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Volumn 70, Issue S1, 2014, Pages S2-S14

Toxicological assessment of kretek cigarettes: Part 1: Background, assessment approach, and summary of findings

Author keywords

Clove cigarettes; Cytotoxicity; Eugenol; Ingredients; Inhalation toxicity; Kretek cigarettes; Mutagenicity; Smoke chemistry

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CHEMICAL ANALYSIS; CHEMICAL COMPOSITION; CLOVE; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; GENOTOXICITY; HEALTH HAZARD; IN VITRO STUDY; IN VIVO STUDY; KRETEK CIGARETTE; MALE; MUTAGENICITY; NONHUMAN; PARTICULATE MATTER; PNEUMONIA; RAT; SMOKE; SMOKING; SOCIOECONOMICS; TOBACCO; TOXICOLOGY; ADVERSE EFFECTS; ANIMAL; EUGENIA; HUMAN; TOXICITY; TOXICITY TESTING;

EID: 84919732756     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2014.11.015     Document Type: Article
Times cited : (22)

References (116)
  • 1
    • 0024232822 scopus 로고
    • Evaluation of the health hazard of clove cigarettes
    • American Medical Association, Council on Scientific Affairs Evaluation of the health hazard of clove cigarettes. JAMA 1988, 260:3641-3644.
    • (1988) JAMA , vol.260 , pp. 3641-3644
  • 2
    • 34547810105 scopus 로고
    • Deaths follow U.S. craze for clove cigarettes
    • Anderson I. Deaths follow U.S. craze for clove cigarettes. New Sci. 1985, 105:7.
    • (1985) New Sci. , vol.105 , pp. 7
    • Anderson, I.1
  • 3
    • 84919760862 scopus 로고    scopus 로고
    • Tobacco and Kretek: Indonesian Drugs in Historical Change
    • Arnez M. Tobacco and Kretek: Indonesian Drugs in Historical Change. J. Southeast Asian Stud. 2009, 2:49-69.
    • (2009) J. Southeast Asian Stud. , vol.2 , pp. 49-69
    • Arnez, M.1
  • 5
    • 0344458882 scopus 로고    scopus 로고
    • AAALAC, Frederick, MD, USA
    • Association for Assessment and Accreditation of Laboratory Animal Care International Guide to the Care and use of Laboratory Animals 2006, AAALAC, Frederick, MD, USA.
    • (2006) Guide to the Care and use of Laboratory Animals
  • 6
    • 0028890761 scopus 로고
    • Mutagenicity and antimutagenicity testing of six chemicals associated with the pungent properties of specific spices as revealed by the Ames Salmonella/microsomal assay
    • Azizan A., Blevins R.D. Mutagenicity and antimutagenicity testing of six chemicals associated with the pungent properties of specific spices as revealed by the Ames Salmonella/microsomal assay. Arch. Environ. Contam. Toxicol. 1995, 28:248-258.
    • (1995) Arch. Environ. Contam. Toxicol. , vol.28 , pp. 248-258
    • Azizan, A.1    Blevins, R.D.2
  • 7
    • 0026797870 scopus 로고
    • Effect of sampling time on chromosome aberration yield for 7 chemicals in Chinese hamster ovary cells
    • Bean C.L., Armstrong M.J., Galloway S.M. Effect of sampling time on chromosome aberration yield for 7 chemicals in Chinese hamster ovary cells. Mutat. Res. 1992, 265:31-44.
    • (1992) Mutat. Res. , vol.265 , pp. 31-44
    • Bean, C.L.1    Armstrong, M.J.2    Galloway, S.M.3
  • 8
    • 0027236698 scopus 로고
    • Evaluation of the need for a late harvest time in the assay for chromosome aberrations in Chinese hamster ovary cells
    • Bean C.L., Galloway S.M. Evaluation of the need for a late harvest time in the assay for chromosome aberrations in Chinese hamster ovary cells. Mutat. Res. 1993, 292:3-16.
    • (1993) Mutat. Res. , vol.292 , pp. 3-16
    • Bean, C.L.1    Galloway, S.M.2
  • 9
    • 0020049498 scopus 로고
    • An empirical approach to the statistical analysis of mutagenesis data from the Salmonella test
    • Bernstein L., Kaldor J., McCann J., Pike M.C. An empirical approach to the statistical analysis of mutagenesis data from the Salmonella test. Mutat. Res. 1982, 97:267-281.
    • (1982) Mutat. Res. , vol.97 , pp. 267-281
    • Bernstein, L.1    Kaldor, J.2    McCann, J.3    Pike, M.C.4
  • 10
    • 0021990499 scopus 로고
    • Toxicity determined in vitro by morphological alterations and neutral red absorption
    • Borenfreund E., Puerner J.A. Toxicity determined in vitro by morphological alterations and neutral red absorption. Toxicol. Lett. 1985, 24:119-124.
    • (1985) Toxicol. Lett. , vol.24 , pp. 119-124
    • Borenfreund, E.1    Puerner, J.A.2
  • 11
    • 0023137496 scopus 로고
    • Short-term quantitative in vitro cytotoxicity assay involving an S-9 activating system
    • Borenfreund E., Puerner J.A. Short-term quantitative in vitro cytotoxicity assay involving an S-9 activating system. Cancer Lett. 1987, 34:243-248.
    • (1987) Cancer Lett. , vol.34 , pp. 243-248
    • Borenfreund, E.1    Puerner, J.A.2
  • 13
    • 0021783331 scopus 로고
    • Differential inhibition of A, B and C fibres in the rat vagus nerve by lidocaine, eugenol and formaldehyde
    • Brodin P. Differential inhibition of A, B and C fibres in the rat vagus nerve by lidocaine, eugenol and formaldehyde. Arch. Oral Biol. 1985, 30:477-480.
    • (1985) Arch. Oral Biol. , vol.30 , pp. 477-480
    • Brodin, P.1
  • 14
    • 0036133235 scopus 로고    scopus 로고
    • Evaluation of the potential effects of ingredients added to cigarettes. Part 1: cigarette design, testing approach, and review of results
    • Carmines E.L. Evaluation of the potential effects of ingredients added to cigarettes. Part 1: cigarette design, testing approach, and review of results. Food Chem. Toxicol. 2002, 40:77-91.
    • (2002) Food Chem. Toxicol. , vol.40 , pp. 77-91
    • Carmines, E.L.1
  • 15
    • 21244432631 scopus 로고    scopus 로고
    • Toxicologic evaluation of licorice extract as a cigarette ingredient
    • Carmines E.L., Lemus R., Gaworski C.L. Toxicologic evaluation of licorice extract as a cigarette ingredient. Food Chem. Toxicol. 2005, 43:1303-1322.
    • (2005) Food Chem. Toxicol. , vol.43 , pp. 1303-1322
    • Carmines, E.L.1    Lemus, R.2    Gaworski, C.L.3
  • 16
    • 0022435291 scopus 로고
    • Illnesses possibly associated with smoking clove cigarettes
    • CDC Illnesses possibly associated with smoking clove cigarettes. MMWR Morb. Mortal. Wkly Rep. 1985, 34:297-299.
    • (1985) MMWR Morb. Mortal. Wkly Rep. , vol.34 , pp. 297-299
  • 17
    • 84919749117 scopus 로고    scopus 로고
    • Available at
    • CDC, 2014. Bidis and kreteks. Available at http://www.cdc.gov/tobacco/data_statistics/fact_sheets/tobacco_industry/bidis_kreteks/.
    • (2014) Bidis and kreteks
  • 18
    • 34250318460 scopus 로고    scopus 로고
    • The chemical composition and biological activity of clove essential oil, Eugenia caryophyllata (Syzigium aromaticum L. Myrtaceae): a short review
    • Chaieb K., Hajlaoui H., Zmantar T., Kahla-Nakbi A.B., Rouabhia M., Mahdouani K., Bakhrouf A. The chemical composition and biological activity of clove essential oil, Eugenia caryophyllata (Syzigium aromaticum L. Myrtaceae): a short review. Phytother. Res. 2007, 21:501-506.
    • (2007) Phytother. Res. , vol.21 , pp. 501-506
    • Chaieb, K.1    Hajlaoui, H.2    Zmantar, T.3    Kahla-Nakbi, A.B.4    Rouabhia, M.5    Mahdouani, K.6    Bakhrouf, A.7
  • 19
    • 0022824289 scopus 로고
    • Toxicity studies on clove cigarette smoke and constituents of clove: determination of the LD50 of eugenol by intratracheal instillation in rats and hamsters by LaVoie
    • Clark G.C., et al. Toxicity studies on clove cigarette smoke and constituents of clove: determination of the LD50 of eugenol by intratracheal instillation in rats and hamsters by LaVoie. Arch. Toxicol. 1986, 59:296-299.
    • (1986) Arch. Toxicol. , vol.59 , pp. 296-299
    • Clark, G.C.1
  • 20
    • 0024234886 scopus 로고
    • Acute inhalation toxicity of eugenol in rats
    • Clark G.C. Acute inhalation toxicity of eugenol in rats. Arch. Toxicol. 1988, 62:381-386.
    • (1988) Arch. Toxicol. , vol.62 , pp. 381-386
    • Clark, G.C.1
  • 21
    • 0024593802 scopus 로고
    • Comparison of the inhalation toxicity of kretek (clove cigarette) smoke with that of American cigarette smoke. I. One day exposure
    • Clark G.C. Comparison of the inhalation toxicity of kretek (clove cigarette) smoke with that of American cigarette smoke. I. One day exposure. Arch. Toxicol. 1989, 63:1-6.
    • (1989) Arch. Toxicol. , vol.63 , pp. 1-6
    • Clark, G.C.1
  • 22
    • 0025085956 scopus 로고
    • Comparison of the inhalation toxicity of kretek (clove cigarette) smoke with that of American cigarette smoke. II. Fourteen days, exposure
    • Clark G.C. Comparison of the inhalation toxicity of kretek (clove cigarette) smoke with that of American cigarette smoke. II. Fourteen days, exposure. Arch. Toxicol. 1990, 64:515-521.
    • (1990) Arch. Toxicol. , vol.64 , pp. 515-521
    • Clark, G.C.1
  • 23
    • 0015402142 scopus 로고
    • A mutational assay system using the thymidine kinase locus in mouse lymphoma cells
    • Clive D., Flamm W.G., Machesko M.R., Bernheim N.J. A mutational assay system using the thymidine kinase locus in mouse lymphoma cells. Mutat. Res. 1972, 16:77-87.
    • (1972) Mutat. Res. , vol.16 , pp. 77-87
    • Clive, D.1    Flamm, W.G.2    Machesko, M.R.3    Bernheim, N.J.4
  • 24
    • 0022549410 scopus 로고
    • The mutagenicity of sodium fluoride to L5178Y [wild-type and TK+/- (3.7.2c)] mouse lymphoma cells
    • Cole J., Muriel W.J., Bridges B.A. The mutagenicity of sodium fluoride to L5178Y [wild-type and TK+/- (3.7.2c)] mouse lymphoma cells. Mutagenesis 1986, 1:157-167.
    • (1986) Mutagenesis , vol.1 , pp. 157-167
    • Cole, J.1    Muriel, W.J.2    Bridges, B.A.3
  • 25
    • 33750623725 scopus 로고    scopus 로고
    • Development of a commercial cigarette "market map" comparison methodology for evaluating new or non-conventional cigarettes
    • Counts M.E., Hsu F.S., Tewes F.J. Development of a commercial cigarette "market map" comparison methodology for evaluating new or non-conventional cigarettes. Regul. Toxicol. Pharmacol. 2006, 46:225-242.
    • (2006) Regul. Toxicol. Pharmacol. , vol.46 , pp. 225-242
    • Counts, M.E.1    Hsu, F.S.2    Tewes, F.J.3
  • 26
    • 0024232822 scopus 로고
    • Evaluation of the health hazard of clove cigarettes. Council on Scientific Affairs
    • CSA Evaluation of the health hazard of clove cigarettes. Council on Scientific Affairs. JAMA 1988, 260:3641-3644.
    • (1988) JAMA , vol.260 , pp. 3641-3644
  • 27
    • 0019364985 scopus 로고
    • Anesthetic, hypothermic, myorelaxant and anticonvulsant effects of synthetic eugenol derivatives and natural analogues
    • Dallmeier K., Carlini E.A. Anesthetic, hypothermic, myorelaxant and anticonvulsant effects of synthetic eugenol derivatives and natural analogues. Pharmacology 1981, 22:113-127.
    • (1981) Pharmacology , vol.22 , pp. 113-127
    • Dallmeier, K.1    Carlini, E.A.2
  • 29
    • 49649088914 scopus 로고    scopus 로고
    • Gas chromatographic-mass spectrometric analysis of acrylamide and acetamide in cigarette mainstream smoke after on-column injection
    • Diekmann J., Wittig A., Stabbert R. Gas chromatographic-mass spectrometric analysis of acrylamide and acetamide in cigarette mainstream smoke after on-column injection. J. Chromatogr. Sci. 2008, 46:659-663.
    • (2008) J. Chromatogr. Sci. , vol.46 , pp. 659-663
    • Diekmann, J.1    Wittig, A.2    Stabbert, R.3
  • 33
    • 0009663357 scopus 로고
    • A multiple comparison procedure for comparing several treatments with a control
    • Dunnett C.W. A multiple comparison procedure for comparing several treatments with a control. J. Am. Stat. Assoc. 1955, 50:1096-1121.
    • (1955) J. Am. Stat. Assoc. , vol.50 , pp. 1096-1121
    • Dunnett, C.W.1
  • 34
    • 84919749116 scopus 로고    scopus 로고
    • Enforcement of General Tobacco Standard Special Rule for Cigarettes
    • (available at In: [Docket No FDA-2009-N-0449].
    • FDA, 2009. Enforcement of General Tobacco Standard Special Rule for Cigarettes (available at In: [Docket No FDA-2009-N-0449]. http://www.gpo.gov/fdsys/pkg/FR-2009-09-25/html/E9-23144.htm.
    • (2009)
  • 35
    • 33747593511 scopus 로고    scopus 로고
    • Lung inflammation in rats following subchronic exposure to cigarette mainstream smoke
    • Friedrichs B., Miert E., Vanscheeuwijck P. Lung inflammation in rats following subchronic exposure to cigarette mainstream smoke. Exp. Lung Res. 2006, 32:151-179.
    • (2006) Exp. Lung Res. , vol.32 , pp. 151-179
    • Friedrichs, B.1    Miert, E.2    Vanscheeuwijck, P.3
  • 37
    • 36849056604 scopus 로고    scopus 로고
    • Toxicological evaluation of potassium sorbate added to cigarette tobacco
    • Gaworski C.L., Lemus-Olalde R., Carmines E.L. Toxicological evaluation of potassium sorbate added to cigarette tobacco. Food Chem. Toxicol. 2008, 46:339-351.
    • (2008) Food Chem. Toxicol. , vol.46 , pp. 339-351
    • Gaworski, C.L.1    Lemus-Olalde, R.2    Carmines, E.L.3
  • 38
    • 79958720434 scopus 로고    scopus 로고
    • An evaluation of the toxicity of 95 ingredients added individually to experimental cigarettes: approach and methods
    • Gaworski C.L., Oldham M.J., Wagner K.A., Coggins C.R., Patskan G.J. An evaluation of the toxicity of 95 ingredients added individually to experimental cigarettes: approach and methods. Inhal. Toxicol. 2011, 23(Suppl. 1):1-12.
    • (2011) Inhal. Toxicol. , vol.23 , pp. 1-12
    • Gaworski, C.L.1    Oldham, M.J.2    Wagner, K.A.3    Coggins, C.R.4    Patskan, G.J.5
  • 39
    • 33745625065 scopus 로고    scopus 로고
    • Pharmacokinetics and anesthetic activity of eugenol in male Sprague-Dawley rats
    • Guenette S.A., Beaudry F., Marier J.F., Vachon P. Pharmacokinetics and anesthetic activity of eugenol in male Sprague-Dawley rats. J. Vet. Pharmacol. Ther. 2006, 29:265-270.
    • (2006) J. Vet. Pharmacol. Ther. , vol.29 , pp. 265-270
    • Guenette, S.A.1    Beaudry, F.2    Marier, J.F.3    Vachon, P.4
  • 40
    • 34547762921 scopus 로고
    • Possible risks to health associated with clove cigarettes
    • Guidotti T.L. Possible risks to health associated with clove cigarettes. Chronic Dis. Can. 1985, 6:3-6.
    • (1985) Chronic Dis. Can. , vol.6 , pp. 3-6
    • Guidotti, T.L.1
  • 41
    • 0024502751 scopus 로고
    • Critique of available studies on the toxicology of kretek smoke and its constituents by routes of entry involving the respiratory tract
    • Guidotti T.L. Critique of available studies on the toxicology of kretek smoke and its constituents by routes of entry involving the respiratory tract. Arch. Toxicol. 1989, 63:7-12.
    • (1989) Arch. Toxicol. , vol.63 , pp. 7-12
    • Guidotti, T.L.1
  • 43
    • 0024373235 scopus 로고
    • Clove cigarettes. The basis for concern regarding health effects
    • Guidotti T.L., Laing L., Prakash U.B. Clove cigarettes. The basis for concern regarding health effects. West. J. Med. 1989, 151:220-228.
    • (1989) West. J. Med. , vol.151 , pp. 220-228
    • Guidotti, T.L.1    Laing, L.2    Prakash, U.B.3
  • 44
    • 85047694931 scopus 로고
    • Clove cigarettes and high-altitude pulmonary edema
    • Hackett P.H., Rodriguez G., Roach R.C. Clove cigarettes and high-altitude pulmonary edema. JAMA 1985, 253:3551-3552.
    • (1985) JAMA , vol.253 , pp. 3551-3552
    • Hackett, P.H.1    Rodriguez, G.2    Roach, R.C.3
  • 45
    • 17644407588 scopus 로고    scopus 로고
    • Determination of "tar", nicotine and carbon monoxide in mainstream smoke
    • Health Canada - Official Method.
    • Health Canada, 1999. Determination of "tar", nicotine and carbon monoxide in mainstream smoke. In: Health Canada - Official Method.
    • (1999)
  • 46
    • 70349780588 scopus 로고    scopus 로고
    • Synergistic interaction of eugenol with antibiotics against Gram negative bacteria
    • Hemaiswarya S., Doble M. Synergistic interaction of eugenol with antibiotics against Gram negative bacteria. Phytomedicine 2009, 16:997-1005.
    • (2009) Phytomedicine , vol.16 , pp. 997-1005
    • Hemaiswarya, S.1    Doble, M.2
  • 52
    • 0014663107 scopus 로고
    • Goblet cell increase in rat bronchial epithelium after exposure to cigarette and cigar tobacco smoke
    • Lamb D., Reid L. Goblet cell increase in rat bronchial epithelium after exposure to cigarette and cigar tobacco smoke. Br. Med. J. 1969, 1:33-35.
    • (1969) Br. Med. J. , vol.1 , pp. 33-35
    • Lamb, D.1    Reid, L.2
  • 53
    • 0022447362 scopus 로고
    • Toxicity studies on clove cigarette smoke and constituents of clove: determination of the LD50 of eugenol by intratracheal instillation in rats and hamsters
    • LaVoie E.J., Adams J.D., Reinhardt J., Rivenson A., Hoffmann D. Toxicity studies on clove cigarette smoke and constituents of clove: determination of the LD50 of eugenol by intratracheal instillation in rats and hamsters. Arch. Toxicol. 1986, 59:78-81.
    • (1986) Arch. Toxicol. , vol.59 , pp. 78-81
    • LaVoie, E.J.1    Adams, J.D.2    Reinhardt, J.3    Rivenson, A.4    Hoffmann, D.5
  • 56
    • 0019496826 scopus 로고
    • Mitotic indices of rat laryngeal epithelia
    • Lewis D.J. Mitotic indices of rat laryngeal epithelia. J. Anat. 1981, 132:419-428.
    • (1981) J. Anat. , vol.132 , pp. 419-428
    • Lewis, D.J.1
  • 58
    • 84959801619 scopus 로고
    • Statistical aspects of the analysis of data from retrospective studies of disease
    • Mantel N., Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J. Natl Cancer Inst. 1959, 22:719-748.
    • (1959) J. Natl Cancer Inst. , vol.22 , pp. 719-748
    • Mantel, N.1    Haenszel, W.2
  • 59
    • 0026725156 scopus 로고
    • Biologic properties of eugenol and zinc oxide-eugenol. A clinically oriented review
    • Markowitz K., Moynihan M., Liu M., Kim S. Biologic properties of eugenol and zinc oxide-eugenol. A clinically oriented review. Oral Surg. Oral Med. Oral Pathol. 1992, 73:729-737.
    • (1992) Oral Surg. Oral Med. Oral Pathol. , vol.73 , pp. 729-737
    • Markowitz, K.1    Moynihan, M.2    Liu, M.3    Kim, S.4
  • 60
    • 0020533372 scopus 로고
    • Revised methods for the Salmonella mutagenicity test
    • Maron D.M., Ames B.N. Revised methods for the Salmonella mutagenicity test. Mutat. Res. 1983, 113:173-215.
    • (1983) Mutat. Res. , vol.113 , pp. 173-215
    • Maron, D.M.1    Ames, B.N.2
  • 61
    • 0020692513 scopus 로고
    • Structure-activity studies of the carcinogenicities in the mouse and rat of some naturally occurring and synthetic alkenylbenzene derivatives related to safrole and estragole
    • Miller E.C., Swanson A.B., Phillips D.H., Fletcher T.L., Liem A., Miller J.A. Structure-activity studies of the carcinogenicities in the mouse and rat of some naturally occurring and synthetic alkenylbenzene derivatives related to safrole and estragole. Cancer Res. 1983, 43:1124-1134.
    • (1983) Cancer Res. , vol.43 , pp. 1124-1134
    • Miller, E.C.1    Swanson, A.B.2    Phillips, D.H.3    Fletcher, T.L.4    Liem, A.5    Miller, J.A.6
  • 63
    • 45849088449 scopus 로고    scopus 로고
    • Reduced toxicological activity of cigarette smoke by the addition of ammonia magnesium phosphate to the paper of an electrically heated cigarette: subchronic inhalation toxicology
    • Moennikes O., Vanscheeuwijck P.M., Friedrichs B., Anskeit E., Patskan G.J. Reduced toxicological activity of cigarette smoke by the addition of ammonia magnesium phosphate to the paper of an electrically heated cigarette: subchronic inhalation toxicology. Inhal. Toxicol. 2008, 20:647-663.
    • (2008) Inhal. Toxicol. , vol.20 , pp. 647-663
    • Moennikes, O.1    Vanscheeuwijck, P.M.2    Friedrichs, B.3    Anskeit, E.4    Patskan, G.J.5
  • 64
    • 33745432484 scopus 로고    scopus 로고
    • Simultaneous determination of aromatic and terpenic constituents of cloves by means of HPLC with diode array detection
    • Musenga A., Ferranti A., Saracino M.A., Fanali S., Raggl M.A. Simultaneous determination of aromatic and terpenic constituents of cloves by means of HPLC with diode array detection. J. Sep. Sci. 2006, 29:1251-1258.
    • (2006) J. Sep. Sci. , vol.29 , pp. 1251-1258
    • Musenga, A.1    Ferranti, A.2    Saracino, M.A.3    Fanali, S.4    Raggl, M.A.5
  • 65
    • 0025744675 scopus 로고
    • Chemical mutagenesis at the thymidine kinase locus in L5178Y mouse lymphoma cells: results for 31 coded compounds in the National Toxicology Program
    • Myhr B.C., Caspary W.J. Chemical mutagenesis at the thymidine kinase locus in L5178Y mouse lymphoma cells: results for 31 coded compounds in the National Toxicology Program. Environ. Mol. Mutagen. 1991, 18:51-83.
    • (1991) Environ. Mol. Mutagen. , vol.18 , pp. 51-83
    • Myhr, B.C.1    Caspary, W.J.2
  • 66
    • 84919776129 scopus 로고
    • Toxicology and carcinogenesis studies of eugenol
    • (CAS no. 97-53-0) in F344/N rats and B6C3F1 mice (feed studies). NTP-TR 223
    • NTP, 1983. Toxicology and carcinogenesis studies of eugenol (CAS no. 97-53-0) in F344/N rats and B6C3F1 mice (feed studies). NTP-TR 223 http://ntp.niehs.nih.gov/ntp/htdocs/LT_rpts/tr223.pdf.
    • (1983)
  • 67
    • 84857311630 scopus 로고    scopus 로고
    • Non-cigarette tobacco products: what have we learnt and where are we headed?
    • O'Connor R.J. Non-cigarette tobacco products: what have we learnt and where are we headed?. Tob. Control 2012, 21:181-190.
    • (2012) Tob. Control , vol.21 , pp. 181-190
    • O'Connor, R.J.1
  • 69
    • 84888416010 scopus 로고    scopus 로고
    • Organization for Economic Cooperation and Development, Paris, France
    • OECD OECD Guideline 471, Bacterial Reverse Mutation Test 1997, Organization for Economic Cooperation and Development, Paris, France.
    • (1997) OECD Guideline 471, Bacterial Reverse Mutation Test
  • 76
    • 34547802649 scopus 로고    scopus 로고
    • Determination of eugenol, anethole, and coumarin in the mainstream cigarette smoke of Indonesian clove cigarettes
    • Polzin G.M., Stanfill S.B., Brown C.R., Ashley D.L., Watson C.H. Determination of eugenol, anethole, and coumarin in the mainstream cigarette smoke of Indonesian clove cigarettes. Food Chem. Toxicol. 2007, 45:1948-1953.
    • (2007) Food Chem. Toxicol. , vol.45 , pp. 1948-1953
    • Polzin, G.M.1    Stanfill, S.B.2    Brown, C.R.3    Ashley, D.L.4    Watson, C.H.5
  • 77
    • 78751519802 scopus 로고    scopus 로고
    • Eugenol: a natural compound with versatile pharmacological actions
    • Pramod K., Ansari S.H., Ali J. Eugenol: a natural compound with versatile pharmacological actions. Nat. Prod. Commun. 2010, 5:1999-2006.
    • (2010) Nat. Prod. Commun. , vol.5 , pp. 1999-2006
    • Pramod, K.1    Ansari, S.H.2    Ali, J.3
  • 79
    • 0032754364 scopus 로고    scopus 로고
    • Comparison of the cytotoxic and mutagenic potential of liquid smoke food flavourings, cigarette smoke condensate and wood smoke condensate
    • Putnam K.P., Bombick D.W., Avalos J.T., Doolittle D.J. Comparison of the cytotoxic and mutagenic potential of liquid smoke food flavourings, cigarette smoke condensate and wood smoke condensate. Food Chem. Toxicol. 1999, 37:1113-1118.
    • (1999) Food Chem. Toxicol. , vol.37 , pp. 1113-1118
    • Putnam, K.P.1    Bombick, D.W.2    Avalos, J.T.3    Doolittle, D.J.4
  • 80
    • 77950898614 scopus 로고    scopus 로고
    • Antibacterial activity of root canal filling materials for primary teeth: zinc oxide and eugenol cement, Calen paste thickened with zinc oxide, Sealapex and EndoREZ
    • Queiroz A.M., Nelson-Filho P., Silva L.A., Assed S., Silva R.A., Ito I.Y. Antibacterial activity of root canal filling materials for primary teeth: zinc oxide and eugenol cement, Calen paste thickened with zinc oxide, Sealapex and EndoREZ. Braz. Dent. J. 2009, 20:290-296.
    • (2009) Braz. Dent. J. , vol.20 , pp. 290-296
    • Queiroz, A.M.1    Nelson-Filho, P.2    Silva, L.A.3    Assed, S.4    Silva, R.A.5    Ito, I.Y.6
  • 82
    • 80053615934 scopus 로고    scopus 로고
    • Mutagenic, cytotoxic, and genotoxic properties of tobacco smoke produced by cigarillos available on the Canadian market
    • Rickert W.S., Trivedi A.H., Momin R.A., Wagstaff W.G., Lauterbach J.H. Mutagenic, cytotoxic, and genotoxic properties of tobacco smoke produced by cigarillos available on the Canadian market. Regul. Toxicol. Pharmacol. 2011, 61:199-209.
    • (2011) Regul. Toxicol. Pharmacol. , vol.61 , pp. 199-209
    • Rickert, W.S.1    Trivedi, A.H.2    Momin, R.A.3    Wagstaff, W.G.4    Lauterbach, J.H.5
  • 84
    • 65549117994 scopus 로고    scopus 로고
    • In vitro and in vivo effects of clove on pro-inflammatory cytokines production by macrophages
    • Rodrigues T.G., Fernandes A., Sousa J.P., Bastos J.K., Sforcin J.M. In vitro and in vivo effects of clove on pro-inflammatory cytokines production by macrophages. Nat. Prod. Res. 2009, 23:319-326.
    • (2009) Nat. Prod. Res. , vol.23 , pp. 319-326
    • Rodrigues, T.G.1    Fernandes, A.2    Sousa, J.P.3    Bastos, J.K.4    Sforcin, J.M.5
  • 85
    • 79954996155 scopus 로고    scopus 로고
    • Limitations of cigarette machine smoking regimens
    • Roemer E., Carchman R.A. Limitations of cigarette machine smoking regimens. Toxicol. Lett. 2011, 203:20-27.
    • (2011) Toxicol. Lett. , vol.203 , pp. 20-27
    • Roemer, E.1    Carchman, R.A.2
  • 86
    • 84919828294 scopus 로고    scopus 로고
    • Toxicological assessment of kretek cigarettes. Part 6: The impact of ingredients added to kretek cigarettes on the smoke chemistry and in vitro toxicity
    • Roemer, E., Dempsey, R., Hirter, J., Deger Evans, A., Weber, S., Ode, A., Wittke, S., Schorp, M.K., 2014a. Toxicological assessment of kretek cigarettes. Part 6: The impact of ingredients added to kretek cigarettes on the smoke chemistry and in vitro toxicity. Regul. Toxicol. Pharmacol. 70, S66-S80.
    • (2014) Regul. Toxicol. Pharmacol , vol.70 , pp. S66-S80
    • Roemer, E.1    Dempsey, R.2    Hirter, J.3    Deger Evans, A.4    Weber, S.5    Ode, A.6    Wittke, S.7    Schorp, M.K.8
  • 88
    • 68649086379 scopus 로고    scopus 로고
    • Cytotoxicity, mutagenicity, and tumorigenicity of mainstream smoke from three reference cigarettes machine-smoked to the same yields of total particulate matter per cigarette
    • Roemer E., Ottmueller T.H., Zenzen V., Wittke S., Radtke F., Blanco I., Carchman R.A. Cytotoxicity, mutagenicity, and tumorigenicity of mainstream smoke from three reference cigarettes machine-smoked to the same yields of total particulate matter per cigarette. Food Chem. Toxicol. 2009, 47:1810-1818.
    • (2009) Food Chem. Toxicol. , vol.47 , pp. 1810-1818
    • Roemer, E.1    Ottmueller, T.H.2    Zenzen, V.3    Wittke, S.4    Radtke, F.5    Blanco, I.6    Carchman, R.A.7
  • 91
    • 0348047603 scopus 로고    scopus 로고
    • Chemical composition, cytotoxicity and mutagenicity of smoke from US commercial and reference cigarettes smoked under two sets of machine smoking conditions
    • Roemer E., Stabbert R., Rustemeier K., Veltel D.J., Meisgen T.J., Reininghaus W., Carchman R.A., Gaworski C.L., Podraza K.F. Chemical composition, cytotoxicity and mutagenicity of smoke from US commercial and reference cigarettes smoked under two sets of machine smoking conditions. Toxicology 2004, 195:31-52.
    • (2004) Toxicology , vol.195 , pp. 31-52
    • Roemer, E.1    Stabbert, R.2    Rustemeier, K.3    Veltel, D.J.4    Meisgen, T.J.5    Reininghaus, W.6    Carchman, R.A.7    Gaworski, C.L.8    Podraza, K.F.9
  • 92
    • 40249105793 scopus 로고    scopus 로고
    • Reduced toxicological activity of cigarette smoke by the addition of ammonium magnesium phosphate to the paper of an electrically heated cigarette: smoke chemistry and in vitro cytotoxicity and genotoxicity
    • Roemer E., Stabbert R., Veltel D., Muller B.P., Meisgen T.J., Schramke H., Anskeit E., Elves R.G., Fournier J.A. Reduced toxicological activity of cigarette smoke by the addition of ammonium magnesium phosphate to the paper of an electrically heated cigarette: smoke chemistry and in vitro cytotoxicity and genotoxicity. Toxicol. In Vitro 2008, 22:671-681.
    • (2008) Toxicol. In Vitro , vol.22 , pp. 671-681
    • Roemer, E.1    Stabbert, R.2    Veltel, D.3    Muller, B.P.4    Meisgen, T.J.5    Schramke, H.6    Anskeit, E.7    Elves, R.G.8    Fournier, J.A.9
  • 93
    • 78650847052 scopus 로고    scopus 로고
    • The addition of cocoa, glycerol, and saccharose to the tobacco of cigarettes: implications for smoke chemistry, in vitro cytotoxicity, mutagenicity, anf further endpoints
    • Roemer E., Wittke S., Trelles Sticken E., Piade J.-J., Bonk T., Schorp M.K. The addition of cocoa, glycerol, and saccharose to the tobacco of cigarettes: implications for smoke chemistry, in vitro cytotoxicity, mutagenicity, anf further endpoints. Beitr. Tabakforsch. Int. 2010, 24:117-132.
    • (2010) Beitr. Tabakforsch. Int. , vol.24 , pp. 117-132
    • Roemer, E.1    Wittke, S.2    Trelles Sticken, E.3    Piade, J.-J.4    Bonk, T.5    Schorp, M.K.6
  • 94
    • 0024328798 scopus 로고
    • The automated bone marrow micronucleus test
    • Romagna F., Staniforth C.D. The automated bone marrow micronucleus test. Mutat. Res. 1989, 213:91-104.
    • (1989) Mutat. Res. , vol.213 , pp. 91-104
    • Romagna, F.1    Staniforth, C.D.2
  • 95
    • 0027533282 scopus 로고
    • High-performance liquid chromatographic determination of nicotine and its urinary metabolites via their 1,3-diethyl-2-thiobarbituric acid derivatives
    • Rustemeier K., Demetriou D., Schepers G., Voncken P. High-performance liquid chromatographic determination of nicotine and its urinary metabolites via their 1,3-diethyl-2-thiobarbituric acid derivatives. J. Chromatogr. 1993, 613:95-103.
    • (1993) J. Chromatogr. , vol.613 , pp. 95-103
    • Rustemeier, K.1    Demetriou, D.2    Schepers, G.3    Voncken, P.4
  • 97
    • 33748750334 scopus 로고    scopus 로고
    • The mouse lymphoma thymidine kinase assay for the assessment and comparison of the mutagenic activity of cigarette mainstream smoke particulate phase
    • Schramke H., Meisgen T.J., Tewes F.J., Gomm W., Roemer E. The mouse lymphoma thymidine kinase assay for the assessment and comparison of the mutagenic activity of cigarette mainstream smoke particulate phase. Toxicology 2006, 227:193-210.
    • (2006) Toxicology , vol.227 , pp. 193-210
    • Schramke, H.1    Meisgen, T.J.2    Tewes, F.J.3    Gomm, W.4    Roemer, E.5
  • 99
    • 0017078278 scopus 로고
    • Anesthetic action of methyleugenol and other eugenol derivatives
    • Sell A.B., Carlini E.A. Anesthetic action of methyleugenol and other eugenol derivatives. Pharmacology 1976, 14:367-377.
    • (1976) Pharmacology , vol.14 , pp. 367-377
    • Sell, A.B.1    Carlini, E.A.2
  • 102
    • 0019788530 scopus 로고
    • The action of transition metals on the genotoxicity of simple phenols, phenolic acids and cinnamic acids
    • Stich H.F., Rosin M.P., Wu C.H., Powrie W.D. The action of transition metals on the genotoxicity of simple phenols, phenolic acids and cinnamic acids. Cancer Lett. 1981, 14:251-260.
    • (1981) Cancer Lett. , vol.14 , pp. 251-260
    • Stich, H.F.1    Rosin, M.P.2    Wu, C.H.3    Powrie, W.D.4
  • 103
    • 0028964384 scopus 로고
    • Inhibition of tobacco-induced mutagenesis by eugenol and plant extracts
    • Sukumaran K., Kuttan R. Inhibition of tobacco-induced mutagenesis by eugenol and plant extracts. Mutat. Res. 1995, 343:25-30.
    • (1995) Mutat. Res. , vol.343 , pp. 25-30
    • Sukumaran, K.1    Kuttan, R.2
  • 105
    • 84919749115 scopus 로고
    • US Consumer Product Safety Commission: Toxicity Testing Plan for Low Ignition-Potential Cigarettes
    • Washington DC.
    • US-CPSC, 1993, US Consumer Product Safety Commission: Toxicity Testing Plan for Low Ignition-Potential Cigarettes, vol. 3, Washington DC.
    • (1993) , vol.3
  • 106
    • 43049090143 scopus 로고    scopus 로고
    • Evaluation of the micronucleus assay in bone marrow and peripheral blood of rats for the determination of cigarette mainstream-smoke activity
    • Van Miert E., Vanscheeuwijck P., Meurrens K., Gomm W., Terpstra P.M. Evaluation of the micronucleus assay in bone marrow and peripheral blood of rats for the determination of cigarette mainstream-smoke activity. Mutat. Res. 2008, 652:131-138.
    • (2008) Mutat. Res. , vol.652 , pp. 131-138
    • Van Miert, E.1    Vanscheeuwijck, P.2    Meurrens, K.3    Gomm, W.4    Terpstra, P.M.5
  • 108
    • 13844314246 scopus 로고    scopus 로고
    • Development of a quantitative method for the analysis of tobacco-specific nitrosamines in mainstream cigarette smoke using isotope dilution liquid chromatography/electrospray ionization tandem mass spectrometry
    • Wagner K.A., Finkel N.H., Fossett J.E., Gillman I.G. Development of a quantitative method for the analysis of tobacco-specific nitrosamines in mainstream cigarette smoke using isotope dilution liquid chromatography/electrospray ionization tandem mass spectrometry. Anal. Chem. 2005, 77:1001-1006.
    • (2005) Anal. Chem. , vol.77 , pp. 1001-1006
    • Wagner, K.A.1    Finkel, N.H.2    Fossett, J.E.3    Gillman, I.G.4
  • 110
    • 84919705788 scopus 로고    scopus 로고
    • WHO Indonesia, Tobacco Free Initiative, Country Situation
    • Available at
    • WHO, 2009. WHO Indonesia, Tobacco Free Initiative, Country Situation. Available at http://ino.searo.who.int/EN/Section4/Section22_64.htm.
    • (2009)
  • 111
    • 80052852254 scopus 로고    scopus 로고
    • World Health Organization
    • Report on the global tobacco epidemic, 2013. Available at
    • WHO, 2013. World Health Organization, Report on the global tobacco epidemic, 2013. Available at http://www.who.int/tobacco/surveillance/policy/country_profile/idn.pdf.
    • (2013)
  • 112
    • 76749164792 scopus 로고    scopus 로고
    • Investigation of antioxidant, anti-inflammatory and DNA-protective properties of eugenol in thioacetamide-induced liver injury in rats
    • Yogalakshmi B., Viswanathan P., Anuradha C.V. Investigation of antioxidant, anti-inflammatory and DNA-protective properties of eugenol in thioacetamide-induced liver injury in rats. Toxicology 2010, 268:204-212.
    • (2010) Toxicology , vol.268 , pp. 204-212
    • Yogalakshmi, B.1    Viswanathan, P.2    Anuradha, C.V.3
  • 113
    • 77957177877 scopus 로고
    • Histopathologic examination of the rat nasal cavity
    • Young J.T. Histopathologic examination of the rat nasal cavity. Fundam. Appl. Toxicol. 1981, 1:309-312.
    • (1981) Fundam. Appl. Toxicol. , vol.1 , pp. 309-312
    • Young, J.T.1
  • 114
    • 84919716216 scopus 로고    scopus 로고
    • Brazil bans sale of clove cigarettes
    • (to be retrieved at ) In: The Jakarta Post Jakarta.
    • Yulisman, L., 2012. Brazil bans sale of clove cigarettes (to be retrieved at ) In: The Jakarta Post Jakarta. http://www.thejakartapost.com/news/2012/04/13/brazil-bans-sale-clove-cigarettes.html.
    • (2012)
    • Yulisman, L.1
  • 116
    • 84868365388 scopus 로고    scopus 로고
    • Reduced exposure evaluation of an Electrically Heated Cigarette Smoking System. Part 2: Smoke chemistry and in vitro toxicological evaluation using smoking regimens reflecting human puffing behavior
    • Zenzen V., Diekmann J., Gerstenberg B., Weber S., Wittke S., Schorp M.K. Reduced exposure evaluation of an Electrically Heated Cigarette Smoking System. Part 2: Smoke chemistry and in vitro toxicological evaluation using smoking regimens reflecting human puffing behavior. Regul. Toxicol. Pharmacol. 2012, 64:S11-34.
    • (2012) Regul. Toxicol. Pharmacol. , vol.64 , pp. S11-34
    • Zenzen, V.1    Diekmann, J.2    Gerstenberg, B.3    Weber, S.4    Wittke, S.5    Schorp, M.K.6


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