Novel semisynthetic analogues of betulinic acid with diverse cytoprotective, antiproliferative, and proapoptotic activities

Molecular Cancer Therapeutics

Volumn 6, Issue 7, 2007, Pages 2113-2119

  Liby, Karen ^a   Honda, Tadashi ^b   Williams, Charlotte R ^a   Risingsong, Renee ^a   Royce, Darlene B ^a   Suh, Nanjoo ^a,c   Dinkova Kostova, Albena T ^d   Stephenson, Katherine K ^d   Talalay, Paul ^d   Sundararajan, Chitra ^b   Gribble, Gordon W ^b   Sporn, Michael B ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b DARTMOUTH COLLEGE   (United States)

^c RUTGERS UNIVERSITY   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 CYANO 3 OXOLUPA 1,20(29) DIEN 28 OYL)IMIDAZOLE; 2 CYANO 3 OXOLUPA 1,20(29) DIEN 28 OIC ACID; 2 CYANO 3,12 DIOXOOLEANA 1,9 DIEN 28 OIC ACID; BETULIC ACID; INDUCIBLE NITRIC OXIDE SYNTHASE; METHYL 2 CARBOXY 3 OXOLUPA 1,20(29) DIEN 28 OATE; METHYL 2 CYANO 3 OXOLUPA 1,20(29) DIEN 28 OATE; METHYL 2 METHOXYCARBONYL 3 OXOLUPA 1,20(29) DIEN 28 OATE; METHYL 30 HYDROXY 2 METHOXYCARBONYL 3 OXOLUPA 1,20(29) DIEN 28 OATE; PROTEIN BAK; PROTEIN BAX; TP 290; TP 291; TP 295; TP 296; TP 297; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BIOLOGICAL ACTIVITY; CELL PROLIFERATION; CELL PROTECTION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG POTENCY; DRUG TISSUE LEVEL; ENZYME ACTIVATION; ENZYME INHIBITION; FIBROBLAST; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL LINE, TUMOR; CELL PROLIFERATION; CYTOPROTECTION; FIBROBLASTS; HUMANS; INFLAMMATION; MACROPHAGES; MALE; MICE; NAD(P)H DEHYDROGENASE (QUINONE); NITRIC OXIDE; TRITERPENES;

EID: 34447332823     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-07-0180     Document Type: Article

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