Toxicological comparisons of three styles of a commercial U.S. cigarette (Marlboro®) with the 1R4F reference cigarette

Inhalation Toxicology

Volumn 20, Issue 7, 2008, Pages 695-721

  Patskan, George J ^a   Podraza, Kenneth F ^a   Meurrens, Kris ^b   Coggins, Christopher R E ^c   Friedrichs, Bärbel ^d   Gerstenberg, Birgit ^d   Gomm, Willy ^d   Schnell, Peter ^d   Stabbert, Regina ^d   Veltel, Detlef ^d   Weber, Susanne ^d   Terpstra, Piter ^d  

^a Philip Morris USA   (United States)

^b Philip Morris Research Laboratories   (Belgium)

^c Carson Watts Consulting   (United States)

^d Philip Morris Research Laboratories GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CIGARETTE SMOKE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL COUNT; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; FEMALE; GAS; HISTOPATHOLOGY; INHALATION; MALE; MUTAGENICITY; NEUTROPHIL; NONHUMAN; PARTICULATE MATTER; PRIORITY JOURNAL; RAT; RESPIRATORY SYSTEM; SALMONELLA; SPRAGUE DAWLEY RAT; TOXICITY TESTING; TRACHEOBRONCHIAL TOILET; VAPOR;

ANIMALS; BALB 3T3 CELLS; BRONCHOALVEOLAR LAVAGE FLUID; CARBOXYHEMOGLOBIN; CELL SURVIVAL; FEMALE; MALE; MICE; MUTAGENS; PARTICULATE MATTER; RATS; RATS, SPRAGUE-DAWLEY; RESPIRATORY FUNCTION TESTS; RESPIRATORY SYSTEM; SALMONELLA; SMOKE; TOBACCO;

RATTUS; SALMONELLA;

EID: 45849083532     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.1080/08958370801935174     Document Type: Article

References (50)

1. AALAS. 1991. American Association for Laboratory Animals Science Policy on the Humane Care and Use of Laboratory Animals. Laboratory Animal Science 41:91.
2. Adams, J. D., O'Mara-Adams, K. J., and Hoffmann, D. 1987. Toxic and carcinogenic agents in undiluted mainstream smoke and sidestream smoke of different types of cigarettes. Carcinogenesis 8:729-731.
3. Bradford, J. A., Harlan, W. R., and Hanmer, H. R. 1936. Nature of cigaret smoke. Technic of experimental smoking. Industrial and Engineering Chemistry 28:836-839.
4. Byrd, G. D., Fowler, K. W., Hicks, R. D., Lovette, M. E., and Borgerding, M. F. 1990. Isotope dilution gas chromatography-mass spectrometry in the determination of benzene, toluene, styrene and acrylonitrile in mainstream cigarette smoke. Journal of Chromatography 503:359-368.
5. Carmines, E. L. 2002. Evaluation of the potential effects of ingredients added to cigarettes. Part 1: Cigarette design, testing approach, and review of results. Food and Chemical Toxicology 40:77-91.
6. Chen, P. X., and Moldoveanu, S. C. 2003. Mainstream smoke chemical analyses for 2R4F Kentucky reference cigarette. Beiträge zur Tabakforschung International 20:448-458.
7. Chepiga, T. A., Morton, M. J., Murphy, P. A., Avalos, J. T., Bombick, B. R., Doolittle, D. J., Borgerding, M. F., and Swauger, J. E. 2000. A comparison of the mainstream smoke chemistry and mutagenicity of a representative sample of the US cigarette market with two Kentucky reference cigarettes (K1R4F and K1R5F). Food and Chemical Toxicology 38:949-962.
8. Coggins, C. R. E., Ayres, P. H., Mosberg, A. T., Burger, G. T., Sagartz, J. W., and Hayes, A. W. 1989a. Comparative inhalation study in rats, using a second prototype of a cigarette that heats rather than burns tobacco. Inhalation Toxicology 1:197-226.
9. Coggins, C. R. E., Ayres, P. H., Mosberg, A. T., Sagartz, J. W., Burger, G. T., and Hayes, A. W. 1989b. Ninety-day inhalation study in rats, comparing smoke from cigarettes that heat tobacco with those that burn tobacco. Fundamental and Applied Toxicology 13:460-483.
10. Coggins, C. R. E., Duchosal, F., Musy, C., and Ventrone, R. 1981. Measurement of respiratory patterns in rodents, using whole-body plethysmography and a pneumotachograph. Laboratory Animals 15:137-140.
11. Coggins, C. R. E., Fouillet, X. L. M., Lam, R., and Morgan, K. T. 1980. Cigarette smoke induced pathology of the rat respiratory tract: a comparison of the effects of the particulate and vapour phases. Toxicology 16:83-101.
12. Counts, M. E., Hsu, F. S., Laffoon, S. W., Dwyer, R. W., and Cox, R. H. 2004. Mainstream smoke constituent yields and predicting relationships from a worldwide market sample of cigarette brands: ISO smoking conditions. Regulatory Toxicology and Pharmacology 39:111-134.
13. Counts, M. E., Morton, M. J., Laffoon, S. W., Cox, R. H., and Lipowicz, P. J. 2005. Smoke composition and predicting relationships for international commercial cigarettes smoked with three machine-smoking conditions. Regulatory Toxicology and Pharmacology 41:185-227.
14. Diana, J. N., and Vaught, A. 1990. Research Cigarettes. Lexington, KY: University of Kentucky Printing Services.
15. Feldman, D. B., and Seely, J. C. 1988. Necropsy guide: rodents and the rabbit. Boca Raton, FL, CRC Press.
16. Friedrichs, B., Miert, E., and Vanscheeuwijck, P. 2006. Lung inflammation in rats following subchronic exposure to cigarette mainstream smoke. Experimental Lung Research 32:151-179.
17. Gaworski, C. L., Dozier, M. M., Heck, J. D., Gerhart, J. M., Rajendran, N., David, R. M., Brennecke, L. H., and Morrissey, R. 1998. Toxicologic evaluation of flavor ingredients added to cigarette tobacco: 13-week inhalation exposures in rats. Inhalation Toxicology 10:357-381.
18. Harrison, P. T. 1984. An ethanol-acetic acid-formol saline fixative for routine use with special application to the fixation of non-perfused rat lung. Laboratory Animals 18:325-331.
19. Haussmann, H.-J., Anskeit, E., Becker, D., Kuhl, P., Stinn, W., Teredesai, A., Voncken, P., and Walk, R.-A. 1998. Comparison of fresh and room-aged cigarette sidestream smoke in a subchronic inhalation study on rats. Toxicological Sciences 41:100-116.
20. Higuchi, M. A., Sagartz, J., Shreve, W. K., and Ayres, P. H. 2004. Comparative subchronic inhalation study of smoke from the 1R4F and 2R4F reference cigarettes. Inhalation Toxicology 16: 1-20.
21. Hotchkiss, J. A., Evans, W. A., Chen, B. T., Finch, G. L., and Harkema, J. R. 1995. Regional differences in the effects of mainstream cigarette smoke on stored mucosubstances and DNA synthesis in F344 rat nasal respiratory epithelium. Toxicology and Applied Pharmacology 131:316-324.
22. ISO. 1989. International Standard ISO 10315. Cigarettes - determination of nicotine in smoke condensates - gas chromatographic method Geneva, Switzerland.
23. ISO. 1991a. International Standard ISO 3308. Routine analytical cigarette-smoking machine. Definitions and standard conditions. Third edition. Geneva, Switzerland.
24. ISO. 1991b. International Standard ISO 3402. Tobacco and tobacco products. Atmosphere for conditioning and testing. Third edition. Geneva, Switzerland.
25. ISO. 1995a. International Standard ISO 8454. Cigarettes - determination of carbon monoxide in the vapour phase of cigarette smoke - NDIR method. Second edition. Geneva, Switzerland.
26. ISO. 1995b. International Standard ISO 10362-2. Cigarettes determination of water in smoke condensates - Part 2. Karl Fischer method. Geneva, Switzerland.
27. ISO. 2000. International Standard ISO 4387. Cigarettes - determination of total and nicotine free dry paniculate matter using a routine analytical smoking machine. Geneva, Switzerland.
28. Klimisch, H.-J., Meißner, K., and Wernicke, H. 1974. Quantitative determination of carbon monoxide in blood by gaschromatography. Zeitschrift fur Klinical Chemie und Klinical Biochemie 12:535-538.
29. Langard, S., and Nordhagen, A.-L. 1980. Small animal inhalation chambers and the significance of dust ingestion from the contaminated coat when exposing rats to zinc chromate. Acta Pharmacologica et Toxicologica 46:43-46.
30. Lemus, R., Carmines, E. L., Van Miert, E., Coggins, C. R. E., Anskeit, E., Gerstenberg, B., Meisgen, T. J., Schramke, H., Stabbert, R., Volkel, H., and Terpstra, P. M. 2007. Toxicological comparisons of cigarettes containing different amounts of vanillin. Inhalation Toxicology 19:683-699.
31. Lewis, D. J. 1981. Factors affecting the distribution of tobacco smoke-induced lesions in the rodent larynx. Toxicology Letters 9:189-194.
32. Lewis, D. J. 1991. Morphological assessment of pathological changes within the rat larynx. Toxicologic Pathology 19:352-357.
33. Loeb, W. F., and Quimby, F. W. 1999. Clinical chemistry of laboratory animals. Second ed. New York, Pergamon Press.
34. Maxwell, J. C. 2004. 2004 Maxwell Tobacco Fact Book. Raleigh, NC, SpecComm International Inc.
35. Nanni, E. J., Lovette, M. E., Hicks, R. D., Fowler, K. W., and Borgerding, M. F. 1990. Separation and quantitation of phenolic compounds in mainstream cigarette smoke by capillary gas chromatography with mass spectrometry in the selected-ion mode. Journal of Chromatography 505:365-374.
36. OECD. 1981. No. 413. Subchronic inhalation toxicity: 90-day study. In OECD Guidelines for the testing of chemicals. Paris, France.
37. OECD. 1997. No. 471. Bacterial reverse mutation test. In OECD guidelines for testing of chemicals. Paris, France.
38. Patskan, G., and Reininghaus, W. 2003. Toxicological evaluation of an electrically heated cigarette. Part 1: Overview of technical concepts and summary of findings. Journal of Applied Toxicology 23:323-328.
39. Ritter, D., Knebel, J., and Aufderheide, M. 2004. Comparative assessment of toxicities of mainstream smoke from commercial cigarettes. Inhalation Toxicology 16:691-700.
40. Roemer, E., Stabbert, R., Rustemeier, K., Veltel, D. J., Meisgen, T. J., Reininghaus, W., Carchman, R. A., Gaworski, C. L., and Podraza, K. F. 2004. Chemical composition, cytotoxicity and mutagenicity of smoke from US commercial and reference cigarettes smoked under two sets of machine smoking conditions. Toxicology 195: 31-52.
41. Roemer, E., Tewes, F. J., Meisgen, T. J., Veltel, D. J., and Carmines, E. L. 2002. Evaluation of the potential effects of ingredients added to cigarettes. Part 3: In vitro genotoxicity and cytotoxity. Food and Chemical Toxicology 40:105-111.
42. Rustemeier, K., Stabbert, R., Haussmann, H.-J., Roemer, E., and Carmines, E. L. 2002. Evaluation of the potential effects of ingredients added to cigarettes. Part 2: Chemical composition of mainstream smoke. Food and Chemical Toxicology 40:93-104.
43. Stabbert, R., Voncken, P., Rustemeier, K., Haussmann, H.-J., Roemer, E., Schaffernicht, H., and Patskan, G. 2003. Toxicological evaluation of an electrically heated cigarette. Part 2. Chemical composition of mainstream smoke. Journal of Applied Toxicology 23:329-339.
44. Steele, R. H., Payne, V. M., Fulp, C. W., Rees, D. C., Lee, C. K., and Doolittle, D. J. 1995. A comparison of the mutagenicity of mainstream cigarette smoke condensates from a representative sample of the U.S. cigarette market with a Kentucky reference cigarette (1R4F). Mutation Research 342:179-190.
45. Stinn, W., Teredesai, A., Anskeit, E., Rustemeier, K., Schepers, G., Schnell, P., Haussmann, H.-J., Carchman, R. A., Coggins, C. R. E., and Reininghaus, W. 2005. Chronic nose-only inhalation study in rats, comparing room-aged sidestream smoke and diesel engine exhaust. Inhalation Toxicology 17:549-576.
46. Stöber, W., and Flachsbart, H. 1969. Size-separating precipitation of aerosols in a spinning spiral duct. Journal of Environmental Science & Technology 3:1280-1296.
47. Terpstra, P. M., Teredesai, A., Vanscheeuwijck, P. M., Verbeeck, J., Schepers, G., Radtke, F., Kuhl, P., Gomm, W., Anskeit, E., and Patskan, G. 2003. Toxicological evaluation of an electrically heated cigarette. Part 4: subchronic inhalation toxicology. Journal of Applied Toxicology 23:349-362.
48. Tewes, F. J., Meisgen, T. J., Veltel, D. J., Roemer, E., and Patskan, G. 2003. Toxicological evaluation of an electrically heated cigarette. Part 3: genotoxicity and cytotoxicity of mainstream smoke. Journal of Applied Toxicology 23:341-348.
49. Vanscheeuwijck, P. M., Teredesai, A., Terpstra, P. M., Verbeek, J., Kuhl, P., Gerstenberg, B., Gebel, S., and Carmines, E. L. 2002. Evaluation of the potential effects of ingredients added to cigarettes. Part 4: subchronic inhalation toxicity. Food and Chemical Toxicology 40:113-131.
50. Young, J. T. 1981. Histopathological examination of the rat nasal cavity. Fundamental and Applied Toxicology 1:309-312.