메뉴 건너뛰기




Volumn 50, Issue 1, 2014, Pages 13-23

The genetics of Crohn's disease and ulcerative colitis-status quo and beyond

Author keywords

Chronic inflammation; Crohn's disease; Early onset IBD; Genetic risk; Genome wide association studies; Inflammatory bowel disease; Risk loci; SNP; Ulcerative colitis

Indexed keywords

GENETIC MARKER; HLA ANTIGEN;

EID: 84919443322     PISSN: 00365521     EISSN: 15027708     Source Type: Journal    
DOI: 10.3109/00365521.2014.990507     Document Type: Review
Times cited : (69)

References (83)
  • 1
    • 48349136889 scopus 로고    scopus 로고
    • Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
    • Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet 2008;40:955-62.
    • (2008) Nat Genet , vol.40 , pp. 955-962
    • Barrett, J.C.1    Hansoul, S.2    Nicolae, D.L.3    Cho, J.H.4    Duerr, R.H.5    Rioux, J.D.6
  • 2
    • 78649489009 scopus 로고    scopus 로고
    • Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
    • Franke A, McGovern DP, Barrett JC, Wang K, Radford-Smith GL, Ahmad T, et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet 2010;42:1118-25.
    • (2010) Nat Genet , vol.42 , pp. 1118-1125
    • Franke, A.1    McGovern, D.P.2    Barrett, J.C.3    Wang, K.4    Radford-Smith, G.L.5    Ahmad, T.6
  • 3
    • 79952195585 scopus 로고    scopus 로고
    • Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
    • Anderson CA, Boucher G, Lees CW, Franke A, D'Amato M, Taylor KD, et al. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet 2011;43: 246-52.
    • (2011) Nat Genet , vol.43 , pp. 246-252
    • Anderson, C.A.1    Boucher, G.2    Lees, C.W.3    Franke, A.4    D'Amato, M.5    Taylor, K.D.6
  • 4
    • 43249125992 scopus 로고    scopus 로고
    • Estimation of the multiple testing burden for genomewide association studies of nearly all common variants
    • Pe'er I, Yelensky R, Altshuler D, Daly MJ. Estimation of the multiple testing burden for genomewide association studies of nearly all common variants. Genet Epidemiol 2008;32: 381-5.
    • (2008) Genet Epidemiol , vol.32 , pp. 381-385
    • Pe'Er, I.1    Yelensky, R.2    Altshuler, D.3    Daly, M.J.4
  • 5
    • 84902292435 scopus 로고    scopus 로고
    • Genetic studies of Crohn's disease: Past, present and future
    • Liu JZ, Anderson CA. Genetic studies of Crohn's disease: past, present and future. Best Pract Res Clin Gastroenterol 2014;28:373-86.
    • (2014) Best Pract Res Clin Gastroenterol , vol.28 , pp. 373-386
    • Liu, J.Z.1    Anderson, C.A.2
  • 6
    • 79959216005 scopus 로고    scopus 로고
    • Genetics and pathogenesis of inflammatory bowel disease
    • Khor B, Gardet A, Xavier RJ. Genetics and pathogenesis of inflammatory bowel disease. Nature 2011;474:307-17.
    • (2011) Nature , vol.474 , pp. 307-317
    • Khor, B.1    Gardet, A.2    Xavier, R.J.3
  • 7
    • 77952574849 scopus 로고    scopus 로고
    • Uncovering the roles of rare variants in common disease through whole-genome sequencing
    • Cirulli ET, Goldstein DB. Uncovering the roles of rare variants in common disease through whole-genome sequencing. Nat Rev Genet 2010;11:415-25.
    • (2010) Nat Rev Genet , vol.11 , pp. 415-425
    • Cirulli, E.T.1    Goldstein, D.B.2
  • 8
    • 84868336049 scopus 로고    scopus 로고
    • Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
    • Jostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP, Hui KY, et al. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Nature 2012;491:119-24.
    • (2012) Nature , vol.491 , pp. 119-124
    • Jostins, L.1    Ripke, S.2    Weersma, R.K.3    Duerr, R.H.4    McGovern, D.P.5    Hui, K.Y.6
  • 9
    • 72549110486 scopus 로고    scopus 로고
    • Clustering in time of familial IBD separates ulcerative colitis from Crohn's disease
    • Bengtson MB, Solberg C, Aamodt G, Jahnsen J, Moum B, Sauar J, et al. Clustering in time of familial IBD separates ulcerative colitis from Crohn's disease. Inflamm Bowel Dis 2009;15:1867-74.
    • (2009) Inflamm Bowel Dis , vol.15 , pp. 1867-1874
    • Bengtson, M.B.1    Solberg, C.2    Aamodt, G.3    Jahnsen, J.4    Moum, B.5    Sauar, J.6
  • 10
    • 84882449068 scopus 로고    scopus 로고
    • Geneticinsights into common pathways and complex relationships among immune-mediated diseases
    • Parkes M, Cortes A, vanHeel DA, Brown MA. Geneticinsights into common pathways and complex relationships among immune-mediated diseases. Nat Rev Genet 2013;14:661-73.
    • (2013) Nat Rev Genet , vol.14 , pp. 661-673
    • Parkes, M.1    Cortes, A.2    Van Heel, D.A.3    Brown, M.A.4
  • 11
    • 80655149205 scopus 로고    scopus 로고
    • New IBD genetics: Common pathways with other diseases
    • Lees CW, Barrett JC, Parkes M, Satsangi J. New IBD genetics: common pathways with other diseases. Gut 2011; 60:1739-53.
    • (2011) Gut , vol.60 , pp. 1739-1753
    • Lees, C.W.1    Barrett, J.C.2    Parkes, M.3    Satsangi, J.4
  • 12
    • 80054975975 scopus 로고    scopus 로고
    • Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease
    • Rivas MA, Beaudoin M, Gardet A, Stevens C, Sharma Y, Zhang CK, et al. Deep resequencing of GWAS loci identifies independent rare variants associated with inflammatory bowel disease. Nat Genet 2011;43:1066-73.
    • (2011) Nat Genet , vol.43 , pp. 1066-1073
    • Rivas, M.A.1    Beaudoin, M.2    Gardet, A.3    Stevens, C.4    Sharma, Y.5    Zhang, C.K.6
  • 13
    • 78651225855 scopus 로고    scopus 로고
    • Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease
    • Momozawa Y, Mni M, Nakamura K, Coppieters W, Almer S, Amininejad L, et al. Resequencing of positional candidates identifies low frequency IL23R coding variants protecting against inflammatory bowel disease. Nat Genet 2011;43:43-7.
    • (2011) Nat Genet , vol.43 , pp. 43-47
    • Momozawa, Y.1    Mni, M.2    Nakamura, K.3    Coppieters, W.4    Almer, S.5    Amininejad, L.6
  • 14
    • 84884683078 scopus 로고    scopus 로고
    • Deep resequen-cing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis
    • Beaudoin M, Goyette P, Boucher G, et al. Deep resequen-cing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis. PLoS Genet 2013;9:e1003723.
    • (2013) PLoS Genet , vol.9 , pp. e1003723
    • Beaudoin, M.1    Goyette, P.2    Boucher, G.3
  • 15
    • 84929259010 scopus 로고    scopus 로고
    • Fine mapping of eight psoriasis susceptibility loci
    • Epub ahead of print] [Accessed 3 September 2014]
    • Das S, Stuart PE, Ding J, Tejasvi T, Li Y, Tsoi LC, et al. Fine mapping of eight psoriasis susceptibility loci. Eur J Hum Genet 2014. [Epub ahead of print] [Accessed 3 September 2014].
    • (2014) Eur J Hum Genet
    • Das, S.1    Stuart, P.E.2    Ding, J.3    Tejasvi, T.4    Li, Y.5    Tsoi, L.C.6
  • 16
    • 84861328957 scopus 로고    scopus 로고
    • Genetics of inflammatory bowel disease in Asia: Systematic review and meta-analysis
    • Ng SC, Tsoi KK, Kamm MA, Xia B, Wu J, Chan FK, et al. Genetics of inflammatory bowel disease in Asia: systematic review and meta-analysis. Inflamm Bowel Dis 2012;18: 1164-76.
    • (2012) Inflamm Bowel Dis , vol.18 , pp. 1164-1176
    • Ng, S.C.1    Tsoi, K.K.2    Kamm, M.A.3    Xia, B.4    Wu, J.5    Chan, F.K.6
  • 17
    • 11144354272 scopus 로고    scopus 로고
    • Inflammatory bowel disease susceptibility loci defined by genome scan meta-analysis of 1952 affected relative pairs
    • Van Heel DA, Fisher SA, Kirby A, Daly MJ, Rioux JD, Lewis CM; Genome Scan Meta-Analysis Group of the IBD International Genetics Consortium. Inflammatory bowel disease susceptibility loci defined by genome scan meta-analysis of 1952 affected relative pairs. Hum Mol Genet 2004;13:763-70.
    • (2004) Hum Mol Genet , vol.13 , pp. 763-770
    • Van Heel, D.A.1    Fisher, S.A.2    Kirby, A.3    Daly, M.J.4    Rioux, J.D.5    Lewis, C.M.6
  • 18
    • 84878802935 scopus 로고    scopus 로고
    • Imputing amino acid polymorphisms in human leukocyte antigens
    • Jia X, Han B, Onengut-Gumuscu S, Chen WM, et al. Imputing amino acid polymorphisms in human leukocyte antigens. PLoS One 2013;8(6):e64683.
    • (2013) PLoS One , vol.8 , Issue.6 , pp. e64683
    • Jia, X.1    Han, B.2    Onengut-Gumuscu, S.3    Chen, W.M.4
  • 19
    • 79953314023 scopus 로고    scopus 로고
    • HLA∗IMP-an integrated framework for imputing classical HLA alleles from SNP genotypes
    • Dilthey AT, Moutsianas L, Leslie S, McVean G. HLA∗IMP-an integrated framework for imputing classical HLA alleles from SNP genotypes. Bioinformatics 2011;27 (7):968-72.
    • (2011) Bioinformatics , vol.27 , Issue.7 , pp. 968-972
    • Dilthey, A.T.1    Moutsianas, L.2    Leslie, S.3    McVean, G.4
  • 20
    • 84859913926 scopus 로고    scopus 로고
    • Amino acid position 11 of HLA-DRbeta1 is a major determinant of chromosome 6p association with ulcerative colitis
    • Achkar JP, Klei L, de Bakker PI, Bellone G, Rebert N, Scott R, et al. Amino acid position 11 of HLA-DRbeta1 is a major determinant of chromosome 6p association with ulcerative colitis. Genes Immun 2012;13:245-52.
    • (2012) Genes Immun , vol.13 , pp. 245-252
    • Achkar, J.P.1    Klei, L.2    De Bakker, P.I.3    Bellone, G.4    Rebert, N.5    Scott, R.6
  • 21
    • 84887179037 scopus 로고    scopus 로고
    • Sequence analysis of T-cell repertoires in health and disease
    • Woodsworth DJ, Castellarin M, Holt RA. Sequence analysis of T-cell repertoires in health and disease. Genome Med 2013;5:98.
    • (2013) Genome Med , vol.5 , pp. 98
    • Woodsworth, D.J.1    Castellarin, M.2    Holt, R.A.3
  • 22
    • 10944270781 scopus 로고    scopus 로고
    • Identification of a naturally processed cyclin D1 T-helper epitope by a novel combination of HLA class II targeting and differential mass spectrometry
    • Dengjel J, Decker P, Schoor O, Altenberend F, Weinschenk T, Rammensee HG, et al. Identification of a naturally processed cyclin D1 T-helper epitope by a novel combination of HLA class II targeting and differential mass spectrometry. Eur J Immunol 2004;34:3644-51.
    • (2004) Eur J Immunol , vol.34 , pp. 3644-3651
    • Dengjel, J.1    Decker, P.2    Schoor, O.3    Altenberend, F.4    Weinschenk, T.5    Rammensee, H.G.6
  • 23
    • 84902281714 scopus 로고    scopus 로고
    • How will insights from genetics translate to clinical practice in inflammatory bowel disease?
    • Festen EA, Weersma RK. How will insights from genetics translate to clinical practice in inflammatory bowel disease? Best Pract Res Clin Gastroenterol 2014;28:387-97.
    • (2014) Best Pract Res Clin Gastroenterol , vol.28 , pp. 387-397
    • Festen, E.A.1    Weersma, R.K.2
  • 24
    • 84887421132 scopus 로고    scopus 로고
    • Monogenic diseases associated with intestinal inflammation: Implications for the understanding of inflammatory bowel disease
    • Uhlig HH. Monogenic diseases associated with intestinal inflammation: implications for the understanding of inflammatory bowel disease. Gut 2013;62:1795-805.
    • (2013) Gut , vol.62 , pp. 1795-1805
    • Uhlig, H.H.1
  • 27
    • 55049111426 scopus 로고    scopus 로고
    • Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility
    • Franke A, Balschun T, Karlsen TH, Sventoraityte J, Nikolaus S, Mayr G, et al. Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility. Nat Genet 2008;40:1319-23.
    • (2008) Nat Genet , vol.40 , pp. 1319-1323
    • Franke, A.1    Balschun, T.2    Karlsen, T.H.3    Sventoraityte, J.4    Nikolaus, S.5    Mayr, G.6
  • 29
    • 84926246638 scopus 로고    scopus 로고
    • XIAP variants in male Crohn's disease
    • [Epub ahead of print] [Accessed 26 February 2014]
    • Zeissig Y, Petersen BS, Milutinovic S, Bosse E, Mayr G, Peuker K, et al. XIAP variants in male Crohn's disease. Gut 2014. [Epub ahead of print] [Accessed 26 February 2014].
    • (2014) Gut
    • Zeissig, Y.1    Petersen, B.S.2    Milutinovic, S.3    Bosse, E.4    Mayr, G.5    Peuker, K.6
  • 30
  • 32
    • 84881030701 scopus 로고    scopus 로고
    • From genetics of inflammatory bowel disease towards mechanistic insights
    • Graham DB, Xavier RJ. From genetics of inflammatory bowel disease towards mechanistic insights. Trends Immunol 2013;34:371-8.
    • (2013) Trends Immunol , vol.34 , pp. 371-378
    • Graham, D.B.1    Xavier, R.J.2
  • 33
    • 33846627302 scopus 로고    scopus 로고
    • A genome-wide association scan of nonsynon-ymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
    • Hampe J, Franke A, Rosenstiel P, Till A, Teuber M, Huse K, et al. A genome-wide association scan of nonsynon-ymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet 2007;39:207-11.
    • (2007) Nat Genet , vol.39 , pp. 207-211
    • Hampe, J.1    Franke, A.2    Rosenstiel, P.3    Till, A.4    Teuber, M.5    Huse, K.6
  • 34
    • 56249135538 scopus 로고    scopus 로고
    • A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
    • Cadwell K, Liu JY, Brown SL, Miyoshi H, Loh J, Lennerz JK, et al. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 2008;456:259-63.
    • (2008) Nature , vol.456 , pp. 259-263
    • Cadwell, K.1    Liu, J.Y.2    Brown, S.L.3    Miyoshi, H.4    Loh, J.5    Lennerz, J.K.6
  • 35
    • 77953904042 scopus 로고    scopus 로고
    • Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine
    • Cadwell K, Patel KK, Maloney NS, Liu TC, Ng AC, Storer CE, et al. Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine. Cell 2010;141:1135-45.
    • (2010) Cell , vol.141 , pp. 1135-1145
    • Cadwell, K.1    Patel, K.K.2    Maloney, N.S.3    Liu, T.C.4    Ng, A.C.5    Storer, C.E.6
  • 37
    • 84908137655 scopus 로고    scopus 로고
    • Autophagy Gene Atg16l1 Prevents Lethal T Cell Alloreactivity Mediated by Dendritic Cells
    • Hubbard-Lucey VM, Shono Y, Maurer K, West ML, Singer NV, Ziegler CG, et al. Autophagy Gene Atg16l1 Prevents Lethal T Cell Alloreactivity Mediated by Dendritic Cells. Immunity 2014;41:579-91.
    • (2014) Immunity , vol.41 , pp. 579-591
    • Hubbard-Lucey, V.M.1    Shono, Y.2    Maurer, K.3    West, M.L.4    Singer, N.V.5    Ziegler, C.G.6
  • 38
    • 84896730900 scopus 로고    scopus 로고
    • A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3
    • Murthy A, Li Y, Peng I, Reichelt M, Katakam AK, Noubade R, et al. A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3. Nature 2014;506: 456-62.
    • (2014) Nature , vol.506 , pp. 456-462
    • Murthy, A.1    Li, Y.2    Peng, I.3    Reichelt, M.4    Katakam, A.K.5    Noubade, R.6
  • 40
    • 56249090667 scopus 로고    scopus 로고
    • Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production
    • Saitoh T, Fujita N, Jang MH, Uematsu S, Yang BG, Satoh T, et al. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature 2008;456:264-8.
    • (2008) Nature , vol.456 , pp. 264-268
    • Saitoh, T.1    Fujita, N.2    Jang, M.H.3    Uematsu, S.4    Yang, B.G.5    Satoh, T.6
  • 41
    • 84885575846 scopus 로고    scopus 로고
    • Genetic factors conferring an increased susceptibility to develop Crohn's disease also influence disease phenotype: Results from the IBDchip European Project
    • Cleynen I, Gonzalez JR, Figueroa C, Franke A, McGovern D, Bortlík M, et al. Genetic factors conferring an increased susceptibility to develop Crohn's disease also influence disease phenotype: results from the IBDchip European Project. Gut 2013;62:1556-65.
    • (2013) Gut , vol.62 , pp. 1556-1565
    • Cleynen, I.1    Gonzalez, J.R.2    Figueroa, C.3    Franke, A.4    McGovern, D.5    Bortlík, M.6
  • 42
    • 82755175640 scopus 로고    scopus 로고
    • Genetic risk prediction in complex disease
    • Jostins L, Barrett JC. Genetic risk prediction in complex disease. Hum Mol Genet 2011;20:R182-8.
    • (2011) Hum Mol Genet , vol.20 , pp. R182-R188
    • Jostins, L.1    Barrett, J.C.2
  • 43
    • 84877707375 scopus 로고    scopus 로고
    • One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering
    • Wang H, Yang H, Shivalila CS, Dawlaty MM, Cheng AW, Zhang F, et al. One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell 2013;153:910-18.
    • (2013) Cell , vol.153 , pp. 910-918
    • Wang, H.1    Yang, H.2    Shivalila, C.S.3    Dawlaty, M.M.4    Cheng, A.W.5    Zhang, F.6
  • 44
    • 84865790047 scopus 로고    scopus 로고
    • An integrated encyclopedia of DNA elements in the human genome
    • Consortium EP. An integrated encyclopedia of DNA elements in the human genome. Nature 2012;489:57-74.
    • (2012) Nature , vol.489 , pp. 57-74
    • Consortium, E.P.1
  • 45
    • 84865822182 scopus 로고    scopus 로고
    • Systematic localization of common disease-associated variation in regulatory DNA
    • Maurano MT, Humbert R, Rynes E, Thurman RE, Haugen E, Wang H, et al. Systematic localization of common disease-associated variation in regulatory DNA. Science 2012;337:1190-5.
    • (2012) Science , vol.337 , pp. 1190-1195
    • Maurano, M.T.1    Humbert, R.2    Rynes, E.3    Thurman, R.E.4    Haugen, E.5    Wang, H.6
  • 46
    • 84880617946 scopus 로고    scopus 로고
    • Association between variants of PRDM1 and NDP52 and Crohn's disease, basedonexome sequencing and functional studies
    • Ellinghaus D, Zhang H, Zeissig S, Lipinski S, Till A, Jiang T, et al. Association between variants of PRDM1 and NDP52 and Crohn's disease, basedonexome sequencing and functional studies. Gastroenterology 2013;145:339-47.
    • (2013) Gastroenterology , vol.145 , pp. 339-347
    • Ellinghaus, D.1    Zhang, H.2    Zeissig, S.3    Lipinski, S.4    Till, A.5    Jiang, T.6
  • 47
    • 50449091647 scopus 로고    scopus 로고
    • Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease
    • McCarroll SA, Huett A, Kuballa P, Chilewski SD, Landry A, Goyette P, et al. Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease. Nat Genet 2008;40:1107-12.
    • (2008) Nat Genet , vol.40 , pp. 1107-1112
    • McCarroll, S.A.1    Huett, A.2    Kuballa, P.3    Chilewski, S.D.4    Landry, A.5    Goyette, P.6
  • 48
    • 84884611024 scopus 로고    scopus 로고
    • Integrative modeling of eQTLs and cis-regulatory elements suggests mechanisms underlying cell type specificity of eQTLs
    • Brown CD, Mangravite LM, Engelhardt BE. Integrative modeling of eQTLs and cis-regulatory elements suggests mechanisms underlying cell type specificity of eQTLs. PLoS Genet 2013;9:e1003649.
    • (2013) PLoS Genet , vol.9 , pp. e1003649
    • Brown, C.D.1    Mangravite, L.M.2    Engelhardt, B.E.3
  • 50
    • 77952557918 scopus 로고    scopus 로고
    • Missing heritability and strategies for finding the underlying causes of complex disease
    • Eichler EE, Flint J, Gibson G, Kong A, Leal SM, Moore JH, et al. Missing heritability and strategies for finding the underlying causes of complex disease. Nat Rev Genet 2010;11:446-50.
    • (2010) Nat Rev Genet , vol.11 , pp. 446-450
    • Eichler, E.E.1    Flint, J.2    Gibson, G.3    Kong, A.4    Leal, S.M.5    Moore, J.H.6
  • 51
    • 33947310031 scopus 로고    scopus 로고
    • Environmental epigenomics and disease susceptibility
    • Jirtle RL, Skinner MK. Environmental epigenomics and disease susceptibility. Nat Rev Genet 2007;8:253-62.
    • (2007) Nat Rev Genet , vol.8 , pp. 253-262
    • Jirtle, R.L.1    Skinner, M.K.2
  • 52
    • 78650446334 scopus 로고    scopus 로고
    • Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals
    • Carone BR, Fauquier L, Habib N, Shea JM, Hart CE, Li R, et al. Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals. Cell 2010;143:1084-96.
    • (2010) Cell , vol.143 , pp. 1084-1096
    • Carone, B.R.1    Fauquier, L.2    Habib, N.3    Shea, J.M.4    Hart, C.E.5    Li, R.6
  • 53
    • 84895893232 scopus 로고    scopus 로고
    • Epigenetics: The sins of the father
    • Hughes V. Epigenetics: The sins of the father. Nature 2014; 507:22-4.
    • (2014) Nature , vol.507 , pp. 22-24
    • Hughes, V.1
  • 54
    • 84893691607 scopus 로고    scopus 로고
    • Parental olfactory experience influences behavior and neural structure in subsequent generations
    • Dias BG, Ressler KJ. Parental olfactory experience influences behavior and neural structure in subsequent generations. Nat Neurosci 2014;17:89-96.
    • (2014) Nat Neurosci , vol.17 , pp. 89-96
    • Dias, B.G.1    Ressler, K.J.2
  • 55
    • 84906088773 scopus 로고    scopus 로고
    • Utero effects. in utero undernourishment perturbs the adult sperm methylome and intergenera-tional metabolism
    • Radford EJ, Ito M, Shi H, Corish JA, Yamazawa K, Isganaitis E, et al. In utero effects. In utero undernourishment perturbs the adult sperm methylome and intergenera-tional metabolism. Science 2014;345:1255903.
    • (2014) Science , vol.345 , pp. 1255903
    • Radford, E.J.1    Ito, M.2    Shi, H.3    Corish, J.A.4    Yamazawa, K.5    Isganaitis, E.6
  • 56
    • 84877696605 scopus 로고    scopus 로고
    • Sperm, but not oocyte, DNA methylome is inherited by zebrafish early embryos
    • Jiang L, Zhang J, Wang JJ, Wang L, Zhang L, Li G, et al. Sperm, but not oocyte, DNA methylome is inherited by zebrafish early embryos. Cell 2013;153:773-84.
    • (2013) Cell , vol.153 , pp. 773-784
    • Jiang, L.1    Zhang, J.2    Wang, J.J.3    Wang, L.4    Zhang, L.5    Li, G.6
  • 57
    • 84887980478 scopus 로고    scopus 로고
    • Ancestral dichlorodiphenyltrichlor-oethane (DDT) exposure promotes epigenetic transgenera-tional inheritance of obesity
    • Skinner MK, Manikkam M, Tracey R, Guerrero-Bosagna C, Haque M, Nilsson EE. Ancestral dichlorodiphenyltrichlor-oethane (DDT) exposure promotes epigenetic transgenera-tional inheritance of obesity. BMC Med 2013;11:228.
    • (2013) BMC Med , vol.11 , pp. 228
    • Skinner, M.K.1    Manikkam, M.2    Tracey, R.3    Guerrero-Bosagna, C.4    Haque, M.5    Nilsson, E.E.6
  • 60
    • 70749123464 scopus 로고    scopus 로고
    • Towards a molecular risk map-recent advances onthe etiologyof inflammatory bowel disease
    • Rosenstiel P, Sina C, Franke A, Schreiber S. Towards a molecular risk map-recent advances onthe etiologyof inflammatory bowel disease. Semin Immunol 2009;21:334-45.
    • (2009) Semin Immunol , vol.21 , pp. 334-345
    • Rosenstiel, P.1    Sina, C.2    Franke, A.3    Schreiber, S.4
  • 61
    • 82755168804 scopus 로고    scopus 로고
    • Colonic mucosa-associated microbiota is influenced by an interaction of Crohn disease and FUT2 (Secretor) genotype
    • Rausch P, Rehman A, Kunzel S, Häsler R, Ott SJ, Schreiber S, et al. Colonic mucosa-associated microbiota is influenced by an interaction of Crohn disease and FUT2 (Secretor) genotype. Proc Natl Acad Sci USA 2011;108: 19030-5.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 19030-19035
    • Rausch, P.1    Rehman, A.2    Kunzel, S.3    Häsler, R.4    Ott, S.J.5    Schreiber, S.6
  • 62
    • 84876889703 scopus 로고    scopus 로고
    • The impact of Crohn's disease genes on healthy human gut microbiota: A pilot study
    • Quince C, Lundin EE, Andreasson AN, Greco D, Rafter J, Talley NJ, et al. The impact of Crohn's disease genes on healthy human gut microbiota: a pilot study. Gut 2013;62: 952-4.
    • (2013) Gut , vol.62 , pp. 952-954
    • Quince, C.1    Lundin, E.E.2    Andreasson, A.N.3    Greco, D.4    Rafter, J.5    Talley, N.J.6
  • 63
  • 64
    • 33845340501 scopus 로고    scopus 로고
    • A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
    • Duerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS, Daly MJ, et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 2006; 314:1461-3.
    • (2006) Science , vol.314 , pp. 1461-1463
    • Duerr, R.H.1    Taylor, K.D.2    Brant, S.R.3    Rioux, J.D.4    Silverberg, M.S.5    Daly, M.J.6
  • 65
    • 37249034766 scopus 로고    scopus 로고
    • Systematic association mapping identifies NELL1 as a novel IBD disease gene
    • Franke A, Hampe J, Rosenstiel P, Becker C, Wagner F, Häsler R, et al. Systematic association mapping identifies NELL1 as a novel IBD disease gene. PLoS One 2007;2:e691.
    • (2007) PLoS One , vol.2 , pp. e691
    • Franke, A.1    Hampe, J.2    Rosenstiel, P.3    Becker, C.4    Wagner, F.5    Häsler, R.6
  • 66
    • 35548958718 scopus 로고    scopus 로고
    • Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci
    • Raelson JV, Little RD, Ruether A, Fournier H, Paquin B, Van Eerdewegh P, et al. Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci. Proc Natl Acad Sci USA 2007;104:14747-52.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 14747-14752
    • Raelson, J.V.1    Little, R.D.2    Ruether, A.3    Fournier, H.4    Paquin, B.5    Van Eerdewegh, P.6
  • 67
    • 34247579326 scopus 로고    scopus 로고
    • Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4
    • Libioulle C, Louis E, Hansoul S, Sandor C, Farnir F, Franchimont D, et al. Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4. PLoS Genet 2007;3:e58.
    • (2007) PLoS Genet , vol.3 , pp. e58
    • Libioulle, C.1    Louis, E.2    Hansoul, S.3    Sandor, C.4    Farnir, F.5    Franchimont, D.6
  • 68
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wide association study of 14, 000 cases of seven common diseases and 3, 000 shared controls
    • The Welcome Trust Case Control Consortium. Genome-wide association study of 14, 000 cases of seven common diseases and 3, 000 shared controls. Nature 2007;447: 661-78.
    • (2007) Nature , vol.447 , pp. 661-678
  • 69
    • 44349136821 scopus 로고    scopus 로고
    • Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
    • Fisher SA, Tremelling M, Anderson CA, Gwilliam R, Bumpstead S, Prescott NJ, et al. Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease. Nat Genet 2008;40: 710-12.
    • (2008) Nat Genet , vol.40 , pp. 710-712
    • Fisher, S.A.1    Tremelling, M.2    Anderson, C.A.3    Gwilliam, R.4    Bumpstead, S.5    Prescott, N.J.6
  • 71
    • 59149087627 scopus 로고    scopus 로고
    • Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study
    • Silverberg MS, Cho JH, Rioux JD, McGovern DP, Wu J, Annese V, et al. Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. Nat Genet 2009;41:216-20.
    • (2009) Nat Genet , vol.41 , pp. 216-220
    • Silverberg, M.S.1    Cho, J.H.2    Rioux, J.D.3    McGovern, D.P.4    Wu, J.5    Annese, V.6
  • 72
    • 70649086082 scopus 로고    scopus 로고
    • A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population
    • Asano K, Matsushita T, Umeno J, Hosono N, Takahashi A, Kawaguchi T, et al. A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population. Nat Genet 2009;41:1325-9.
    • (2009) Nat Genet , vol.41 , pp. 1325-1329
    • Asano, K.1    Matsushita, T.2    Umeno, J.3    Hosono, N.4    Takahashi, A.5    Kawaguchi, T.6
  • 73
    • 70649103789 scopus 로고    scopus 로고
    • Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region
    • Consortium UIG. Barrett JC, Lee JC, Lees CW, Prescott NJ, Anderson CA, Phillips A, et al. Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. Nat Genet 2009;41: 1330-4.
    • (2009) Nat Genet , vol.41 , pp. 1330-1334
    • Barrett, J.C.1    Lee, J.C.2    Lees, C.W.3    Prescott, N.J.4    Anderson, C.A.5    Phillips, A.6
  • 75
    • 77950296637 scopus 로고    scopus 로고
    • Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL)
    • Franke A, Balschun T, Sina C, Ellinghaus D, Häsler R, Mayr G, et al. Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL). Nat Genet 2010;42:292-4.
    • (2010) Nat Genet , vol.42 , pp. 292-294
    • Franke, A.1    Balschun, T.2    Sina, C.3    Ellinghaus, D.4    Häsler, R.5    Mayr, G.6
  • 76
    • 77952480892 scopus 로고    scopus 로고
    • Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects
    • Wang K, Baldassano R, Zhang H, Qu HQ, Imielinski M, Kugathasan S, et al. Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects. Hum Mol Genet 2010;19:2059-67.
    • (2010) Hum Mol Genet , vol.19 , pp. 2059-2067
    • Wang, K.1    Baldassano, R.2    Zhang, H.3    Qu, H.Q.4    Imielinski, M.5    Kugathasan, S.6
  • 77
    • 77950298959 scopus 로고    scopus 로고
    • Genome-wide association identifies multiple ulcerative colitis susceptibility loci
    • McGovern DP, Gardet A, Torkvist L, Goyette P, Essers J, Taylor KD, et al. Genome-wide association identifies multiple ulcerative colitis susceptibility loci. NatGenet 2010;42:332-7.
    • (2010) NatGenet , vol.42 , pp. 332-337
    • McGovern, D.P.1    Gardet, A.2    Torkvist, L.3    Goyette, P.4    Essers, J.5    Taylor, K.D.6
  • 78
    • 84859253322 scopus 로고    scopus 로고
    • A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci
    • Kenny EE, Pe'er I, Karban A, Ozelius L, Mitchell AA, Ng SM, et al. A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. PLoS Genet 2012;8:e1002559.
    • (2012) PLoS Genet , vol.8 , pp. e1002559
    • Kenny, E.E.1    Pe'Er, I.2    Karban, A.3    Ozelius, L.4    Mitchell, A.A.5    Ng, S.M.6
  • 79
    • 84878550316 scopus 로고    scopus 로고
    • A genome-wide association study on a southern European population identifies a new Crohn's disease susceptibility locus at RBX1-EP300
    • Julia A, Domenech E, Ricart E, Tortosa R, García-Sánchez V, Gisbert JP, et al. A genome-wide association study on a southern European population identifies a new Crohn's disease susceptibility locus at RBX1-EP300. Gut 2013;62: 1440-5.
    • (2013) Gut , vol.62 , pp. 1440-1445
    • Julia, A.1    Domenech, E.2    Ricart, E.3    Tortosa, R.4    García-Sánchez, V.5    Gisbert, J.P.6
  • 80
    • 84875234775 scopus 로고    scopus 로고
    • A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population
    • Yamazaki K, Umeno J, Takahashi A, Hirano A, Johnson TA, Kumasaka N, et al. A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population. Gastroenterology 2013;144:781-8.
    • (2013) Gastroenterology , vol.144 , pp. 781-788
    • Yamazaki, K.1    Umeno, J.2    Takahashi, A.3    Hirano, A.4    Johnson, T.A.5    Kumasaka, N.6
  • 81
    • 84889680996 scopus 로고    scopus 로고
    • Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations
    • Yang SK, Hong M, Zhao W, Jung Y, Baek J, Tayebi N, et al. Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations. Gut 2014;63:80-7.
    • (2014) Gut , vol.63 , pp. 80-87
    • Yang, S.K.1    Hong, M.2    Zhao, W.3    Jung, Y.4    Baek, J.5    Tayebi, N.6
  • 82
    • 84919428213 scopus 로고    scopus 로고
    • A genome-wide association study identifies a novel locus at 6q22.1 associated with ulcerative colitis
    • [Epub ahead of print] [Accessed 29 July 2014]
    • Julia A, Domenech E, Chaparro M, García-Sánchez V, Gomollón F, Panés J, et al. A genome-wide association study identifies a novel locus at 6q22.1 associated with ulcerative colitis. Hum Mol Genet 2014. [Epub ahead of print] [Accessed 29 July 2014].
    • (2014) Hum Mol Genet
    • Julia, A.1    Domenech, E.2    Chaparro, M.3    García-Sánchez, V.4    Gomollón, F.5    Panés, J.6
  • 83
    • 77957867461 scopus 로고    scopus 로고
    • Genes and environment: How will our concepts on the pathophysiology of IBD develop in the future?
    • Kaser A, Zeissig S, Blumberg RS. Genes and environment: how will our concepts on the pathophysiology of IBD develop in the future? Dig Dis 2010;28:395-405.
    • (2010) Dig Dis , vol.28 , pp. 395-405
    • Kaser, A.1    Zeissig, S.2    Blumberg, R.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.