumor activity of CCI-779 in relapsed mantle cell lymphoma
-
Ansell S.M., Geyer S.M., Kurtin P.J., Rowland K.M., Flynn P.J., Morton R.F., Dakhil S.R., Gross H.M., Maurer M.J., Kaufmann S.H., et al. Anti-tumor activity of CCI-779 in relapsed mantle cell lymphoma. Haematologica Reports 1 (2005) 92-94
-
(2005)
Haematologica Reports
, vol.1
, pp. 92-94
-
-
Ansell, S.M.1
Geyer, S.M.2
Kurtin, P.J.3
Rowland, K.M.4
Flynn, P.J.5
Morton, R.F.6
Dakhil, S.R.7
Gross, H.M.8
Maurer, M.J.9
Kaufmann, S.H.10
-
36
-
-
23044465228
-
Mutasynthesis of rapamycin analogues through the manipulation of a gene governing starter unit biosynthesis
-
Gregory M.A., Petkovic H., Lill R.E., Moss S.J., Wilkinson B., Gaisser S., Leadlay P.F., and Sheridan R.M. Mutasynthesis of rapamycin analogues through the manipulation of a gene governing starter unit biosynthesis. Angew Chem Int Ed Engl 44 (2005) 4757-4760
-
(2005)
Angew Chem Int Ed Engl
, vol.44
, pp. 4757-4760
-
-
Gregory, M.A.1
Petkovic, H.2
Lill, R.E.3
Moss, S.J.4
Wilkinson, B.5
Gaisser, S.6
Leadlay, P.F.7
Sheridan, R.M.8
-
37
-
-
27144509740
-
Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes
-
This paper describes the multiple recombination of gene modules from eight different polyketide synthase clusters and their expression in Escherichia coli to produce new molecules.
-
Menzella H.G., Reid R., Carney J.R., Chandran S.S., Reisinger S.J., Patel K.G., Hopwood D.A., and Santi D.V. Combinatorial polyketide biosynthesis by de novo design and rearrangement of modular polyketide synthase genes. Nat Biotechnol 23 (2005) 1171-1176. This paper describes the multiple recombination of gene modules from eight different polyketide synthase clusters and their expression in Escherichia coli to produce new molecules.
-
(2005)
Nat Biotechnol
, vol.23
, pp. 1171-1176
-
-
Menzella, H.G.1
Reid, R.2
Carney, J.R.3
Chandran, S.S.4
Reisinger, S.J.5
Patel, K.G.6
Hopwood, D.A.7
Santi, D.V.8
-
38
-
-
27844461167
-
Recent developments towards the heterologous expression of complex bacterial natural product biosynthetic pathways
-
Wenzel S.C., and Mueller R. Recent developments towards the heterologous expression of complex bacterial natural product biosynthetic pathways. Curr Opin Biotechnol 16 (2005) 594-606
-
(2005)
Curr Opin Biotechnol
, vol.16
, pp. 594-606
-
-
Wenzel, S.C.1
Mueller, R.2
-
39
-
-
33751241216
-
Manipulating microbial metabolites for drug discovery and production
-
Hutchinson C.R. Manipulating microbial metabolites for drug discovery and production. Natural Products (2005) 77-93
-
(2005)
Natural Products
, pp. 77-93
-
-
Hutchinson, C.R.1
-
40
-
-
33144469102
-
The proteasome and proteasome inhibitors in cancer therapy
-
Voorhees P.M., and Orlowski R.Z. The proteasome and proteasome inhibitors in cancer therapy. Annu Rev Pharmacol Toxicol 46 (2006) 189-213
-
(2006)
Annu Rev Pharmacol Toxicol
, vol.46
, pp. 189-213
-
-
Voorhees, P.M.1
Orlowski, R.Z.2
-
42
-
-
33645961605
-
Natural products inhibiting the ubiquitin-proteasome proteolytic pathway, a target for drug development
-
Tsukamoto S., and Yokosawa H. Natural products inhibiting the ubiquitin-proteasome proteolytic pathway, a target for drug development. Curr Med Chem 13 (2006) 745-754
-
(2006)
Curr Med Chem
, vol.13
, pp. 745-754
-
-
Tsukamoto, S.1
Yokosawa, H.2
-
43
-
-
0037455147
-
salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus Salinospora
-
Feling R.H., Buchanan G.O., Mincer T.J., Kauffman C.A., Jensen P.R., and Fenical W. salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus Salinospora. Angew Chem Int Ed Engl 42 (2003) 355-357
-
(2003)
Angew Chem Int Ed Engl
, vol.42
, pp. 355-357
-
-
Feling, R.H.1
Buchanan, G.O.2
Mincer, T.J.3
Kauffman, C.A.4
Jensen, P.R.5
Fenical, W.6
-
44
-
-
0033022744
-
Total synthesis and biological activity of lactacystin, omuralide and analogs
-
Corey E.J., and Li W.-D. Total synthesis and biological activity of lactacystin, omuralide and analogs. Chem Pharm Bull (Tokyo) 47 (1999) 1-10
-
(1999)
Chem Pharm Bull (Tokyo)
, vol.47
, pp. 1-10
-
-
Corey, E.J.1
Li, W.-D.2
-
45
-
-
33646137808
-
Crystal structures of salinosporamide A (NPI-0052) and B (NPI-0047) in complex with the 20S proteasome reveal important consequences of β-lactone ring opening and a mechanism for irreversible binding
-
An insightful X-ray study and discussion showing the unique structural characteristics involved in an elegantly potent natural product inhibitor. The work fully illustrates how nature optimizes natural product structures.
-
Groll M., Huber R., and Potts B.C.M. Crystal structures of salinosporamide A (NPI-0052) and B (NPI-0047) in complex with the 20S proteasome reveal important consequences of β-lactone ring opening and a mechanism for irreversible binding. J Am Chem Soc 128 (2006) 5136-5141. An insightful X-ray study and discussion showing the unique structural characteristics involved in an elegantly potent natural product inhibitor. The work fully illustrates how nature optimizes natural product structures.
-
(2006)
J Am Chem Soc
, vol.128
, pp. 5136-5141
-
-
Groll, M.1
Huber, R.2
Potts, B.C.M.3
-
46
-
-
21244463812
-
An efficient, stereocontrolled synthesis of a potent omuralide-salinosporin hybrid for selective proteasome inhibition
-
Reddy L.R., Fournier J.-F., Reddy B.V.S., and Corey E.J. An efficient, stereocontrolled synthesis of a potent omuralide-salinosporin hybrid for selective proteasome inhibition. J Am Chem Soc 127 (2005) 8974-8976
-
(2005)
J Am Chem Soc
, vol.127
, pp. 8974-8976
-
-
Reddy, L.R.1
Fournier, J.-F.2
Reddy, B.V.S.3
Corey, E.J.4
-
47
-
-
27644594831
-
Proteasome inhibition by a totally synthetic β-lactam related to salinosporamide A and omuralide
-
Hogan P.C., and Corey E.J. Proteasome inhibition by a totally synthetic β-lactam related to salinosporamide A and omuralide. J Am Chem Soc 127 (2005) 15386-15387
-
(2005)
J Am Chem Soc
, vol.127
, pp. 15386-15387
-
-
Hogan, P.C.1
Corey, E.J.2
-
48
-
-
27644562277
-
A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from bortezomib
-
Chauhan D., Catley L., Li G., Podar K., Hideshima T., Velankar M., Mitsiades C., Mitsiades N., Yasui H., Letai A., et al. A novel orally active proteasome inhibitor induces apoptosis in multiple myeloma cells with mechanisms distinct from bortezomib. Cancer Cell 8 (2005) 407-419
-
(2005)
Cancer Cell
, vol.8
, pp. 407-419
-
-
Chauhan, D.1
Catley, L.2
Li, G.3
Podar, K.4
Hideshima, T.5
Velankar, M.6
Mitsiades, C.7
Mitsiades, N.8
Yasui, H.9
Letai, A.10
-
49
-
-
23044479278
-
New cytotoxic salinosporamides from the marine actinomycete Salinispora tropica
-
Williams P.G., Buchanan G.O., Feling R.H., Kauffman C.A., Jensen P.R., and Fenical W. New cytotoxic salinosporamides from the marine actinomycete Salinispora tropica. J Org Chem 70 (2005) 6196-6203
-
(2005)
J Org Chem
, vol.70
, pp. 6196-6203
-
-
Williams, P.G.1
Buchanan, G.O.2
Feling, R.H.3
Kauffman, C.A.4
Jensen, P.R.5
Fenical, W.6
-
50
-
-
1842560595
-
Tapping into microbial biodiversity
-
Keller M., and Zengler K. Tapping into microbial biodiversity. Nat Rev Microbiol 2 (2004) 141-150
-
(2004)
Nat Rev Microbiol
, vol.2
, pp. 141-150
-
-
Keller, M.1
Zengler, K.2
-
51
-
-
33745024719
-
From natural products discovery to commercialization: a success story
-
Demain A. From natural products discovery to commercialization: a success story. Int Microbiol Biotechnol 33 (2006) 486-495
-
(2006)
Int Microbiol Biotechnol
, vol.33
, pp. 486-495
-
-
Demain, A.1
-
52
-
-
27544456830
-
The impact of bacterial genomics on natural product research
-
Bode H.B., and Muller R. The impact of bacterial genomics on natural product research. Angew Chem Int Ed Engl 44 (2006) 6828-6846
-
(2006)
Angew Chem Int Ed Engl
, vol.44
, pp. 6828-6846
-
-
Bode, H.B.1
Muller, R.2
-
53
-
-
0037023901
-
Optimizing the heterologous production of epothilone D in Myxococcus xanthus
-
Lau J., Frykman S., Regentin R., Ou S., Tsuruta H., and Licari P. Optimizing the heterologous production of epothilone D in Myxococcus xanthus. Biotechnol Bioeng 78 (2002) 280-288
-
(2002)
Biotechnol Bioeng
, vol.78
, pp. 280-288
-
-
Lau, J.1
Frykman, S.2
Regentin, R.3
Ou, S.4
Tsuruta, H.5
Licari, P.6
|