A short enantioselective pathway for the synthesis of the anti-influenza neuramidase inhibitor oseltamivir from 1,3-butadiene and acrylic acid

Journal of the American Chemical Society

Volumn 128, Issue 19, 2006, Pages 6310-6311

  Yeung, Ying Yeung ^a   Hong, Sungwoo ^a   Corey, E J ^a  

^a HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,3 BUTADIENE; ACRYLIC ACID; ANTIVIRUS AGENT; OSELTAMIVIR; QUINIC ACID; SHIKIMIC ACID; SIALIDASE INHIBITOR;

ARTICLE; CYCLIZATION; DRUG SYNTHESIS; ENANTIOMER; REACTION ANALYSIS;

ACRYLATES; ANTIVIRAL AGENTS; BUTADIENES; HUMANS; INFLUENZA, HUMAN; NEURAMINIDASE; OSELTAMIVIR; STEREOISOMERISM;

EID: 33646567839     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0616433     Document Type: Article

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11. The yield for the transformation 11 → 12 has not been optimized, with regard to catalyst and temperature.