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Volumn 24, Issue 3, 2010, Pages 117-138

The addition of cocoa, glycerol, and saccharose to the tobacco of cigarettes: Implications for smoke chemistry, in vitro cytotoxicity, mutagenicity and further endpoints

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA (MICROORGANISMS); MAMMALIA; NICOTIANA TABACUM; THEOBROMA CACAO;

EID: 78650847052     PISSN: 0173783X     EISSN: 16129237     Source Type: Journal    
DOI: 10.2478/cttr-2013-0890     Document Type: Article
Times cited : (11)

References (75)
  • 1
    • 0013539285 scopus 로고
    • The mighty leaf
    • Tobacco through the centuries Alvin Redman, London and Sydney
    • Brooks, J.E.: The Mighty Leaf. Tobacco through the centuries; Alvin Redman, London and Sydney, 1953.
    • (1953)
    • Brooks, J.E.1
  • 2
    • 1842467055 scopus 로고    scopus 로고
    • Some Studies of the Effects of Additives on Cigarette Mainstream Smoke Properties. II
    • Casing Materials and Humectants
    • Rodgman, A.: Some Studies of the Effects of Additives on Cigarette Mainstream Smoke Properties. II. Casing Materials and Humectants; Beitr. Tabakforsch. Int. 20 (2002) 279-299.
    • (2002) Beitr. Tabakforsch. Int , vol.20 , pp. 279-299
    • Rodgman, A.1
  • 3
    • 0005402492 scopus 로고    scopus 로고
    • Cigarette manufacture, 11A, Tobacco blending
    • edited by D.L. Davis and M.T. Nielsen, Blackwell Science Inc., Malden, MA
    • Fisher, P.: Cigarette manufacture, 11A, Tobacco blending; in: Tobacco Production, Chemistry and Technology, edited by D.L. Davis and M.T. Nielsen, Blackwell Science Inc., Malden, MA., 1999, pp. 346-352.
    • (1999) Tobacco Production, Chemistry and Technology , pp. 346-352
    • Fisher, P.1
  • 4
    • 0003118126 scopus 로고
    • Thermal degradation of carbohydrates
    • Fagerson, I.S.: Thermal degradation of carbohydrates. A review; J. Agric. Food Chem. 17 (1969) 747-750.
    • (1969) J. Agric. Food Chem , vol.17 , pp. 747-750
    • Fagerson, I.S.1
  • 5
    • 0003090297 scopus 로고
    • The Effect of the Natural Sugar Content of Tobacco Upon the Acetaldehyde Concentration Found in Cigarette Smoke
    • Phillpotts, D.F., D. Spincer, and D.T. Westcott: The Effect of the Natural Sugar Content of Tobacco Upon the Acetaldehyde Concentration Found in Cigarette Smoke; Beitr. Tabakforsch. Int. 8 (1975) 7-10.
    • (1975) Beitr. Tabakforsch. Int , vol.8 , pp. 7-10
    • Phillpotts, D.F.1    Spincer, D.2    Westcott, D.T.3
  • 6
    • 0002375575 scopus 로고    scopus 로고
    • The Roles of Amino Acids and Sugars in the Production of Volatile Materials in Microwave Heated Tobacco Dust Suspensions
    • Coleman III, W.M. and T.A. Perfetti: The Roles of Amino Acids and Sugars in the Production of Volatile Materials in Microwave Heated Tobacco Dust Suspensions; Beitr. Tabakforsch. Int. 17 (1997) 75-95.
    • (1997) Beitr. Tabakforsch. Int , vol.17 , pp. 75-95
    • Coleman, W.M.1    Perfetti, T.A.2
  • 7
    • 0036853540 scopus 로고    scopus 로고
    • Acetaldehyde in Mainstream Tobacco Smoke: Formation and Occurrence in Smoke and Bioavailability in the Smoker
    • Seeman, J.I., M. Dixon, and H.J. Haussmann: Acetaldehyde in Mainstream Tobacco Smoke: Formation and Occurrence in Smoke and Bioavailability in the Smoker; Chem. Res. Toxicol. 15 (2002) 1331-1350.
    • (2002) Chem. Res. Toxicol , vol.15 , pp. 1331-1350
    • Seeman, J.I.1    Dixon, M.2    Haussmann, H.J.3
  • 8
    • 0036133254 scopus 로고    scopus 로고
    • Evaluation of the potential effects of ingredients added to cigarettes. Part 2: Chemical composition of mainstream smoke
    • Rustemeier, K., R. Stabbert, H.-J. Haussmann, E. Roemer, and E. Carmines:. Evaluation of the potential effects of ingredients added to cigarettes. Part 2: Chemical composition of mainstream smoke; Food Chem. Toxicol. 40 (2002) 93-104.
    • (2002) Food Chem. Toxicol , vol.40 , pp. 93-104
    • Rustemeier, K.1    Stabbert, R.2    Haussmann, H.-J.3    Roemer, E.4    Carmines, E.5
  • 9
    • 0037211697 scopus 로고    scopus 로고
    • A model that distinguishes the pyrolysis of D-Glucose, D-Fructose, and sucrose from that of cellulose. Application to the understanding of cigarette smoke formation
    • Sanders, E.B., A.I. Goldsmith, and J.I. Seeman: A model that distinguishes the pyrolysis of D-Glucose, D-Fructose, and sucrose from that of cellulose. Application to the understanding of cigarette smoke formation; J. Anal. Appl. Pyrolysis 66 (2003) 29-50.
    • (2003) J. Anal. Appl. Pyrolysis , vol.66 , pp. 29-50
    • Sanders, E.B.1    Goldsmith, A.I.2    Seeman, J.I.3
  • 10
    • 0037395425 scopus 로고    scopus 로고
    • Evaluation of Relationships Between Mainstream Smoke Acetaldehyde and Ttar and Carbon Monoxide Yields in Tobacco Smoke and Reducing Sugars in Tobacco Blends of U. S. Commercial Cigarettes
    • Seeman, J.I., S.W. Laffoon, and A.J. Kassman: Evaluation of Relationships Between Mainstream Smoke Acetaldehyde and Ttar and Carbon Monoxide Yields in Tobacco Smoke and Reducing Sugars in Tobacco Blends of U. S. Commercial Cigarettes; Inhal. Toxicol. 15 (2003) 373-395.
    • (2003) Inhal. Toxicol , vol.15 , pp. 373-395
    • Seeman, J.I.1    Laffoon, S.W.2    Kassman, A.J.3
  • 11
  • 12
    • 19744380118 scopus 로고    scopus 로고
    • The pyrolysis of saccharide tobacco ingredients: A TGA-FTIR investigation
    • Baker, R.R., S. Coburn, C. Liu, and J. Tetteh: The pyrolysis of saccharide tobacco ingredients: a TGA-FTIR investigation; J. Anal. Appl. Pyrolysis 74 (2005) 171-180.
    • (2005) J. Anal. Appl. Pyrolysis , vol.74 , pp. 171-180
    • Baker, R.R.1    Coburn, S.2    Liu, C.3    Tetteh, J.4
  • 13
    • 1842571577 scopus 로고    scopus 로고
    • The effect of tobacco ingredients on smoke chemistry
    • 42S1 Part I: Flavourings and additives
    • Baker, R.R., J.R. Pereira da Silva, and G. Smith: The effect of tobacco ingredients on smoke chemistry. Part I: Flavourings and additives; Food Chem. Toxicol. 42S1 (2004) 3-37.
    • (2004) Food Chem. Toxicol , pp. 3-37
    • Baker, R.R.1    da Silva, P.J.R.2    Smith, G.3
  • 14
    • 33750728442 scopus 로고    scopus 로고
    • The generation of formaldehyde in cigarettes - Overview and recent experiments
    • Baker, R.R.: The generation of formaldehyde in cigarettes - Overview and recent experiments; Food Chem. Toxicol. 44 (2006) 1799-1822.
    • (2006) Food Chem. Toxicol , vol.44 , pp. 1799-1822
    • Baker, R.R.1
  • 15
    • 33646896952 scopus 로고    scopus 로고
    • The pyrolytic formation of formaldehyde from sugars and tobacco
    • Baker, R.R., S. Coburn, and C. Liu: The pyrolytic formation of formaldehyde from sugars and tobacco; J. Anal. Appl. Pyrolysis 77 (2006) 12-21.
    • (2006) J. Anal. Appl. Pyrolysis , vol.77 , pp. 12-21
    • Baker, R.R.1    Coburn, S.2    Liu, C.3
  • 16
    • 0018406281 scopus 로고
    • Reduction in mutagenicity of cigarette smoke condensate by added sugars
    • Sato, S., T. Ohka, M. Nagao, K. Tsuji, and T. Kosuge: Reduction in mutagenicity of cigarette smoke condensate by added sugars; Mutat. Res. 60 (1979) 155-161.
    • (1979) Mutat. Res , vol.60 , pp. 155-161
    • Sato, S.1    Ohka, T.2    Nagao, M.3    Tsuji, K.4    Kosuge, T.5
  • 17
    • 0036845623 scopus 로고    scopus 로고
    • Toxicologic evaluation of humectants added to cigarette tobacco: 13-week smoke inhalation study of glycerin and propylene glycol in Fischer 344 rats
    • Heck, J.D., C.L. Gaworski, N. Rajendran, and R.L. Morrissey: Toxicologic evaluation of humectants added to cigarette tobacco: 13-week smoke inhalation study of glycerin and propylene glycol in Fischer 344 rats; Inhal. Toxicol. 14 (2002) 1135-52.
    • (2002) Inhal. Toxicol , vol.14 , pp. 1135-1152
    • Heck, J.D.1    Gaworski, C.L.2    Rajendran, N.3    Morrissey, R.L.4
  • 18
    • 0036132804 scopus 로고    scopus 로고
    • Evaluation of the potential effects of ingredients added to cigarettes
    • Part 3: In vitro genotoxicity and cytotoxicity
    • Roemer, E., F.J. Tewes, T.J. Meisgen, D.J. Veltel, and E. Carmines: Evaluation of the potential effects of ingredients added to cigarettes. Part 3: In vitro genotoxicity and cytotoxicity; Food Chem. Toxicol. 40 (2002) 105-111.
    • (2002) Food Chem. Toxicol , vol.40 , pp. 105-111
    • Roemer, E.1    Tewes, F.J.2    Meisgen, T.J.3    Veltel, D.J.4    Carmines, E.5
  • 20
    • 1842609944 scopus 로고    scopus 로고
    • An overview of the effects of tobacco ingredients on smoke chemistry and toxicity
    • Baker, R.R., E.D. Massey, and G. Smith: An overview of the effects of tobacco ingredients on smoke chemistry and toxicity; Food Chem. Toxicol. 42S (2004) S53-S83.
    • (2004) Food Chem. Toxicol , vol.42 S
    • Baker, R.R.1    Massey, E.D.2    Smith, G.3
  • 23
    • 0003470701 scopus 로고    scopus 로고
    • General requirements for the competence of testing and calibration laboratories
    • ISO, International Organization for Standardization: ISO/IEC 17025:2005, Geneva, ISO
    • ISO, International Organization for Standardization: ISO/IEC 17025:2005, General requirements for the competence of testing and calibration laboratories. Geneva, ISO (2000).
    • (2000)
  • 24
    • 0003803672 scopus 로고    scopus 로고
    • Routine analytical cigarette-smoking machine - definitions and standard conditions
    • ISO, International Organization for Standardization: ISO 3308:2000, Geneva, ISO
    • ISO, International Organization for Standardization: ISO 3308:2000, Routine analytical cigarette-smoking machine - Definitions and standard conditions. Geneva, ISO (2000).
    • (2000)
  • 25
    • 78650840238 scopus 로고    scopus 로고
    • Test methodologies with their designated test numbers have been posted by Health Canada in the internet at the site
    • Health Canada: Health Canada Tobacco Reporting Regulations Part 3, Emissions from designated tobacco products. Canada Gazette, Part II, 134 (2000) (15, Part 3). Accessed Sep. 25
    • Health Canada: Health Canada Tobacco Reporting Regulations Part 3, Emissions from designated tobacco products. Canada Gazette, Part II, 134 (2000) (15, Part 3). Test methodologies with their designated test numbers have been posted by Health Canada in the internet at the site http://www.hc-sc.gc.ca/hc-ps/tobactabac/legislation/reg/indust/method/index-eng.php. (Accessed Sep. 25, 2010).
    • (2010)
  • 26
    • 78650831309 scopus 로고
    • CPSC, U.S. Consumer Products Safety Commission in Consultation with the US Department of Health and Human Services, Toxicity Testing Plan 5. DHHS, Washington, DC 20207
    • CPSC, U.S. Consumer Products Safety Commission in Consultation with the US Department of Health and Human Services, Toxicity Testing Plan 5. DHHS, Washington, DC 20207 (1993) pp D1-D38.
    • (1993)
  • 27
    • 78650819024 scopus 로고    scopus 로고
    • Bundesgesetzblatt, Deutschland (Federal Register, Germany): Grundsätze der Guten Laborpraxis (GLP), Neufassung des Chemikaliengesetzes vom 20. Juni 2002 (Principles of Good Laboratory Practice (GLP), revised version of the Chemical Acts of 20 June 2002). Bundesgesetzblatt I 40
    • Bundesgesetzblatt, Deutschland (Federal Register, Germany): Grundsätze der Guten Laborpraxis (GLP), Neufassung des Chemikaliengesetzes vom 20. Juni 2002 (Principles of Good Laboratory Practice (GLP), revised version of the Chemical Acts of 20 June 2002). Bundesgesetzblatt I 40 (2002) pp. 2090-2130.
    • (2002) , pp. 2090-2130
  • 28
    • 0027050771 scopus 로고
    • Cytotoxic and morphological effects of phenylpropanolamine, caffeine, nicotine, and some of their metabolites studied In Vitro
    • Babich, H. and E. Borenfreund: Cytotoxic and morphological effects of phenylpropanolamine, caffeine, nicotine, and some of their metabolites studied In Vitro; Toxicol. In Vitro 6 (1992) 493-502.
    • (1992) Toxicol. In Vitro , vol.6 , pp. 493-502
    • Babich, H.1    Borenfreund, E.2
  • 29
    • 0021990499 scopus 로고
    • Toxicity determined in vitro by morphological alterations and neutral red absorption
    • Borenfreund, E. and J.A. Puerner: Toxicity determined in vitro by morphological alterations and neutral red absorption; Toxicol. Lett. 24 (1985) 119-124.
    • (1985) Toxicol. Lett , vol.24 , pp. 119-124
    • Borenfreund, E.1    Puerner, J.A.2
  • 30
    • 0020533372 scopus 로고
    • Reviewed methods for the Salmonella mutagenicity test
    • Maron, D.M. and B.N. Ames: Reviewed methods for the Salmonella mutagenicity test; Mutat. Res. 113 (1983) 173-215.
    • (1983) Mutat. Res , vol.113 , pp. 173-215
    • Maron, D.M.1    Ames, B.N.2
  • 31
    • 84888416010 scopus 로고    scopus 로고
    • Guideline 471, bacterial reverse mutation test
    • OECD, Organization for Economic Cooperation and Development, OECD, Paris, France
    • OECD, Organization for Economic Cooperation and Development, 1997. Guideline 471, bacterial reverse mutation test. In: OECD Guidelines for Testing of Chemicals. OECD, Paris, France.
    • (1997) OECD Guidelines For Testing of Chemicals
  • 33
    • 33748801463 scopus 로고    scopus 로고
    • Towards an evidence based toxicology
    • Hoffmann, S. and T. Hartung: Towards an evidence based toxicology; Human Exp. Toxicol. 25 (2006) 497-513.
    • (2006) Human Exp. Toxicol , vol.25 , pp. 497-513
    • Hoffmann, S.1    Hartung, T.2
  • 34
    • 78650830821 scopus 로고    scopus 로고
    • Directive 2001/37/EC of the European Parliament and of the council of 5 June 2001 on the approximation of the laws, regulations and administrative provisions of the Member States concerning the manufacture, presentation and sale of tobacco products
    • European Community: Accessible at, (Accessed Sep. 25
    • European Community: Directive 2001/37/EC of the European Parliament and of the council of 5 June 2001 on the approximation of the laws, regulations and administrative provisions of the Member States concerning the manufacture, presentation and sale of tobacco products. Accessible at http://eurlex. europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L: 2001:194:0026:0034:EN:PDF (Accessed Sep. 25, 2010).
    • (2010)
  • 35
  • 36
    • 35748953798 scopus 로고    scopus 로고
    • Pharmacological and Chemical Effects of Cigarette Additives
    • Rabinoff, M., N. Caskey, A. Rissling, and C. Park: Pharmacological and Chemical Effects of Cigarette Additives; Am. J. Public Health 97 (2007) 1981-1991.
    • (2007) Am. J. Public Health , vol.97 , pp. 1981-1991
    • Rabinoff, M.1    Caskey, N.2    Rissling, A.3    Park, C.4
  • 37
    • 85013194526 scopus 로고
    • Caffeine and Theobromine Levels in Cocoa and Carob Products
    • Craig, W.J. and T.T. Nguyen: Caffeine and Theobromine Levels in Cocoa and Carob Products; J. Food Sci. 49 (1984) 302-303.
    • (1984) J. Food Sci , vol.49 , pp. 302-303
    • Craig, W.J.1    Nguyen, T.T.2
  • 38
    • 0024265435 scopus 로고
    • Methylxanthines: Toxicity to humans. 3. Theobromine, paraxanthine and the combined effects of methylxanthines
    • Stavric, B.: Methylxanthines: toxicity to humans. 3. Theobromine, paraxanthine and the combined effects of methylxanthines; Food Chem. Toxicol. 26 (1988) 725-733.
    • (1988) Food Chem. Toxicol , vol.26 , pp. 725-733
    • Stavric, B.1
  • 39
    • 78650846185 scopus 로고    scopus 로고
    • Chocolate and nutrition - divine food, fattening junk or nutritious supplementation
    • Rossner, S.: Chocolate and nutrition - divine food, fattening junk or nutritious supplementation; Manufact. Confectioner 79 (1999) 57-60.
    • (1999) Manufact. Confectioner , vol.79 , pp. 57-60
    • Rossner, S.1
  • 41
    • 78650846766 scopus 로고    scopus 로고
    • RIVM report 650270002/2002, the contribution of cocoa additive to cigarette smoking addiction
    • RIVM, Bilthoven, Netherlands
    • Rambali, B., I. van Andel, E. Schenk, G. Wolterink, G. van de Werken, H. Stevenson, and W. Vleeming: RIVM report 650270002/2002, The contribution of cocoa additive to cigarette smoking addiction; RIVM, Bilthoven, Netherlands, 2003.
    • (2003)
    • Rambali, B.1    van Andel, I.2    Schenk, E.3    Wolterink, G.4    van de Werken, G.5    Stevenson, H.6    Vleeming, W.7
  • 42
    • 0022181291 scopus 로고
    • The bronchodilator effect and pharmacokinetics of theobromine in young patients with asthma
    • Simons, F.E.R, A.B. Becker, K.J. Simons, and C.A. Gillespie: The bronchodilator effect and pharmacokinetics of theobromine in young patients with asthma; J. Allergy Clin. Immunol. 76 (1985) 703-707.
    • (1985) J. Allergy Clin. Immunol , vol.76 , pp. 703-707
    • Simons, F.E.R.1    Becker, A.B.2    Simons, K.J.3    Gillespie, C.A.4
  • 43
    • 0026086250 scopus 로고
    • IARC, International agency for Research on Cancer, Coffee, Tea, Mate, Methylxanthines and Methylglyoxal; IARC, Lyon, France
    • IARC, International agency for Research on Cancer: IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. Volume 51. Coffee, Tea, Mate, Methylxanthines and Methylglyoxal; IARC, Lyon, France, 1991, pp. 421-441.
    • (1991) IARC Monographs on the Evaluation of Carcinogenic Risks to Humans , vol.51 , pp. 421-441
  • 44
    • 0019763210 scopus 로고
    • Testing of lung function after theophylline inhalation (author's transl)
    • Greger, G.: Testing of lung function after theophylline inhalation (author's transl.); Z. Erkr. Atmungsorgane 157 (1981) 270-275.
    • (1981) Z. Erkr. Atmungsorgane , vol.157 , pp. 270-275
    • Greger, G.1
  • 45
    • 78650848881 scopus 로고    scopus 로고
    • IITRI, Illinois Institute of Technology Research Institute, Chemical analysis of mainstream smoke from cigarettes containing target levels of 0, 10,000, 20,000 or 40,000 ppm of cocoa. Final Report, IITRI Project Number 8739-117-002; IITRI, Chicago
    • IITRI, Illinois Institute of Technology Research Institute: Chemical analysis of mainstream smoke from cigarettes containing target levels of 0, 10,000, 20,000 or 40,000 ppm of cocoa. Final Report, IITRI Project Number 8739-117-002; IITRI, Chicago, 2003.
    • (2003)
  • 46
    • 78650827243 scopus 로고    scopus 로고
    • Illinois Institute of Technology Research Institute, Cytotoxicity assay (neutral red uptake) of smoke fractions from cigarettes containing target levels of 0, 10,000, 20,000 or 40,000 ppm of cocoa
    • IITRI, Final Report, IITRI Project Number 8739-117-004; IITRI, Chicago
    • IITRI, Illinois Institute of Technology Research Institute: Cytotoxicity assay (neutral red uptake) of smoke fractions from cigarettes containing target levels of 0, 10,000, 20,000 or 40,000 ppm of cocoa. Final Report, IITRI Project Number 8739-117-004; IITRI, Chicago, 2003.
    • (2003)
  • 47
    • 78650823947 scopus 로고    scopus 로고
    • IITRI, Illinois Institute of Technology Research Institute: In vitro mutagenicity of mainstream smoke from cigarettes containing target levels of 10,000, 20,000 or 40,000 ppm cocoa in Salmonella/microsome assay. Final Report, IITRI Project Number 8739-117-003; IITRI, Chicago
    • IITRI, Illinois Institute of Technology Research Institute: In vitro mutagenicity of mainstream smoke from cigarettes containing target levels of 10,000, 20,000 or 40,000 ppm cocoa in Salmonella/microsome assay. Final Report, IITRI Project Number 8739-117-003; IITRI, Chicago, 2003.
    • (2003)
  • 49
    • 78650805736 scopus 로고
    • NCI, National Cancer Institute, Report No. 3, Towards less hazardous cigarettes: the third set of cigarettes, G.B. Gori, Editor. DHEW, Washington
    • NCI, National Cancer Institute: Smoking and Health Program, Report No. 3, Towards less hazardous cigarettes: the third set of cigarettes, G.B. Gori, Editor. DHEW, Washington, 1977.
    • (1977) Smoking and Health Program
  • 50
    • 0025106564 scopus 로고
    • Mouse skin bioassay of smoke condensates from cigarettes containing different levels of cocoa
    • Roemer, E. and U. Hackenberg: Mouse skin bioassay of smoke condensates from cigarettes containing different levels of cocoa; Food Addit. Contam. 7 (1990) 563-569.
    • (1990) Food Addit. Contam , vol.7 , pp. 563-569
    • Roemer, E.1    Hackenberg, U.2
  • 51
    • 0032722409 scopus 로고    scopus 로고
    • Toxicologic evaluation of flavor ingredients added to cigarette tobacco: Skin painting bioassay of cigarette smoke condensate in SENCAR mice
    • Gaworski, C.L., J.D. Heck, M.B. Bennett, and M.L. Wenk: Toxicologic evaluation of flavor ingredients added to cigarette tobacco: skin painting bioassay of cigarette smoke condensate in SENCAR mice; Toxicology 139 (1999) 1-17.
    • (1999) Toxicology , vol.139 , pp. 1-17
    • Gaworski, C.L.1    Heck, J.D.2    Bennett, M.B.3    Wenk, M.L.4
  • 52
    • 70350594380 scopus 로고    scopus 로고
    • Does use of flue-cured rather than blended cigarettes affect international variation in mortality from lung cancer and COPD
    • Lee, P.N, B.A. Forey, J.S. Fry, J.S. Hamling, J.F. Hamling, E.B. Sanders, and R.A. Carchman: Does use of flue-cured rather than blended cigarettes affect international variation in mortality from lung cancer and COPD?; Inhal. Toxicol. 21 (2009) 404-30.
    • (2009) Inhal. Toxicol , vol.21 , pp. 404-430
    • Lee, P.N.1    Forey, B.A.2    Fry, J.S.3    Hamling, J.S.4    Hamling, J.F.5    Sanders, E.B.6    Carchman, R.A.7
  • 54
    • 0023680260 scopus 로고
    • The genotoxic activity of glycerol in an in vitro test battery
    • Doolittle, D.J., D.A. Lee, and C.K. Lee: The genotoxic activity of glycerol in an in vitro test battery; Food Chem. Toxicol. 26 (1988) 631-635.
    • (1988) Food Chem. Toxicol , vol.26 , pp. 631-635
    • Doolittle, D.J.1    Lee, D.A.2    Lee, C.K.3
  • 55
    • 0005993999 scopus 로고
    • R.A.: 2-Week and 13-Week Inhalation Studies of Aerosolized Glycerol in Rats
    • Renne
    • Renne, R.A.: 2-Week and 13-Week Inhalation Studies of Aerosolized Glycerol in Rats; Inhal. Toxicol. 4 (1992) 95-111.
    • (1992) Inhal. Toxicol , vol.4 , pp. 95-111
  • 56
    • 0022655270 scopus 로고
    • Respiration of F-344 rats in nose-only inhalation exposure tubes
    • Mauderly, J.L.: Respiration of F-344 rats in nose-only inhalation exposure tubes; J. Appl. Toxicol. 6 (1986) 25-30.
    • (1986) J. Appl. Toxicol , vol.6 , pp. 25-30
    • Mauderly, J.L.1
  • 57
    • 0002830274 scopus 로고
    • Determination of glycerol and propylene glycol in cigarette smoke
    • Laurene, A.H., R.H. Cundiff, and G.H. Greene: Determination of glycerol and propylene glycol in cigarette smoke; Tob. Sci. 9 (1965) 1-4.
    • (1965) Tob. Sci , vol.9 , pp. 1-4
    • Laurene, A.H.1    Cundiff, R.H.2    Greene, G.H.3
  • 58
    • 33745722063 scopus 로고    scopus 로고
    • Glycerol Transfer in Cigarette Mainstream Smoke
    • Liu, C.: Glycerol Transfer in Cigarette Mainstream Smoke; Beitr. Tabakforsch. Int. 21 (2004) 111-116.
    • (2004) Beitr. Tabakforsch. Int , vol.21 , pp. 111-116
    • Liu, C.1
  • 59
    • 21844479263 scopus 로고    scopus 로고
    • Toxicological evaluation of glycerin as a cigarette ingredient
    • Carmines, E.L. and C.L. Gaworski: Toxicological evaluation of glycerin as a cigarette ingredient; Food Chem. Toxicol. 43 (2005) 1521-1539.
    • (2005) Food Chem. Toxicol , vol.43 , pp. 1521-1539
    • Carmines, E.L.1    Gaworski, C.L.2
  • 60
    • 78650848611 scopus 로고    scopus 로고
    • Illinois Institute of Technology Research Institute: 90-day rat inhalation toxicity study of the mainstream smoke from cigarettes containing target levels of 0, 50,000, 100,000 or 150,000 ppm of glycerin
    • IITRI, Volumes I to III. Final Report, IITRI Project Number 8739-114-001, Chicago
    • IITRI, Illinois Institute of Technology Research Institute: 90-day rat inhalation toxicity study of the mainstream smoke from cigarettes containing target levels of 0, 50,000, 100,000 or 150,000 ppm of glycerin. Volumes I to III. Final Report, IITRI Project Number 8739-114-001, Chicago, 2004.
    • (2004)
  • 62
    • 85086423662 scopus 로고    scopus 로고
    • ®: Threshold Limit Values for Chemical Substances and Physical Agents, ACGIH, Cincinnat
    • ®: Threshold Limit Values for Chemical Substances and Physical Agents, ACGIH, Cincinnati 2002.
    • (2002)
  • 65
    • 78650825867 scopus 로고    scopus 로고
    • Philip Morris International, R&D, Market Map Study on 202 cigarette brands from 10 countries, 2008, Internal Report, not published
    • G. Jaccard, Philip Morris International, R&D, Market Map Study on 202 cigarette brands from 10 countries, 2008, Internal Report, not published.
    • Jaccard, G.1
  • 66
    • 33846781400 scopus 로고    scopus 로고
    • Relationship between machinederived smoke yields and biomarkers in cigarette smokers in Germany
    • Scherer, G., J. Engl, M. Urban, G. Gilch, D. Janket, and K. Riedel, K.: Relationship between machinederived smoke yields and biomarkers in cigarette smokers in Germany; Regul. Toxicol. Pharmacol. 47 (2007) 171-183.
    • (2007) Regul. Toxicol. Pharmacol , vol.47 , pp. 171-183
    • Scherer, G.1    Engl, J.2    Urban, M.3    Gilch, G.4    Janket, D.5    Riedel, K.K.6
  • 67
    • 78650841760 scopus 로고    scopus 로고
    • Occupational Safety and Health Standard 1919.1048, Formaldehyde
    • OSHA, Occupational Safety & Health Administration Washington
    • OSHA, Occupational Safety & Health Administration: Occupational Safety and Health Standard 1919.1048, Formaldehyde, OSHA, Washington, 2008.
    • (2008)
  • 69
    • 8444227400 scopus 로고    scopus 로고
    • Human Respiratory Tract Cancer Risks of Inhaled Formaldehyde: Dose-response Predictions Derived from Biologically-motivated Computational Modeling of a Combined Rodent and Human Dataset
    • Conolly R.B., J.S. Kimbell, D. Janszen, P.M. Schlosser, D. Kalisak, J. Preston, and F.J. Miller: Human Respiratory Tract Cancer Risks of Inhaled Formaldehyde: Dose-response Predictions Derived from Biologically-motivated Computational Modeling of a Combined Rodent and Human Dataset; Toxicol. Sci. 82 (2004) 279-296.
    • (2004) Toxicol. Sci , vol.82 , pp. 279-296
    • Conolly, R.B.1    Kimbell, J.S.2    Janszen, D.3    Schlosser, P.M.4    Kalisak, D.5    Preston, J.6    Miller, F.J.7
  • 70
    • 49449098781 scopus 로고    scopus 로고
    • C, and R. Subramaniam: Sensitivity Analysis of Biologically Motivated Model for Formaldehyde-induced Respiratory Cancer in Humans
    • Crump K.S., C. Chen, J.F. Fox, C. Van Landingham C, and R. Subramaniam: Sensitivity Analysis of Biologically Motivated Model for Formaldehyde-induced Respiratory Cancer in Humans; Ann. Occup. Hyg. 52 (2008) 481-495.
    • (2008) Ann. Occup. Hyg , vol.52 , pp. 481-495
    • Crump, K.S.1    Chen, C.2    Fox, J.F.3    van Landingham, C.4
  • 72
    • 78650819023 scopus 로고    scopus 로고
    • IITRI, Illinois Institute of Technology Research Institute, Cytotoxicity assay (neutral red uptake) of smoke fractions from cigarettes containing target levels of 0, 36,000, 72,000 or 100,000 ppm of sucrose. Final Report, IITRI Project Number 8739-106-004, Chicago
    • IITRI, Illinois Institute of Technology Research Institute: Cytotoxicity assay (neutral red uptake) of smoke fractions from cigarettes containing target levels of 0, 36,000, 72,000 or 100,000 ppm of sucrose. Final Report, IITRI Project Number 8739-106-004, Chicago, 2002.
    • (2002)
  • 73
    • 78650844609 scopus 로고    scopus 로고
    • Illinois Institute of Technology Research Institute: 90-day rat inhalation toxicity study of the mainstream smoke from cigarettes containing target levels of 0, 36,000, 72,000 or 100,000 ppm of sucrose
    • IITRI, Final Report, IITRI Project Number 8739-106-001, Chicago
    • IITRI, Illinois Institute of Technology Research Institute: 90-day rat inhalation toxicity study of the mainstream smoke from cigarettes containing target levels of 0, 36,000, 72,000 or 100,000 ppm of sucrose. Final Report, IITRI Project Number 8739-106-001, Chicago, 2003.
    • (2003)
  • 75
    • 78650806796 scopus 로고    scopus 로고
    • European Community: Directive 2001/37/EC of the European Parliament and of the council of 5 June 2001on the approximation of the laws, regulations and administrative provisions of the Member States concerning the manufacture, presentation and sale of tobacco products. Accessible at, Accessed Sep. 25
    • European Community: Directive 2001/37/EC of the European Parliament and of the council of 5 June 2001on the approximation of the laws, regulations and administrative provisions of the Member States concerning the manufacture, presentation and sale of tobacco products. Accessible at http://eurlex. europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L: 2001:194:0026:0034:EN:PDF (Accessed Sep. 25,2010).
    • (2010)


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