Clustering in time of familial IBD separates ulcerative colitis from Crohn's Disease

Inflammatory Bowel Diseases

Volumn 15, Issue 12, 2009, Pages 1867-1874

  Bengtson, May Bente ^a   Solberg, Camilla ^b   Aamodt, Geir ^c   Jahnsen, Jørgen ^d   Bjørn, Moum ^d   Sauar, Jostein ^e   Vatn, Morten H ^f,g  

^a Medical Department   (Norway)

^b ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

^c Norwegian Directorate of Health   (Norway)

^d AKER UNIVERSITY HOSPITAL   (Norway)

^e Telemark Hospital   (Norway)

^f OSLO METROPOLITAN UNIVERSITY   (Norway)

^g OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Clustering in time of diagnosis; Concordance of disease; Genetic anticipation; Inflammatory bowel disease; Shared environment

Indexed keywords

ADOLESCENT; ADULT; AGE DISTRIBUTION; AGED; ARTICLE; CHILD; CHILD PARENT RELATION; CLINICAL FEATURE; CLUSTER ANALYSIS; COLON RESECTION; CONTROLLED STUDY; CROHN DISEASE; ENTERITIS; FAMILIAL DISEASE; FEMALE; FOLLOW UP; GENETIC SUSCEPTIBILITY; HUMAN; INFANT; INTERVIEW; INTESTINE RESECTION; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD; NORWAY; ONSET AGE; PHENOTYPE; PRIORITY JOURNAL; SIBLING RELATION; SMOKING HABIT; ULCERATIVE COLITIS;

ADULT; CLUSTER ANALYSIS; COHORT STUDIES; COLITIS, ULCERATIVE; CROHN DISEASE; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INCIDENCE; MALE; MIDDLE AGED; NORWAY; SMOKING; YOUNG ADULT;

EID: 72549110486     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1002/ibd.20978     Document Type: Article

References (39)

1. Halfvarson J, Bodin L, Tysk C, et al. Inflammatory bowel disease in a Swedish twin cohort: a long-term follow-up of concordance and clinical characteristics. Gastroenterology. 2003;124:1767-1773. (Pubitemid 36666773)
2. Monsen U, Brostrom O, Nordenvall B, et al. Prevalence of inflammatory bowel disease among relatives of patients with ulcerative colitis. Scand J Gastroenterol. 1987;22:214-218. (Pubitemid 17024407)
3. Monsen U, Bernell O, Johansson C, et al. Prevalence of inflammatory bowel disease among relatives of patients with Crohn's disease. Scand J Gastroenterol. 1991;26:302-306.
4. Orholm M, Munkholm P, Langholz E, et al. Familial occurrence of inflammatory bowel disease. N Engl J Med. 1991;324:84-88.
5. Orholm M, Binder V, Sorensen TI, et al. Concordance of inflammatory bowel disease among Danish twins. Results of a nationwide study. Scand J Gastroenterol. 2000;35:1075-1081. (Pubitemid 30836260)
6. Yang H, McElree C, Roth MP, et al. Familial empirical risks for inflammatory bowel disease: differences between Jews and non-Jews. Gut. 1993;34:517-524. (Pubitemid 23093496)
7. Bonen DK, Cho JH. The genetics of inflammatory bowel disease. Gastroenterology. 2003;124:521-536.
8. Karban AS, Okazaki T, Panhuysen CI, et al. Functional annotation of a novel NFKB1 promoter polymorphism that increases risk for ulcerative colitis. Hum Mol Genet. 2004;13:35-45. (Pubitemid 38072133)
9. Yamamoto-Furusho JK. Genetic factors associated with the development of inflammatory bowel disease. World J Gastroenterol. 2007;13:5594-5597. (Pubitemid 350031479)
10. Hugot JP, Laurent-Puig P, Gower-Rousseau C, et al. Mapping of a susceptibility locus for Crohn's disease on chromosome 16. Nature. 1996;379:821-823. (Pubitemid 26067722)
11. Hugot JP, Chamaillard M, Zouali H, et al. Association of NOD2 leucine- rich repeat variants with susceptibility to Crohn's disease. Nature. 2001;411:599-603. (Pubitemid 32531408)
12. Lee JC, Bridger S, McGregor C, et al. Why children with inflammatory bowel disease are diagnosed at a younger age than their affected parent. Gut. 1999;44:808-811. (Pubitemid 29244215)
13. Satsangi J, Grootscholten C, Holt H, et al. Clinical patterns of familial inflammatory bowel disease. Gut. 1996;38:738-741. (Pubitemid 26167483)
14. Lee JC, Lennard-Jones JE. Inflammatory bowel disease in 67 families each with three or more affected first-degree relatives. Gastroenterology. 1996;111:587-596.
15. Moum B, Vatn MH, Ekbom A, et al. Incidence of ulcerative colitis and indeterminate colitis in four counties of southeastern Norway, 1990-1993. A prospective population-based study. The Inflammatory Bowel South-Eastern Norway (IBSEN) Study Group of Gastroenterologists. Scand J Gastroenterol. 1996;31:362-366.
16. Moum B, Vatn MH, Ekbom A, et al. Incidence of Crohn's disease in four counties in southeastern Norway, 1990-1993. A prospective population-based study. The Inflammatory Bowel South-Eastern Norway (IBSEN) Study Group of Gastroenterologists. Scand J Gastroenterol. 1996;31:355-361.
17. Gasche C, Scholmerich J, Brynskov J, et al. A simple classification of Crohn's disease: report of the Working Party for the World Congresses of Gastroenterology, Vienna 1998. Inflamm Bowel Dis. 2000;6:8-15.
18. Cohen J. A coefficient of agreement for nominal scales. Educat Psychol Measure. 1960;20:37-46.
19. Peeters M, Nevens H, Baert F, et al. Familial aggregation in Crohn's disease: increased age-adjusted risk and concordance in clinical characteristics. Gastroenterology. 1996;111:597-603. (Pubitemid 26293222)
20. Polito JM, Childs B, Mellits ED, et al. Crohn's disease: influence of age at diagnosis on site and clinical type of disease. Gastroenterology. 1996;111:580-586. (Pubitemid 26293220)
21. Colombel JF, Grandbastien B, Gower-Rousseau C, et al. Clinical characteristics of Crohn's disease in 72 families. Gastroenterology. 1996;111:604-607. (Pubitemid 26293223)
22. Faybush EM, Blanchard JF, Rawsthorne P, et al. Generational differences in the age at diagnosis with IBD: genetic anticipation, bias, or temporal effects. Am J Gastroenterol. 2002;97:636-640. (Pubitemid 34245892)
23. Hodge SE, Wickramaratne P. Statistical pitfalls in detecting age-ofonset anticipation: the role of correlation in studying anticipation and detecting ascertainment bias. Psychiatr Genet. 1995;5:43-47.
24. Grandbastien B, Peeters M, Franchimont D, et al. Anticipation in familial Crohn's disease. Gut. 1998;42:170-174.
25. Rabinowitz D, Betensky RA. Testing for familial correlation in ageat- onset. Biostatistics. 2002;3:77-85. (Pubitemid 34374244)
26. Ashley CT Jr, Warren ST. Trinucleotide repeat expansion and human disease. Annu Rev Genet. 1995;29:703-728.
27. Lindblad K, Nylander PO, De bA, et al. Detection of expanded CAG repeats in bipolar affective disorder using the repeat expansion detection (RED) method. Neurobiol Dis. 1995;2:55-62.
28. Fraga MF, Ballestar E, Paz MF, et al. Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci U S A. 2005;102:10604-10609. (Pubitemid 41061601)
29. Brignola C, Belloli C, Ardizzone S, et al. The relationship between heritability and smoking habits in Crohn's disease. Italian Cooperative Study Group. Am J Gastroenterol. 2000;95:3171-3175.
30. Louis E, Michel V, Hugot JP, et al. Early development of stricturing or penetrating pattern in Crohn's disease is influenced by disease location, number of flares, and smoking but not by NOD2/CARD15 genotype. Gut. 2003;52:552-557.
31. Bridger S, Lee JC, Bjarnason I, et al. In siblings with similar genetic susceptibility for inflammatory bowel disease, smokers tend to develop Crohn's disease and non-smokers develop ulcerative colitis. Gut. 2002;51:21-25.
32. Comes MC, Gower-Rousseau C, Colombel JF, et al. Inflammatory bowel disease in married couples: 10 cases in Nord Pas de Calais region of France and Liege county of Belgium. Gut. 1994;35:1316-1318. (Pubitemid 24277352)
33. Laharie D, Debeugny S, Peeters M, et al. Inflammatory bowel disease in spouses and their offspring. Gastroenterology. 2001;120:816-819. (Pubitemid 32193177)
34. Rabinowitz D, Yang Q. Testing for age-at-onset anticipation with affected parent-child pairs. Biometrics. 1999;55:834-838. (Pubitemid 29427085)
35. Heiman GA, Hodge SE, Wickramaratne P, et al. Age-at-interview bias in anticipation studies: computer simulations and an example with panic disorder. Psychiatr Genet. 1996;6:61-66. (Pubitemid 26290130)
36. Carbonnel F, Macaigne G, Beaugerie L, et al. Crohn's disease severity in familial and sporadic cases. Gut. 1999;44:91-95. (Pubitemid 29143286)
37. Willoughby CP, Truelove SC. Ulcerative colitis and pregnancy. Gut. 1980;21:469-474.
38. Baird DD, Narendranathan M, Sandler RS. Increased risk of preterm birth for women with inflammatory bowel disease. Gastroenterology. 1990;99:987-994. (Pubitemid 20338455)
39. Hudson M, Flett G, Sinclair TS, et al. Fertility and pregnancy in inflammatory bowel disease. Int J Gynaecol Obstet. 1997;58:229-237. (Pubitemid 27281303)