-
1
-
-
0025939859
-
Complexities of the protein kinase C pathway
-
Blumberg P.M. Complexities of the protein kinase C pathway. Mol Carcinog. 4:1991;339-344.
-
(1991)
Mol Carcinog
, vol.4
, pp. 339-344
-
-
Blumberg, P.M.1
-
2
-
-
0026083513
-
Modification of multistage skin carcinogenesis in mice
-
DiGiovanni J. Modification of multistage skin carcinogenesis in mice. Prog Exp Tumor Res. 33:1991;192-229.
-
(1991)
Prog Exp Tumor Res
, vol.33
, pp. 192-229
-
-
DiGiovanni, J.1
-
3
-
-
0023880172
-
Protein kinase C as the receptor for the phorbol ester tumor promoters: Sixth Rhoads Memorial Award Lecture
-
Blumberg P.M. Protein kinase C as the receptor for the phorbol ester tumor promoters Sixth Rhoads Memorial Award Lecture . Cancer Res. 48:1988;1-8.
-
(1988)
Cancer Res
, vol.48
, pp. 1-8
-
-
Blumberg, P.M.1
-
4
-
-
0027212503
-
Nonpromoting 12-deoxyphorbol 13-esters inhibit phorbol 12-myristate 13-acetate induced tumor promotion in CD-1 mouse skin
-
Szallasi Z., Krsmanovic L., Blumberg P.M. Nonpromoting 12-deoxyphorbol 13-esters inhibit phorbol 12-myristate 13-acetate induced tumor promotion in CD-1 mouse skin. Cancer Res. 53:1993;2507-2512.
-
(1993)
Cancer Res
, vol.53
, pp. 2507-2512
-
-
Szallasi, Z.1
Krsmanovic, L.2
Blumberg, P.M.3
-
5
-
-
0023253596
-
Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin
-
Hennings H., Blumberg P.M., Pettit G.R., Herald C.L., Shores R., Yuspa S.H. Bryostatin 1, an activator of protein kinase C, inhibits tumor promotion by phorbol esters in SENCAR mouse skin. Carcinogenesis. 8:1987;1343-1346.
-
(1987)
Carcinogenesis
, vol.8
, pp. 1343-1346
-
-
Hennings, H.1
Blumberg, P.M.2
Pettit, G.R.3
Herald, C.L.4
Shores, R.5
Yuspa, S.H.6
-
6
-
-
0020326790
-
Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters
-
Castagna M., Takai Y., Kaibuchi K., Sano K., Kikkawa U., Nishizuka Y. Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters. J Biol Chem. 257:1982;7847-7851.
-
(1982)
J Biol Chem
, vol.257
, pp. 7847-7851
-
-
Castagna, M.1
Takai, Y.2
Kaibuchi, K.3
Sano, K.4
Kikkawa, U.5
Nishizuka, Y.6
-
7
-
-
0003053406
-
Characterization of a specific phorbol ester aporeceptor in mouse brain cytosol
-
Leach K.L., James M.L., Blumberg P.M. Characterization of a specific phorbol ester aporeceptor in mouse brain cytosol. Proc Natl Acad Sci USA. 80:1983;4208-4212.
-
(1983)
Proc Natl Acad Sci USA
, vol.80
, pp. 4208-4212
-
-
Leach, K.L.1
James, M.L.2
Blumberg, P.M.3
-
8
-
-
1842394775
-
Competitive inhibition by diacylglycerol of specific phorbol ester binding
-
Sharkey N.A., Leach K.L., Blumberg P.M. Competitive inhibition by diacylglycerol of specific phorbol ester binding. Proc Natl Acad Sci USA. 81:1984;607-610.
-
(1984)
Proc Natl Acad Sci USA
, vol.81
, pp. 607-610
-
-
Sharkey, N.A.1
Leach, K.L.2
Blumberg, P.M.3
-
10
-
-
0032167579
-
Lipid structure and not membrane structure is the major determinant in the regulation of protein kinase C by phosphatidylserine
-
Johnson J.E., Zimmerman M.L., Daleke D.L. Lipid structure and not membrane structure is the major determinant in the regulation of protein kinase C by phosphatidylserine. Biochemistry. 37:1998;12020-12025.
-
(1998)
Biochemistry
, vol.37
, pp. 12020-12025
-
-
Johnson, J.E.1
Zimmerman, M.L.2
Daleke, D.L.3
-
12
-
-
0029038685
-
Low affinity binding of phorbol esters to PKC and its cysteine-rich region in the absence of phospholipids
-
Kazanietz M.G., Barchi J.J. Jr, Omichinski J.G., Blumberg P.M. Low affinity binding of phorbol esters to PKC and its cysteine-rich region in the absence of phospholipids. J Biol Chem. 270:1995;14679-14684.
-
(1995)
J Biol Chem
, vol.270
, pp. 14679-14684
-
-
Kazanietz, M.G.1
Barchi J.J., Jr.2
Omichinski, J.G.3
Blumberg, P.M.4
-
13
-
-
0029965696
-
Protein kinase C isozymes and substrates
-
Jaken S. Protein kinase C isozymes and substrates. Curr Opin Cell Biol. 8:1996;168-173.
-
(1996)
Curr Opin Cell Biol
, vol.8
, pp. 168-173
-
-
Jaken, S.1
-
14
-
-
0030987070
-
Regulation of protein kinase C
-
Newton A.C. Regulation of protein kinase C. Curr Opin Cell Biol. 9:1997;161-167.
-
(1997)
Curr Opin Cell Biol
, vol.9
, pp. 161-167
-
-
Newton, A.C.1
-
15
-
-
0032104245
-
The extended protein kinase C superfamily
-
Mellor H., Parker P.J. The extended protein kinase C superfamily. Biochem J. 332:1998;281-292.
-
(1998)
Biochem J
, vol.332
, pp. 281-292
-
-
Mellor, H.1
Parker, P.J.2
-
16
-
-
0032849088
-
New insights into the regulation of protein kinase C and novel phorbol ester receptors
-
Ron D., Kazanietz M.G. New insights into the regulation of protein kinase C and novel phorbol ester receptors. FASEB J. 13:1999;1658-1676.
-
(1999)
FASEB J
, vol.13
, pp. 1658-1676
-
-
Ron, D.1
Kazanietz, M.G.2
-
17
-
-
0027964870
-
Molecular cloning and characterization of protein kinase D: A target for diacylglycerol and phorbol esters with a distinctive catalytic domain
-
Valverde A.M., Sinnett-Smith J., Van Lint J., Rozengurt E. Molecular cloning and characterization of protein kinase D A target for diacylglycerol and phorbol esters with a distinctive catalytic domain . Proc Natl Acad Sci USA. 91:1994;8572-8576.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 8572-8576
-
-
Valverde, A.M.1
Sinnett-Smith, J.2
Van Lint, J.3
Rozengurt, E.4
-
18
-
-
0028023004
-
PKCμ is a novel, atypical member of the protein kinase C family
-
Johannes F.J., Prestle J., Eis S., Oberhagemann P., Pfizenmaier K. PKCμ is a novel, atypical member of the protein kinase C family. J Biol Chem. 269:1994;6140-6148.
-
(1994)
J Biol Chem
, vol.269
, pp. 6140-6148
-
-
Johannes, F.J.1
Prestle, J.2
Eis, S.3
Oberhagemann, P.4
Pfizenmaier, K.5
-
19
-
-
0033528865
-
PKCν, a new member of the protein kinase C family, composes a fourth subfamily with PKCμ
-
Hayashi A., Seki N., Hattori A., Kozuma S., Saito T. PKCν, a new member of the protein kinase C family, composes a fourth subfamily with PKCμ Biochim Biophys Acta. 1450:1999;99-106.
-
(1999)
Biochim Biophys Acta
, vol.1450
, pp. 99-106
-
-
Hayashi, A.1
Seki, N.2
Hattori, A.3
Kozuma, S.4
Saito, T.5
-
20
-
-
0027297104
-
Characterization of ligand and substrate specificity for the calcium-dependent and calcium-independent protein kinase C isozymes
-
Kazanietz M.G., Areces L.B., Bahador A., Mischak H., Goodnight J., Mushinski J.F., Blumberg P.M. Characterization of ligand and substrate specificity for the calcium-dependent and calcium-independent protein kinase C isozymes. Mol Pharmacol. 44:1993;298-307.
-
(1993)
Mol Pharmacol
, vol.44
, pp. 298-307
-
-
Kazanietz, M.G.1
Areces, L.B.2
Bahador, A.3
Mischak, H.4
Goodnight, J.5
Mushinski, J.F.6
Blumberg, P.M.7
-
21
-
-
0001098447
-
Phorbol ester binding to protein kinase C requires a cysteine-rich zinc-finger-like sequence
-
Ono Y., Fujii T., Igarashi K., Kuno T., Tanaka C., Kikkawa U., Nishizuka Y. Phorbol ester binding to protein kinase C requires a cysteine-rich zinc-finger-like sequence. Proc Natl Acad Sci USA. 86:1989;4868-4871.
-
(1989)
Proc Natl Acad Sci USA
, vol.86
, pp. 4868-4871
-
-
Ono, Y.1
Fujii, T.2
Igarashi, K.3
Kuno, T.4
Tanaka, C.5
Kikkawa, U.6
Nishizuka, Y.7
-
22
-
-
0028086467
-
A phorbol ester binding domain of protein kinase Cγ. Deletion analysis of the Cys2 domain defines a minimal 43-amino acid peptide
-
Quest A.F.G., Bardes E.S.G., Bell R.M. A phorbol ester binding domain of protein kinase Cγ. Deletion analysis of the Cys2 domain defines a minimal 43-amino acid peptide. J Biol Chem. 269:1994;2961-2970.
-
(1994)
J Biol Chem
, vol.269
, pp. 2961-2970
-
-
Quest, A.F.G.1
Bardes, E.S.G.2
Bell, R.M.3
-
23
-
-
0028310840
-
Zinc finger domains and phorbol ester pharmacophore. Analysis of binding to mutated form of protein kinase C ξ and the vav and c-raf proto-oncogene products
-
Kazanietz M.G., Bustelo X.R., Barbacid M., Kolch W., Mischak H., Wong G., Pettit G.R., Bruns J.D., Blumberg P.M. Zinc finger domains and phorbol ester pharmacophore. Analysis of binding to mutated form of protein kinase C ξ and the vav and c-raf proto-oncogene products. J Biol Chem. 269:1994;11590-11594.
-
(1994)
J Biol Chem
, vol.269
, pp. 11590-11594
-
-
Kazanietz, M.G.1
Bustelo, X.R.2
Barbacid, M.3
Kolch, W.4
Mischak, H.5
Wong, G.6
Pettit, G.R.7
Bruns, J.D.8
Blumberg, P.M.9
-
24
-
-
0029102822
-
Residues in the second cysteine-rich region of protein kinase C δ relevant to phorbol ester binding as revealed by site-directed mutagenesis
-
Kazanietz M.G., Wang S., Milne G.W.A., Lewin N.E., Liu H.L., Blumberg P.M. Residues in the second cysteine-rich region of protein kinase C δ relevant to phorbol ester binding as revealed by site-directed mutagenesis. J Biol Chem. 270:1995;21852-21859.
-
(1995)
J Biol Chem
, vol.270
, pp. 21852-21859
-
-
Kazanietz, M.G.1
Wang, S.2
Milne, G.W.A.3
Lewin, N.E.4
Liu, H.L.5
Blumberg, P.M.6
-
25
-
-
0028979464
-
Crystal structure of the cys2 activator-binding domain of protein kinase Cδ in complex with phorbol ester
-
Zhang G., Kazanietz M.G., Blumberg P.M., Hurley J.H. Crystal structure of the cys2 activator-binding domain of protein kinase Cδ in complex with phorbol ester. Cell. 81:1995;917-924.
-
(1995)
Cell
, vol.81
, pp. 917-924
-
-
Zhang, G.1
Kazanietz, M.G.2
Blumberg, P.M.3
Hurley, J.H.4
-
26
-
-
0028961287
-
Solution structure of cysteine-rich domain of protein kinase C alpha
-
Ichikawa S., Hatanaka H., Takeuchi Y., Ohno S., Inagaki F. Solution structure of cysteine-rich domain of protein kinase C alpha. J Biochem (Tokyo). 117:1995;566-574.
-
(1995)
J Biochem (Tokyo)
, vol.117
, pp. 566-574
-
-
Ichikawa, S.1
Hatanaka, H.2
Takeuchi, Y.3
Ohno, S.4
Inagaki, F.5
-
27
-
-
0030764306
-
NMR structure of a protein kinase C-γ phorbol-binding domain and study of protein-lipid micelle interactions
-
Xu R.X., Pawelczyk T., Xia T.-H., Brown S.C. NMR structure of a protein kinase C-γ phorbol-binding domain and study of protein-lipid micelle interactions. Biochemistry. 36:1997;10709-10717.
-
(1997)
Biochemistry
, vol.36
, pp. 10709-10717
-
-
Xu, R.X.1
Pawelczyk, T.2
Xia, T.-H.3
Brown, S.C.4
-
28
-
-
0033539133
-
Probing the binding of indolactam-V to protein kinase C through site-directed mutagenesis and computational docking simulations
-
Wang S., Liu M., Lewin N.E., Lorenzo P.S., Bhattacharrya D., Qiao L., Kozikowski A.P., Blumberg P.M. Probing the binding of indolactam-V to protein kinase C through site-directed mutagenesis and computational docking simulations. J Med Chem. 42:1999;3436-3446.
-
(1999)
J Med Chem
, vol.42
, pp. 3436-3446
-
-
Wang, S.1
Liu, M.2
Lewin, N.E.3
Lorenzo, P.S.4
Bhattacharrya, D.5
Qiao, L.6
Kozikowski, A.P.7
Blumberg, P.M.8
-
29
-
-
0022341259
-
Activation of protein kinase C by Triton X-100 mixed micelles containing diacylglycerol and phosphatidylserine
-
Hannun Y.A., Loomis C.R., Bell R.M. Activation of protein kinase C by Triton X-100 mixed micelles containing diacylglycerol and phosphatidylserine. J Biol Chem. 260:1985;10039-10043.
-
(1985)
J Biol Chem
, vol.260
, pp. 10039-10043
-
-
Hannun, Y.A.1
Loomis, C.R.2
Bell, R.M.3
-
30
-
-
0031014220
-
Cysteine-rich regions of protein kinase Cδ are functionally non-equivalent. Differences between cysteine-rich regions of non-calcium-dependent protein kinase Cδ and calcium-dependent protein kinase Cγ
-
Hunn M., Quest A. Cysteine-rich regions of protein kinase Cδ are functionally non-equivalent. Differences between cysteine-rich regions of non-calcium-dependent protein kinase Cδ and calcium-dependent protein kinase Cγ FEBS Lett. 400:1997;226-232.
-
(1997)
FEBS Lett
, vol.400
, pp. 226-232
-
-
Hunn, M.1
Quest, A.2
-
31
-
-
0030792726
-
Comparison of chemical characteristics of the first and the second cysteine-rich domains of protein kinase C gamma
-
Irie K., Yanai Y., Oie K., Ishizawa J., Nakagawa Y., Ohigashi H., Wender P.A., Kikkawa U. Comparison of chemical characteristics of the first and the second cysteine-rich domains of protein kinase C gamma. Bioorg Med Chem. 5:1997;1725-1737.
-
(1997)
Bioorg Med Chem
, vol.5
, pp. 1725-1737
-
-
Irie, K.1
Yanai, Y.2
Oie, K.3
Ishizawa, J.4
Nakagawa, Y.5
Ohigashi, H.6
Wender, P.A.7
Kikkawa, U.8
-
32
-
-
0029670030
-
Protein kinase Cα contains two activator binding sites that bind phorbol esters and diacylglycerols with opposite affinities
-
Slater S.J., Ho C., Kelly M.B., Larkin J.D., Taddeo F.J., Yeager M.D., Stubbs C.D. Protein kinase Cα contains two activator binding sites that bind phorbol esters and diacylglycerols with opposite affinities. J Biol Chem. 271:1996;4627-4631.
-
(1996)
J Biol Chem
, vol.271
, pp. 4627-4631
-
-
Slater, S.J.1
Ho, C.2
Kelly, M.B.3
Larkin, J.D.4
Taddeo, F.J.5
Yeager, M.D.6
Stubbs, C.D.7
-
33
-
-
0032483386
-
Inhibition of membrane lipid-independent protein kinase Cα activity by phorbol esters, diacylglycerols, and bryostatin-1
-
Slater S.J., Taddeo F.J., Mazurek A., Stagliano B.A., Milano S.K., Kelly M.B., Ho C., Stubbs C.D. Inhibition of membrane lipid-independent protein kinase Cα activity by phorbol esters, diacylglycerols, and bryostatin-1. J Biol Chem. 273:1998;23160-23168.
-
(1998)
J Biol Chem
, vol.273
, pp. 23160-23168
-
-
Slater, S.J.1
Taddeo, F.J.2
Mazurek, A.3
Stagliano, B.A.4
Milano, S.K.5
Kelly, M.B.6
Ho, C.7
Stubbs, C.D.8
-
34
-
-
0032538616
-
Dissimilar phorbol ester binding properties of the individual cysteine-rich motifs of protein kinase D
-
Iglesias T., Matthews S., Rozengurt E. Dissimilar phorbol ester binding properties of the individual cysteine-rich motifs of protein kinase D. FEBS Lett. 437:1998;19-23.
-
(1998)
FEBS Lett
, vol.437
, pp. 19-23
-
-
Iglesias, T.1
Matthews, S.2
Rozengurt, E.3
-
35
-
-
0029785953
-
Non-equivalent roles for the first and second zinc fingers of protein kinase Cδ.
-
Effect of their mutation on phorbol ester-induced translocation in NIH 3T3 cells.
-
Szallasi Z, Bögi K, Gohari S, Biro T, Acs P and Blumberg PM, Non-equivalent roles for the first and second zinc fingers of protein kinase Cδ. Effect of their mutation on phorbol ester-induced translocation in NIH 3T3 cells. J Biol Chem 271: 18299-18301, 1996.
-
(1996)
J Biol Chem
, vol.271
, pp. 18299-18301
-
-
Szallasi Z1
Bögi K2
Gohari S3
Biro T4
Acs P5
Blumberg PM6
-
36
-
-
0343692517
-
Differential selectivity of ligands for the C1a and C1b phorbol ester binding domains of protein kinase Cδ: Possible correlation with tumor-promoting activity
-
Bögi K., Lorenzo P.S., Szállási Z., Ács P., Wagner G.S., Blumberg P.M. Differential selectivity of ligands for the C1a and C1b phorbol ester binding domains of protein kinase Cδ Possible correlation with tumor-promoting activity . Cancer Res. 58:1998;1423-1428.
-
(1998)
Cancer Res
, vol.58
, pp. 1423-1428
-
-
Bögi, K.1
Lorenzo, P.S.2
Szállási, Z.3
Ács, P.4
Wagner, G.S.5
Blumberg, P.M.6
-
37
-
-
0343819883
-
Differential roles of the tandem C1 domains of protein kinase C δ in the biphasic down-regulation induced by bryostatin 1
-
Lorenzo P.S., Bögi K., Hughes K.M., Beheshti M., Bhattacharyya D., Garfield S.H., Pettit G.R., Blumberg P.M. Differential roles of the tandem C1 domains of protein kinase C δ in the biphasic down-regulation induced by bryostatin 1. Cancer Res. 59:1999;6137-6144.
-
(1999)
Cancer Res
, vol.59
, pp. 6137-6144
-
-
Lorenzo, P.S.1
Bögi, K.2
Hughes, K.M.3
Beheshti, M.4
Bhattacharyya, D.5
Garfield, S.H.6
Pettit, G.R.7
Blumberg, P.M.8
-
38
-
-
0028948167
-
Differential protein kinase C ligand regulation detected in vivo by a phenotypic yeast assay
-
Shieh H.L., Hansen H., Zhu J., Riedel H. Differential protein kinase C ligand regulation detected in vivo by a phenotypic yeast assay. Mol Carcinog. 12:1995;166-176.
-
(1995)
Mol Carcinog
, vol.12
, pp. 166-176
-
-
Shieh, H.L.1
Hansen, H.2
Zhu, J.3
Riedel, H.4
-
39
-
-
0031050299
-
Taxonomy and function of C1 protein kinase C homology domains
-
Hurley J.H., Newton A.C., Parker P.J., Blumberg P.M., Nishizuka Y. Taxonomy and function of C1 protein kinase C homology domains. Protein Sci. 6:1997;477-480.
-
(1997)
Protein Sci
, vol.6
, pp. 477-480
-
-
Hurley, J.H.1
Newton, A.C.2
Parker, P.J.3
Blumberg, P.M.4
Nishizuka, Y.5
-
40
-
-
0029757119
-
The solution structure of the Raf-1 cysteine-rich domain: A novel Ras and phospholipid binding site
-
Mott H.R., Carpenter J.W., Zhong S., Ghosh S., Bell R.M., Campbell S.L. The solution structure of the Raf-1 cysteine-rich domain A novel Ras and phospholipid binding site . Proc Natl Acad Sci USA. 93:1996;8312-8317.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 8312-8317
-
-
Mott, H.R.1
Carpenter, J.W.2
Zhong, S.3
Ghosh, S.4
Bell, R.M.5
Campbell, S.L.6
-
41
-
-
0028277981
-
Direct stimulation of Vav guanine nucleotide exchange activity for Ras by phorbol esters and diglycerides
-
Gulbins E., Coggeshall K.M., Baier G., Telford D., Langlet C., Baier-Bitterlich G., Bonnefoy-Berard N., Burn P., Wittinghofer A., Altman A. Direct stimulation of Vav guanine nucleotide exchange activity for Ras by phorbol esters and diglycerides. Mol Cell Biol. 14:1994;4749-4758.
-
(1994)
Mol Cell Biol
, vol.14
, pp. 4749-4758
-
-
Gulbins, E.1
Coggeshall, K.M.2
Baier, G.3
Telford, D.4
Langlet, C.5
Baier-Bitterlich, G.6
Bonnefoy-Berard, N.7
Burn, P.8
Wittinghofer, A.9
Altman, A.10
-
42
-
-
0028144758
-
Close similarity of baculovirus-expressed n-chimaerin and protein kinase Cα as phorbol ester receptors
-
Areces L.B., Kazanietz M.G., Blumberg P.M. Close similarity of baculovirus-expressed n-chimaerin and protein kinase Cα as phorbol ester receptors. J Biol Chem. 269:1994;19553-19558.
-
(1994)
J Biol Chem
, vol.269
, pp. 19553-19558
-
-
Areces, L.B.1
Kazanietz, M.G.2
Blumberg, P.M.3
-
43
-
-
0030611884
-
β2-Chimaerin is a high affinity receptor for the phorbol ester tumor promoters
-
Caloca M.J., Fernandez N., Lewin N.E., Ching D., Modali R., Blumberg P.M., Kazanietz M.G. β2-Chimaerin is a high affinity receptor for the phorbol ester tumor promoters. J Biol Chem. 272:1997;26488-26496.
-
(1997)
J Biol Chem
, vol.272
, pp. 26488-26496
-
-
Caloca, M.J.1
Fernandez, N.2
Lewin, N.E.3
Ching, D.4
Modali, R.5
Blumberg, P.M.6
Kazanietz, M.G.7
-
44
-
-
0032589433
-
β2-Chimaerin is a novel target for diacylglycerol: Binding properties and changes in subcellular localization mediated by ligand binding to its C1 domain
-
Caloca M.J., Garcia-Bermejo M.L., Blumberg P.M., Lewin N.L., Kremmer E., Mischak H., Wang S., Nacro K., Bienfait B., Marquez V.E., Kazanietz M.G. β2-Chimaerin is a novel target for diacylglycerol Binding properties and changes in subcellular localization mediated by ligand binding to its C1 domain . Proc Natl Acad Sci USA. 96:1999;11854-11859.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 11854-11859
-
-
Caloca, M.J.1
Garcia-Bermejo, M.L.2
Blumberg, P.M.3
Lewin, N.L.4
Kremmer, E.5
Mischak, H.6
Wang, S.7
Nacro, K.8
Bienfait, B.9
Marquez, V.E.10
Kazanietz, M.G.11
-
45
-
-
0032524389
-
RasGRP, a Ras guanyl nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs
-
Ebinu J.O., Bottorff D.A., Chan E.Y.W., Stang S.L., Dunn R.J., Stone J.C. RasGRP, a Ras guanyl nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Science. 280:1998;1082-1086.
-
(1998)
Science
, vol.280
, pp. 1082-1086
-
-
Ebinu, J.O.1
Bottorff, D.A.2
Chan, E.Y.W.3
Stang, S.L.4
Dunn, R.J.5
Stone, J.C.6
-
46
-
-
0031784267
-
Der CJ and Kay RJ, Regulation of RasGRP via a phorbol ester-responsive C1 domain
-
Tognon C.E., Kirk H.E., Passmore L.A., Whitehead I.P. Der CJ and Kay RJ, Regulation of RasGRP via a phorbol ester-responsive C1 domain. Mol Cell Biol. 18:1998;6995-7008.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 6995-7008
-
-
Tognon, C.E.1
Kirk, H.E.2
Passmore, L.A.3
Whitehead, I.P.4
-
47
-
-
0034061660
-
The guanine nucleotide exchange factor RasGRP is a high affinity target for diacylglycerol and phorbol esters
-
Lorenzo P.S., Behshti M., Pettit G.R., Stonne J.C., Blumberg P.M. The guanine nucleotide exchange factor RasGRP is a high affinity target for diacylglycerol and phorbol esters. Mol Pharmacol. 57:2000;840-846.
-
(2000)
Mol Pharmacol
, vol.57
, pp. 840-846
-
-
Lorenzo, P.S.1
Behshti, M.2
Pettit, G.R.3
Stonne, J.C.4
Blumberg, P.M.5
-
48
-
-
0026053020
-
Phorbol ester/diacylglycerol-binding protein encoded by the unc-13 gene of Caenorhabditis elegans
-
Maruyama I.N., Brenner S. Phorbol ester/diacylglycerol-binding protein encoded by the unc-13 gene of Caenorhabditis elegans. Proc Natl Acad Sci USA. 88:1991;5729-5733.
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 5729-5733
-
-
Maruyama, I.N.1
Brenner, S.2
-
49
-
-
18544399674
-
Munc13-1 is a presynaptic phorbol ester receptor that enhances neurotransmitter release
-
Betz A., Ashery U., Rickmann M., Augustin I., Neher E., Südhof T.C., Rettig J., Brose N. Munc13-1 is a presynaptic phorbol ester receptor that enhances neurotransmitter release. Neuron. 21:1998;123-136.
-
(1998)
Neuron
, vol.21
, pp. 123-136
-
-
Betz, A.1
Ashery, U.2
Rickmann, M.3
Augustin, I.4
Neher, E.5
Südhof, T.C.6
Rettig, J.7
Brose, N.8
-
50
-
-
0033600807
-
Transient, phorbol ester-induced DOC2-Munc13 interactions in vivo
-
Duncan R.R., Betz A., Shipston M.J., Brose N., Chow R.H. Transient, phorbol ester-induced DOC2-Munc13 interactions in vivo. J Biol Chem. 274:1999;27347-27350.
-
(1999)
J Biol Chem
, vol.274
, pp. 27347-27350
-
-
Duncan, R.R.1
Betz, A.2
Shipston, M.J.3
Brose, N.4
Chow, R.H.5
-
51
-
-
0032948523
-
Human munc13 is a diacylglycerol receptor that induces apoptosis and may contribute to renal cell injury in hyperglycemia
-
Song Y., Ailenberg M., Silverman M. Human munc13 is a diacylglycerol receptor that induces apoptosis and may contribute to renal cell injury in hyperglycemia. Mol Biol Cell. 10:1999;1609-1619.
-
(1999)
Mol Biol Cell
, vol.10
, pp. 1609-1619
-
-
Song, Y.1
Ailenberg, M.2
Silverman, M.3
-
52
-
-
0028914673
-
Characterization of the cysteine-rich region of the Caenorhabditis elegans protein Unc-13 as a high affinity phorbol ester receptor. Analysis of ligand-binding interactions, lipid cofactor requirements, and inhibitor sensitivity
-
Kazanietz M.G., Lewin N.E., Bruns J.D., Blumberg P.M. Characterization of the cysteine-rich region of the Caenorhabditis elegans protein Unc-13 as a high affinity phorbol ester receptor. Analysis of ligand-binding interactions, lipid cofactor requirements, and inhibitor sensitivity. J Biol Chem. 270:1995;10777-10783.
-
(1995)
J Biol Chem
, vol.270
, pp. 10777-10783
-
-
Kazanietz, M.G.1
Lewin, N.E.2
Bruns, J.D.3
Blumberg, P.M.4
-
53
-
-
13144282666
-
A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia
-
Kawasaki H., Springett G.M., Toki S., Canales J.J., Harlan P., Blumenstiel J.P., Chen E.J., Bany I.A., Mochizuki N., Ashbacher A., Matsuda M., Housman D.E., Graybiel A.M. A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia. Proc Natl Acad Sci USA. 95:1998;13278-13283.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 13278-13283
-
-
Kawasaki, H.1
Springett, G.M.2
Toki, S.3
Canales, J.J.4
Harlan, P.5
Blumenstiel, J.P.6
Chen, E.J.7
Bany, I.A.8
Mochizuki, N.9
Ashbacher, A.10
Matsuda, M.11
Housman, D.E.12
Graybiel, A.M.13
-
54
-
-
0031964645
-
Anchoring proteins for protein kinase C: A means for isozyme selectivity
-
Mochly-Rosen D., Gordon A.S. Anchoring proteins for protein kinase C A means for isozyme selectivity . FASEB J. 12:1998;35-42.
-
(1998)
FASEB J
, vol.12
, pp. 35-42
-
-
Mochly-Rosen, D.1
Gordon, A.S.2
-
55
-
-
0028900634
-
Immunocytochemical localization of eight protein kinase C isozymes overexpressed in NIH 3T3 fibroblasts. Isoform-specific association with microfilaments, Golgi, endoplasmic reticulum, and nuclear and cell membranes
-
Goodnight J.A., Mischak H., Kolch W., Mushinski J.F. Immunocytochemical localization of eight protein kinase C isozymes overexpressed in NIH 3T3 fibroblasts. Isoform-specific association with microfilaments, Golgi, endoplasmic reticulum, and nuclear and cell membranes. J Biol Chem. 270:1995;9991-10001.
-
(1995)
J Biol Chem
, vol.270
, pp. 9991-10001
-
-
Goodnight, J.A.1
Mischak, H.2
Kolch, W.3
Mushinski, J.F.4
-
56
-
-
0033233483
-
Protein kinase Cδ targets mitochondria, alters mitochondrial membrane potential, and induces apoptosis in normal and neoplastic keratinocytes when overexpressed by an adenoviral vector
-
Li L., Lorenzo P.S., Bogi K., Blumberg P.M., Yuspa S.H. Protein kinase Cδ targets mitochondria, alters mitochondrial membrane potential, and induces apoptosis in normal and neoplastic keratinocytes when overexpressed by an adenoviral vector. Mol Cell Biol. 19:1999;8547-8558.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 8547-8558
-
-
Li, L.1
Lorenzo, P.S.2
Bogi, K.3
Blumberg, P.M.4
Yuspa, S.H.5
-
57
-
-
0033601367
-
Differential localization of protein kinase C δ by phorbol esters and related compounds using a fusion protein with green fluorescent protein
-
Wang Q.J., Bhattacharyya D., Garfield S., Nacro K., Marquez V.E., Blumberg P.M. Differential localization of protein kinase C δ by phorbol esters and related compounds using a fusion protein with green fluorescent protein. J Biol Chem. 274:1999;37233-37239.
-
(1999)
J Biol Chem
, vol.274
, pp. 37233-37239
-
-
Wang, Q.J.1
Bhattacharyya, D.2
Garfield, S.3
Nacro, K.4
Marquez, V.E.5
Blumberg, P.M.6
-
58
-
-
0034697324
-
The lipophilicity of phorbol esters as a critical factor in determining the pattern of translocation of protein kinase C δ fused to green fluorescent protein
-
Wang Q.J., Fang T.-W., Fenick D., Garfield S., Bienfait B., Marquez V.E., Blumberg P.M. The lipophilicity of phorbol esters as a critical factor in determining the pattern of translocation of protein kinase C δ fused to green fluorescent protein. J Biol Chem. 275:2000;12136-12146.
-
(2000)
J Biol Chem
, vol.275
, pp. 12136-12146
-
-
Wang, Q.J.1
Fang, T.-W.2
Fenick, D.3
Garfield, S.4
Bienfait, B.5
Marquez, V.E.6
Blumberg, P.M.7
-
59
-
-
0032986851
-
The transition from a pharmacophore-guided approach to a receptor-guided approach in the design of potent protein kinase C ligands
-
Marquez V.E., Nacro K., Benzaria S., Lee J., Sharma R., Teng K., Milne G.W., Bienfait B., Wang S., Lewin N.E., Blumberg P.M. The transition from a pharmacophore-guided approach to a receptor-guided approach in the design of potent protein kinase C ligands. Pharmacol Ther. 82:1999;251-261.
-
(1999)
Pharmacol Ther
, vol.82
, pp. 251-261
-
-
Marquez, V.E.1
Nacro, K.2
Benzaria, S.3
Lee, J.4
Sharma, R.5
Teng, K.6
Milne, G.W.7
Bienfait, B.8
Wang, S.9
Lewin, N.E.10
Blumberg, P.M.11
-
60
-
-
0034599717
-
Diacylglycerols with lipophilically equivalent branched acyl chains display high affinity for protein kinase C (PK-C). A direct measure of the effect of constraining the glycerol backbone in DAG lactones
-
Nacro K., Bienfait B., Lewin N.E., Blumberg P.M., Marquez V.E. Diacylglycerols with lipophilically equivalent branched acyl chains display high affinity for protein kinase C (PK-C). A direct measure of the effect of constraining the glycerol backbone in DAG lactones. Bioorg Med Chem Lett. 10:2000;653-655.
-
(2000)
Bioorg Med Chem Lett
, vol.10
, pp. 653-655
-
-
Nacro, K.1
Bienfait, B.2
Lewin, N.E.3
Blumberg, P.M.4
Marquez, V.E.5
-
61
-
-
0034624775
-
Conformationally constrained analogues of diacylglycerol (DAG). 16. How much structural complexity is necessary for recognition and high binding affinity to protein kinase C?
-
Nacro K., Bienfait B., Lee J., Han K.C., Kang J.H., Benzaria S., Lewin N.E., Bhattacharyya D.K., Blumberg P.M., Marquez V.E. Conformationally constrained analogues of diacylglycerol (DAG). 16. How much structural complexity is necessary for recognition and high binding affinity to protein kinase C? J Med Chem. 43:2000;921-944.
-
(2000)
J Med Chem
, vol.43
, pp. 921-944
-
-
Nacro, K.1
Bienfait, B.2
Lee, J.3
Han, K.C.4
Kang, J.H.5
Benzaria, S.6
Lewin, N.E.7
Bhattacharyya, D.K.8
Blumberg, P.M.9
Marquez, V.E.10
-
62
-
-
0031058595
-
Protein kinase C: A worthwhile target for anticancer drugs?
-
Caponigro F., French R.C., Kaye S.B. Protein kinase C A worthwhile target for anticancer drugs? Anticancer Drugs. 8:1997;26-33.
-
(1997)
Anticancer Drugs
, vol.8
, pp. 26-33
-
-
Caponigro, F.1
French, R.C.2
Kaye, S.B.3
-
63
-
-
0033407483
-
Treatment of patients with metastatic melanoma with bryostatin-1 - A phase II study
-
Gonzalez R., Ebbinghaus S., Henthorn T.K., Miller D., Kraft A.S. Treatment of patients with metastatic melanoma with bryostatin-1 - A phase II study. Melanoma Res. 9:1999;599-606.
-
(1999)
Melanoma Res
, vol.9
, pp. 599-606
-
-
Gonzalez, R.1
Ebbinghaus, S.2
Henthorn, T.K.3
Miller, D.4
Kraft, A.S.5
-
64
-
-
12944249449
-
Phase II trial of bryostatin 1 in patients with relapsed low-grade non-Hodgkin's lymphoma and chronic lymphocytic leukemia
-
Varterasian M.L., Mohammad R.M., Shurafa M.S., Hulburd K., Pemberton P.A., Rodriguez D.H., Spadoni V., Eilender D.S., Murgo A., Wall N., Dan M., Al-Katib A.M. Phase II trial of bryostatin 1 in patients with relapsed low-grade non-Hodgkin's lymphoma and chronic lymphocytic leukemia. Clin Cancer Res. 6:2000;825-828.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 825-828
-
-
Varterasian, M.L.1
Mohammad, R.M.2
Shurafa, M.S.3
Hulburd, K.4
Pemberton, P.A.5
Rodriguez, D.H.6
Spadoni, V.7
Eilender, D.S.8
Murgo, A.9
Wall, N.10
Dan, M.11
Al-Katib, A.M.12
-
65
-
-
0000356405
-
Effect of intravenous infusions of 12-O-tetradecanoylphorbol-13-acetate (TPA) in patients with myelocytic leukemia: Preliminary studies on therapeutic efficacy and toxicity
-
Han Z.T., Zhu X.X., Yang R.Y., Sun J.Z., Tian G.F., Liu X.J., Cao G.S., Newmark H.L., Conney A.H., Chang R.L. Effect of intravenous infusions of 12-O-tetradecanoylphorbol-13-acetate (TPA) in patients with myelocytic leukemia Preliminary studies on therapeutic efficacy and toxicity . Proc Natl Acad Sci USA. 95:1998;5357-5361.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 5357-5361
-
-
Han, Z.T.1
Zhu, X.X.2
Yang, R.Y.3
Sun, J.Z.4
Tian, G.F.5
Liu, X.J.6
Cao, G.S.7
Newmark, H.L.8
Conney, A.H.9
Chang, R.L.10
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