Progress in clinical, pharmacological, chemical and structural biological studies of huperzine A: A drug of traditional Chinese medicine origin for the treatment of Alzheimer's disease

Current Medicinal Chemistry

Volumn 10, Issue 21, 2003, Pages 2231-2252

  Jiang, Hualiang ^a   Luo, Xiaomin ^a   Bai, Donglu ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Acetylcholinesterase; Alzheimer's disease; Huperzine A; Molecular modeling; X ray crystallography

Indexed keywords

CHINESE DRUG; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; DIZOCILPINE; DONEPEZIL; GALANTAMINE; HUPERZINE A; HUPERZINE A DERIVATIVE; HUPERZINE B; HUPRINE X; HUPRINE Y; HUPYRIDONE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NOOTROPIC AGENT; PHYSOSTIGMINE; TACRINE; UNCLASSIFIED DRUG;

ABDOMINAL DISCOMFORT; ALZHEIMER DISEASE; BLOOD BRAIN BARRIER; CHINESE MEDICINE; CLINICAL TRIAL; DOSE RESPONSE; DRUG APPROVAL; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG HALF LIFE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; DRUG TARGETING; DRUG TRANSPORT; HUMAN; INSOMNIA; LEARNING; MEMORY; NEUROPROTECTION; NONHUMAN; REVIEW; STRUCTURE ACTIVITY RELATION; TRADITIONAL MEDICINE; VERTIGO; X RAY CRYSTALLOGRAPHY;

ANIMALS; CLINICAL TRIALS; CRYSTALLOGRAPHY, X-RAY; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NEUROPROTECTIVE AGENTS; SESQUITERPENES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0141953955     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/0929867033456747     Document Type: Review

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